{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:46:08Z","timestamp":1785933968462,"version":"3.56.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.joms.2021.04.019","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T03:20:23Z","timestamp":1619148023000},"page":"2203-2214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antibiotics in Dentoalveolar Surgery, a Closer Look at Infection, Alveolar Osteitis and Adverse Drug Reaction"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-7345","authenticated-orcid":false,"given":"Simra","family":"Azher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2021.04.019_bib0001","first-page":"141","article-title":"Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates","volume":"9","author":"Bermudez-Bejarano","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0002","first-page":"186","article-title":"Antibiotic use in dental practice. A review","volume":"12","author":"Poveda Roda","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2021.04.019_bib0003","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bjoms.2006.11.005","article-title":"Routine antibiotic prophylaxis is not necessary during operations to remove third molars","volume":"46","author":"Ataoglu","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0004","first-page":"123","article-title":"What are the risk factors for postoperative infections of third molar extraction surgery: A retrospective clinical study?","volume":"24","author":"Sukegawa","year":"2019","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2021.04.019_bib0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.oooo.2011.10.022","article-title":"Are antibiotics necessary after lower third molar removal?","volume":"114","author":"Calvo","year":"2012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2021.04.019_bib0006","first-page":"10","article-title":"Systemic review of dry socket: aetiology, treatment, and prevention","volume":"9","author":"Tarakji","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0007-117X(79)90009-X","article-title":"Metronidazole in the prevention of 'dry socket'","volume":"17","author":"Rood","year":"1979","journal-title":"Br J Oral Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0008","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/1119-3077.116897","article-title":"Dry socket following surgical removal of impacted third molar in an Iranian population: incidence and risk factors","volume":"16","author":"Eshghpour","year":"2013","journal-title":"Niger J Clin Pract"},{"key":"10.1016\/j.joms.2021.04.019_bib0009","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.joms.2010.11.006","article-title":"Factors affecting incidence of dry socket: a prospective community-based study","volume":"69","author":"Parthasarathi","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0010","first-page":"1042-1046","article-title":"The most common complications after wisdom-tooth removal: part 1: a retrospective study of 1,199 cases in the mandible","volume":"124","author":"Sigron","year":"2014","journal-title":"Swiss Dent J"},{"key":"10.1016\/j.joms.2021.04.019_bib0011","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12663-017-1031-x","article-title":"Infection, alveolar osteitis, and adverse effects using metronidazole in healthy patients undergoing third molar surgery: A meta-analysis","volume":"17","author":"Isiordia-Espinoza","year":"2018","journal-title":"J Maxillofac Oral Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0012","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bjoms.2015.06.013","article-title":"Risk of wound infection and safety profile of amoxicillin in healthy patients which required third molar surgery: a systematic review and meta-analysis","volume":"53","author":"Isiordia-Espinoza","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0013","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ijom.2009.03.717","article-title":"Infective endocarditis and antibiotic prophylaxis prior to dental\/oral procedures: latest revision to the guidelines by the American Heart Association published April 2007","volume":"38","author":"Farbod","year":"2009","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0014","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1177\/0022034519863645","article-title":"Risk of adverse reactions to oral antibiotics prescribed by dentists","volume":"98","author":"Thornhill","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/1751-2980.12839","article-title":"Which probiotic has the best effect on preventing Clostridium difficile-associated diarrhea? A systematic review and network meta-analysis","volume":"21","author":"Ma","year":"2020","journal-title":"J Dig Dis"},{"key":"10.1016\/j.joms.2021.04.019_bib0016","first-page":"1","article-title":"Antibiotics to prevent complications following tooth extractions","author":"Lodi","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joms.2021.04.019_bib0017","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.joms.2016.09.044","article-title":"Do antibiotics decrease the risk of inflammatory complications after third molar removal in community practices?","volume":"75","author":"Lang","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0018","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.joms.2011.03.055","article-title":"Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg)","volume":"69","author":"Bezerra","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0019","first-page":"26","article-title":"A single dose of amoxicillin and dexamethasone for prevention of postoperative complications in third molar surgery: a randomized, double-blind, placebo controlled clinical trial","volume":"5","author":"Bortoluzzi","year":"2013","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0020","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.joms.2008.12.066","article-title":"Evaluation of antibiotic prophylaxis in reducing postoperative infection after mandibular third molar extraction in young patients","volume":"67","author":"Monaco","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0021","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/SCS.0b013e31820745c7","article-title":"Antibiotic