{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:39:23Z","timestamp":1775767163435,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.joms.2024.06.179","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T18:31:10Z","timestamp":1719685870000},"page":"1456-1474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Number of Positive Lymph Nodes Instead of Extranodal Extension and Nodal Diameter is an Independent Predictor of Survival and Treatment Outcome of High-Grade Parotid Gland Carcinoma"],"prefix":"10.1016","volume":"82","author":[{"given":"Denis","family":"Brajkovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Kiralj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Ilic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Mijatov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borivoj","family":"Bijelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2024.06.179_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2023.106484","article-title":"Prognostic factors in surgically treated malignant salivary gland tumors","volume":"144","author":"Hofmann","year":"2023","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s00405-024-08711-z","article-title":"Prognostic factors for development of distant metastases in surgically treated high-grade salivary gland carcinomas: Results of retrospective single center study with 213 patients","author":"Brajkovic","year":"2024","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"1","key":"10.1016\/j.joms.2024.06.179_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","article-title":"Update from the 5th edition of the World Health Organization classification of head and neck tumors: Salivary glands","volume":"16","author":"Sk\u00e1lov\u00e1","year":"2022","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.joms.2024.06.179_bib4","doi-asserted-by":"crossref","first-page":"E2041","DOI":"10.1002\/hed.24375","article-title":"High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype","volume":"38","author":"Haderlein","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2024.06.179_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105577","article-title":"Prognostic indicators in clinically node-negative malignant primary salivary tumours of the parotid: A multicentre experience","volume":"123","author":"Fussey","year":"2021","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109554","article-title":"Adjuvant radiotherapy in node-negative salivary malignancies of the parotid gland: A multi-institutional analysis","volume":"183","author":"Park","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.105076","article-title":"The impact of nodal status in major salivary gland carcinoma: A multicenter experience and proposal of a novel N-classification","volume":"112","author":"Lombardi","year":"2021","journal-title":"Oral Oncol"},{"issue":"15","key":"10.1016\/j.joms.2024.06.179_bib8","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/cncr.31535","article-title":"Development of a novel salivary gland cancer lymph node staging system","volume":"124","author":"Aro","year":"2018","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.joms.2024.06.179_bib9","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hed.26135","article-title":"Positive lymph node number and extranodal extension for predicting recurrence and survival in patients with salivary gland cancer","volume":"42","author":"Lee","year":"2020","journal-title":"Head Neck"},{"issue":"6","key":"10.1016\/j.joms.2024.06.179_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.ejso.2018.11.008","article-title":"The number and ratio of positive lymph nodes are independent prognostic factors for patients\u00a0with major salivary gland cancer: Results from the surveillance, epidemiology, and end results dataset","volume":"45","author":"Qian","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib11","series-title":"AJCC cancer staging manual","first-page":"55","article-title":"Staging head and neck cancer","author":"William","year":"2017"},{"key":"10.1016\/j.joms.2024.06.179_bib12","series-title":"Head and Neck Tumours","article-title":"Introduction. WHO classification of tumours edited by the WHO classification of tumours Editorial board","author":"Hyrcza","year":"2022"},{"issue":"5","key":"10.1016\/j.joms.2024.06.179_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.5858\/arpa.2018-0422-SA","article-title":"Data set for the reporting of carcinomas of the major salivary glands: Explanations and recommendations of the guidelines from the international collaboration on cancer reporting","volume":"143","author":"Seethala","year":"2019","journal-title":"Arch Pathol Lab Med"},{"issue":"8","key":"10.1016\/j.joms.2024.06.179_bib14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.joms.2020.03.029","article-title":"Are oral pain and otalgia predictive of perineural invasion in squamous cell carcinoma of the oral tongue?","volume":"78","author":"Hechler","year":"2020","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.joms.2024.06.179_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijrobp.2004.03.018","article-title":"The role of radiotherapy in the treatment of malignant salivary gland tumors","volume":"61","author":"Terhaard","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.joms.2024.06.179_bib16","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.3892\/ol.2015.3814","article-title":"Lymph node density is a prognostic factor in patients with major salivary gland carcinoma","volume":"10","author":"Suzuki","year":"2015","journal-title":"Oncol Lett"},{"issue":"6","key":"10.1016\/j.joms.2024.06.179_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jso.23874","article-title":"Prognostic value of lymph node density in high-grade salivary gland cancers","volume":"111","author":"Hong","year":"2015","journal-title":"J Surg Oncol"},{"issue":"8","key":"10.1016\/j.joms.2024.06.179_bib18","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ejso.2023.04.002","article-title":"Association between factor of parotid lymph node and prognosis in parotid cancer","volume":"49","author":"Fang","year":"2023","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"10.1016\/j.joms.2024.06.179_bib19","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/hed.23507","article-title":"Clinical significance of intraparotid lymph node metastasis in primary parotid cancer","volume":"36","author":"Lim","year":"2014","journal-title":"Head Neck"},{"issue":"8","key":"10.1016\/j.joms.2024.06.179_bib20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ejso.2008.02.004","article-title":"Patterns of lymph node spread and its influence on outcome in resectable parotid cancer","volume":"34","author":"Klussmann","year":"2008","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"10.1016\/j.joms.2024.06.179_bib21","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00405-013-2616-8","article-title":"Deep lobe parotidectomy: Clinical rationale in the management of primary and metastatic cancer","volume":"271","author":"Olsen","year":"2014","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"6","key":"10.1016\/j.joms.2024.06.179_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2023.103973","article-title":"Locoregional metastatic behavior in a complex mosaic of primary malignant tumors of the parotid gland","volume":"44","author":"Varga","year":"2023","journal-title":"Am J Otolaryngol"},{"issue":"7","key":"10.1016\/j.joms.2024.06.179_bib23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jop.13034","article-title":"Elective neck dissection in patients with salivary gland