{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:26:32Z","timestamp":1791872792938,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.joms.2020.06.001","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T21:28:54Z","timestamp":1591738134000},"page":"2281.e1-2281.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits"],"prefix":"10.1016","volume":"78","author":[{"given":"Huseyin Can","family":"Tukel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Kenan","family":"Daglioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Tatli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leman Sencar","family":"Gundogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kurkcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Emre","family":"Benlidayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2020.06.001_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1054\/ijom.2002.0244","article-title":"Bone growth factors in maxillofacial skeletal reconstruction","volume":"31","author":"Schilephake","year":"2002","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib2","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2005.07.019","article-title":"Current concepts of molecular aspects of bone healing","volume":"36","author":"Dimitriou","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.joms.2020.06.001_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.22203\/eCM.v035a25","article-title":"Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover","volume":"35","author":"Fischer","year":"2018","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.joms.2020.06.001_bib4","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.joms.2010.07.063","article-title":"Effects of zoledronic acid on healing of mandibular fractures: An experimental study in rabbits","volume":"69","author":"Tatli","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0021-9290(02)00086-6","article-title":"A mechano-regulation model for tissue differentiation during fracture healing: Analysis of gap size and loading","volume":"35","author":"Lacroix","year":"2002","journal-title":"J Biomech"},{"key":"10.1016\/j.joms.2020.06.001_bib6","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jor.20824","article-title":"Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: Preliminary evidence of efficacy","volume":"27","author":"Goodship","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joms.2020.06.001_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1054\/jcms.1999.0104","article-title":"Effect of electrical stimulation on mandibular distraction osteogenesis","volume":"28","author":"Hagiwara","year":"2000","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib8","article-title":"Treatment of nonunions with electric and electromagnetic fields","volume":"21","author":"Aaron","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joms.2020.06.001_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.joms.2005.10.027","article-title":"Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: An experimental study in rabbits","volume":"64","author":"Erdo\u011fan","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib10","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.2106\/00004623-200707000-00022","article-title":"Timely fracture-healing requires optimization of axial fixation stability","volume":"89","author":"Epari","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.joms.2020.06.001_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jbiomech.2009.09.016","article-title":"Boning up on Wolff's law: Mechanical regulation of the cells that make and maintain bone","volume":"43","author":"Chen","year":"2010","journal-title":"J Biomech"},{"key":"10.1016\/j.joms.2020.06.001_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijom.2009.10.022","article-title":"Clinical use of botulinum toxins in oral and maxillofacial surgery","volume":"39","author":"Majid","year":"2010","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib13","first-page":"734","article-title":"Botulinum toxin injection of eye muscles to correct strabismus","volume":"79","author":"Scott","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.joms.2020.06.001_bib14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijom.2017.11.006","article-title":"Botulinum toxin A for patients with orofacial dystonia: Prospective, observational, single-centre study","volume":"47","author":"Ruiz-de-Leon-Hernandez","year":"2018","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijom.2016.11.004","article-title":"Clinical outcomes of Botox injections for chronic temporomandibular disorders: Do we understand how Botox works on muscle, pain, and the brain?","volume":"46","author":"Connelly","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.ijom.2019.04.015","article-title":"Botulinum toxin for ductal stenosis and fistulas of the main salivary glands","volume":"48","author":"Graillon","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jcms.2016.01.021","article-title":"Botulinum toxin as a therapeutic agent to prevent relapse in deep bite patients","volume":"44","author":"Mucke","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/mus.23229","article-title":"Influence of botulinum toxin on rabbit jaw muscle activity and anatomy","volume":"45","author":"Korfage","year":"2012","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.joms.2020.06.001_bib19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bone.2011.11.015","article-title":"Botulinum toxin in masticatory muscles: Short- and long-term effects on muscle, bone, and craniofacial function in adult rabbits","volume":"50","author":"Rafferty","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.joms.2020.06.001_bib20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jor.21553","article-title":"Short-term muscle atrophy caused by botulinum toxin-A local injection impairs fracture healing in the rat femur","volume":"30","author":"Hao","year":"2012","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joms.2020.06.001_bib21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00776-012-0269-x","article-title":"Effects of botulinum toxin A on fracture healing in rats: An experimental study","volume":"17","author":"Aydin","year":"2012","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.joms.2020.06.001_bib22","article-title":"Levofloxacin and trovafloxacin inhibition of experimental fracture-healing","volume":"95","author":"Perry","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joms.2020.06.001_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2020.06.001_bib24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/01.sap.0000244987.68092.6e","article-title":"Botulinum toxin in closed treatment of mandibular condylar fracture","volume":"58","author":"Canter","year":"2007","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib25","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.joms.2012.03.036","article-title":"Bite force evaluation of mandibular fractures treated with microplates and miniplates","volume":"70","author":"Gupta","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0278-2391(94)90489-8","article-title":"Bite forces in patients treated for mandibular angle fractures: Implications for fixation recommendations","volume":"52","author":"Tate","year":"1994","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2020.06.001_bib27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jcms.2018.09.025","article-title":"A retrospective comparative study of mandibular fracture treatment with internal fixation using reconstruction plate versus miniplates","volume":"47","author":"Sukegawa","year":"2019","journal-title":"J Craniomaxillofac Surg"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027823912030567X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027823912030567X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:03:40Z","timestamp":1759511020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027823912030567X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S027823912030567X"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2020.06.001","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2020.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}