{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:37:45Z","timestamp":1791632265644,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.joms.2018.05.025","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T23:25:25Z","timestamp":1527549925000},"page":"2332-2339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care"],"prefix":"10.1016","volume":"76","author":[{"given":"Danny","family":"Hadaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akrivoula","family":"Soundia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Freymiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elashoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-1855","authenticated-orcid":false,"given":"Sotirios","family":"Tetradis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Aghaloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2018.05.025_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161435.GL","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis\u20142016","volume":"22","author":"Camacho","year":"2016","journal-title":"Endocr Pract"},{"key":"10.1016\/j.joms.2018.05.025_bib2","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1200\/JCO.2005.05.116","article-title":"Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial","volume":"23","author":"Kohno","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0025-6196(11)60752-0","article-title":"Adverse effects of bisphosphonates: Implications for osteoporosis management","volume":"84","author":"Kennel","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.joms.2018.05.025_bib4","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 Update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2018.05.025_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025","volume":"22","author":"Burge","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2018.05.025_bib7","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/jbmr.2269","article-title":"The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine","volume":"29","author":"Wright","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2018.05.025_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/edrv.23.1.0453","article-title":"Antiresorptive treatment of postmenopausal osteoporosis: Comparison of study designs and outcomes in large clinical trials with fracture as an endpoint","volume":"23","author":"Marcus","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.joms.2018.05.025_bib9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1200\/JCO.2010.32.5209","article-title":"American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer","volume":"29","author":"Van Poznak","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Definition and management of the risk related to zoledronic acid","volume":"8","author":"Cafro","year":"2008","journal-title":"Clin Lymphoma Myeloma"},{"key":"10.1016\/j.joms.2018.05.025_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1634\/theoncologist.2010-0183","article-title":"Quality of life implications of bisphosphonate-associated osteonecrosis of the jaw","volume":"16","author":"Miksad","year":"2011","journal-title":"Oncologist"},{"key":"10.1016\/j.joms.2018.05.025_bib12","first-page":"e253","article-title":"Medication-related osteonecrosis of the jaws (MRONJ) and quality of life evaluation: A pilot study","volume":"168","author":"Capocci","year":"2017","journal-title":"Clin Ter"},{"key":"10.1016\/j.joms.2018.05.025_bib13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tripleo.2010.05.067","article-title":"Management of bisphosphonate-associated osteonecrosis: Pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series","volume":"110","author":"Epstein","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joms.2018.05.025_bib14","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.joms.2015.09.024","article-title":"Disease stage and mode of therapy are important determinants of treatment outcomes for medication-related osteonecrosis of the jaw","volume":"73","author":"Ruggiero","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib16","doi-asserted-by":"crossref","first-page":"w13605","DOI":"10.4414\/smw.2012.13605","article-title":"Osteopathology of the jaw associated with bone resorption inhibitors: What have we learned in the last 8 years?","volume":"142","author":"Jacobsen","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.joms.2018.05.025_bib17","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.joms.2008.11.015","article-title":"Bisphosphonate-related osteonecrosis of the jaws: A single-center study of 101 patients","volume":"67","author":"Lazarovici","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib19","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.joms.2016.12.014","article-title":"Extensive surgical procedures result in better treatment outcomes for bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis","volume":"75","author":"Kim","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.oraloncology.2010.11.007","article-title":"Surgery-triggered and non surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Italian multicenter study","volume":"47","author":"Vescovi","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib21","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bjoms.2016.06.015","article-title":"Conservative surgical management of patients with bisphosphonate-related osteonecrosis of the jaws: A series of 120 patients","volume":"54","author":"Nisi","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib22","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.joms.2012.05.019","article-title":"Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: A retrospective survey of 347 cases","volume":"70","author":"Graziani","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/annonc\/mdr039","article-title":"Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: A single-center clinical experience","volume":"23","author":"Vandone","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib24","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.4317\/medoral.20092","article-title":"Osteonecrosis of the jaws in 194 patients who have undergone intravenous bisphosphonate therapy in Spain","volume":"20","author":"Vidal-Real","year":"2015","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2018.05.025_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11914-010-0008-1","article-title":"The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy","volume":"8","author":"Kumar","year":"2010","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.joms.2018.05.025_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.14219\/jada.archive.2011.0220","article-title":"Osteonecrosis of the jaw\u00a0in patients with cancer who received zoledronic acid and bevacizumab","volume":"142","author":"Francini","year":"2011","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2018.05.025_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.21130","article-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: An emerging oral complication of supportive cancer therapy","volume":"104","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2018.05.025_bib28","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: Mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.joms.2018.05.025_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","article-title":"Denosumab and bisphosphonates: Different mechanisms of action and effects","volume":"48","author":"Baron","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.joms.2018.05.025_bib30","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jcms.2016.08.001","article-title":"Evaluation of surgical outcome and influencing risk factors in patients with medication-related osteonecrosis of the jaws","volume":"44","author":"Klingelhoffer","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib31","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jso.20491","article-title":"Complete rehabilitation of the mandible following segmental resection","volume":"94","author":"Schrag","year":"2006","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib32","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/lary.21062","article-title":"Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws","volume":"120","author":"Seth","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joms.2018.05.025_bib33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jcms.2014.01.005","article-title":"Outcomes of osseous free flap reconstruction in stage III bisphosphonate-related osteonecrosis of the jaw: Systematic review and a new case series","volume":"42","author":"Vercruysse","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib34","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jcms.2015.07.035","article-title":"Surgical treatment of bisphosphonate-associated osteonecrosis: Prognostic score and long-term results","volume":"43","author":"Reich","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib35","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.joms.2013.05.014","article-title":"Metastatic cancer identified in osteonecrosis specimens of the jaws in patients receiving intravenous bisphosphonate medications","volume":"71","author":"Carlson","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib36","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.oraloncology.2013.05.012","article-title":"Conservative management of bisphosphonate-related osteonecrosis of the jaws: Staging and treatment outcomes","volume":"49","author":"Lerman","year":"2013","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2018.05.025_bib37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bjoms.2017.06.014","article-title":"Medication-related osteonecrosis of the jaw in oncological patients with skeletal metastases: Conservative treatment is effective up to stage 2","volume":"55","author":"Coropciuc","year":"2017","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.05.025_bib38","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jbmr.3191","article-title":"Evaluation of the treatment strategies for medication-related osteonecrosis of the jaws (MRONJ) and the factors affecting treatment outcome: A multicenter retrospective study with propensity score matching analysis","volume":"32","author":"Hayashida","year":"2017","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2018.05.025_bib39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: A systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118305007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118305007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:56:20Z","timestamp":1759510580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239118305007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0278239118305007"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2018.05.025","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2018.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}