{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:56:21Z","timestamp":1794012981908,"version":"4.8.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Intensive Medicine"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jointm.2022.01.001","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T03:39:08Z","timestamp":1644637148000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Mitochondrial ACOD1\/IRG1 in infection and sterile inflammation"],"prefix":"10.1016","volume":"2","author":[{"given":"Runliu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-6180","authenticated-orcid":false,"given":"Daolin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0001","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0002","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Innate immunity","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0003","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0004","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.it.2012.09.004","article-title":"The inflammatory response in sepsis","volume":"34","author":"Bosmann","year":"2013","journal-title":"Trends Immunol"},{"issue":"23","key":"10.1016\/j.jointm.2022.01.001_bib0005","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.3390\/ijms20236008","article-title":"Cytokines in inflammatory disease","volume":"20","author":"Kany","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jointm.2022.01.001_bib0006","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-032414-112043","article-title":"Innate immune recognition of cancer","volume":"33","author":"Woo","year":"2015","journal-title":"Annu Rev Immunol"},{"issue":"21","key":"10.1016\/j.jointm.2022.01.001_bib0007","article-title":"STING1 in sepsis: Mechanisms, functions, and implications","volume":"S1008-1275","author":"Zhang","year":"2021","journal-title":"Chin J Traumatol"},{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0008","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.cell.2021.02.029","article-title":"COVID-19 and the human innate immune system","volume":"184","author":"Schultze","year":"2021","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008536","article-title":"The hallmarks of COVID-19 disease","volume":"16","author":"Tang","year":"2020","journal-title":"PLoS Pathog"},{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0010","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0011","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0012","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.jointm.2022.01.001_bib0013","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.4049\/jimmunol.0903002","article-title":"Metabolic shifts in immunity and inflammation","volume":"184","author":"Kominsky","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0014","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1038\/ncomms5436","article-title":"PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis","volume":"5","author":"Yang","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jointm.2022.01.001_bib0015","doi-asserted-by":"crossref","first-page":"13280","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.jointm.2022.01.001_bib0016","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0017","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2020.09.014","article-title":"Modification of proteins by metabolites in immunity","volume":"54","author":"Diskin","year":"2021","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0018","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","article-title":"Succinate: a metabolic signal in inflammation","volume":"24","author":"Mills","year":"2014","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0019","article-title":"Itaconate: A metabolite regulates inflammation response and oxidative stress","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"10.1016\/j.jointm.2022.01.001_bib0020","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1128\/IAI.05451-11","article-title":"Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation","volume":"79","author":"Gautam","year":"2011","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0021","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/jir.2008.0013","article-title":"The proinflammatory cytokine-induced IRG1 protein associates with mitochondria","volume":"29","author":"Degrandi","year":"2009","journal-title":"J Interferon Cytokine Res"},{"issue":"8","key":"10.1016\/j.jointm.2022.01.001_bib0022","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41423-020-0489-5","article-title":"ACOD1 in immunometabolism and disease","volume":"17","author":"Wu","year":"2020","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0023","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00172150","article-title":"Cloning and analysis of gene regulation of a novel LPS-inducible cDNA","volume":"41","author":"Lee","year":"1995","journal-title":"Immunogenetics"},{"issue":"19","key":"10.1016\/j.jointm.2022.01.001_bib0024","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1\u20132","key":"10.1016\/j.jointm.2022.01.001_bib0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11010-011-0784-7","article-title":"Expression profile of human immune-responsive gene 1 and generation and characterization of polyclonal antiserum","volume":"353","author":"Xiao","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"41","key":"10.1016\/j.jointm.2022.01.001_bib0026","doi-asserted-by":"crossref","first-page":"20644","DOI":"10.1073\/pnas.1908770116","article-title":"Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis","volume":"116","author":"Chen","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10.1016\/j.jointm.2022.01.001_bib0027","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s004270000095","article-title":"Expression pattern of XIRG, a marker for non-neural ectoderm","volume":"210","author":"Schmidt","year":"2000","journal-title":"Dev Genes Evol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0028","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.fsi.2020.07.034","article-title":"Immune-responsive