{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:40Z","timestamp":1792179460137,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.joms.2009.04.085","type":"journal-article","created":{"date-parts":[[2009,8,16]],"date-time":"2009-08-16T04:12:55Z","timestamp":1250395975000},"page":"1947-1960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":237,"title":["Pivotal, Randomized, Parallel Evaluation of Recombinant Human Bone Morphogenetic Protein-2\/Absorbable Collagen Sponge and Autogenous Bone Graft for Maxillary Sinus Floor Augmentation"],"prefix":"10.1016","volume":"67","author":[{"given":"R. Gilbert","family":"Triplett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Nevins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Oates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Moy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Boyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2009.04.085_bib1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne","year":"1980","journal-title":"J Oral Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0011-8532(22)02107-3","article-title":"Maxillary and sinus implant reconstructions","volume":"30","author":"Tatum","year":"1986","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joms.2009.04.085_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0011-8532(22)02464-8","article-title":"Sinus lift grafts and endosseous implants: Treatment of the atrophic posterior maxilla","volume":"36","author":"Smiler","year":"1992","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joms.2009.04.085_bib4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: Formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.joms.2009.04.085_bib5","doi-asserted-by":"crossref","first-page":"20805","DOI":"10.1016\/S0021-9258(19)47133-0","article-title":"Purification and characterization of a unique osteoinductive factor from bovine bone","volume":"264","author":"Bentz","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joms.2009.04.085_bib6","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1073\/pnas.76.4.1828","article-title":"Solubilized and insolubilized bone morphogenetic protein","volume":"76","author":"Urist","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joms.2009.04.085_bib7","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: Molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.joms.2009.04.085_bib8","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00007632-200208151-00002","article-title":"Overview of bone morphogenetic proteins","volume":"27","author":"Wozney","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.joms.2009.04.085_bib9","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.87.6.2220","article-title":"Recombinant human bone morphogenetic protein induces bone formation","volume":"87","author":"Wang","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joms.2009.04.085_bib10","series-title":"Cellular and Biology of Bone","first-page":"p 131","article-title":"Bone morphogenetic proteins and their gene expression","author":"Wozney","year":"1993"},{"key":"10.1016\/j.joms.2009.04.085_bib11","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1097\/00007632-200208151-00014","article-title":"Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications","volume":"27","author":"McKay","year":"2002","journal-title":"Spine"},{"issue":"Suppl 1","key":"10.1016\/j.joms.2009.04.085_bib12","first-page":"S136","article-title":"Augmentation of alveolar bone and dental implant osseointegration: Clinical implications of studies with rhBMP-2","volume":"83A","author":"Wikesjo","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joms.2009.04.085_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5173(99)00174-X","article-title":"Characterization of absorbable collagen sponges as rhBMP-2 carriers","volume":"187","author":"Friess","year":"1999","journal-title":"Int J Pharm"},{"key":"10.1016\/j.joms.2009.04.085_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/(SICI)1097-4636(199824)43:4<356::AID-JBM3>3.0.CO;2-7","article-title":"Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration","volume":"43","author":"Hollinger","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.joms.2009.04.085_bib15","series-title":"The Science of rhBMP-2","author":"McKay","year":"2006"},{"issue":"Suppl 1","key":"10.1016\/j.joms.2009.04.085_bib16","first-page":"S128","article-title":"Delivery systems for BMPs: Factors contributing to protein retention at an application site","volume":"83A","author":"Uludag","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joms.2009.04.085_bib17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.addr.2003.08.010","article-title":"Collagen sponges for bone regeneration with rhBMP-2","volume":"55","author":"Geiger","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.joms.2009.04.085_bib18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00003086-200202000-00011","article-title":"Clinical evaluation of recombinant human bone morphogenetic protein-2","volume":"395","author":"Valentin-Opran","year":"2002","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joms.2009.04.085_bib19","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00007632-200208151-00010","article-title":"Safety profile for the clinical use of bone morphogenetic proteins in the spine","volume":"27","author":"Poynton","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.joms.2009.04.085_bib20","doi-asserted-by":"crossref","first-page":"83S","DOI":"10.1016\/S8756-3282(96)00144-5","article-title":"Animal studies of application of rhBMP-2 in maxillofacial reconstruction","volume":"19","author":"Boyne","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.joms.2009.04.085_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1054\/bjom.1999.0205","article-title":"Evaluation of the long-term effect of function on rhBMP-2 regenerated hemimandibulectomy defects","volume":"37","author":"Boyne","year":"1999","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1902\/jop.1999.70.2.139","article-title":"Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants","volume":"70","author":"Cochran","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.04.085_bib23","first-page":"604","article-title":"Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2","volume":"12","author":"Hanisch","year":"1997","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.04.085_bib24","first-page":"8","article-title":"Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2","volume":"16","author":"Nevins","year":"1996","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.joms.2009.04.085_bib25","first-page":"11","article-title":"A