{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:44:37Z","timestamp":1759538677401,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100744","81500878"],"award-info":[{"award-number":["81100744","81500878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.joms.2018.09.012","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T06:10:18Z","timestamp":1537423818000},"page":"493-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Leptin Levels in the Synovial Fluid of Patients With Temporomandibular Disorders"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-9312","authenticated-orcid":false,"given":"Haofei","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-5900","authenticated-orcid":false,"given":"Lili","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2018.09.012_bib1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/joms.2003.50096","article-title":"Structure and function of the temporomandibular joint disc: Implications for tissue engineering","volume":"61","author":"Detamore","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2842.1992.tb01486.x","article-title":"Remarks on probability theory and TMJ diagnosis","volume":"19","author":"Christensen","year":"1992","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joms.2018.09.012_bib3","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.joms.2007.06.640","article-title":"Modeling of the effect of friction in the temporomandibular joint on displacement of its disc during prolonged clenching","volume":"66","author":"Tanaka","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cyto.2015.11.005","article-title":"Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review","volume":"77","author":"Kellesarian","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.joms.2018.09.012_bib5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0266-4356(02)00215-2","article-title":"Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders","volume":"40","author":"Kaneyama","year":"2002","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.joms.2018.09.012_bib7","doi-asserted-by":"crossref","first-page":"5468023","DOI":"10.1155\/2017\/5468023","article-title":"Adipokine contribution to the pathogenesis of osteoarthritis","volume":"2017","author":"Azamar-Llamas","year":"2017","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.joms.2018.09.012_bib8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/382250a0","article-title":"Role of leptin in the neuroendocrine response to fasting","volume":"382","author":"Ahima","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.joms.2018.09.012_bib9","first-page":"1","article-title":"Role of leptin in immunity","volume":"4","author":"Lam","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.joms.2018.09.012_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrrheum.2016.209","article-title":"Leptin in the interplay of inflammation, metabolism and immune system disorders","volume":"13","author":"Abella","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joms.2018.09.012_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nri1350","article-title":"The weight of leptin in immunity","volume":"4","author":"La Cava","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joms.2018.09.012_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.metabol.2014.10.014","article-title":"Leptin in autoimmune diseases","volume":"64","author":"Procaccini","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.joms.2018.09.012_bib13","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1002\/art.11303","article-title":"Evidence for a key role of leptin in osteoarthritis","volume":"11","author":"Dumond","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joms.2018.09.012_bib14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00296-008-0764-8","article-title":"Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis","volume":"29","author":"Seven","year":"2009","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joms.2018.09.012_bib15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s10067-009-1242-8","article-title":"Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis","volume":"28","author":"Ku","year":"2009","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.joms.2018.09.012_bib16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/BF00184499","article-title":"Interleukin-6 in autoimmune disease. Role of IL-6 in physiology and pathology of the immune defense","volume":"71","author":"Graeve","year":"1993","journal-title":"Clin Investig"},{"key":"10.1016\/j.joms.2018.09.012_bib17","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jcms.2017.02.019","article-title":"Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis","volume":"45","author":"de Alc\u00e2ntara Camejo","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib18","doi-asserted-by":"crossref","first-page":"e75551","DOI":"10.1371\/journal.pone.0075551","article-title":"Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joms.2018.09.012_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/joor.12265","article-title":"Histamine and substance P in synovial fluid of patients with temporomandibular disorders","volume":"42","author":"Li","year":"2015","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joms.2018.09.012_bib20","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.joms.2010.01.018","article-title":"Boundary-lubricating ability and lubricin in synovial fluid of patients with temporomandibular joint disorders","volume":"68","author":"Wei","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.joms.2018.09.012_bib22","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.mehy.2007.07.033","article-title":"A hypothetical biological synovial fluid for treatment of temporomandibular joint disease","volume":"70","author":"Meng","year":"2008","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.joms.2018.09.012_bib23","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s00264-014-2416-9","article-title":"Adipokines correlate with pain in lower limb osteoarthritis: Different associations in hip and knee","volume":"38","author":"Bas","year":"2014","journal-title":"Int Orthop"},{"key":"10.1016\/j.joms.2018.09.012_bib24","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s10067-010-1429-z","article-title":"The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis","volume":"29","author":"Gandhi","year":"2010","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.joms.2018.09.012_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/annrheumdis-2011-200372","article-title":"Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases","volume":"71","author":"Hui","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joms.2018.09.012_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2842.2007.01759.x","article-title":"Osteoarthritis of the temporomandibular joint: An evaluation of the effects and complications of corticosteroid injection compared with injection with sodium hyaluronate","volume":"34","author":"Bjornland","year":"2007","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joms.2018.09.012_bib27","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.joca.2007.01.018","article-title":"Differential expression of leptin and leptin\u2019s receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; Effect on cartilage metabolism","volume":"15","author":"Simopoulou","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joms.2018.09.012_bib28","doi-asserted-by":"crossref","first-page":"3009e12","DOI":"10.1002\/art.11315","article-title":"Systemic and local regulation of articular cartilage metabolism: Where does leptin fit in the puzzle?","volume":"48","author":"Loeser","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joms.2018.09.012_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0901-5027(05)80805-7","article-title":"Pathology of temporomandibular joint internal derangement and osteoarthrosis","volume":"22","author":"de Bont","year":"1993","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2018.09.012_bib30","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1002\/art.24857","article-title":"Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage","volume":"60","author":"Sui","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joms.2018.09.012_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biocel.2016.08.003","article-title":"Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption","volume":"79","author":"Sims","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.joms.2018.09.012_bib32","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1002\/1529-0131(200109)44:9<2176::AID-ART371>3.0.CO;2-4","article-title":"Interleukin-17 enhances tumor necrosis factor \u03b1-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts","volume":"44","author":"Katz","year":"2001","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118310826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239118310826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:57:16Z","timestamp":1759510636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239118310826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0278239118310826"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2018.09.012","relation":{},"ISSN":["0278-2391"],"issn-type":[{"type":"print","value":"0278-2391"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin Levels in the Synovial Fluid of Patients With Temporomandibular Disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2018.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}