{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:51:28Z","timestamp":1767901888687,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.joms.2013.06.202","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T22:00:56Z","timestamp":1376344856000},"page":"1835-1842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Safety and Efficacy of Intranasal Dexmedetomidine During Electrochemotherapy for Facial Vascular Malformation: A Double-Blind, Randomized Clinical Trial"],"prefix":"10.1016","volume":"71","author":[{"given":"Xia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xukai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2013.06.202_bib1","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1345\/aph.1M310","article-title":"An updated focused review of dexmedetomidine in adults","volume":"43","author":"Gerlach","year":"2009","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.joms.2013.06.202_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1213\/ane.0b013e3181ae0856","article-title":"Monitored anesthesia care with dexmedetomidine: A prospective, randomized, double-blind, multicenter trial","volume":"110","author":"Candiotti","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1016\/j.joms.2013.06.202_bib3","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1460-9592.2006.01857.x","article-title":"Monitored anesthesia care with a combination of ketamine and dexmedetomidine during magnetic resonance imaging in three children with trisomy 21 and obstructive sleep apnea","volume":"16","author":"Luscri","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.joms.2013.06.202_bib4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00228-011-1002-y","article-title":"Bioavailability of dexmedetomidine after intranasal administration","volume":"67","author":"Iirola","year":"2011","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.joms.2013.06.202_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/BCR.0b013e3181abff90","article-title":"Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery","volume":"30","author":"Talon","year":"2009","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.joms.2013.06.202_bib6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1365-2044.2012.07309.x","article-title":"A randomised comparison of two intranasal dexmedetomidine doses for premedication in children","volume":"67","author":"Yuen","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.joms.2013.06.202_bib7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1213\/01.ane.0000269488.06546.7c","article-title":"A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine","volume":"105","author":"Yuen","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.joms.2013.06.202_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2012.03.003","article-title":"Intranasal drug delivery: An efficient and non-invasive route for systemic administration: Focus on opioids","volume":"134","author":"Grassin-Delyle","year":"2012","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.joms.2013.06.202_bib9","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1213\/ane.0b013e31816c8929","article-title":"A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: A double-blinded randomized controlled trial","volume":"106","author":"Yuen","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.joms.2013.06.202_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/bja\/aer164","article-title":"Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia","volume":"107","author":"Cheung","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.joms.2013.06.202_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/EJA.0b013e32831a47cb","article-title":"Dexmedetomidine anaesthesia for patients with obstructive sleep apnoea undergoing bariatric surgery","volume":"26","author":"Bamgbade","year":"2009","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.joms.2013.06.202_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2044.2011.06817.x","article-title":"Postoperative respiratory and analgesic effects of dexmedetomidine or morphine for adenotonsillectomy in children with obstructive sleep apnoea","volume":"66","author":"Zhuang","year":"2011","journal-title":"Anaesthesia"},{"key":"10.1016\/j.joms.2013.06.202_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.36076\/ppj.2010\/13\/19","article-title":"Novel use of intraoperative dexmedetomidine infusion for sedation during spinal cord stimulator lead placement via surgical laminectomy","volume":"13","author":"Harned","year":"2010","journal-title":"Pain Physician"},{"key":"10.1016\/j.joms.2013.06.202_bib14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bjoms.2012.08.013","article-title":"Comparison of dexmedetomidine and midazolam for conscious sedation in dental surgery monitored by bispectral index","volume":"51","author":"Fan","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2013.06.202_bib15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.joms.2009.09.107","article-title":"Prolonged recovery associated with dexmedetomidine when used as a sole sedative agent in office-based oral and maxillofacial surgery procedures","volume":"68","author":"Makary","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2013.06.202_bib16","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1460-9592.2012.03802.x","article-title":"Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia","volume":"22","author":"Akin","year":"2012","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.joms.2013.06.202_bib17","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1365-2044.2010.06453.x","article-title":"Optimal timing for the administration of intranasal dexmedetomidine for premedication in children","volume":"65","author":"Yuen","year":"2010","journal-title":"Anaesthesia"},{"key":"10.1016\/j.joms.2013.06.202_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0169-409X(97)00059-8","article-title":"Nasal mucociliary clearance as a factor in nasal drug delivery","volume":"29","author":"Merkus","year":"1998","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.joms.2013.06.202_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0168-3659(02)00363-2","article-title":"Nasal drug delivery\u2014Possibilities, problems and solutions","volume":"87","author":"Illum","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.joms.2013.06.202_bib20","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1046\/j.1365-2125.2003.01944.x","article-title":"Bioavailability of dexmedetomidine after extravascular doses in healthy subjects","volume":"56","author":"Anttila","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.joms.2013.06.202_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1213\/ANE.0b013e3182326d5a","article-title":"Cardiovascular effects of dexmedetomidine sedation in children","volume":"114","author":"Wong","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.joms.2013.06.202_bib22","first-page":"401","article-title":"Comparison of drops versus spray administration of intranasal midazolam in two- and three-year-old children for dental sedation","volume":"27","author":"Primosch","year":"2005","journal-title":"Pediatr Dent"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239113008070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239113008070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:42:08Z","timestamp":1759509728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239113008070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0278239113008070"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2013.06.202","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Safety and Efficacy of Intranasal Dexmedetomidine During Electrochemotherapy for Facial Vascular Malformation: A Double-Blind, Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2013.06.202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}