prophylaxis in third molar surgery","volume":"22","author":"Pasupathy","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0022","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tripleo.2011.08.018","article-title":"Clinical and surgical evaluation of the indication of postoperative antibiotic prescription in third molar surgery","volume":"114","author":"Adde","year":"2012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2021.04.019_bib0023","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0975-5950.154821","article-title":"Antibiotics in third molar extraction; are they really necessary: A non-inferiority randomized controlled trial","volume":"5","author":"Arora","year":"2014","journal-title":"Natl J Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.oooo.2014.08.014","article-title":"Amoxicillin\/clavulanic acid 2000\/125 mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial","volume":"119","author":"Arteagoitia","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2021.04.019_bib0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ijom.2006.11.007","article-title":"Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin\/clavulanic acid (1000\/62.5 mg)","volume":"36","author":"Lacasa","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0026","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijom.2006.12.003","article-title":"Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery","volume":"36","author":"Kaczmarzyk","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0027","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.ebd.6400307","article-title":"No benefit from prophylactic antibiotics in third molar surgery","volume":"6","author":"Hill","year":"2005","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0028","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1054\/bjom.2000.0557","article-title":"Role of antimicrobials in third molar surgery: prospective, double blind,randomized, placebo-controlled clinical study","volume":"39","author":"Sekhar","year":"2001","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0029","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0266-4356(04)00136-6","article-title":"Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial","volume":"42","author":"Bergdahl","year":"2004","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0901-5027(05)80743-X","article-title":"Does metronidazole prevent alveolitis sicca dolorosa? A double-blind, placebo-controlled clinical study","volume":"21","author":"Ritzau","year":"1992","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/1117-1936.170331","article-title":"Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study","volume":"18","author":"Olusanya","year":"2011","journal-title":"Niger Postgrad Med J"},{"key":"10.1016\/j.joms.2021.04.019_bib0032","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bjoms.2015.02.001","article-title":"Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial","volume":"53","author":"Xue","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0033","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.joms.2011.01.019","article-title":"Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study","volume":"69","author":"Lopez-Cedrun","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0034","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.joms.2003.04.003","article-title":"The impact of intravenous antibiotics on health-related quality of life outcomes and clinical recovery after third molar surgery","volume":"62","author":"Foy","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joms.2006.10.016","article-title":"Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery?","volume":"65","author":"Halpern","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0036","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tripleo.2005.03.025","article-title":"Efficacy of amoxicillin\/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction","volume":"100","author":"Arteagoitia","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joms.2021.04.019_bib0037","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.joms.2017.03.038","article-title":"Does administration of oral versus intravenous antibiotics for third molar removal have an effect on the incidence of alveolar osteitis or postoperative surgical site infections?","volume":"75","author":"Reiland","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0038","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijom.2009.12.014","article-title":"Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique","volume":"39","author":"Siddiqi","year":"2010","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0039","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/1117-6806.179830","article-title":"Comparative efficacy of amoxicillin\/clavulanic acid and levofloxacin in the reduction of postsurgical sequelae after third molar surgery: A randomized, double-blind, clinical trial in a nigerian university teaching hospital","volume":"22","author":"Ndukwe","year":"2016","journal-title":"Niger J Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10266-020-00492-1","article-title":"Evaluation of intravenous prophylaxis antibiotics for third molar extraction under general anesthesia","volume":"108","author":"Iguchi","year":"2020","journal-title":"Odontology"},{"key":"10.1016\/j.joms.2021.04.019_bib0041","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5125\/jkaoms.2018.44.3.103","article-title":"Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection","volume":"44","author":"Sayd","year":"2018","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0042","first-page":"30","article-title":"Prevention of dry socket with clindamycin. A retrospective study","volume":"61","author":"Kupfer","year":"1995","journal-title":"N Y State Dent J"},{"key":"10.1016\/j.joms.2021.04.019_bib0043","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.oooo.2018.12.004","article-title":"The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anesthetics