{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:07:35Z","timestamp":1789589255299,"version":"build-2803163510"},"reference-count":94,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104928"],"award-info":[{"award-number":["82104928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474577"],"award-info":[{"award-number":["82474577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M701123"],"award-info":[{"award-number":["2021M701123"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.joim.2026.04.001","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:54:25Z","timestamp":1775231665000},"page":"634-644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chikungunya fever\u2014What we know and have done in the face of a new global public health threat"],"prefix":"10.1016","volume":"24","author":[{"given":"Xiao-lu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-yue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41572-023-00429-2","article-title":"Chikungunya fever","volume":"9","author":"Bartholomeeusen","year":"2023","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0010","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3390\/cells12040556","article-title":"Chikungunya virus and its envelope protein E2 induce hyperalgesia in mice: inhibition by anti-E2 monoclonal antibodies and by targeting TRPV1","volume":"12","author":"Segato-Vendrameto","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0015","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3390\/v14050969","article-title":"A review on chikungunya virus epidemiology, pathogenesis and current vaccine development","volume":"14","author":"de Lima Cavalcanti","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.joim.2026.04.001_b0020","unstructured":"World Health Organization. Chikungunya virus disease\u2014global situation. (2025-10-03) [2026-01-27]. https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2025-DON581."},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0025","first-page":"582","article-title":"Research progress on the epidemiology and pathogenic biology of chikungunya fever in China","volume":"25","author":"Feng","year":"2025","journal-title":"Zhongguo Re Dai Yi Xue"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0030","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1038\/s41467-025-64687-2","article-title":"Neutralizing antibodies against chikungunya virus and structural elucidation of their mechanism of action","volume":"16","author":"Han","year":"2025","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.joim.2026.04.001_b0035","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41579-025-01177-8","article-title":"Chikungunya virus and other emerging arthritogenic alphaviruses","volume":"23","author":"de Souza","year":"2025","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0040","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2301573","article-title":"Ixchiq (VLA1553): the first FDA-approved vaccine to prevent disease caused by chikungunya virus infection","volume":"15","author":"Ly","year":"2024","journal-title":"Virulence"},{"issue":"9","key":"10.1016\/j.joim.2026.04.001_b0045","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S1473-3099(22)00226-2","article-title":"Safety and immunogenicity of PXVX0317, an aluminium hydroxide-adjuvanted chikungunya virus-like particle vaccine: a randomised, double-blind, parallel-group, phase 2 trial","volume":"22","author":"Bennett","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.joim.2026.04.001_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153279","article-title":"Contribution of traditional Chinese medicine to the treatment of COVID-19","volume":"85","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.joim.2026.04.001_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.1095549","article-title":"The research progress of chikungunya fever","volume":"10","author":"Cai","year":"2023","journal-title":"Front Public Health"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/v15010048","article-title":"Understanding the biology and immune pathogenesis of chikungunya virus infection for diagnostic and vaccine development","volume":"15","author":"Hakim","year":"2022","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0065","first-page":"187","article-title":"Chikungunya virus: history, geographic distribution, clinical picture, and treatment","volume":"37","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2018","journal-title":"P R Health Sci J"},{"issue":"6748","key":"10.1016\/j.joim.2026.04.001_b0070","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1126\/science.ady9887","article-title":"Mosquito-borne viral disease sweeps Indian Ocean islands","volume":"388","author":"Wadman","year":"2025","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266450","article-title":"Molecular and biological characterization of an Asian\u2013American isolate of chikungunya virus","volume":"17","author":"Archila","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.joim.2026.04.001_b0080","unstructured":"World Health Organization. Chikungunya epidemiology update\u2014June 2025. (2025-06-11) [2026-01-27]. https:\/\/www.who.int\/publications\/m\/item\/chikungunya-epidemiology-update-june-2025."