{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:50Z","timestamp":1790949890731,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.joms.2015.11.004","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T13:47:28Z","timestamp":1447163248000},"page":"982-990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Histopathological Features of Secondary Squamous Cell Carcinoma Around a Dental Implant in the Mandible After Chemoradiotherapy: A Case Report With a Clinicopathological Review"],"prefix":"10.1016","volume":"74","author":[{"given":"Yoshiki","family":"Nariai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2015.11.004_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.oraloncology.2009.01.004","article-title":"Oral squamous cell carcinoma overview","volume":"45","author":"Scully","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2015.11.004_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/107327480200900504","article-title":"Treatment of locally advanced head and neck cancer: Historical and critical review","volume":"9","author":"Al-Sarraf","year":"2002","journal-title":"Cancer Control"},{"key":"10.1016\/j.joms.2015.11.004_bib3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.oraloncology.2009.01.015","article-title":"Functional outcomes of free tissue transfer in head and neck cancer reconstruction","volume":"45","author":"Vaughan","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2015.11.004_bib4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.oraloncology.2013.05.010","article-title":"Consensus recommendations for management of head and neck cancer in Asian countries: A review of international guidelines","volume":"49","author":"D'Cruz","year":"2013","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2015.11.004_bib5","first-page":"261","article-title":"Osseointegrated implants: A review of the literature","volume":"45","author":"Shearer","year":"1995","journal-title":"Int Dent J"},{"key":"10.1016\/j.joms.2015.11.004_bib6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.oraloncology.2010.10.004","article-title":"Implant survival rate after oral cancer therapy: A review","volume":"46","author":"Javed","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2015.11.004_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2842.2005.01551.x","article-title":"Rehabilitation by means of osseointegrated implants in oral cancer patients with about four to six years follow-up","volume":"33","author":"Sekine","year":"2006","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joms.2015.11.004_bib8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","article-title":"Definition and prevalence of peri-implant diseases","volume":"35","author":"Zitzmann","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joms.2015.11.004_bib9","first-page":"707","article-title":"Oral squamous cell carcinoma around dental implants","volume":"37","author":"Czerninski","year":"2006","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joms.2015.11.004_bib10","first-page":"489","article-title":"Primary oral squamous cell carcinoma arising around dental osseointegrated implants mimicking peri-implantitis","volume":"13","author":"Eguia del Valle","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2015.11.004_bib11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.joms.2015.11.004_bib12","first-page":"350","article-title":"Inflammation and stem cells in gastrointestinal carcinogenesis","volume":"23","author":"Quante","year":"2008","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.joms.2015.11.004_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0959-8049(99)00312-3","article-title":"Evaluation of the carcinogenic risks to humans associated with surgical implants and other foreign bodies\u2014A report of an IARC Monographs Programme Meeting. International Agency for Research on Cancer","volume":"36","author":"McGregor","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.joms.2015.11.004_bib14","first-page":"1358","article-title":"Multiple primary malignant tumors. A survey of the literature and a statistical study","volume":"16","author":"Warren","year":"1932","journal-title":"Am J Cancer"},{"key":"10.1016\/j.joms.2015.11.004_bib15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/hed.10042","article-title":"Second primary tumors and field cancerization in oral and oropharyngeal cancer: Molecular techniques provide new insights and definitions","volume":"24","author":"Braakhuis","year":"2002","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2015.11.004_bib16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/jnci\/90.13.972","article-title":"Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma","volume":"90","author":"Leong","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.joms.2015.11.004_bib17","first-page":"1081","article-title":"Second malignancies after radiotherapy: Analysis of cases accumulated by a questionnaire in Japan","volume":"50","author":"Fukumoto","year":"2004","journal-title":"Jpn J Cancer Clin"},{"key":"10.1016\/j.joms.2015.11.004_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<8::AID-CNCR3>3.0.CO;2-W","article-title":"Sarcoma arising in irradiated bone: Report of eleven cases","volume":"82","author":"Cahan","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2015.11.004_bib19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/1097-0142(19910115)67:2<398::AID-CNCR2820670214>3.0.CO;2-A","article-title":"Second cancer after radiation therapy for cancer of the uterine cervix","volume":"67","author":"Arai","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2015.11.004_bib20","first-page":"811","article-title":"Second cancers following radiotherapy of malignant tumors. The second mail survey in Japan","volume":"46","author":"Sakai","year":"1986","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.joms.2015.11.004_bib21","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/hed.21088","article-title":"Local