{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:48:31Z","timestamp":1789847311887,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.joms.2015.07.004","type":"journal-article","created":{"date-parts":[[2015,7,11]],"date-time":"2015-07-11T04:57:08Z","timestamp":1436590628000},"page":"2257-2272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Acceleration of Alveolar Ridge Augmentation Using a Low Dose of Recombinant Human Bone Morphogenetic Protein-2 Loaded on a Resorbable Bioactive Ceramic"],"prefix":"10.1016","volume":"73","author":[{"given":"Rania A.","family":"Fahmy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naguiba","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Nouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El-Ghannam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2015.07.004_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/107632700418065","article-title":"Options for tissue engineering to address challenges of the aging skeleton","volume":"6","author":"Hollinger","year":"2000","journal-title":"Tissue Eng"},{"key":"10.1016\/j.joms.2015.07.004_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/sj.bdj.4801009","article-title":"Ridge augmentation using\u00a0mandibular tori. Case report","volume":"190","author":"Barker","year":"2001","journal-title":"Br Dent J"},{"key":"10.1016\/j.joms.2015.07.004_bib3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0278-2391(94)90309-3","article-title":"Severe retroperitoneal hemorrhage complicating anterior iliac bone graft acquisition","volume":"52","author":"Brazitis","year":"1994","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.07.004_bib4","first-page":"709","article-title":"Immediate nonfunctional loading of single tooth implants in the anterior maxilla following augmentation with freeze-dried cancellous block allograft: A case series","volume":"23","author":"Nissan","year":"2008","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.joms.2015.07.004_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.coms.2010.04.005","article-title":"Vertical ridge augmentation using titanium mesh","volume":"22","author":"Louis","year":"2010","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.joms.2015.07.004_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1034\/j.1600-0501.1999.100403.x","article-title":"Effects of barrier membranes on bone resorption and implant stability in onlay bone grafts. An experimental study","volume":"10","author":"Rasmusson","year":"1999","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0501.2004.00998.x","article-title":"Vertical bone augmentation with titanium mesh","volume":"15","author":"Roccuzzo","year":"2004","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/0972-124X.99268","article-title":"Alveolar ridge augmentation using chin bone graft, bovine bone mineral, and titanium mesh: Clinical, histological, and histomorphometric study","volume":"16","author":"Khamees","year":"2012","journal-title":"J Indian Soc Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1708-8208.2009.00257.x","article-title":"Alveolar ridge reconstruction with titanium mesh and autogenous particulate bone graft: Computed tomography-based evaluations of augmented bone quality and quantity","volume":"14","author":"Miyamoto","year":"2012","journal-title":"Clin Implant Dent Relat Res"},{"key":"10.1016\/j.joms.2015.07.004_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1902\/jop.1998.69.9.1044","article-title":"Preservation of alveolar bone in extraction sockets using bioabsorbable membranes","volume":"69","author":"Lekovic","year":"1998","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0757.1999.tb00153.x","article-title":"Localized ridge augmentation with autografts and barrier membranes","volume":"19","author":"Buser","year":"1999","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.joms.2015.07.004_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1600-0501.2004.01029.x","article-title":"A comparative study of barrier membranes as graft protectors in the treatment of localized bone defects. An experimental study in a canine model","volume":"15","author":"Stavropoulos","year":"2004","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib13","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.87.6.2220","article-title":"Recombinant human bone morphogenetic protein induces bone formation","volume":"87","author":"Wang","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joms.2015.07.004_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2106\/00004623-199274050-00005","article-title":"The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats","volume":"74","author":"Yasko","year":"1992","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joms.2015.07.004_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1034\/j.1600-0501.1997.080503.x","article-title":"Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration","volume":"8","author":"Sigurdsson","year":"1997","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1902\/jop.1999.70.2.139","article-title":"Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants","volume":"70","author":"Cochran","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.biomaterials.2004.02.010","article-title":"Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG\/hydroxyapatite composite","volume":"26","author":"Kaito","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.joms.2015.07.004_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jbm.820231306","article-title":"Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a collagenous delivery vehicle","volume":"23","author":"Lucas","year":"1989","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.joms.2015.07.004_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1007502828372","article-title":"Growth factors delivery for tissue engineering","volume":"17","author":"Babensee","year":"2000","journal-title":"Pharm Res"},{"issue":"Suppl 1","key":"10.1016\/j.joms.2015.07.004_bib20","first-page":"S128","article-title":"Delivery system for BMPs: Factors contributing to protein retention at an application site","volume":"83-A","author":"Uludag","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joms.2015.07.004_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-0501.2006.01324.x","article-title":"Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects","volume":"18","author":"Jovanovic","year":"2007","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib22","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1902\/jop.2000.71.3.488","article-title":"Ridge