},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0085","first-page":"12","article-title":"Cross-border spread, indigenous transmission, development trend, and control strategy for dengue fever and chikungunya fever in Yunnan Province, China","volume":"32","author":"Zhang","year":"2021","journal-title":"Zhongguo Mei Jie Sheng Wu Xue Ji Kong Zhi Za Zhi"},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0090","first-page":"539","article-title":"Epidemiological characteristics of imported chikungunya fever cases in China, 2010\u20132019","volume":"36","author":"Chen","year":"2021","journal-title":"Ji Bing Jian Ce"},{"key":"10.1016\/j.joim.2026.04.001_b0095","unstructured":"Guangdong Provincial Center for Disease Control and Prevention. Chikungunya fever monitoring information in Guangdong Province. (2025-09-21) [2026-01-27]. https:\/\/cdcp.gd.gov.cn\/ywdt\/index.html [Chinese]."},{"issue":"Pt 2","key":"10.1016\/j.joim.2026.04.001_b0100","article-title":"Drugs targeting structural and nonstructural proteins of the chikungunya virus: a review","volume":"262","author":"Wang","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0105","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(16)30385-1","article-title":"Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"Burt","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"10.1016\/j.joim.2026.04.001_b0110","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41564-022-01164-2","article-title":"Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography","volume":"7","author":"Chmielewski","year":"2022","journal-title":"Nat Microbiol"},{"issue":"Pt 2","key":"10.1016\/j.joim.2026.04.001_b0115","first-page":"471","article-title":"Re-emergence of chikungunya and o\u2019nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships","volume":"81","author":"Powers","year":"2000","journal-title":"J Gen Virol"},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0120","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.chom.2014.05.008","article-title":"Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential","volume":"15","author":"Stapleford","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.joim.2026.04.001_b0125","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.chom.2020.01.008","article-title":"An evolutionary insertion in the Mxra8 receptor-binding site confers resistance to alphavirus infection and pathogenesis","volume":"27","author":"Kim","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"7843","key":"10.1016\/j.joim.2026.04.001_b0130","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41586-020-3036-8","article-title":"Capping pores of alphavirus nsP1 gate membranous viral replication factories","volume":"589","author":"Jones","year":"2021","journal-title":"Nature"},{"issue":"7706","key":"10.1016\/j.joim.2026.04.001_b0135","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41586-018-0121-3","article-title":"Mxra8 is a receptor for multiple arthritogenic alphaviruses","volume":"557","author":"Zhang","year":"2018","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.joim.2026.04.001_b0140","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/s41564-023-01449-0","article-title":"Chikungunya virus cell-to-cell transmission is mediated by intercellular extensions in vitro and in vivo","volume":"8","author":"Yin","year":"2023","journal-title":"Nat Microbiol"},{"issue":"17","key":"10.1016\/j.joim.2026.04.001_b0145","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1016\/j.cell.2021.07.033","article-title":"Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress","volume":"184","author":"Williamson","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.joim.2026.04.001_b0150","first-page":"467","article-title":"Interferon-inducible protein (IFI) 16 regulates chikungunya and zika virus infection in human skin fibroblasts","volume":"18","author":"Wichit","year":"2019","journal-title":"EXCLI J"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0155","doi-asserted-by":"crossref","first-page":"e2441","DOI":"10.1002\/rmv.2441","article-title":"Immunological impact of cytokines on the chikungunya virus pathophysiology: a literature narrative review","volume":"33","author":"Nunes","year":"2023","journal-title":"Rev Med Virol"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0160","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cell.2015.11.006","article-title":"Potent antibody protection against an emerging alphavirus threat","volume":"163","author":"Kielian","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.joim.2026.04.001_b0165","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41584-019-0276-9","article-title":"Rheumatic manifestations of chikungunya: emerging concepts and interventions","volume":"15","author":"Suhrbier","year":"2019","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.joim.2026.04.001_b0170","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s13337-019-00534-5","article-title":"Persistence of antibody response in chikungunya","volume":"30","author":"Chelluboina","year":"2019","journal-title":"Virusdisease"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0175","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1017\/S0950268811001300","article-title":"Acute chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study","volume":"140","author":"Chopra","year":"2012","journal-title":"Epidemiol Infect"},{"issue":"2","key":"10.1016\/j.joim.2026.04.001_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2025.102068","article-title":"Chikungunya and other viral arthritis","volume":"39","author":"Chopra","year":"2025","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0185","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1038\/s41598-025-86761-x","article-title":"Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint disease","volume":"15","author":"Ramundo","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.joim.2026.04.001_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.958820","article-title":"Increased platelet activation and platelet-inflammasome engagement during chikungunya infection","volume":"13","author":"Gomes de Azevedo-Quintanilha","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0195","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1086\/605496","article-title":"Chikungunya fever: an epidemiological review of a re-emerging infectious disease","volume":"49","author":"Staples","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.joim.2026.04.001_b0200","unstructured":"Centers for Disease Control and Prevention. Clinical signs and symptoms of chikungunya virus disease. (2024-05-15) [2026-01-27]. https:\/\/www.cdc.gov\/chikungunya\/hcp\/clinical-signs\/index.html."