{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:44:14Z","timestamp":1785321854458,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.joms.2005.10.045","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T10:11:18Z","timestamp":1181988678000},"page":"1365-1369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Multiple Symmetric Lipomatosis: Case Report and Review of the Literature"],"prefix":"10.1016","volume":"65","author":[{"given":"Jean-Paul","family":"Meningaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poramate","family":"Pitak-Arnnop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques-Charles","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2005.10.045_bib1","series-title":"Clinical Lectures on Surgery Delivered at St. George\u2019s Hospital","first-page":"201","author":"Brodie","year":"1846"},{"key":"10.1016\/j.joms.2005.10.045_bib2","first-page":"106","article-title":"Ueber Den Fetthals","volume":"37","author":"Madelung","year":"1888","journal-title":"Arch Klin Chir"},{"key":"10.1016\/j.joms.2005.10.045_bib3","first-page":"298","article-title":"L\u2019ad\u00e9nolipomatose sym\u00e9trique","volume":"15","author":"Launois","year":"1898","journal-title":"Bull Mem Soc Med Hosp Paris"},{"key":"10.1016\/j.joms.2005.10.045_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00000637-200101000-00008","article-title":"Madelung\u2019s disease: Case report and discussion of treatment options","volume":"46","author":"Adamo","year":"2001","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0190-9622(87)70253-9","article-title":"Benign symmetrical lipomatosis Launois-Bensaude","volume":"17","author":"Ruzicka","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib6","first-page":"CS5","article-title":"Launois-Bensaude syndrome in a female with type 2 diabetes","volume":"9","author":"Harsch","year":"2003","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.joms.2005.10.045_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00005792-198401000-00004","article-title":"Multiple symmetrical lipomatosis: An updated clinical report","volume":"63","author":"Enzi","year":"1984","journal-title":"Medicine"},{"key":"10.1016\/j.joms.2005.10.045_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/ejpn.2000.0264","article-title":"Multiple symmetric lipomatosis: An unusual cause of childhood obesity and mental retardation","volume":"4","author":"Kratz","year":"2000","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.joms.2005.10.045_bib9","first-page":"42311","article-title":"Benigne symmetrische Lipomatose Launois-Bensaude Typ III und Bureau-Barriere-Syndrom","volume":"42","author":"Donhauser","year":"1991","journal-title":"Der Hautartzt"},{"key":"10.1016\/j.joms.2005.10.045_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s003300050233","article-title":"MR of laryngeal and scrotal involvement in multiple symmetrical lipomatosis","volume":"7","author":"Soler","year":"1997","journal-title":"Eur Radiol"},{"key":"10.1016\/j.joms.2005.10.045_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/archotol.1973.00780010509016","article-title":"Laryngeal involvement in benign symmetrical lipomatosis (Madelung\u2019s disease)","volume":"97","author":"Moretti","year":"1973","journal-title":"Arch Otolaryngol"},{"key":"10.1016\/j.joms.2005.10.045_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1148\/radiology.144.1.7089242","article-title":"Computed tomography of deep fat masses in multiple symmetric lipomatosis","volume":"144","author":"Enzi","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.joms.2005.10.045_bib13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0190-9622(00)90230-5","article-title":"Madelung\u2019s disease involving the tongue","volume":"42","author":"Vargas-D\u00edez","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/oby.2002.85","article-title":"Insulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome","volume":"10","author":"Harsch","year":"2002","journal-title":"Obesity Res"},{"key":"10.1016\/j.joms.2005.10.045_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0953-6205(00)00086-8","article-title":"Benign symmetrical lipomatosis (Madelung\u2019s disease)","volume":"11","author":"Iglesias","year":"2000","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.joms.2005.10.045_bib16","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/brain\/111.5.1157","article-title":"Neuropathy in multiple symmetric lipomatosis","volume":"111","author":"Pollack","year":"1988","journal-title":"Brain"},{"key":"10.1016\/j.joms.2005.10.045_bib17","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-2133.2000.03757.x","article-title":"Peripheral neuropathy as the first manifestation of Madelung\u2019s disease","volume":"143","author":"Saiz-Herv\u00e1s","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0738-081X(99)00026-7","article-title":"Alcohol intake, lipid metabolism, and the skin","volume":"17","author":"Grosshans","year":"1999","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(70)90120-8","article-title":"Benign symmetrical lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia","volume":"48","author":"Greene","year":"1970","journal-title":"Am J Med"},{"key":"10.1016\/j.joms.2005.10.045_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0190-9622(99)70452-4","article-title":"Protease