carcinoma: A systematic review and meta-analysis","volume":"49","author":"Westergaard-Nielsen","year":"2020","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"10.1016\/j.joms.2024.06.179_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2022.100602","article-title":"Salivary gland cancer: ESMO-European Reference Network on Rare Adult Solid Cancers (EURACAN) clinical practice guideline for diagnosis, treatment and follow-up","volume":"7","author":"van Herpen","year":"2022","journal-title":"ESMO Open"},{"issue":"9","key":"10.1016\/j.joms.2024.06.179_bib25","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1002\/lary.27814","article-title":"The role of elective neck dissection in patients with adenoid cystic carcinoma of the head and neck","volume":"129","author":"Xiao","year":"2019","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.joms.2024.06.179_bib26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.otohns.2004.09.029","article-title":"Elective neck dissection versus observation in primary parotid carcinoma","volume":"132","author":"Zb\u00e4ren","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.joms.2024.06.179_bib27","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00405-016-4407-5","article-title":"Probability and pattern of occult cervical lymph node metastases in primary parotid carcinoma","volume":"274","author":"Stodulski","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.joms.2024.06.179_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.oraloncology.2016.12.007","article-title":"Surgical treatment of salivary malignant tumors","volume":"65","author":"Lombardi","year":"2017","journal-title":"Oral Oncol"},{"issue":"19","key":"10.1016\/j.joms.2024.06.179_bib28","doi-asserted-by":"crossref","first-page":"19667","DOI":"10.1002\/cam4.6612","article-title":"Distribution of sentinel nodes from parotid tumors-A feasibility study","volume":"12","author":"Hammarstedt-Nordenvall","year":"2023","journal-title":"Cancer Med"},{"issue":"3","key":"10.1016\/j.joms.2024.06.179_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11864-021-00820-9","article-title":"Postoperative management of salivary gland tumors","volume":"22","author":"Joshi","year":"2021","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2022.105764","article-title":"Baseline prognostic factors affecting survival in recurrent and\/or metastatic salivary gland adenoid cystic carcinoma","volume":"126","author":"Lombardi","year":"2022","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.joms.2024.06.179_bib31","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1007\/s00405-021-07024-9","article-title":"High-grade salivary gland cancer: Is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases","volume":"279","author":"Freitag","year":"2022","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"7","key":"10.1016\/j.joms.2024.06.179_bib33","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/hed.24984","article-title":"Adjuvant therapy in major salivary gland cancers: Analysis of 8580 patients in the National Cancer Database","volume":"40","author":"Cheraghlou","year":"2018","journal-title":"Head Neck"},{"issue":"7","key":"10.1016\/j.joms.2024.06.179_bib34","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joms.2018.01.033","article-title":"Cervical lymph node metastatic status and adjuvant therapy predict the prognosis of salivary duct carcinoma","volume":"76","author":"Qian","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.joms.2024.06.179_bib35","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00405-023-07862-9","article-title":"Predictive factors for survival and treatment outcomes of patients with minor salivary gland malignancies: A retrospective study","volume":"280","author":"Brajkovic","year":"2023","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"12","key":"10.1016\/j.joms.2024.06.179_bib36","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1245\/s10434-015-4454-y","article-title":"Distant metastases in patients with carcinoma of the major salivary glands","volume":"22","author":"Ali","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib37","series-title":"NCCN clinical practice guidelines in oncology head and neck cancers","year":"2022"},{"key":"10.1016\/j.joms.2024.06.179_bib38","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1002\/cncr.32792","article-title":"Distant metastasis of salivary gland cancer: Incidence, management, and outcomes","volume":"126","author":"Mimica","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.joms.2024.06.179_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.oraloncology.2018.01.009","article-title":"Prognostic significance and optimal can-didates of primary tumor resection in major salivary gland carcinoma patients with distant metastases at initial presentation: A popula-tion-based study","volume":"78","author":"Shi","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.oraloncology.2016.10.018","article-title":"Lung metastasectomy in adenoid cystic cancer: Is it worth it?","volume":"65","author":"Girelli","year":"2017","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.joms.2024.06.179_bib41","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00432-021-03518-5","article-title":"Metastasis-directed stereotactic body radiation therapy in the management of oligometastatic head and neck cancer","volume":"147","author":"Franzese","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"10.1016\/j.joms.2024.06.179_bib42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/annonc\/mdx771","article-title":"A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma","volume":"29","author":"Fushimi","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1200\/JCO.18.00545","article-title":"Phase II trial of trastuzumab and docetaxel in patients with human epidermal growth factor receptor 2\u2013positive salivary duct carcinoma","volume":"37","author":"Takahashi","year":"2019","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2024.06.179_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105213","article-title":"Prognosis and management of recurrent and\/or metastatic head and neck adenoid cystic carcinoma","volume":"115","author":"Lorini","year":"2021","journal-title":"Oral Oncol"},{"issue":"4","key":"10.1016\/j.joms.2024.06.179_bib45","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3390\/cancers15041236","article-title":"Histopathological aspects of the prognostic factors for salivary gland cancers","volume":"15","author":"Nishida","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.joms.2024.06.179_bib46","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1007\/s00405-023-08110-w","article-title":"Salivary gland pathologies: Evolution in classification and association with unique genetic alterations","volume":"280","author":"\u017burek","year":"2023","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239124005895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239124005895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:40:22Z","timestamp":1769643622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239124005895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0278239124005895"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2024.06.179","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Number of Positive Lymph Nodes Instead of Extranodal Extension and Nodal Diameter is an Independent Predictor of Survival and Treatment Outcome of High-Grade Parotid Gland Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2024.06.179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}