{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:04:10Z","timestamp":1771477450789,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["TRYJ2021LC02"],"award-info":[{"award-number":["TRYJ2021LC02"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Intensive Medicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jointm.2024.10.004","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T15:32:05Z","timestamp":1733844725000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study"],"prefix":"10.1016","volume":"5","author":[{"given":"Xiaofeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou","family":"Shaohua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6103-2115","authenticated-orcid":false,"given":"Pu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jointm.2024.10.004_bib0001","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jointm.2024.10.004_bib0002","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0003","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","article-title":"Organ failure due to systemic injury in acute pancreatitis","volume":"156","author":"Garg","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"Petrov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jointm.2024.10.004_bib0006","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jointm.2024.10.004_bib0007","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.3748\/wjg.v27.i30.5019","article-title":"Gut microbiome in acute pancreatitis: a review based on current literature","volume":"27","author":"Patel","year":"2021","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104849","article-title":"Shotgun metagenomics reveals significant gut microbiome features in different grades of acute pancreatitis","volume":"154","author":"Yu","year":"2021","journal-title":"Microb Pathog"},{"key":"10.1016\/j.jointm.2024.10.004_bib0009","first-page":"81","article-title":"Intestinal microbial community differs between acute pancreatitis patients and healthy volunteers","volume":"31","author":"Zhang","year":"2018","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.jointm.2024.10.004_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.988326","article-title":"Gut microbiota on admission as predictive biomarker for acute necrotizing pancreatitis","volume":"13","author":"Zou","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0011","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/bph.15980","article-title":"Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling","volume":"180","author":"Liu","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0012","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fphar.2018.00690","article-title":"Supplemented use of pre-, pro-, and synbiotics in severe acute pancreatitis: an updated systematic review and meta-analysis of 13 randomized controlled trials","volume":"9","author":"Tian","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0013","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2013.02.007","article-title":"Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer","volume":"144","author":"Gukovsky","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0014","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/path.4555","article-title":"CXCR2 inhibition suppresses acute and chronic pancreatic inflammation","volume":"237","author":"Steele","year":"2015","journal-title":"J Pathol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0015","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI64931","article-title":"IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality","volume":"123","author":"Zhang","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jointm.2024.10.004_bib0016","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1172\/JCI30876","article-title":"Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo","volume":"117","author":"Baumann","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jointm.2024.10.004_bib0017","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.09.040","article-title":"NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis","volume":"158","author":"Sendler","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0018","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0019","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jointm.2024.10.004_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1091780","article-title":"Causal associations between modifiable risk factors and pancreatitis: a comprehensive Mendelian randomization study","volume":"14","author":"Mao","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0021","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41525-021-00189-6","article-title":"Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: mendelian randomization study","volume":"6","author":"Yuan","year":"2021","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.jointm.2024.10.004_bib0022","article-title":"Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study","volume":"14","author":"Wang","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0023","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ije\/dyv071","article-title":"Mendelian randomization studies: a review of the approaches used and the quality of reporting","volume":"44","author":"Boef","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0024","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jointm.2024.10.004_bib0025","doi-asserted-by":"crossref","first-page":"e28734","DOI":"10.1002\/jmv.28734","article-title":"Association of gut microbiota with COVID-19 susceptibility and severity: a two-sample Mendelian randomization study","volume":"95","author":"Shang","year":"2023","journal-title":"J Med Virol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0026","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2016.11.007","article-title":"Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors","volume":"100","author":"Ahola-Olli","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jointm.2024.10.004_bib0027","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.jointm.2024.10.004_bib0028","article-title":"Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: a Mendelian randomization","volume":"13","author":"Xiang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0029","doi-asserted-by":"crossref","first-page":"lqaa028","DOI":"10.1093\/nargab\/lqaa028","article-title":"MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropy","volume":"2","author":"Cheng","year":"2020","journal-title":"NAR Genom