{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:18:40Z","timestamp":1788304720736,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007195","name":"University of Naples Federico II","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.joms.2020.04.022","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T15:23:42Z","timestamp":1588001022000},"page":"1572-1582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Amyloidoma of the Tongue: Case Report, Surgical Management, and Review of the Literature"],"prefix":"10.1016","volume":"78","author":[{"given":"Daniela","family":"Adamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-7806","authenticated-orcid":false,"given":"Roberta","family":"Gasparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Marenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-220X","authenticated-orcid":false,"given":"Massimo","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Cervasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cerciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"De Novellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Davide","family":"Mignogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2020.04.022_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5858\/arpa.2018-0509-RA","article-title":"An organ system-based approach to differential diagnosis of amyloid type in surgical pathology","volume":"144","author":"Giannini","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.joms.2020.04.022_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imj.12288","article-title":"How to diagnose amyloidosis","volume":"44","author":"Mollee","year":"2014","journal-title":"Intern Med J"},{"key":"10.1016\/j.joms.2020.04.022_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF01930815","article-title":"Uebereine im Gehirn und R\u00fcckenmark des Menschen aufgefundene Substanz mit der chemischen Reaction der Cellulose","volume":"6","author":"Virchow","year":"1854","journal-title":"Virchows Arch Pathol Anat"},{"key":"10.1016\/j.joms.2020.04.022_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13506129.2016.1257986","article-title":"Amyloid fibril proteins and amyloidosis: Chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines","volume":"23","author":"Sipe","year":"2016","journal-title":"Amyloid"},{"key":"10.1016\/j.joms.2020.04.022_bib5","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1182\/blood-2013-01-453001","article-title":"Systemic light chain amyloidosis: An update for treating physicians","volume":"121","author":"Merlini","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.joms.2020.04.022_bib6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0030-4220(73)90302-2","article-title":"Amyloidosis: Its significance in oral surgery. Review of the literature and report of a case","volume":"36","author":"van der Waal","year":"1973","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joms.2020.04.022_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.oraloncology.2005.09.010","article-title":"Head and neck amyloidosis: A clinicopathologic study of 15 cases","volume":"42","author":"Penner","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2020.04.022_bib8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0030-6665(03)00026-4","article-title":"Plasma cell dyscrasias and amyloidosis","volume":"36","author":"Lebowitz","year":"2003","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.joms.2020.04.022_bib9","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/ajh.25608","article-title":"Lower respiratory tract amyloidosis: Presentation, survival and prognostic factors. A multicenter consecutive case series","volume":"94","author":"Rech","year":"2019","journal-title":"Am J Hematol"},{"key":"10.1016\/j.joms.2020.04.022_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-225414","article-title":"Primary bladder amyloidosis as a cause of haematuria","volume":"2018","author":"Nesbitt","year":"2018","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.joms.2020.04.022_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.anorl.2011.10.010","article-title":"Localized nasopharyngeal amyloidosis","volume":"129","author":"Durbec","year":"2012","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.joms.2020.04.022_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-0347(199801)20:1<73::AID-HED12>3.0.CO;2-Q","article-title":"Localized amyloidosis of the parotid gland: A case report and review of the localized amyloidosis of the head and neck","volume":"20","author":"Nandapalan","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2020.04.022_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/13506120500537343","article-title":"Localized oral amyloidosis of the palate","volume":"13","author":"Pentenero","year":"2006","journal-title":"Amyloid"},{"key":"10.1016\/j.joms.2020.04.022_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/1752-1947-8-198","article-title":"Localized amyloidosis of the upper gingiva: A case report","volume":"8","author":"Bucci","year":"2014","journal-title":"J Med Case Rep"},{"key":"10.1016\/j.joms.2020.04.022_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10006-009-0158-4","article-title":"Local amyloidosis in the hard palate: A case report","volume":"13","author":"Aono","year":"2009","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.04.022_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/bmb\/ldt021","article-title":"Imaging in systemic amyloidosis","volume":"107","author":"Sachchithanantham","year":"2013","journal-title":"Br Med Bull"},{"key":"10.1016\/j.joms.2020.04.022_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/01913123.2016.1152339","article-title":"Concomitant use of Congo red staining and confocal laser scanning microscopy to detect amyloidosis in oral biopsy: A clinicopathological study of 16 patients","volume":"40","author":"Scivetti","year":"2016","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.joms.2020.04.022_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41408-020-0291-8","article-title":"Blood mass spectrometry detects residual disease better than standard techniques in light-chain amyloidosis","volume":"10","author":"Dispenzieri","year":"2020","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.joms.2020.04.022_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-8722-4-47","article-title":"Light chain (AL) amyloidosis: Update on diagnosis and management","volume":"4","author":"Rosenzweig","year":"2011","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.joms.2020.04.022_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/10428194.2018.1485914","article-title":"Daratumumab for the treatment of AL amyloidosis","volume":"60","author":"Sidiqi","year":"2019","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.joms.2020.04.022_bib21","first-page":"336","article-title":"Amyloidosis of the oral cavity: Report of five cases","volume":"12","author":"Madani","year":"1991","journal-title":"Compendium"},{"key":"10.1016\/j.joms.2020.04.022_bib22","first-page":"179","article-title":"Localized amyloid tumor of the tongue. A case report and review of the literature","volume":"44","author":"Koren","year":"1998","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.joms.2020.04.022_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.amjoto.2004.01.007","article-title":"Localized amyloidosis of the tongue: A review","volume":"25","author":"Fahrner","year":"2004","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.joms.2020.04.022_bib24","first-page":"515068","article-title":"Solitary amyloid tumor of the tongue base","volume":"2009","author":"Akyildiz","year":"2009","journal-title":"Int J Otolaryngol"},{"key":"10.1016\/j.joms.2020.04.022_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12105-011-0251-5","article-title":"Localized