{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:38:37Z","timestamp":1792269517151,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.joms.2023.01.010","type":"journal-article","created":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T23:43:58Z","timestamp":1676245438000},"page":"622-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-1913","authenticated-orcid":false,"given":"Shaimaa Mohsen","family":"Refahee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-1384","authenticated-orcid":false,"given":"Inass","family":"Aboulmagd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-8219","authenticated-orcid":false,"given":"Reham","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-3421","authenticated-orcid":false,"given":"Omniya","family":"Abdel Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-5475","authenticated-orcid":false,"given":"Walaa Abd el Aty","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-4999","authenticated-orcid":false,"given":"Alshaimaa Ahmed","family":"Shabaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2023.01.010_bib1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1834-7819.2008.00073.x","article-title":"The incidence of mandibular third molar impactions in different skeletal face types","volume":"53","author":"Breik","year":"2008","journal-title":"Aust Dent J"},{"key":"10.1016\/j.joms.2023.01.010_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.joms.2009.07.063","article-title":"Frequency of agenesis, impaction, angulation, and related pathologic changes of third molar teeth in orthodontic patients","volume":"68","author":"Celikoglu","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ajodo.2003.10.010","article-title":"Eruption of third molars: Relationship to inclination of adjacent molars","volume":"125","author":"Fayad","year":"2004","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.joms.2023.01.010_bib4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joms.2006.06.281","article-title":"Relationships between surgical difficulty and postoperative pain in lower third molar extractions","volume":"65","author":"Lago-M\u00e9ndez","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10103-011-0936-8","article-title":"Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study","volume":"27","author":"L\u00f3pez-Ram\u00edrez","year":"2012","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12663-009-0063-2","article-title":"Changes in quality of life after surgical removal of impacted mandibular third molar teeth","volume":"8","author":"Deepti","year":"2009","journal-title":"J Maxillofac Oral Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tripleo.2005.02.063","article-title":"Risk of periodontal defects after third molar surgery: An exercise in evidence based clinical decision-making","volume":"100","author":"Richardson","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2023.01.010_bib8","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.4317\/medoral.24260","article-title":"A systematic review and meta-analysis on the effectiveness of xenograft to prevent periodontal defects after mandibular third molar extraction","volume":"26","author":"Toledano-Serrabona","year":"2021","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2023.01.010_bib9","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.bcp.2010.07.041","article-title":"Melatonin: A pleiotropic molecule regulating inflammation","volume":"80","author":"Radogna","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.joms.2023.01.010_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/2042018813476084","article-title":"Therapeutic applications of melatonin","volume":"4","author":"Kostoglou-Athanassiou","year":"2013","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.joms.2023.01.010_bib11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1902\/jop.2007.060244","article-title":"Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal\u2013induced oxidative stress","volume":"78","author":"Cutando","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.joms.2023.01.010_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.lfs.2009.01.024","article-title":"Melatonin: A hormone that modulates pain","volume":"84","author":"Ambriz-Tututi","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/157015912800604489","article-title":"Melatonin in antinociception: Its therapeutic applications","volume":"10","author":"Srinivasan","year":"2012","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.joms.2023.01.010_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-079X.2003.00028.x","article-title":"Melatonin effects on bone: Experimental facts and clinical perspectives","volume":"34","author":"Cardinali","year":"2003","journal-title":"J Pineal Res"},{"key":"10.1016\/j.joms.2023.01.010_bib15","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1359\/jbmr.2002.17.7.1219","article-title":"Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation","volume":"17","author":"Koyama","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joms.2023.01.010_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1568026023394443","article-title":"Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger","volume":"2","author":"Tan","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.joms.2023.01.010_bib17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1349-7006.2005.00096.x","article-title":"Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis","volume":"96","author":"Chaiyarit","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib18","first-page":"66","article-title":"Melatonin attenuates inflammation of acute pulpitis subjected to dental pulp injury","volume":"7","author":"Li","year":"2015","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.joms.2023.01.010_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1708-8208.2010.00271.x","article-title":"Effects of local melatonin application on implant osseointegration","volume":"14","author":"Tresguerres","year":"2012","journal-title":"Clin Implant Dent Relat Res"},{"key":"10.1016\/j.joms.2023.01.010_bib20","first-page":"14","article-title":"World medical association declaration of helsinki: Ethical principles for medical research involving human subjects","volume":"81","year":"2014","journal-title":"J Am Coll Dent"},{"key":"10.1016\/j.joms.2023.01.010_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-6215-11-32","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"11","author":"Schulz","year":"2010","journal-title":"Trials"},{"key":"10.1016\/j.joms.2023.01.010_bib22","doi-asserted-by":"crossref","first-page":"e628","DOI":"10.4317\/medoral.19851","article-title":"Effects