},{"issue":"8","key":"10.1016\/j.joim.2026.04.001_b0205","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/0074-02760170044","article-title":"Chikungunya virus: clinical aspects and treatment\u2014a review","volume":"112","author":"Cunha","year":"2017","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"2","key":"10.1016\/j.joim.2026.04.001_b0210","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/tropicalmed10020054","article-title":"Chikungunya fever and rheumatoid arthritis: a systematic review and meta-analysis","volume":"10","author":"Amaral","year":"2025","journal-title":"Trop Med Infect Dis"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0215","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4103\/ijccm.IJCCM_459_17","article-title":"Atypical neurological manifestations of chikungunya fever: two case reports","volume":"22","author":"Mahto","year":"2018","journal-title":"Indian J Crit Care Med"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0220","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1212\/WNL.0000000000002234","article-title":"Chikungunya virus-associated encephalitis: a cohort study on La R\u00e9union Island, 2005\u20132009","volume":"86","author":"G\u00e9rardin","year":"2016","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.joim.2026.04.001_b0225","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s13365-017-0515-2","article-title":"Chikungunya infection presenting as mild encephalitis with a reversible lesion in the splenium: a case report","volume":"23","author":"Nagpal","year":"2017","journal-title":"J Neurovirol"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0230","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/pathogens11040412","article-title":"Ocular manifestations of chikungunya infection: a systematic review","volume":"11","author":"da Silva","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.joim.2026.04.001_b0235","article-title":"Cognitive dysfunction of chikungunya virus infection in older adults. Front","volume":"13","author":"Peixoto","year":"2022","journal-title":"Psychiatry"},{"key":"10.1016\/j.joim.2026.04.001_b0240","article-title":"Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms","volume":"16","author":"Sun","year":"2025","journal-title":"Front Immunol"},{"issue":"22","key":"10.1016\/j.joim.2026.04.001_b0245","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1016\/j.cell.2023.09.007","article-title":"Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8","volume":"186","author":"Zimmerman","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.joim.2026.04.001_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105446","article-title":"Inhibition of chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 epitope-rich region","volume":"208","author":"Deng","year":"2022","journal-title":"Antiviral Res"},{"key":"10.1016\/j.joim.2026.04.001_b0255","doi-asserted-by":"crossref","first-page":"31819","DOI":"10.1038\/srep31819","article-title":"The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection","volume":"6","author":"Delang","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0260","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1038\/s41598-022-14790-x","article-title":"Characterization of the RNA-dependent RNA polymerase from chikungunya virus and discovery of a novel ligand as a potential drug candidate","volume":"12","author":"Freire","year":"2022","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.joim.2026.04.001_b0265","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1093\/jac\/dku209","article-title":"Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral","volume":"69","author":"Delang","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0270","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/microorganisms9050944","article-title":"Favipiravir does not inhibit chikungunya virus replication in mosquito cells and Aedes aegypti mosquitoes","volume":"9","author":"Jacobs","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.joim.2026.04.001_b0275","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2016.01.006","article-title":"Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo","volume":"127","author":"Rothan","year":"2016","journal-title":"Antiviral Res"},{"issue":"8","key":"10.1016\/j.joim.2026.04.001_b0280","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/infdis\/jiw358","article-title":"Chikungunya virus: in vitro response to combination therapy with ribavirin and interferon alfa 2a","volume":"214","author":"Gallegos","year":"2016","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.joim.2026.04.001_b0285","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/microorganisms9020307","article-title":"Combination regimens of favipiravir plus interferon \u03b1 inhibit chikungunya virus replication in clinically relevant human cell lines","volume":"9","author":"Franco","year":"2021","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.joim.2026.04.001_b0290","doi-asserted-by":"crossref","first-page":"e00693","DOI":"10.1128\/mBio.00693-16","article-title":"Antagonism