{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:25:35Z","timestamp":1778858735154,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.joms.2009.09.017","type":"journal-article","created":{"date-parts":[[2010,3,21]],"date-time":"2010-03-21T04:13:13Z","timestamp":1269144793000},"page":"790-796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Bisphosphonate-Related Osteonecrosis of the Jaw Associated With Dental Implants"],"prefix":"10.1016","volume":"68","author":[{"given":"Towy Sorel","family":"Lazarovici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Yahalom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo","family":"Taicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devorah","family":"Schwartz-Arad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oren","family":"Peleg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Yarom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2009.09.017_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01623652","article-title":"Rationale for the use of alendronate in osteoporosis","volume":"5","author":"Kanis","year":"1995","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joms.2009.09.017_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1652::AID-CNCR15>3.0.CO;2-Z","article-title":"Overview of bisphosphonates","volume":"80","author":"Rogers","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2009.09.017_bib3","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1359\/jbmr.1999.14.9.1557","article-title":"A dose-finding study of zoledronate in hypercalcemic cancer patients","volume":"14","author":"Body","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2009.09.017_bib4","first-page":"2949","article-title":"Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases","volume":"60","author":"Boissier","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.joms.2009.09.017_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1034\/j.1600-0609.2002.02796.x","article-title":"Bisphosphonate therapy in multiple myeloma: Past, present, future","volume":"6","author":"Jantunen","year":"2002","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.joms.2009.09.017_bib6","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/1097-0142(19941201)74:11<2949::AID-CNCR2820741110>3.0.CO;2-Q","article-title":"Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer","volume":"74","author":"Glover","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2009.09.017_bib7","first-page":"21","article-title":"Zoledronate in the treatment of osteolytic bone metastases","volume":"87","author":"Lipton","year":"1996","journal-title":"Br J Clin Pract Suppl"},{"key":"10.1016\/j.joms.2009.09.017_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/sonc.2002.37420","article-title":"The antitumor potential of bisphosphonates","volume":"29","author":"Cl\u00e9zardin","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.joms.2009.09.017_bib9","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/S0149-2918(03)80327-2","article-title":"Zoledronic acid: A new parenteral bisphosphonate","volume":"25","author":"Li","year":"2003","journal-title":"Clin Ther"},{"key":"10.1016\/j.joms.2009.09.017_bib10","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJM199511303332201","article-title":"Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis","volume":"333","author":"Liberman","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joms.2009.09.017_bib11","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1007\/BF01623002","article-title":"Clinical pharmacology of alendronate sodium","volume":"3","author":"Gertz","year":"1993","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joms.2009.09.017_bib12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.joms.2005.01.010","article-title":"Bisphosphonate osteochemonecrosis (bis-phossy jaw): Is this phossy jaw of the 21st century?","volume":"63","author":"Hellstein","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joms.2009.09.017_bib14","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0278-2391(03)00328-8","article-title":"Osteonecrosis of the jaws associated with cancer chemotherapy","volume":"61","author":"Wang","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib15","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib17","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM200507073530120","article-title":"Osteonecrosis of the jaw and bisphosphonates","volume":"353","author":"Durie","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joms.2009.09.017_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2257.2006.00841.x","article-title":"Osteomyelitis and necrosis of the jaw in patients treated with bisphosphonates: A comparative study focused on multiple myeloma","volume":"28","author":"Elad","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"10.1016\/j.joms.2009.09.017_bib20","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.14219\/jada.archive.2005.0108","article-title":"Managing the care of patients with bisphosphonate-associated osteonecrosis: An American Academy of Oral Medicine position paper","volume":"136","author":"Migliorati","year":"2005","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2009.09.017_bib21","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.joms.2007.03.006","article-title":"Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy","volume":"65","author":"Wang","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.21130","article-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: An emerging oral complication of supportive cancer therapy","volume":"104","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2009.09.017_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"Position paper on bisphosphonate-related osteonecrosis of the jaws","volume":"65","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","article-title":"\u201cBis-phossy jaws\u201d\u2014High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw","volume":"36","author":"Abu-Id","year":"2008","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib26","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.joms.2008.11.015","article-title":"Bisphosphonate-related osteonecrosis of the jaws: A single-center study of 101 patients","volume":"67","author":"Lazarovici","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib27","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","article-title":"Oral