and without the use of systemic antibiotics","volume":"128","author":"Oyri","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2021.04.019_bib0044","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0278-2391(87)90158-3","article-title":"The effect of tetracycline on the incidence of postextraction alveolar osteitis","volume":"45","author":"Sorensen","year":"1987","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0045","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.joms.2003.08.035","article-title":"Tetracycline compound placement to prevent dry socket: a postoperative study of 200 impacted mandibular third molars","volume":"62","author":"Sanchis","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0046","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2165\/11640880-000000000-00000","article-title":"The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day","volume":"72","author":"Angiolillo","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.joms.2021.04.019_bib0047","first-page":"1","article-title":"Effects of antibiotics on dental implants: a review","volume":"4","author":"Ahmad","year":"2012","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0048","first-page":"143","article-title":"Single preoperative dose of prophylactic amoxicillin versus a 2-day postoperative course in dental implant surgery: A two-centre randomised controlled trial","volume":"8","author":"Arduino","year":"2015","journal-title":"Eur J Oral Implantol"},{"key":"10.1016\/j.joms.2021.04.019_bib0049","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/clr.12124","article-title":"The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial","volume":"25","author":"Nolan","year":"2014","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0050","article-title":"A multicentre placebo-controlled randomised clinical trial of antibiotic prophylaxis for placement of single dental implants","volume":"2","author":"Anitua","year":"2009","journal-title":"Eur J Oral Implantol"},{"key":"10.1016\/j.joms.2021.04.019_bib0051","first-page":"135","article-title":"Effectiveness of prophylactic antibiotics at placement of dental implants: a pragmatic multicentre placebo-controlled randomised clinical trial","volume":"3","author":"Esposito","year":"2010","journal-title":"Eur J Oral Implantol"},{"key":"10.1016\/j.joms.2021.04.019_bib0052","first-page":"23","article-title":"Efficacy of prophylactic antibiotics for dental implants: a multicentre placebo-controlled randomised clinical trial","volume":"1","author":"Esposito","year":"2008","journal-title":"Eur J Oral Implantol"},{"key":"10.1016\/j.joms.2021.04.019_bib0053","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/clr.12098","article-title":"Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial","volume":"25","author":"Tan","year":"2014","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0054","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1563\/AAID-JOI-D-09-00134.1","article-title":"A pilot study to determine the effectiveness of different amoxicillin regimens in implant surgery","volume":"37","author":"Caiazzo","year":"2011","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.joms.2021.04.019_bib0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ijom.2013.09.013","article-title":"Efficacy of two antibiotic regimens in the reduction of early dental implant failure: a pilot study","volume":"43","author":"El-Kholey","year":"2014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0056","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.adaj.2018.10.015","article-title":"Prophylactic antibiotic regimens in dental implant failure: A systematic review and meta-analysis","volume":"150","author":"Braun","year":"2019","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2021.04.019_bib0057","first-page":"309","article-title":"Effect of Postoperative Amoxicillin on Early Bacterial Colonization of Peri-Implant Sulcus: A Randomized Controlled Clinical Trial","volume":"13","author":"Moslemi","year":"2016","journal-title":"J Dent (Tehran)"},{"key":"10.1016\/j.joms.2021.04.019_bib0058","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4317\/jced.51499","article-title":"Prevalence, etiology, diagnosis, treatment and complications of supernumerary teeth","volume":"6","author":"Ata-Ali","year":"2014","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0059","first-page":"89","article-title":"Antibiotic prophylaxis for preventing dental implant failure and postoperative infection: A systematic review of randomized controlled trials","volume":"30","author":"Chen","year":"2017","journal-title":"Am J Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0060","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10006-020-00872-5","article-title":"Efficacy of preoperative antibiotics in prevention of dental implant failure: a Meta-analysis of randomized controlled trials","volume":"24","author":"Jain","year":"2020","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0061","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1177\/154405910708601203","article-title":"Efficacy of Antibiotic Prophylactic Regimens for the Prevention of Bacterial Endocarditis of Oral Origin","volume":"86","author":"Carmona","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.joms.2021.04.019_bib0062","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0140-6736(92)90207-J","article-title":"Efficacy of antibiotic prophylaxis for prevention of native-valve endocarditis","volume":"339","author":"Van der Meer","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.joms.2021.04.019_bib0063","first-page":"150","article-title":"Adverse reaction to prophylactic amoxicillin: a case report","volume":"13","author":"Sadaghiani","year":"2005","journal-title":"Eur J Prosthodont Restor Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0064","first-page":"401","article-title":"Adverse reaction to amoxicillin: a case report","volume":"22","author":"da Fonseca","year":"2000","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joms.2021.04.019_bib0065","first-page":"20","article-title":"Clostridium difficile