of the sodium-potassium ATPase impairs chikungunya virus infection","volume":"7","author":"Ashbrook","year":"2016","journal-title":"MBio"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0295","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41598-017-03316-5","article-title":"Imipramine inhibits chikungunya virus replication in human skin fibroblasts through interference with intracellular cholesterol trafficking","volume":"7","author":"Wichit","year":"2017","journal-title":"Sci Rep"},{"issue":"1\u20133","key":"10.1016\/j.joim.2026.04.001_b0300","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ejphar.2009.06.063","article-title":"Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies","volume":"625","author":"Solomon","year":"2009","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0305","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1084\/jem.20110996","article-title":"Chikungunya virus-induced autophagy delays caspase-dependent cell death","volume":"209","author":"Joubert","year":"2012","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0310","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s42003-020-01285-6","article-title":"Macrophage scavenger receptor 1 controls chikungunya virus infection through autophagy in mice","volume":"3","author":"Yang","year":"2020","journal-title":"Commun Biol"},{"issue":"7","key":"10.1016\/j.joim.2026.04.001_b0315","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001629","article-title":"Targeting cap-dependent translation to inhibit chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK","volume":"102","author":"Mudaliar","year":"2021","journal-title":"J Gen Virol"},{"issue":"8","key":"10.1016\/j.joim.2026.04.001_b0320","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4161\/auto.20751","article-title":"Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy","volume":"8","author":"Joubert","year":"2012","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.joim.2026.04.001_b0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111305","article-title":"Cytokines in acute chikungunya","volume":"9","author":"Venugopalan","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0330","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01143-21","article-title":"Interferon \u03b1, but not interferon \u03b2, acts early to control chronic chikungunya virus pathogenesis","volume":"96","author":"Locke","year":"2022","journal-title":"J Virol"},{"issue":"7344","key":"10.1016\/j.joim.2026.04.001_b0335","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.joim.2026.04.001_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008910","article-title":"Adenovirus vectored IFN-\u03b1 protects mice from lethal challenge of chikungunya virus infection","volume":"14","author":"Chen","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"10.1016\/j.joim.2026.04.001_b0345","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2015.10.050","article-title":"Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress","volume":"163","author":"Fox","year":"2015","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.joim.2026.04.001_b0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008061","article-title":"Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins","volume":"15","author":"Quiroz","year":"2019","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.joim.2026.04.001_b0355","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ajp.22213","article-title":"Dengue, Japanese encephalitis and chikungunya virus antibody prevalence among captive monkey (Macaca nemestrina) colonies of Northern Thailand","volume":"76","author":"Nakgoi","year":"2014","journal-title":"Am J Primatol"},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0360","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chom.2024.02.011","article-title":"Pathophysiology of chikungunya virus infection associated with fatal outcomes","volume":"32","author":"de Souza","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006510","article-title":"Mother-to-child transmission of chikungunya virus: a systematic review and meta-analysis","volume":"12","author":"Contopoulos-Ioannidis","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"10.1016\/j.joim.2026.04.001_b0370","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2174\/0115733971278715231208114037","article-title":"Chikungunya arthritis treatment with methotrexate and dexamethasone: a randomized, double-blind, placebo-controlled trial","volume":"20","author":"Amaral","year":"2024","journal-title":"Curr Rheumatol Rev"},{"issue":"2","key":"10.1016\/j.joim.2026.04.001_b0375","doi-asserted-by":"crossref","first-page":"001965","DOI":"10.1099\/jgv.0.001965","article-title":"Immunogenicity, safety and duration of protection afforded by chikungunya virus vaccines undergoing human clinical trials","volume":"105","author":"Rao","year":"2024","journal-title":"J Gen Virol"},{"key":"10.1016\/j.joim.2026.04.001_b0380","unstructured":"Valneva. Valneva reports positive six-month antibody persistence and safety phase 2 results in children for its single-shot chikungunya vaccine IXCHIQ\u00ae. (2025-06-05) [2026-01-27]. https:\/\/valneva.com\/press-release\/valneva-reports-positive-six-month-antibody-persistence-and-safety-phase-2-results-in-children-for-its-single-shot-chikungunya-vaccine-ixchiq\/."},{"key":"10.1016\/j.joim.2026.04.001_b0385","unstructured":"Valneva. Valneva announces lifting of European medicines agency\u2019s temporary restriction on use of chikungunya vaccine IXCHIQ\u00ae in elderly. (2025-07-11) [2026-01-27]. https:\/\/valneva.com\/press-release\/valneva-announces-lifting-of-european-medicines-agencys-temporary-restriction-on-use-of-chikungunya-vaccine-ixchiq-in-elderly\/."