inhibitor-induced lipodystrophy","volume":"40","author":"Williamson","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0194-5998(96)70159-6","article-title":"Benign symmetric lipomatosis (Madelung\u2019s disease)","volume":"115","author":"Josephson","year":"1996","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib22","first-page":"707","article-title":"Madelung\u2019s disease: Distribution of cervical fat and preoperative findings at sonography, MR, and CT","volume":"19","author":"Ahuja","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.joms.2005.10.045_bib23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00007611-199506000-00020","article-title":"Multiple symmetrical lipomatosis: Computed tomographic appearance","volume":"88","author":"Feldman","year":"1995","journal-title":"South Med J"},{"key":"10.1016\/j.joms.2005.10.045_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1053\/crad.1999.0260","article-title":"Ultrasound, CT and MRI in patients with multiple symmetric lipomatosis","volume":"55","author":"Ahuja","year":"2000","journal-title":"Clin Radiol"},{"key":"10.1016\/j.joms.2005.10.045_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/01.PRS.0000128639.00060.3F","article-title":"Ultrasound-assisted liposuction in the treatment of lipodystrophy secondary to Cushingoid-type disease of unknown cause","volume":"114","author":"Baynosa","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1006\/bbrc.2000.3828","article-title":"Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations","volume":"278","author":"Vil\u00e0","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joms.2005.10.045_bib27","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0026-0495(74)90043-2","article-title":"Benign symmetric lipomatosis: Functional sympathetic denervation of adipose tissue and possible hypertrophy of brown fat","volume":"23","author":"Kodish","year":"1974","journal-title":"Metabolism"},{"key":"10.1016\/j.joms.2005.10.045_bib28","first-page":"253","article-title":"Multiple symmetric lipomatosis: Ultrastructural investigation of the tissue and preadipocytes in primary culture","volume":"63","author":"Zancanaro","year":"1990","journal-title":"Lab Invest"},{"key":"10.1016\/j.joms.2005.10.045_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/path.1212","article-title":"Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells","volume":"198","author":"Nisoli","year":"2002","journal-title":"J Pathol"},{"key":"10.1016\/j.joms.2005.10.045_bib30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/ana.410290519","article-title":"Mitochondrial dysfunction in multiple symmetrical lipomatosis","volume":"29","author":"Berkovic","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.joms.2005.10.045_bib31","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1212\/WNL.44.5.862","article-title":"Multiple symmetrical lipomatosis: Abnormalities in complex IV and multiple deletions in mitochondrial DNA","volume":"44","author":"Klopstock","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.joms.2005.10.045_bib32","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1212\/WNL.47.4.1012","article-title":"Single large-scale mitochodrial DNA deletion in a patient with mitochondrial myopathy associated with multiple symmetric lipomatosis","volume":"47","author":"Campos","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.joms.2005.10.045_bib33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1212\/WNL.51.1.258","article-title":"Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondria DNA","volume":"51","author":"Gamez","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.joms.2005.10.045_bib34","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s004030050368","article-title":"Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis","volume":"290","author":"Becker-Wegerich","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.joms.2005.10.045_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/jpsu.2001.24775","article-title":"Benign symmetric lipomatosis with myelomeningocele in an adolescent: An uncommon association\u2013Case report","volume":"36","author":"Nounla","year":"2001","journal-title":"J Paediatr Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib36","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI108881","article-title":"Multiple symmetric lipomatosis: A defect in adrenergic-stimulated lipolysis","volume":"60","author":"Enzi","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joms.2005.10.045_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1210\/jcem-49-2-307","article-title":"Multiple symmetrical lipomatosis (Launois-Bensaude syndrome)","volume":"49","author":"Desai","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.joms.2005.10.045_bib38","first-page":"64","article-title":"Adipocytic adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis","volume":"33","author":"Pecquery","year":"1980","journal-title":"Biomedicine"},{"key":"10.1016\/j.joms.2005.10.045_bib39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2362.1982.tb02227.x","article-title":"Adrenergic regulation of fat-cell lipolysis in multiple symmetric