{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:24:19Z","timestamp":1782361459833,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["JYTZD2023194"],"award-info":[{"award-number":["JYTZD2023194"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2002004"],"award-info":[{"award-number":["XLYC2002004"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.joim.2025.12.004","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:40:10Z","timestamp":1765593610000},"page":"210-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aconitum coreanum (H.L\u00e9v l.) Rapaics exerts neuroprotective effects on cerebral ischemic stroke by inhibiting autophagy through the AMPK\/mTOR\/ULK1 pathway"],"prefix":"10.1016","volume":"24","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12916-019-1397-3","article-title":"Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017","volume":"17","author":"Avan","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.joim.2025.12.004_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116889","article-title":"The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: a supplementary strategy to endovascular thrombectomy","volume":"236","author":"Yang","year":"2019","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.joim.2025.12.004_b0015","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/CIRCRESAHA.116.308427","article-title":"Cerebral vascular disease and neurovascular injury in ischemic stroke","volume":"120","author":"Hu","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.joim.2025.12.004_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106896","article-title":"Apolipoproteins in ischemic stroke progression and recovery: key molecular mechanisms and therapeutic potential","volume":"209","author":"Etuze","year":"2025","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.joim.2025.12.004_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105458","article-title":"Stroke: molecular mechanisms and therapies\u2014update on recent developments","volume":"162","author":"Shehjar","year":"2023","journal-title":"Neurochem Int"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5853\/jos.2019.00584","article-title":"tPA helpers in the treatment of acute ischemic stroke: are they ready for clinical use?","volume":"21","author":"Kim","year":"2019","journal-title":"J Stroke"},{"key":"10.1016\/j.joim.2025.12.004_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107216","article-title":"Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: potential mechanisms, targets, therapeutic drugs and biomarkers","volume":"90","author":"Ma","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.joim.2025.12.004_b0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.wneu.2017.01.091","article-title":"Risk Factors for hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: a retrospective single-center study","volume":"101","author":"Xu","year":"2017","journal-title":"World Neurosurg"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.expneurol.2012.09.003","article-title":"Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial","volume":"238","author":"Culman","year":"2012","journal-title":"Exp Neurol"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/jcbfm.2013.203","article-title":"Hemorrhagic transformation after ischemic stroke in animals and humans","volume":"34","author":"Jickling","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.joim.2025.12.004_b0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ijcard.2017.03.129","article-title":"Increased arterial stiffness is an independent risk factor for hemorrhagic transformation in ischemic stroke undergoing thrombolysis","volume":"243","author":"Acampa","year":"2017","journal-title":"Int J Cardiol"},{"issue":"9958","key":"10.1016\/j.joim.2025.12.004_b0060","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(14)60584-5","article-title":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials","volume":"384","author":"Emberson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.joim.2025.12.004_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153526","article-title":"Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK\/mTOR-mediated autophagy","volume":"85","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.joim.2025.12.004_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113684","article-title":"An updated review of autophagy in ischemic stroke: from mechanisms to therapies","volume":"340","author":"Wang","year":"2021","journal-title":"Exp Neurol"},{"key":"10.1016\/j.joim.2025.12.004_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.641157","article-title":"Oxidative stress, inflammation, and autophagy: potential targets of mesenchymal stem cells-based therapies in ischemic stroke","volume":"15","author":"He","year":"2021","journal-title":"Front Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.joim.2025.12.004_b0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/ars.2006.8.185","article-title":"Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy","volume":"8","author":"Butler","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.joim.2025.12.004_b0085","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","volume":"163\u2013164","author":"Wang","year":"2018","journal-title":"Prog Neurobiol"},{"issue":"5","key":"10.1016\/j.joim.2025.12.004_b0090","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.2353\/ajpath.2009.090463","article-title":"Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms","volume":"175","author":"Ginet","year":"2009","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.joim.2025.12.004_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051469","article-title":"Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra","volume":"7","author":"Pamenter","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10571-017-0505-1","article-title":"Shear stress induces phenotypic modulation of vascular smooth muscle cells via AMPK\/mTOR\/ULK1-mediated autophagy","volume":"38","author":"Sun","year":"2018","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.joim.2025.12.004_b0105","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4103\/1673-5374.233441","article-title":"Puerarin protects rat brain against ischemia\/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway","volume":"13","author":"Wang","year":"2018","journal-title":"Neural Regen Res"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0110","article-title":"Enzyme-based autophagy in anti-neoplastic management: from molecular mechanisms to clinical therapeutics","volume":"1874","author":"Ajoolabady","year":"2020","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.joim.2025.12.004_b0115","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/1073858411404948","article-title":"Neuronal autophagy as a mediator of life and death: contrasting roles in chronic neurodegenerative and acute neural disorders","volume":"18","author":"Puyal","year":"2012","journal-title":"Neuroscientist"},{"issue":"8","key":"10.1016\/j.joim.2025.12.004_b0120","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.joim.2025.12.004_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.joim.2025.12.004_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107229","article-title":"Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke","volume":"205","author":"Wu","year":"2024","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.joim.2025.12.004_b0135","first-page":"299","article-title":"Antioxidant activities of Aconitum coreanum extracts","volume":"14","author":"Zhai","year":"2013","journal-title":"Bei Hua Da Xue Xue Bao Zi Ran Ke Xue Ban"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0140","first-page":"91","article-title":"Anti-tumor mechanism of Radix Aconiti Coreani decoction based on network pharmacology Henan","volume":"38","author":"Wang","year":"2019","journal-title":"Da Xue Xue Bao Yi Xue Ban"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24008","article-title":"Aconitum coreanum alleviates cerebral ischemic stroke through the PI3K\/Akt signaling pathway in gerbils model","volume":"10","author":"Jia","year":"2024","journal-title":"Heliyon"},{"issue":"19","key":"10.1016\/j.joim.2025.12.004_b0150","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1021\/acschemneuro.3c00299","article-title":"Study on the difference of protective efficacy and mechanism of Radix Aconiti Coreani and Rhizoma Typhonii in gerbils with ischemic stroke","volume":"14","author":"Zhou","year":"2023","journal-title":"ACS Chem Nerosci"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0155","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/bab.2104","article-title":"The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation","volume":"69","author":"Kma","year":"2022","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.joim.2025.12.004_b0160","unstructured":"National Research Council Committee for the Update of the Guide for the Care and Use of laboratory Animals. Guide for the care and use of laboratory animals. 