gene 1 (IRG1) and dimethyl itaconate are involved in the mussel immune response","volume":"106","author":"Sendra","year":"2020","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0029","doi-asserted-by":"crossref","first-page":"11305","DOI":"10.1038\/s41598-020-68419-y","article-title":"Enzymatic reaction mechanism of cis-aconitate decarboxylase based on the crystal structure of IRG1 from Bacillus subtilis","volume":"10","author":"Chun","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2013.06.018","article-title":"Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating \u03b2-oxidation-dependent mitochondrial ROS production","volume":"18","author":"Hall","year":"2013","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0031","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/cmi.2015.02","article-title":"IRG1 induced by heme oxygenase-1\/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production","volume":"13","author":"Jamal Uddin","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0032","doi-asserted-by":"crossref","first-page":"fcab187","DOI":"10.1093\/braincomms\/fcab187","article-title":"Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia","volume":"3","author":"Kuo","year":"2021","journal-title":"Brain Commun"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0033","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.immuni.2018.11.017","article-title":"The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons","volume":"50","author":"Daniels","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jointm.2022.01.001_bib0034","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2180-13-293","article-title":"Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice","volume":"13","author":"Preusse","year":"2013","journal-title":"BMC Microbiol"},{"issue":"16","key":"10.1016\/j.jointm.2022.01.001_bib0035","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1128\/JVI.00563-16","article-title":"Suppression of IRG-1 reduces inflammatory cell infiltration and lung injury in respiratory syncytial virus infection by reducing production of reactive oxygen species","volume":"90","author":"Ren","year":"2016","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0036","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1152\/physiolgenomics.00011.2007","article-title":"MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae","volume":"30","author":"Rodr\u00edguez","year":"2007","journal-title":"Physiol Genomics"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005408","article-title":"IFNs modify the proteome of Legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid","volume":"12","author":"Naujoks","year":"2016","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0038","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/ar2435","article-title":"Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes","volume":"10","author":"Pessler","year":"2008","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149050","article-title":"Gene regulatory network inference of immunoresponsive gene 1 (IRG1) identifies interferon regulatory factor 1 (IRF1) as its transcriptional regulator in mammalian macrophages","volume":"11","author":"Tallam","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02121-21","article-title":"The tumor necrosis factor alpha and interleukin 6 auto-paracrine signaling loop controls Mycobacterium avium infection via induction of IRF1\/IRG1 in human primary macrophages","volume":"12","author":"Gidon","year":"2021","journal-title":"mBio"},{"issue":"10","key":"10.1016\/j.jointm.2022.01.001_bib0041","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.4049\/jimmunol.167.10.5887","article-title":"Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes","volume":"167","author":"Kawai","year":"2001","journal-title":"J Immunol"},{"issue":"23","key":"10.1016\/j.jointm.2022.01.001_bib0042","doi-asserted-by":"crossref","first-page":"16225","DOI":"10.1074\/jbc.M113.454538","article-title":"Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species","volume":"288","author":"Li","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0043","doi-asserted-by":"crossref","first-page":"18173","DOI":"10.1038\/s41598-021-97352-x","article-title":"Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS","volume":"11","author":"Zhu","year":"2021","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0044","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1021\/acs.jproteome.8b00139","article-title":"Identification of immune-responsive gene 1 (IRG1) as a target of A20","volume":"17","author":"Van Quickelberghe","year":"2018","journal-title":"J Proteome Res"},{"issue":"7702","key":"10.1016\/j.jointm.2022.01.001_bib0045","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the I\u03baB\u03b6-ATF3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0046","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.4049\/jimmunol.175.5.3318","article-title":"Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1","volume":"175","author":"Shi","year":"2005","journal-title":"J Immunol"},{"issue":"41","key":"10.1016\/j.jointm.2022.01.001_bib0047","doi-asserted-by":"crossref","first-page":"16386","DOI":"10.1021\/ja2070889","article-title":"Itaconic acid is a mammalian metabolite induced during macrophage activation","volume":"133","author":"Strelko","year":"2011","journal-title":"J Am Chem Soc"},{"issue":"27","key":"10.1016\/j.jointm.2022.01.001_bib0048","doi-asserted-by":"crossref","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","article-title":"Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels","volume":"291","author":"Cordes","year":"2016","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0049","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.ejhg.5200793","article-title":"Succinate dehydrogenase and human diseases: New insights into a well-known enzyme","volume":"10","author":"Rustin","year":"2002","journal-title":"Eur J Hum