{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:14:41Z","timestamp":1782695681427,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.joms.2018.05.012","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T12:29:35Z","timestamp":1526905775000},"page":"1882.e1-1882.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial"],"prefix":"10.1016","volume":"76","author":[{"given":"Majid","family":"Eshghpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahand","family":"Samieirad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Sharifian","family":"Attar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-2751","authenticated-orcid":false,"given":"Hamed","family":"Kermani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-4266","authenticated-orcid":false,"given":"Sadaf","family":"Seddigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2018.05.012_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2344\/anpr-63-03-04","article-title":"Remifentanil reduces blood loss during orthognathic surgery","volume":"64","author":"Matsuura","year":"2017","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joms.2018.05.012_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jcms.2016.01.004","article-title":"Effects of oral clonidine premedication on hemodynamic status in bimaxillary orthognathic surgery: A double-blind randomized clinical trial","volume":"44","author":"Mohammadi","year":"2016","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.ijom.2013.02.001","article-title":"Effect of remifentanil on the hemodynamic responses and recovery profile of patients undergoing single jaw orthognathic surgery","volume":"42","author":"Nooh","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.joms.2014.07.033","article-title":"Effect of tranexamic acid irrigation on perioperative blood loss during orthognathic surgery: A double-blind, randomized controlled clinical trial","volume":"73","author":"Eftekharian","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.joms.2010.07.019","article-title":"Blood loss in orthognathic surgery: A systematic review","volume":"69","author":"Pi\u00f1eiro-Aguilar","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib6","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/SCS.0b013e31822e5edb","article-title":"Assessment of the related factors of blood loss and blood ingredients among patients under hypotensive anesthesia in orthognathic surgery","volume":"22","author":"Chen","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/bjs.9193","article-title":"Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss","volume":"100","author":"Ker","year":"2013","journal-title":"Br J Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1292\/jvms.17-0319","article-title":"Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits","volume":"80","author":"Hirata","year":"2017","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.joms.2018.05.012_bib9","first-page":"19","article-title":"Blood biomarkers alterations with administration of propofol for anaesthesia maintenance during long term oral and maxillofacial surgeries","volume":"33","author":"Dahi","year":"2015","journal-title":"Shahid Beheshti Univ Dent J"},{"key":"10.1016\/j.joms.2018.05.012_bib10","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.joms.2008.06.008","article-title":"Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits","volume":"67","author":"Kemmochi","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijom.2016.11.005","article-title":"Sedative-analgesic activity of remifentanil and effects of preoperative anxiety on perceived pain in outpatient mandibular third molar surgery","volume":"46","author":"Torun","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib12","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.joms.2014.12.035","article-title":"A randomized trial to identify the most effective dose of remifentanil during Le Fort I osteotomy","volume":"73","author":"Abukawa","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib13","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ijom.2010.09.003","article-title":"Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: A prospective, single-blinded, randomized, controlled clinical study","volume":"39","author":"Ervens","year":"2010","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1365-2044.2007.05055.x","article-title":"Propofol infusion syndrome","volume":"62","author":"Kam","year":"2007","journal-title":"Anaesthesia"},{"key":"10.1016\/j.joms.2018.05.012_bib15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1053\/joms.2000.8194","article-title":"The effect of hypotensive anesthesia on blood loss and operative time during Le Fort I osteotomies","volume":"58","author":"Dolman","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib16","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.joms.2010.12.056","article-title":"Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits","volume":"69","author":"Koshika","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.joms.2008.08.015","article-title":"The effect of tranexamic acid on blood loss during orthognathic surgery: A randomized controlled trial","volume":"67","author":"Choi","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.oooo.2012.09.085","article-title":"The effect of tranexamic acid on blood loss in orthognathic surgery: A meta-analysis of randomized controlled trials","volume":"115","author":"Song","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2018.05.012_bib19","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.1016\/j.joms.2010.11.041","article-title":"Does tranexamic acid in an irrigating fluid reduce intraoperative blood loss in orthognathic surgery? A double-blind, randomized clinical trial","volume":"69","author":"Kaewpradub","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jcms.2009.10.012","article-title":"The role of controlled hypotension upon transfusion requirement during maxillary downfracture in double-jaw surgery","volume":"38","author":"Varol","year":"2010","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijom.2012.01.008","article-title":"Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study","volume":"41","author":"Sankar","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib22","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1007\/s00167-011-1754-z","article-title":"The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: A meta-analysis","volume":"20","author":"Zhang","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.joms.2018.05.012_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S0265021506001955","article-title":"Aprotinin; friend or foe? A review of recent medical literature","volume":"24","author":"Royston","year":"2007","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.joms.2018.05.012_bib24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jtcvs.2004.03.041","article-title":"Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials","volume":"128","author":"Sedrakyan","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib25","doi-asserted-by":"crossref","first-page":"S681","DOI":"10.3928\/0147-7447-20040602-10","article-title":"Aprotinin in spine surgery: Review of the literature","volume":"27","author":"Bitan","year":"2004","journal-title":"Orthopedics"},{"key":"10.1016\/j.joms.2018.05.012_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.joms.2008.12.012","article-title":"Desflurane versus sevoflurane to reduce blood loss in maxillofacial surgery","volume":"68","author":"Rossi","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0049-3848(01)00316-4","article-title":"Influence of hypotensive and normotensive anesthesia on platelet aggregability and hemostatic markers in orthognathic surgery","volume":"103","author":"Felfernig-Boehm","year":"2001","journal-title":"Thromb Res"},{"key":"10.1016\/j.joms.2018.05.012_bib28","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.amjcard.2009.05.065","article-title":"Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure","volume":"104","author":"Jorens","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.joms.2018.05.012_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00540-014-1944-1","article-title":"Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits","volume":"29","author":"Kasahara","year":"2015","journal-title":"J Anesth"},{"key":"10.1016\/j.joms.2018.05.012_bib30","doi-asserted-by":"crossref","first-page":"e456","DOI":"10.1016\/j.joms.2011.02.085","article-title":"Factors that determine intraoperative blood loss in bimaxillary osteotomies and the need for preoperative blood preparation","volume":"69","author":"Rummasak","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.joms.2004.05.226","article-title":"The assessment of blood loss in orthognathic surgery for prognathia","volume":"63","author":"Ueki","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bjoms.2008.03.017","article-title":"Template bleeding time for preoperative screening in patients having orthognathic surgery","volume":"46","author":"Modig","year":"2008","journal-title":"Br\u00a0J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.012_bib33","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.joms.2015.03.076","article-title":"Intraoperative blood loss during orthognathic surgery: A comparison of remifentanil-based anesthesia with sevoflurane or isoflurane","volume":"73","author":"Wakasugi","year":"2015","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118304373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118304373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:56:38Z","timestamp":1759510598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239118304373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0278239118304373"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2018.05.012","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propofol Versus Remifentanil: Which One Is More Effective in Reducing Blood Loss During Orthognathic Surgery? A Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2018.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}