feasibility study evaluating rhBMP-2\/absorbable collagen sponge for maxillary sinus floor augmentation","volume":"17","author":"Boyne","year":"1997","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.joms.2009.04.085_bib26","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.joms.2005.08.018","article-title":"De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation","volume":"63","author":"Boyne","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib27","first-page":"758","article-title":"Two-stage maxillary sinus reconstruction with endosseous implants: A prospective study","volume":"13","author":"Blomqvist","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.04.085_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0278-2391(90)90175-2","article-title":"Reconstruction of the severely resorbed maxilla with bone grafting and osseointegrated implants: A preliminary report","volume":"48","author":"Jensen","year":"1990","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib29","first-page":"760","article-title":"Augmentation of the maxillary sinus floor with particulated mandible: A histologic and histomorphometric study","volume":"11","author":"Lundgren","year":"1996","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.04.085_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0901-5027(97)80007-0","article-title":"Bone grafting to the maxillary sinuses, nasal floor and anterior maxilla in the atrophic edentulous maxilla: A two-stage technique","volume":"26","author":"Lundgren","year":"1997","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0901-5027(05)80219-X","article-title":"Composite grafting of the maxillary sinus for placement of endosteal implants: A preliminary report of 48 patients","volume":"21","author":"Tidwell","year":"1992","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1034\/j.1600-0501.1996.090608.x","article-title":"Sinus floor elevation and grafting with autogenous iliac crest bone","volume":"9","author":"van den Bergh","year":"1998","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2009.04.085_bib33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0901-5027(98)80031-3","article-title":"Treatment of patients with extreme maxillary atrophy using sinus floor augmentation and implants: Preliminary results","volume":"27","author":"Watzek","year":"1998","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"Suppl","key":"10.1016\/j.joms.2009.04.085_bib34","first-page":"11","article-title":"Report of the Sinus Consensus Conference of 1996","volume":"13","author":"Jensen","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.04.085_bib35","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.85.24.9484","article-title":"Purification and characterization of other distinct bone-inducing factors","volume":"85","author":"Wang","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joms.2009.04.085_bib36","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1073\/pnas.87.24.9843","article-title":"Identification of transforming growth factor \u03b2 family members present in bone-inductive protein purified from bovine bone","volume":"87","author":"Celeste","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joms.2009.04.085_bib37","first-page":"175","article-title":"A review of survival rates for implants placed in grafted maxillary sinuses using meta-analysis","volume":"13","author":"Tong","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.04.085_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0011-8532(22)02100-0","article-title":"Osseointegrated dental implants","volume":"30","author":"Albrektsson","year":"1986","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joms.2009.04.085_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0278-2391(91)90389-4","article-title":"Method for insuring parallelism of implants placed simultaneously with maxillary sinus bone grafts","volume":"49","author":"Block","year":"1991","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.04.085_bib40","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1902\/jop.2000.71.8.1241","article-title":"Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-Year results of a pilot study in humans","volume":"71","author":"Cochran","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.04.085_bib41","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1902\/jop.2005.76.4.605","article-title":"Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation","volume":"76","author":"Fiorellini","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.04.085_bib42","first-page":"124","article-title":"A feasibility study evaluating rhBMP-2\/absorbable collagen sponge device for local alveolar ridge preservation or augmentation","volume":"17","author":"Howell","year":"1997","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.joms.2009.04.085_bib43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00024720-200210000-00001","article-title":"Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages","volume":"15","author":"Burkus","year":"2002","journal-title":"J Spinal Disord Tech"},{"key":"10.1016\/j.joms.2009.04.085_bib44","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2106\/00004623-200212000-00001","article-title":"Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients","volume":"84A","author":"Govender","year":"2002","journal-title":"J Bone Joint Surg Am"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239109005898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239109005898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:26:19Z","timestamp":1759508779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239109005898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0278239109005898"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2009.04.085","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pivotal, Randomized, Parallel Evaluation of Recombinant Human Bone Morphogenetic Protein-2\/Absorbable Collagen Sponge and Autogenous Bone Graft for Maxillary Sinus Floor Augmentation","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2009.04.085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}