Genet"},{"issue":"7444","key":"10.1016\/j.jointm.2022.01.001_bib0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0051","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0052","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s42255-020-0210-0","article-title":"Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages","volume":"2","author":"Swain","year":"2020","journal-title":"Nat Metab"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0053","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2018.09.003","article-title":"The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell Metab"},{"issue":"499","key":"10.1016\/j.jointm.2022.01.001_bib0054","doi-asserted-by":"crossref","first-page":"eaav4634","DOI":"10.1126\/scitranslmed.aav4634","article-title":"CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection","volume":"11","author":"Riquelme","year":"2019","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0055","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cellsig.2010.08.003","article-title":"The diverse functions of GAPDH: Views from different subcellular compartments","volume":"23","author":"Tristan","year":"2011","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0056","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1038\/s41467-019-13078-5","article-title":"4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects","volume":"10","author":"Liao","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jointm.2022.01.001_bib0057","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.bi.65.070196.001325","article-title":"Protein prenylation: Molecular mechanisms and functional consequences","volume":"65","author":"Zhang","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jointm.2022.01.001_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.669308","article-title":"The emerging application of itaconate: Promising molecular targets and therapeutic opportunities","volume":"9","author":"Lin","year":"2021","journal-title":"Front Chem"},{"issue":"10","key":"10.1016\/j.jointm.2022.01.001_bib0059","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11064-019-02759-8","article-title":"The effect of 2-ketobutyrate on mitochondrial substrate-level phosphorylation","volume":"44","author":"Bui","year":"2019","journal-title":"Neurochem Res"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0060","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1096\/fj.15-279398","article-title":"Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage","volume":"30","author":"N\u00e9meth","year":"2016","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0061","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jointm.2022.01.001_bib0062","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/936486","article-title":"Reactive oxygen species in health and disease","volume":"2012","author":"Alfadda","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0063","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.intimp.2017.04.012","article-title":"IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species","volume":"48","author":"Liu","year":"2017","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0064","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"7699","key":"10.1016\/j.jointm.2022.01.001_bib0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0066","first-page":"1155","article-title":"Irg1-itaconate axis protects against acute kidney injury via activation of Nrf2","volume":"13","author":"Zhu","year":"2021","journal-title":"Am J Transl Res"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0067","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.31147","article-title":"Immune-responsive gene 1\/itaconate activates nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury","volume":"72","author":"Yi","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jointm.2022.01.001_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102832","article-title":"Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2","volume":"57","author":"Song","year":"2020","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0069","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: In vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jointm.2022.01.001_bib0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0071","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2018.11.008","article-title":"High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss","volume":"157","author":"Duffy","year":"2019","journal-title":"Neurobiol Learn Mem"},{"issue":"24","key":"10.1016\/j.jointm.2022.01.001_bib0072","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1161\/CIRCULATIONAHA.116.025490","article-title":"A microRNA93-interferon regulatory factor-9-immunoresponsive gene-1-itaconic acid pathway modulates M2-like macrophage polarization to revascularize ischemic muscle","volume":"135","author":"Ganta","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0073","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: Signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol Rev"},{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0074","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: Mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0075","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jointm.2022.01.001_bib0076","article-title":"Inflammasome-dependent coagulation activation in sepsis","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0077","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.chom.2020.02.004","article-title":"TMEM173 drives lethal coagulation in sepsis","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0078","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","article-title":"Inflammasome activation triggers blood clotting and host death through pyroptosis","volume":"50","author":"Wu","year":"2019","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0079","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.immuni.2019.11.005","article-title":"Bacterial endotoxin activates the coagulation cascade through gasdermin D-dependent phosphatidylserine