lipomatosis","volume":"12","author":"Kather","year":"1982","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.joms.2005.10.045_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1259\/0007-1285-46-544-245","article-title":"Advanced laryngeal compression due to diffuse, symmetric lipomatosis (Madelung\u2019s disease)","volume":"46","author":"Birnholz","year":"1973","journal-title":"Br J Radiol"},{"key":"10.1016\/j.joms.2005.10.045_bib41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/hed.2890030312","article-title":"Benign symmetrical lipomatosis (Madelung\u2019s disease)","volume":"3","author":"Argenta","year":"1981","journal-title":"Head Neck Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1067\/msy.2001.105032","article-title":"Multiple symmetrical lipomatosis (Madelung\u2019s disease)","volume":"129","author":"Gabriel","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.joms.2005.10.045_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0007-1226(83)90089-9","article-title":"Malignant degeneration in Madelung\u2019s disease (benign lipomatosis of the neck): Case report","volume":"36","author":"Tizian","year":"1983","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1067\/mhn.2002.122004","article-title":"Madelung\u2019s lipomatosis associated with head and neck malignant neoplasia: A study of 2 cases","volume":"126","author":"Guastella","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib45","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2337\/diacare.27.3.794","article-title":"Multiple symmetric lipomatosis","volume":"27","author":"Haap","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.joms.2005.10.045_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0278-2391(92)90332-T","article-title":"Benign symmetrical lipomatosis with mediastinal involvement and growth retardation","volume":"50","author":"Fern\u00e1ndez Sanrom\u00e1n","year":"1992","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/019459989310800208","article-title":"Madelung\u2019s disease: Case reports and literature review","volume":"108","author":"Kohan","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0266-4356(96)90110-2","article-title":"Madelung\u2019s disease: An uncommon disorder of unknown aetiology?","volume":"34","author":"Parmar","year":"1996","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s002660010118","article-title":"Ultrasound assisted liposuction for the palliative treatment of Madelung\u2019s disease: A case report","volume":"25","author":"Faga","year":"2001","journal-title":"Aesth Plast Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/alp.37.1.34.40","article-title":"Aesthetic considerations in the cervicofacial management of Madelung\u2019s syndrome","volume":"37","author":"Wong","year":"2003","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00266-004-3123-5","article-title":"Benign symmetric lipomatosis (Madelung\u2019s disease): Case reports and current management","volume":"28","author":"Gonz\u00e1lez-Garc\u00eda","year":"2004","journal-title":"Aesthetic Plast Surg"},{"key":"10.1016\/j.joms.2005.10.045_bib52","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/thx.52.9.834","article-title":"Surgical management of Launois-Bensaude syndrome","volume":"52","author":"Brackenbury","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.joms.2005.10.045_bib53","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1288\/00005537-199201000-00019","article-title":"Surgical management of massive benign symmetric lipomatosis","volume":"102","author":"Boozan","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joms.2005.10.045_bib54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0385-8146(99)00007-3","article-title":"A case of multiple symmetrical lipomatosis (Madelung\u2019s disease)","volume":"26","author":"Morinaka","year":"1999","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.joms.2005.10.045_bib55","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-2265.1987.tb01190.x","article-title":"Multiple symmetrical lipomatosis (Launois-Bensaude syndrome): Effect of oral salbutamol","volume":"7","author":"Leung","year":"1987","journal-title":"Clin Endocrin"},{"key":"10.1016\/j.joms.2005.10.045_bib56","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1365-2133.2001.04102.x","article-title":"Intralesional injection of enoxaparin in benign symmetrical lipomatosis: An alternative to surgery?","volume":"144","author":"Fisher","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.joms.2005.10.045_bib57","first-page":"267","article-title":"Launois-Bensaude syndrome and Bureau-Barriere syndrome in a psoriatic patient: Successful treatment with carbamazepine","volume":"12","author":"Preisz","year":"2002","journal-title":"Eur J Dermatol"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027823910601144X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027823910601144X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:20:06Z","timestamp":1759508406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027823910601144X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S027823910601144X"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2005.10.045","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple Symmetric Lipomatosis: Case Report and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2005.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}