augmentation following implantation of recombinant human bone morphogenetic protein-2 in the dog","volume":"71","author":"Barboza","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jbm.a.30022","article-title":"Advanced bioceramic composite for bone tissue engineering: Design principles and structure-bioactivity relationship","volume":"69A","author":"El-Ghannam","year":"2004","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.joms.2015.07.004_bib24","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.joms.2006.10.031","article-title":"Bone engineering of rabbit ulna","volume":"65","author":"El-Ghannam","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.07.004_bib25","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1002\/jbm.a.34585","article-title":"Mechanical properties and cytotoxicity of a resorbable bioactive implant prepared by rapid prototyping technique","volume":"101","author":"El-Ghannam","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib26","first-page":"91","article-title":"Alveolar ridge preservation using resorbable bioactive ceramic composite: A histological study","volume":"15","author":"Al-Sabbagh","year":"2013","journal-title":"J Int Acad Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib27","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jbm.a.30517","article-title":"Effect of bioactive ceramic dissolution on the mechanism of bone mineralization and guided tissue growth in\u00a0vitro","volume":"76","author":"El-Ghannam","year":"2006","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10856-005-0635-8","article-title":"Effects of silica on the bioactivity of calcium phosphate composite in\u00a0vitro","volume":"16","author":"Ning","year":"2005","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.joms.2015.07.004_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/jbm.a.33228","article-title":"Evaluation of a bioresorbable drug delivery system for the treatment of hepatocellular carcinoma","volume":"100A","author":"Vedantham","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/jbm.a.32915","article-title":"Effects of exogenous phosphorus and silicon on osteoblast differentiation at the interface with bioactive ceramics","volume":"95A","author":"Gupta","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jbm.a.31005","article-title":"Dissolution kinetics of a Si-rich nanocomposite and its effect on osteoblast gene expression","volume":"80A","author":"Gupta","year":"2007","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jbm.b.30675","article-title":"Enhancement of osteoblast gene expression by mechanically compatible porous Si-rich nanocomposite","volume":"81B","author":"Gupta","year":"2007","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.joms.2015.07.004_bib33","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1002\/jbm.a.34280","article-title":"Promotion of pro-osteogenic responses by a bioactive ceramic coating","volume":"100A","author":"Aniket","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib34","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/jbm.a.35326","article-title":"The synergistic relationship between surface roughness and chemistry of bioactive ceramic coating on early osteoblast responses","volume":"103","author":"Aniket","year":"2015","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1034\/j.1600-0765.2002.00021.x","article-title":"Peri-implant bone regeneration using rhBMP-2\/ACS in a canine model: A dose-response study","volume":"37","author":"Tatakis","year":"2002","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.joms.2015.07.004_bib36","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.biomaterials.2005.10.007","article-title":"Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2)","volume":"27","author":"Kato","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.joms.2015.07.004_bib37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0501.2007.01431.x","article-title":"Bone morphogenetic protein-2 enhances bone formation when delivered by a synthetic matrix containing hydroxyapatite\/tricalcium phosphate","volume":"19","author":"Jung","year":"2008","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2015.07.004_bib38","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/jbm.820281003","article-title":"Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats","volume":"28","author":"Marden","year":"1994","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.joms.2015.07.004_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0142-9612(95)93857-A","article-title":"Healing of mandibular defects with different biodegradable and non-degradable membranes. An experimental study in rats","volume":"16","author":"Zellin","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.joms.2015.07.004_bib40","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbm.a.30128","article-title":"Cyclosilicate nanocomposite: A novel resorbable bioactive tissue engineering scaffold for BMP and bone-marrow cell delivery","volume":"71A","author":"El-Ghannam","year":"2004","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joms.2015.07.004_bib41","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1902\/jop.2001.72.5.651","article-title":"Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study","volume":"72","author":"Hunt","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2015.07.004_bib42","first-page":"461","article-title":"Alveolar bone augmentation with rhBMP-2 and bone-to-implant contact in induced bone","volume":"21","author":"Sigurdsson","year":"2001","journal-title":"Int J Periodontics Restorative Dent"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239115009192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239115009192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:47:29Z","timestamp":1759510049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239115009192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0278239115009192"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2015.07.004","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acceleration of Alveolar Ridge Augmentation Using a Low Dose of Recombinant Human Bone Morphogenetic Protein-2 Loaded on a Resorbable Bioactive Ceramic","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2015.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}