colitis following antibiotic prophylaxis for dental procedures","volume":"67","author":"Bombassaro","year":"2001","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.joms.2021.04.019_bib0066","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/jac\/25.6.975","article-title":"Comparative efficacy and tolerance of erythromycin and josamycin in the prevention of bacteraemia following dental extraction","volume":"25","author":"Sefton","year":"1990","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.joms.2021.04.019_bib0067","first-page":"1","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","author":"Beth-Tasdogan","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joms.2021.04.019_bib0068","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0069","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jcms.2017.05.027","article-title":"The impact of surgical intervention and antibiotics on MRONJ stage II and III - Retrospective study","volume":"45","author":"Zirk","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0070","first-page":"63","article-title":"The Prevention of Medication-related Osteonecrosis of the Jaw","volume":"114","author":"Poxleitner","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.joms.2021.04.019_bib0071","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1080\/10428190802483778","article-title":"Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates","volume":"49","author":"Montefusco","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.joms.2021.04.019_bib0072","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10006-018-0732-8","article-title":"A literature review of perioperative antibiotic administration in surgery for medication-related osteonecrosis of the jaw","volume":"22","author":"Akashi","year":"2018","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0073","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s12663-015-0762-9","article-title":"Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update","volume":"14","author":"Nadella","year":"2015","journal-title":"J Maxillofac Oral Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0074","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2021.04.019_bib0075","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.oooo.2020.07.001","article-title":"Osteonecrosis of the jaw and dental extractions: A single-center experience","volume":"130","author":"Sandhu","year":"2020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2021.04.019_bib0076","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14219\/jada.archive.1985.0074","article-title":"Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin","volume":"111","author":"Marx","year":"1985","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joms.2021.04.019_bib0077","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijom.2010.10.005","article-title":"Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review","volume":"40","author":"Nabil","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0078","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1834-7819.1999.tb00220.x","article-title":"Incidence of complicated healing and osteoradionecrosis following tooth extraction in patients receiving radiotherapy for treatment of nasopharyngeal carcinoma","volume":"44","author":"Tong","year":"1999","journal-title":"Aust Dent J"},{"key":"10.1016\/j.joms.2021.04.019_bib0079","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1054\/ijom.2002.0332","article-title":"Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients\u2013a report of a thirty year retrospective review","volume":"32","author":"Reuther","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tripleo.2008.01.007","article-title":"Dental extractions related to head and neck radiotherapy: ten-year experience of a single institution","volume":"105","author":"Koga","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joms.2021.04.019_bib0081","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bjoms.2009.06.128","article-title":"Management of patients at risk of osteoradionecrosis: results of survey of dentists and oral & maxillofacial surgery units in the United Kingdom, and suggestions for best practice","volume":"48","author":"McLeod","year":"2010","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0082","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijom.2006.11.006","article-title":"The effect of prior radiation therapy for treatment of nasopharyngeal cancer on wound healing following extractions: incidence of complications and risk factors","volume":"36","author":"Lye","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0083","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0278-2391(03)00669-4","article-title":"Dental extractions in the irradiated head and neck patient: a retrospective analysis of Memorial Sloan-Kettering Cancer Center protocols, criteria, and end results","volume":"61","author":"Sulaiman","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2021.04.019_bib0084","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofx250","article-title":"Use of Antibiotic Prophylaxis for Tooth Extractions, Dental Implants, and Periodontal Surgical Procedures","volume":"5","author":"Suda","year":"2018","journal-title":"Open Forum Infect Dis"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239121004055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239121004055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:04:40Z","timestamp":1759511080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239121004055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":84,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0278239121004055"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2021.04.019","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotics in Dentoalveolar Surgery, a Closer Look at Infection, Alveolar Osteitis and Adverse Drug Reaction","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2021.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The American Association of Oral and Maxillofacial Surgeons.","name":"copyright","label":"Copyright"}]}}