{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:20:38Z","timestamp":1777508438678,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.joms.2011.08.033","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T08:08:37Z","timestamp":1337155717000},"page":"1844-1853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure: Clinical Course and Outcomes"],"prefix":"10.1016","volume":"70","author":[{"given":"Felice S.","family":"O'Ryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan C.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2011.08.033_bib1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib2","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1200\/JCO.2003.99.132","article-title":"Bisphosphonates and oral cavity avascular bone necrosis","volume":"21","author":"Migliorati","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2011.08.033_bib3","first-page":"A3078","article-title":"Kiefernekrosen nach hoch dosierter bisphosphonattherapie","volume":"103","author":"Felsenberg","year":"2006","journal-title":"Dtsch Arztebl"},{"key":"10.1016\/j.joms.2011.08.033_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib5","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","article-title":"Oral bisphosphonate-induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment","volume":"65","author":"Marx","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib6","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00198-007-0384-2","article-title":"Osteonecrosis of the jaw induced by orally administered bisphosphonates: Incidence, clinical features, predisposing factors and treatment outcome","volume":"18","author":"Yarom","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joms.2011.08.033_bib7","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","article-title":"Osteoporosis","volume":"367","author":"Sambrook","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.joms.2011.08.033_bib8","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2011.08.033_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib10","article-title":"Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence\u2014A multi-centre study","author":"Otto","year":"2010","journal-title":"J Craniomaxillofac Surg Epub"},{"key":"10.1016\/j.joms.2011.08.033_bib11","article-title":"Bisphosphonate-related osteonecrosis of the jaws: A case series of 25 patients affected by osteoporosis","author":"Manfredi","year":"2010","journal-title":"Int J Oral Maxillofac Surg Epub"},{"key":"10.1016\/j.joms.2011.08.033_bib12","article-title":"Bisphosphonate-related osteonecrosis of the maxilla and sinusitis maxillaris","author":"Maurer","year":"2010","journal-title":"Int J Oral Maxillofac Surg Epub"},{"key":"10.1016\/j.joms.2011.08.033_bib13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1200\/JCO.2005.04.2465","article-title":"Osteonecrosis of the jaw in multiple myeloma patients: Clinical features and risk factors","volume":"24","author":"Badros","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2011.08.033_bib15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.joms.2007.11.032","article-title":"Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: A case-control study","volume":"66","author":"Wessel","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib16","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1210\/jc.2006-2036","article-title":"Possible association between diabetes and bisphosphonate-related jaw osteonecrosis","volume":"92","author":"Khamaisi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.joms.2011.08.033_bib17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.joms.2008.11.015","article-title":"Bisphosphonate-related osteonecrosis of the jaws: A single-center study of 101 patients","volume":"67","author":"Lazarovici","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib18","doi-asserted-by":"crossref","first-page":"475.e3","DOI":"10.1016\/j.amjmed.2008.01.047","article-title":"Factors associated with osteonecrosis of the jaw among bisphosphonate users","volume":"121","author":"Hess","year":"2008","journal-title":"Am J Med"},{"key":"10.1016\/j.joms.2011.08.033_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ygyno.2008.11.029","article-title":"Bisphosphonate-induced osteonecrosis of the jaw (ONJ): Incidence and risk factors in patients with breast cancer and gynecological malignancies","volume":"112","author":"Fehm","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.joms.2011.08.033_bib20","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1634\/theoncologist.2009-0115","article-title":"Bisphosphonates and time to osteonecrosis development","volume":"14","author":"Palaska","year":"2009","journal-title":"Oncologist"},{"issue":"Suppl. 1","key":"10.1016\/j.joms.2011.08.033_bib21","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: A still increasing prevalence","volume":"38","author":"Reginster","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.joms.2011.08.033_bib22","unstructured":"SDI Total Patient Tracker, Years 2002-2007. Accessed May 27, 2008"},{"key":"10.1016\/j.joms.2011.08.033_bib23","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","article-title":"Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors","volume":"23","author":"Bamias","year":"2005","journal-title":"J Clin Oncol"},{"issue":"5 Suppl.","key":"10.1016\/j.joms.2011.08.033_bib24","first-page":"2","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20142009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib25","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.joms.2008.02.012","article-title":"Nonexposed bisphosphonate-related osteonecrosis of the jaws: Another clinical variant?","volume":"66","author":"Junquera","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.amjmed.2010.02.028","article-title":"Drug-induced osteoporosis: Mechanisms and clinical implications","volume":"123","author":"Mazziotti","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.joms.2011.08.033_bib27","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.joms.2009.12.030","article-title":"Resolution of oral bisphosphonate and steroid-related osteonecrosis of the jaw\u2014A serial case analysis","volume":"68","author":"Chiu","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2011.08.033_bib28","first-page":"70","article-title":"Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population","volume":"35","author":"de Pablo","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joms.2011.08.033_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1749-799X-4-17","article-title":"The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: An in-vitro study","volume":"4","author":"Malviya","year":"2009","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.joms.2011.08.033_bib30","article-title":"Oral bisphosphonate-related osteonecrosis of the jaw: The first report in Asia","author":"Hong","year":"2009","journal-title":"Osteoporos Int Epub"},{"key":"10.1016\/j.joms.2011.08.033_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14219\/jada.archive.2009.0019","article-title":"Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: An institutional inquiry","volume":"140","author":"Sedghizadeh","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2011.08.033_bib32","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.tripleo.2006.10.010","article-title":"Osteonecrosis of the jaws associated with use of risedronate: Report of 2 new cases","volume":"103","author":"Brooks","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239111014078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239111014078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:40:39Z","timestamp":1759509639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239111014078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0278239111014078"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2011.08.033","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure: Clinical Course and Outcomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2011.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}