},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0390","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s40259-024-00677-y","article-title":"Chikungunya virus vaccines: a review of IXCHIQ and PXVX0317 from pre-clinical evaluation to licensure","volume":"38","author":"Weber","year":"2024","journal-title":"BioDrugs"},{"key":"10.1016\/j.joim.2026.04.001_b0395","unstructured":"National Library of Medicine. Trial of an inactivated chikungunya virus vaccine. (2025-04-10) [2026-01-27]. https:\/\/clinicaltrials.gov\/study\/NCT06669208?cond=Chikungunya&rank=1."},{"key":"10.1016\/j.joim.2026.04.001_b0400","unstructured":"Coalition for Epidemic Preparedness Innovations (CEPI). CEPI awards up to US$14.1 million to consortium of IVI and Bharat Biotech to advance development of chikungunya vaccine in collaboration with Ind-CEPI. (2020-06-03) [2026-01-27]. https:\/\/cepi.net\/cepi-awards-us-141-million-consortium-ivi-and-bharat-biotech-advance-development-chikungunya."},{"key":"10.1016\/j.joim.2026.04.001_b0405","unstructured":"International Vaccine Institute. Advancing the world\u2019s first chikungunya vaccine to combat the re-emerged disease. (2025-03) [2026-01-27]. https:\/\/www.ivi.int\/what-we-do\/research-areas\/chikungunya\/."},{"issue":"4","key":"10.1016\/j.joim.2026.04.001_b0410","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14760584.2019.1562908","article-title":"Measles-vectored vaccine approaches against viral infections: a focus on chikungunya","volume":"18","author":"Gerke","year":"2019","journal-title":"Expert Rev Vaccines"},{"issue":"26","key":"10.1016\/j.joim.2026.04.001_b0415","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1016\/j.vaccine.2023.04.064","article-title":"A phase 1, randomized, placebo-controlled, dose-ranging study to evaluate the safety and immunogenicity of an mRNA-based chikungunya virus vaccine in healthy adults","volume":"41","author":"Shaw","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.joim.2026.04.001_b0420","series-title":"Inner canon of Yellow Emperor","first-page":"165","author":"Tian","year":"2017"},{"key":"10.1016\/j.joim.2026.04.001_b0425","series-title":"Treatise on pestilence","first-page":"287","author":"Tang","year":"2020"},{"issue":"6","key":"10.1016\/j.joim.2026.04.001_b0430","first-page":"524","article-title":"Chikungunya fever diagnosis and treatment protocol (2025 edition)","volume":"15","author":"National Health Commission of the People's Republic of China","year":"2025","journal-title":"Zhongguo Bing Du Bing Za Zhi"},{"key":"10.1016\/j.joim.2026.04.001_b0435","series-title":"Detailed analysis of epidemic warm disease","first-page":"171","author":"Wu","year":"2023"},{"issue":"2","key":"10.1016\/j.joim.2026.04.001_b0440","first-page":"130","article-title":"A discussion on the idea of \u201cnever too late to adopt the purgation and sweating methods\u201d in Guang Wenyi Lun","volume":"39","author":"Zhou","year":"2023","journal-title":"Changchun Zhong Yi Yao Da Xue Xue Bao"},{"key":"10.1016\/j.joim.2026.04.001_b0445","unstructured":"Gao LJ, Liu CY, Zheng N, Sun M. Based on the theory of \u201cpoison attacking evil,\u201d this paper analyzes the application of \u201ctoxic\u201d drugs in rheumatoid arthritis. Zhonghua Zhong Yi Yao Xue Kan 2025;44(5):27\u201331 [Chinese with abstract in English]."},{"issue":"18","key":"10.1016\/j.joim.2026.04.001_b0450","first-page":"3595","article-title":"Study on the clinical medication rules of Chinese herbal medicine for chronic gouty arthritis based on data mining","volume":"36","author":"Wu","year":"2025","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"issue":"10","key":"10.1016\/j.joim.2026.04.001_b0455","first-page":"7","article-title":"Treatment of insomnia in convalescent period of COVID-19 based on method of invigorating body and expelling pathogenic factors in traditional Chinese medicine","volume":"51","author":"Liang","year":"2024","journal-title":"Liaoning Zhong Yi Za Zhi"},{"issue":"7","key":"10.1016\/j.joim.2026.04.001_b0460","first-page":"155","article-title":"Acupuncture treatment of 14 cases of chikungunya arthritis clinical observation","volume":"28","author":"Xue","year":"2014","journal-title":"Shi Yong Zhong Yi Nei Ke Za Zhi"},{"issue":"9","key":"10.1016\/j.joim.2026.04.001_b0465","first-page":"1281","article-title":"Clinical analysis of 12 cases of chikungunya fever arthritis treated with acupuncture and Chinese herbal medicine","volume":"31","author":"Peng","year":"2011","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"11","key":"10.1016\/j.joim.2026.04.001_b0470","first-page":"254","article-title":"Expert consensus on Chinese medicine diagnosis and treatment of chikungunya fever (first edition, 2025)","volume":"43","author":"Lu","year":"2025","journal-title":"Zhonghua Zhong Yi Yao Xue Kan"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496426000403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496426000403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:55:52Z","timestamp":1789588552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496426000403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":94,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2095496426000403"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2026.04.001","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chikungunya fever\u2014What we know and have done in the face of a new global public health threat","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2026.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}