exposure","volume":"51","author":"Yang","year":"2019","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.jointm.2022.01.001_bib0080","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41564-020-00795-7","article-title":"Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling","volume":"5","author":"Zhou","year":"2020","journal-title":"Nat Microbiol"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0081","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/viru.2.2.15480","article-title":"HMGB1 release by inflammasomes","volume":"2","author":"Vande Walle","year":"2011","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0082","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","article-title":"Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis","volume":"24","author":"Kang","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0083","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.chom.2020.02.004","article-title":"TMEM173 drives lethal coagulation in sepsis","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"12","key":"10.1016\/j.jointm.2022.01.001_bib0084","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1080\/15548627.2020.1843253","article-title":"Extracellular SQSTM1 as an inflammatory mediator","volume":"16","author":"Zou","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.jointm.2022.01.001_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","article-title":"HMGB1 in health and disease","volume":"40","author":"Kang","year":"2014","journal-title":"Mol Aspects Med"},{"issue":"12","key":"10.1016\/j.jointm.2022.01.001_bib0086","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0087","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0088","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.jointm.2022.01.001_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108756","article-title":"Itaconate confers tolerance to late NLRP3 inflammasome activation","volume":"34","author":"Bambouskova","year":"2021","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/j.jointm.2022.01.001_bib0090","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jointm.2022.01.001_bib0091","article-title":"Pharmacological modulation of BET family in sepsis","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0092","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.it.2021.04.001","article-title":"Emerging mechanisms of immunocoagulation in sepsis and septic shock","volume":"42","author":"Tang","year":"2021","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0093","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0094","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.20180118","article-title":"Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection","volume":"215","author":"Nair","year":"2018","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0095","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1189\/jlb.0905520","article-title":"Mycobacterium paratuberculosis, Mycobacterium smegmatis, and lipopolysaccharide induce different transcriptional and post-transcriptional regulation of the IRG1 gene in murine macrophages","volume":"79","author":"Basler","year":"2006","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0096","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02629-19","article-title":"IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila","volume":"10","author":"Price","year":"2019","journal-title":"mBio"},{"issue":"6502","key":"10.1016\/j.jointm.2022.01.001_bib0097","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1126\/science.aaz1333","article-title":"Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella","volume":"369","author":"Chen","year":"2020","journal-title":"Science"},{"issue":"7344","key":"10.1016\/j.jointm.2022.01.001_bib0098","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jointm.2022.01.001_bib0099","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fmicb.2015.00171","article-title":"Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study","volume":"6","author":"Dix","year":"2015","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0100","first-page":"282","article-title":"Involvement of the MyD88-independent pathway in controlling the intracellular fate of Burkholderia pseudomallei infection in the mouse macrophage cell line RAW 264.7","volume":"54","author":"Tangsudjai","year":"2010","journal-title":"Microbiol Immunol"},{"issue":"10","key":"10.1016\/j.jointm.2022.01.001_bib0101","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00156-21","article-title":"MyD88-dependent glucose restriction and itaconate production control Brucella infection","volume":"89","author":"Lacey","year":"2021","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0102","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nm.3108","article-title":"Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses","volume":"19","author":"Cho","year":"2013","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jointm.2022.01.001_bib0103","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/jmv.24756","article-title":"Polymorphisms in IRG1 gene associated with immune responses to hepatitis B vaccination in a Chinese Han population and function to restrain the HBV life cycle","volume":"89","author":"Liu","year":"2017","journal-title":"J Med Virol"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006165","article-title":"Transcriptional profiling in experimental visceral leishmaniasis reveals a broad splenic inflammatory environment that conditions macrophages toward a disease-promoting phenotype","volume":"13","author":"Kong","year":"2017","journal-title":"PLoS Pathog"},{"issue":"6","key":"10.1016\/j.jointm.2022.01.001_bib0105","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.4049\/jimmunol.177.6.3644","article-title":"Different neurotropic pathogens elicit neurotoxic CCR9- or neurosupportive CXCR3-expressing microglia","volume":"177","author":"Li","year":"2006","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0106","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0034-1393976","article-title":"Overview