8th ed. Washington (DC): National Academies Press (US); 2011. p. 113\u201323."},{"key":"10.1016\/j.joim.2025.12.004_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.572624","article-title":"Network pharmacology reveals the mechanism of activity of Tongqiao Huoxue Decoction extract against middle cerebral artery occlusion-induced cerebral ischemia\u2013reperfusion injury","volume":"11","author":"Wu","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.joim.2025.12.004_b0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2018.01.143","article-title":"Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway","volume":"100","author":"Liu","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1570161115666161104095522","article-title":"Apoptosis and acute brain ischemia in ischemic stroke","volume":"15","author":"Radak","year":"2017","journal-title":"Curr Vasc Pharmacol"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbadis.2009.09.002","article-title":"Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia","volume":"1802","author":"Niizuma","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"10.1016\/j.joim.2025.12.004_b0190","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/cns.12005","article-title":"A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury","volume":"18","author":"Wei","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.joim.2025.12.004_b0195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-981-15-4272-5_7","article-title":"Autophagy and ischemic stroke","volume":"1207","author":"Zhang","year":"2020","journal-title":"Adv Exp Med Biol"},{"issue":"1\u20132","key":"10.1016\/j.joim.2025.12.004_b0200","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jns.2012.05.030","article-title":"Mitochondria, oxidative stress and neurodegeneration","volume":"322","author":"Federico","year":"2012","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0205","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Dr\u00f6ge","year":"2002","journal-title":"Physiol Rev"},{"issue":"11","key":"10.1016\/j.joim.2025.12.004_b0210","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00018-010-0277-y","article-title":"Oxidative damage to RNA: mechanisms, consequences, and diseases","volume":"67","author":"Kong","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"10.1016\/j.joim.2025.12.004_b0215","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett"},{"key":"10.1016\/j.joim.2025.12.004_b0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.redox.2013.12.013","article-title":"Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease","volume":"2","author":"Giordano","year":"2013","journal-title":"Redox Biol"},{"issue":"12","key":"10.1016\/j.joim.2025.12.004_b0225","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1007\/s12035-021-02533-4","article-title":"Inhibition of autophagy flux promotes secretion of chondroitin sulfate proteoglycans in primary rat astrocytes","volume":"58","author":"Alizadeh","year":"2021","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.joim.2025.12.004_b0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and autophagic degradation systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annu Rev Biochem"},{"issue":"6","key":"10.1016\/j.joim.2025.12.004_b0235","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/jnc.12268","article-title":"Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism","volume":"126","author":"Meng","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.joim.2025.12.004_b0240","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.lfs.2018.10.054","article-title":"Adipose-derived stem cells reduce liver oxidative stress and autophagy induced by ischemia\u2013reperfusion and hepatectomy injury in swine","volume":"214","author":"Ge","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.joim.2025.12.004_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112167","article-title":"Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.joim.2025.12.004_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joim.2025.12.004_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154644","article-title":"Gomisin N attenuated cerebral ischemia-reperfusion injury through inhibition of autophagy by activating the PI3K\/AKT\/mTOR pathway","volume":"110","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.joim.2025.12.004_b0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2018.05.029","article-title":"Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK\/mTOR\/ULK1 signaling pathway","volume":"832","author":"Zhang","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.joim.2025.12.004_b0265","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.joim.2025.12.004_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(12)70725-9","article-title":"Neuronal autophagy in cerebral ischemia\u2014a potential target for neuroprotective strategies?","volume":"64","author":"Gabryel","year":"2012","journal-title":"Pharmacol Rep"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0275","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1016\/j.joim.2025.12.004_b0280","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/eji.201243008","article-title":"AMPK\u03b11: a glucose sensor that controls CD8 T-cell memory","volume":"43","author":"Rolf","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.joim.2025.12.004_b0285","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuint.2015.03.001","article-title":"Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen\u2013glucose deprivation and reoxygenation","volume":"83\u201384","author":"Li","year":"2015","journal-title":"Neurochem Int"},{"issue":"20","key":"10.1016\/j.joim.2025.12.004_b0290","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1111\/febs.12969","article-title":"Baicalein induces autophagic cell death through AMPK\/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells","volume":"281","author":"Aryal","year":"2014","journal-title":"FEBS J"},{"issue":"2","key":"10.1016\/j.joim.2025.12.004_b0295","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.joim.2025.12.004_b0300","doi-asserted-by":"crossref","first-page":"764","DOI":"10.4161\/auto.6.6.12709","article-title":"Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins","volume":"6","author":"Itakura","year":"2010","journal-title":"Autophagy"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209549642500192X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209549642500192X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:45:19Z","timestamp":1775868319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209549642500192X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S209549642500192X"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2025.12.004","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aconitum coreanum (H.L\u00e9v l.) Rapaics exerts neuroprotective effects on cerebral ischemic stroke by inhibiting autophagy through the AMPK\/mTOR\/ULK1 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2025.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}