recurrences and second primary tumors from squamous cell carcinoma of the oral cavity: A retrospective analytic study of 500 patients","volume":"31","author":"Gonz\u00e1lez-Garc\u00eda","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2015.11.004_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.oraloncology.2003.09.019","article-title":"Recurrent carcinoma of the head and neck: Treatment strategies and survival analysis in a 20-year period","volume":"40","author":"Eckardt","year":"2004","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2015.11.004_bib23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.joms.2006.05.026","article-title":"Surgical salvage for local and regional recurrence in oral cancer","volume":"64","author":"Ord","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib24","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.joms.2009.11.016","article-title":"Survival analysis and risk factors for recurrence in oral squamous cell carcinoma: Does surgical salvage affect outcome?","volume":"68","author":"Sklenicka","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ijom.2008.12.015","article-title":"Second primary tumours after a squamous cell carcinoma of the oral cavity or oropharynx using the cumulative incidence method","volume":"38","author":"van der Haring","year":"2009","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0278-2391(83)90272-0","article-title":"Squamous cell carcinoma developing in conjunction with a mandibular staple bone plate","volume":"41","author":"Friedman","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib27","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1001\/archotol.1996.01890240108024","article-title":"Oral squamous cell carcinoma in association with dental osseointegrated implants. An unusual occurrence","volume":"122","author":"Clapp","year":"1996","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib28","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0278-2391(97)90083-5","article-title":"Squamous cell carcinoma associated with a mandibular staple implant","volume":"55","author":"Moxley","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib29","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1053\/joms.2001.27532","article-title":"Squamous cell carcinoma appearing as peri-implant bone loss: A case report","volume":"59","author":"Block","year":"2001","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijom.2003.09.017","article-title":"Further malignancy in field change adjacent to osseointegrated implants","volume":"33","author":"Shaw","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib31","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/sj.bdj.2008.980","article-title":"Dental implants and squamous cell carcinoma in the at risk patient\u2014Report of three cases","volume":"205","author":"Kwok","year":"2008","journal-title":"Br Dent J"},{"key":"10.1016\/j.joms.2015.11.004_bib32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.14219\/jada.archive.2008.0308","article-title":"Oral squamous cell carcinoma associated with symphyseal dental implants: An unusual case report","volume":"139","author":"Gallego","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2015.11.004_bib33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bjoms.2007.09.009","article-title":"Osseointegrated implants: A potential route of entry for squamous cell carcinoma of the mandible","volume":"46","author":"Schache","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1308\/147870809X450584","article-title":"Squamous cell carcinoma presenting as peri-implantitis: A case report","volume":"91","author":"Gulati","year":"2009","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.joms.2015.11.004_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10006-010-0208-y","article-title":"Removal of an oral squamous cell carcinoma including parts of osseointegrated implants in the marginal mandibulectomy. A case report","volume":"14","author":"Meijer","year":"2010","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib36","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/j.joms.2010.01.023","article-title":"Squamous cell carcinoma recurrence around dental implants","volume":"68","author":"De Ceulaer","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/ID.0b013e31824cde85","article-title":"Oral squamous cell carcinoma arising around osseointegrated dental implants","volume":"21","author":"Javed","year":"2012","journal-title":"Implant Dent"},{"key":"10.1016\/j.joms.2015.11.004_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00020840-200304000-00006","article-title":"Mechanisms of cancer invasion of the mandible","volume":"11","author":"Brown","year":"2003","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2015.11.004_bib39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0901-5027(05)80471-0","article-title":"Factors influencing the patterns of invasion of the mandible by oral squamous cell carcinoma","volume":"24","author":"Brown","year":"1995","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239115014408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239115014408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:50:20Z","timestamp":1759510220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239115014408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0278239115014408"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2015.11.004","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathological Features of Secondary Squamous Cell Carcinoma Around a Dental Implant in the Mandible After Chemoradiotherapy: A Case Report With a Clinicopathological Review","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2015.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}