Bioinform"},{"key":"10.1016\/j.jointm.2024.10.004_bib0030","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ije\/dyq151","article-title":"Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants","volume":"40","author":"Pierce","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0031","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0032","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0033","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0034","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/EDE.0000000000000559","article-title":"Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants","volume":"28","author":"Burgess","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0035","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0036","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/gepi.22207","article-title":"Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective","volume":"43","author":"Ong","year":"2019","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0037","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jointm.2024.10.004_bib0038","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jointm.2024.10.004_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1111950","article-title":"An inverse causal association between genetically predicted vitamin D and chronic obstructive pulmonary disease risk","volume":"10","author":"Lu","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.jointm.2024.10.004_bib0040","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/MPA.0000000000000355","article-title":"Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis","volume":"44","author":"Tan","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.jointm.2024.10.004_bib0041","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00059-19","article-title":"Commensal Escherichia coli aggravates acute necrotizing pancreatitis through targeting of intestinal epithelial cells","volume":"85","author":"Zheng","year":"2019","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0042","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.immuni.2012.05.024","article-title":"Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis","volume":"37","author":"Tsuji","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jointm.2024.10.004_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111850","article-title":"Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies","volume":"141","author":"Zhu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jointm.2024.10.004_bib0044","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.pan.2017.09.002","article-title":"The potential role of gut microbiota in pancreatic disease: a systematic review","volume":"17","author":"Memba","year":"2017","journal-title":"Pancreatology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41575-019-0242-7","article-title":"Microbiota in pancreatic health and disease: the next frontier in microbiome research","volume":"17","author":"Thomas","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0046","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/microorganisms8060835","article-title":"Gallstone disease and microbiome","volume":"8","author":"Grigor'eva","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.jointm.2024.10.004_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2023.105052","article-title":"Causal relationship between gut microbiota and obstructive sleep apnea","volume":"113","author":"Wei","year":"2023","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jointm.2024.10.004_bib0048","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s10194-023-01609-x","article-title":"A causal effects of gut microbiota in the development of migraine","volume":"24","author":"He","year":"2023","journal-title":"J Headache Pain"},{"key":"10.1016\/j.jointm.2024.10.004_bib0049","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jointm.2024.10.004_bib0050","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.3748\/wjg.v13.i20.2826","article-title":"Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease","volume":"13","author":"Tedelind","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0051","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jointm.2024.10.004_bib0052","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1111\/bph.14806","article-title":"Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms","volume":"176","author":"Pan","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0053","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s10620-015-3586-z","article-title":"Sodium butyrate reduces organ injuries in mice with severe acute pancreatitis through inhibiting HMGB1 expression","volume":"60","author":"Zhang","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jointm.2024.10.004_bib0054","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","article-title":"Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice","volume":"54","author":"Zhu","year":"2019","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0055","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","article-title":"Role of gut microbiota on intestinal barrier function in acute pancreatitis","volume":"26","author":"Li","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jointm.2024.10.004_bib0056","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1053\/j.gastro.2017.08.071","article-title":"Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis","volume":"153","author":"Gukovskaya","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0057","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI119714","article-title":"Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis","volume":"100","author":"Gukovskaya","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jointm.2024.10.004_bib0058","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/gast.2002.31060","article-title":"NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response","volume":"122","author":"Chen","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jointm.2024.10.004_bib0059","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/1753425919881502","article-title":"Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway","volume":"26","author":"Jia","year":"2020","journal-title":"Innate Immun"},{"key":"10.1016\/j.jointm.2024.10.004_bib0060","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2016.10.026","article-title":"GM-CSF: from growth factor to central mediator of tissue inflammation","volume":"45","author":"Becher","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jointm.2024.10.004_bib0061","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/JLB.3MA1020-647R","article-title":"STAT5 promotes chronic pancreatitis by enhancing GM-CSF-dependent neutrophil augmentation","volume":"110","author":"Lin","year":"2021","journal-title":"J Leukoc Biol"}],"container-title":["Journal of Intensive Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667100X24001063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667100X24001063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:41:27Z","timestamp":1762641687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667100X24001063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2667100X24001063"],"URL":"https:\/\/doi.org\/10.1016\/j.jointm.2024.10.004","relation":{},"ISSN":["2667-100X"],"issn-type":[{"value":"2667-100X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Journal of Intensive Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jointm.2024.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of Chinese Medical Association.","name":"copyright","label":"Copyright"}]}}