bisphosphonate-induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment","volume":"65","author":"Marx","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib28","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.tripleo.2006.10.010","article-title":"Osteonecrosis of the jaws associated with use of risedronate: Report of 2 new cases","volume":"103","author":"Brooks","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joms.2009.09.017_bib29","first-page":"74","article-title":"Failure of osseointegrated dental implants after diphosphonate therapy for osteoporosis: A case report","volume":"10","author":"Starck","year":"1995","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.09.017_bib30","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1902\/jop.2007.060514","article-title":"Implant placement with or without simultaneous tooth extraction in patients taking oral bisphosphonates: Postoperative healing, early follow-up, and the incidence of complications in two private practices","volume":"78","author":"Fugazzotto","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joms.2007.09.019","article-title":"Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases","volume":"66","author":"Grant","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib32","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.joms.2007.12.040","article-title":"Oral bisphosphonates and dental implants: A retrospective study","volume":"66","author":"Bell","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib33","first-page":"349","article-title":"Safety of oral bisphosphonates: Controlled studies on alveolar bone","volume":"21","author":"Jeffcoat","year":"2006","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2009.09.017_bib34","first-page":"70","article-title":"Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis","volume":"9","author":"Jeffcoat","year":"2007","journal-title":"J Int Acad Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib35","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1902\/jop.2005.76.11.1901","article-title":"Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats","volume":"76","author":"Menezes","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.14219\/jada.archive.2008.0245","article-title":"Alendronate may enhance implant osseointegration, study finds","volume":"139","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2009.09.017_bib37","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1902\/jop.2007.060390","article-title":"Effect of 17beta-estradiol and alendronate on the removal torque of osseointegrated titanium implants in ovariectomized rats","volume":"78","author":"Giro","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1902\/jop.2005.76.1.107","article-title":"Alendronate therapy may be effective in the prevention of bone loss around titanium implants inserted in estrogen-deficient rats","volume":"76","author":"Duarte","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1902\/jop.1999.70.2.151","article-title":"Use of alendronate in peri-implant defect regeneration","volume":"70","author":"Meraw","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2009.09.017_bib40","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.14219\/jada.archive.2008.0110","volume":"139","author":"Edwards","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2009.09.017_bib41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/01.id.0000236120.22719.02","article-title":"Dental endosseous implants in patients on bisphosphonate therapy","volume":"15","author":"Scully","year":"2006","journal-title":"Implant Dent"},{"key":"10.1016\/j.joms.2009.09.017_bib42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.joms.2007.11.032","article-title":"Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: A case-control study","volume":"66","author":"Wessel","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib43","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00198-007-0384-2","article-title":"Osteonecrosis of the jaw induced by orally administered bisphosphonates: Incidence, clinical features, predisposing factors and treatment outcome","volume":"18","author":"Yarom","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joms.2009.09.017_bib44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/pds.1229","article-title":"Prevalence of glucose metabolism abnormalities and cardiovascular co-morbidity in the US elderly adult population","volume":"15","author":"Varas-Lorenzo","year":"2006","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.joms.2009.09.017_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1464-5491.2005.01787.x","article-title":"Diabetes prevalence in England, 2001\u2014Estimates from an epidemiological model","volume":"23","author":"Forouhi","year":"2006","journal-title":"Diabet Med"},{"key":"10.1016\/j.joms.2009.09.017_bib46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.joms.2008.09.037","article-title":"Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws","volume":"67","author":"Pautke","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2009.09.017_bib47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1359\/JBMR.051109","article-title":"A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: Early actions of teriparatide","volume":"21","author":"Lindsay","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2009.09.017_bib48","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/j.tripleo.2006.05.007","article-title":"In vivo tetracycline labeling of bone: An intraoperative aid in the surgical therapy of osteoradionecrosis of the mandible","volume":"102","author":"Pautke","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239109017212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239109017212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:32:10Z","timestamp":1759509130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239109017212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0278239109017212"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2009.09.017","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphosphonate-Related Osteonecrosis of the Jaw Associated With Dental Implants","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2009.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}