tongue amyloidosis in a patient with neurofibromatosis type II","volume":"5","author":"Andreadis","year":"2011","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.joms.2020.04.022_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-0714.2011.01073.x","article-title":"Head and neck amyloidosis: Clinicopathological features and immunohistochemical analysis of 14 cases","volume":"41","author":"Gouv\u00eaa","year":"2012","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.joms.2020.04.022_bib27","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-015-1649-3","article-title":"Involvement of oral tissues by AL amyloidosis: A literature review and report of eight new cases","volume":"20","author":"Matsuo","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joms.2020.04.022_bib28","first-page":"258","article-title":"Rare amyloidoma of the tongue base: A case report and review of the literature","volume":"12","author":"Musat","year":"2020","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.joms.2020.04.022_bib29","first-page":"3009","article-title":"Amyloid deposition in the tongue: Clinical and histopathological profile","volume":"30","author":"Angiero","year":"2010","journal-title":"Anticancer Res"},{"key":"10.1016\/j.joms.2020.04.022_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/0194599813490896","article-title":"Localized tongue amyloidosis: A single institutional case series","volume":"149","author":"O\u2019Reilly","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.joms.2020.04.022_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000276907","article-title":"Primary localized nodular tongue amyloidosis associated with Sj\u00f6gren's syndrome","volume":"59","author":"Haraguchi","year":"1997","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.joms.2020.04.022_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000444206","article-title":"The prevalence and management of systemic amyloidosis in Western countries","volume":"2","author":"Nienhuis","year":"2016","journal-title":"Kidney Dis (Basel)"},{"key":"10.1016\/j.joms.2020.04.022_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/13506129.2017.1342235","article-title":"Changing epidemiology of AA amyloidosis: Clinical observations over 25 years at a single national referral centre","volume":"24","author":"Lane","year":"2017","journal-title":"Amyloid"},{"key":"10.1016\/j.joms.2020.04.022_bib34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/scd.12331","article-title":"Lingual amyloidosis associated to long-term hemodialysis: Two case reports","volume":"38","author":"Picciani","year":"2018","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.joms.2020.04.022_bib35","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2215\/CJN.02740806","article-title":"Light-chain (AL) amyloidosis: Diagnosis and treatment","volume":"1","author":"Sanchorawala","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.joms.2020.04.022_bib36","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/bloodadvances.2018016402","article-title":"Epidemiology of AL amyloidosis: A real-world study using US claims data","volume":"2","author":"Quock","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.joms.2020.04.022_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/pin.12902","article-title":"Human amyloidosis, still intractable but becoming curable: The essential role of pathological diagnosis in the selection of type-specific therapeutics","volume":"70","author":"Naiki","year":"2020","journal-title":"Pathol Int"},{"key":"10.1016\/j.joms.2020.04.022_bib38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1601-0825.2003.03940.x","article-title":"Oral involvement in a case of AA amyloidosis","volume":"9","author":"Koloktronis","year":"2003","journal-title":"Oral Dis"},{"key":"10.1016\/j.joms.2020.04.022_bib39","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00259-017-3814-1","article-title":"Visualization of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB PET imaging","volume":"45","author":"Ezawa","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.joms.2020.04.022_bib40","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1182\/blood-2015-01-620302","article-title":"A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis","volume":"126","author":"Palladini","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.joms.2020.04.022_bib41","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/odi.12870","article-title":"Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis","volume":"25","author":"Deng","year":"2019","journal-title":"Oral Dis"},{"key":"10.1016\/j.joms.2020.04.022_bib42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jormas.2018.06.009","article-title":"Macroglossia, the first manifestation of systemic amyloidosis associated with multiple myeloma: Case report","volume":"119","author":"Maturana-Ram\u00edrez","year":"2018","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.04.022_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/scd.12299","article-title":"Dysphagia due to macroglossia in a patient with amyloidosis associated with multiple myeloma: A case report","volume":"38","author":"da Costa","year":"2018","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.joms.2020.04.022_bib44","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/odi.12901","article-title":"Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis","volume":"24","author":"Leiba","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.joms.2020.04.022_bib45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/1573397113666170103152537","article-title":"Coexistance of amyloidosis and primary Sj\u00f6gren's syndrome: An overview","volume":"14","author":"Hernandez-Molina","year":"2018","journal-title":"Curr Rheumatol Rev"},{"key":"10.1016\/j.joms.2020.04.022_bib46","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1016\/S2352-3026(15)00068-X","article-title":"Natural history and outcomes in localised immunoglobulin light-chain amyloidosis: A long-term observational study","volume":"2","author":"Mahmood","year":"2015","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.joms.2020.04.022_bib47","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1097\/00005537-200312000-00007","article-title":"Amyloidosis of the upper aerodigestive tract","volume":"113","author":"Pribitkin","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joms.2020.04.022_bib48","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1053\/ajot.2002.124195","article-title":"Nasopharyngeal amyloidosis","volume":"23","author":"Patel","year":"2002","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.joms.2020.04.022_bib49","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/000348948409300418","article-title":"Localised amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts","volume":"93","author":"Simpson","year":"1984","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.joms.2020.04.022_bib50","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ajh.2830110414","article-title":"Factor-X deficiency in amyloidosis: A critical review","volume":"11","author":"Greipp","year":"1981","journal-title":"Am J Hematol"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239120304286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239120304286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:01:52Z","timestamp":1759510912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239120304286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0278239120304286"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2020.04.022","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloidoma of the Tongue: Case Report, Surgical Management, and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2020.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}