of classification systems in peripheral artery disease","volume":"31","author":"Hardman","year":"2014","journal-title":"Semin Intervent Radiol"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0107","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/micc.12261","article-title":"Macrophage recruitment and polarization during collateral vessel remodeling in murine adipose tissue","volume":"23","author":"Seaman","year":"2016","journal-title":"Microcirculation"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0108","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0109","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"17","key":"10.1016\/j.jointm.2022.01.001_bib0110","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009384","article-title":"Soluble CD74 reroutes MIF\/CXCR4\/AKT-mediated survival of cardiac myofibroblasts to necroptosis","volume":"7","author":"Soppert","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.jointm.2022.01.001_bib0111","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00281-013-0382-8","article-title":"Microglia and macrophages of the central nervous system: The contribution of microglia priming and systemic inflammation to chronic neurodegeneration","volume":"35","author":"Perry","year":"2013","journal-title":"Semin Immunopathol"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0112","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12974-020-01768-7","article-title":"Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis","volume":"17","author":"Kuo","year":"2020","journal-title":"J Neuroinflammat"},{"key":"10.1016\/j.jointm.2022.01.001_bib0113","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fimmu.2020.00033","article-title":"Molecular signatures of neuroinflammation induced by \u03b1synuclein aggregates in microglial cells","volume":"11","author":"Sarkar","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jointm.2022.01.001_bib0114","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcf.2015.03.003","article-title":"Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy","volume":"14","author":"Cantin","year":"2015","journal-title":"J Cyst Fibros"},{"issue":"2","key":"10.1016\/j.jointm.2022.01.001_bib0115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/ars.2007.1897","article-title":"The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis","volume":"10","author":"Bringardner","year":"2008","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0116","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41467-021-21718-y","article-title":"Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation","volume":"12","author":"Tomlinson","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jointm.2022.01.001_bib0117","doi-asserted-by":"crossref","first-page":"17074","DOI":"10.1038\/nrdp.2017.74","article-title":"Idiopathic pulmonary fibrosis","volume":"3","author":"Martinez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0118","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"52","key":"10.1016\/j.jointm.2022.01.001_bib0119","doi-asserted-by":"crossref","first-page":"eabc1884","DOI":"10.1126\/sciimmunol.abc1884","article-title":"Itaconate controls the severity of pulmonary fibrosis","volume":"5","author":"Ogger","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jointm.2022.01.001_bib0120","doi-asserted-by":"crossref","first-page":"16040","DOI":"10.1038\/ncomms16040","article-title":"BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases","volume":"8","author":"Papathanassiu","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jointm.2022.01.001_bib0121","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12964-020-00678-8","article-title":"Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions","volume":"18","author":"Saeki","year":"2020","journal-title":"Cell Commun Signal"},{"issue":"10","key":"10.1016\/j.jointm.2022.01.001_bib0122","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00109-020-01963-2","article-title":"The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer","volume":"98","author":"Wang","year":"2020","journal-title":"J Mol Med (Berl)"},{"issue":"3","key":"10.1016\/j.jointm.2022.01.001_bib0123","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.jointm.2022.01.001_bib0124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188317","article-title":"NF-\u03baB pathways are involved in M1 polarization of RAW 264.7 macrophage by polyporus polysaccharide in the tumor microenvironment","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jointm.2022.01.001_bib0125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbrc.2021.10.054","article-title":"Itaconic acid induces ferroptosis by activating ferritinophagy","volume":"583","author":"Qu","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.jointm.2022.01.001_bib0126","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"6458","key":"10.1016\/j.jointm.2022.01.001_bib0127","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.aax4468","article-title":"N (6)-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication","volume":"365","author":"Liu","year":"2019","journal-title":"Science"}],"container-title":["Journal of Intensive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667100X22000147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667100X22000147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:01:41Z","timestamp":1763024501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667100X22000147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2667100X22000147"],"URL":"https:\/\/doi.org\/10.1016\/j.jointm.2022.01.001","relation":{},"ISSN":["2667-100X"],"issn-type":[{"value":"2667-100X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial ACOD1\/IRG1 in infection and sterile inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Intensive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jointm.2022.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of Chinese Medical Association.","name":"copyright","label":"Copyright"}]}}