of localmelatonin application on post-extraction sockets after third molar surgery","volume":"19","author":"Cobo-V\u00e1zquez","year":"2014","journal-title":"A Pilot Study Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.joms.2023.01.010_bib23","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jmrt.2020.12.012","article-title":"Preparation of cellulose-based hydrogel: A review","volume":"1","author":"Zainal","year":"2021","journal-title":"J Mater Res Technol"},{"key":"10.1016\/j.joms.2023.01.010_bib24","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.3390\/ma13143090","article-title":"Autogenous dentin graft in bone defects after lower third molar extraction: A split-mouth clinical trial","volume":"13","author":"S\u00e1nchez-Labrador","year":"2020","journal-title":"J Mater"},{"key":"10.1016\/j.joms.2023.01.010_bib25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3889\/oamjms.2016.123","article-title":"The effect of orthognathic surgery on osteoprotegerin as immunological caliper of bone healing. Open Access","volume":"4","author":"Soliman","year":"2016","journal-title":"Maced J Med Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.joms.2005.12.046","article-title":"Assessing postoperative discomfort after third molar surgery: A prospective study","volume":"65","author":"Grossi","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijom.2006.10.006","article-title":"Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: A clinical trial","volume":"36","author":"Markovic","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s12663-014-0638-4","article-title":"Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: A comparative study","volume":"14","author":"Yelamali","year":"2015","journal-title":"J Maxillofac Oral Surg"},{"key":"10.1016\/j.joms.2023.01.010_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.17126\/joralres.2020.067","article-title":"Pre-emptive low-dose ketamine with local anesthesia reduces postoperative morbidity after third molar surgery: A systematic review and meta-analysis","volume":"9","author":"Refahee","year":"2020","journal-title":"J Oral Res"},{"key":"10.1016\/j.joms.2023.01.010_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/AAP.0b013e31823ebc74","article-title":"Beyond repeated-measures analysis of variance: Advanced statistical methods for the analysis of longitudinal data in anesthesia research","volume":"37","author":"Ma","year":"2012","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.joms.2023.01.010_bib31","first-page":"32","article-title":"Comparison of generalized estimating equations (GEE), mixed effects models (MEM) and repeated measures ANOVA in analysis of menorrhagia data","volume":"7","author":"Naseri","year":"2016","journal-title":"Arch Biol Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib32","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/iej.13138","article-title":"Anti-inflammatory and antiresorptive functions of melatonin on experimentally induced periapical lesions","volume":"52","author":"Sar\u0131tekin","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joms.2023.01.010_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12464","article-title":"Prophylactic supplement with melatonin successfully suppresses the pathogenesis of periodontitis through normalizing RANKL\/OPG ratio and depressing the TLR 4\/MyD88 signaling pathway","volume":"64","author":"Renn","year":"2018","journal-title":"J Pineal Res"},{"key":"10.1016\/j.joms.2023.01.010_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.npep.2016.09.005","article-title":"Accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells","volume":"60","author":"Gu","year":"2016","journal-title":"Neuropeptides"},{"key":"10.1016\/j.joms.2023.01.010_bib35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000492576","article-title":"Melatonin induces osteoblastic differentiation of mesenchymal stem cells and promotes fracture healing in a rat model of femoral fracture via neuropeptide Y\/neuropeptide Y receptor Y1 signaling","volume":"102","author":"Dong","year":"2018","journal-title":"Pharmacol"},{"key":"10.1016\/j.joms.2023.01.010_bib36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1530\/eje.0.1450681","article-title":"Serum measurement of osteoprotegerin-clinical relevance and potential applications","volume":"145","author":"Hofbauer","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.joms.2023.01.010_bib37","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1021\/ja01531a060","article-title":"Structure of melatonin","volume":"81","author":"Lerner","year":"1959","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.joms.2023.01.010_bib38","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/ALN.0b013e3181e7d626","article-title":"Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: A qualitative systematic review of randomized trials","volume":"113","author":"Yousaf","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.joms.2023.01.010_bib39","doi-asserted-by":"crossref","first-page":"666","DOI":"10.11622\/smedj.2015186","article-title":"Melatonin premedication versus placebo in wisdom teeth extraction: A randomised controlled trial","volume":"56","author":"Seet","year":"2015","journal-title":"Singapore Med J"},{"key":"10.1016\/j.joms.2023.01.010_bib40","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.3390\/ijms140510063","article-title":"Melatonin effects on hard tissues: Bone and tooth","volume":"14","author":"Liu","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joms.2023.01.010_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.105037","article-title":"Effects of melatonin in wound healing of dental pulp and periodontium: Evidence from in\u00a0vitro, in\u00a0vivo and clinical studies","volume":"123","author":"Vaseenon","year":"2021","journal-title":"Arch Oral Biol"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239123000952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239123000952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:07:04Z","timestamp":1759511224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239123000952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0278239123000952"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2023.01.010","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2023.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}