{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:05:04Z","timestamp":1760598304149,"version":"3.40.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.joms.2024.08.002","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T01:36:13Z","timestamp":1723253773000},"page":"1585-1595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Statins on Patients With Osteoradionecrosis of the Jaw"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-1852","authenticated-orcid":false,"given":"Junya","family":"Kusumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shungo","family":"Furudoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joms.2024.08.002_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0032-1329923","article-title":"Osteoradionecrosis of the jaws: A review of conservative and surgical treatment options","volume":"29","author":"Cheriex","year":"2013","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.joms.2024.08.002_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10006-019-00783-0","article-title":"Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: A single-arm prospective study","volume":"23","author":"Muraki","year":"2019","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01701-5","article-title":"Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma","volume":"16","author":"Kubota","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13014-016-0679-6","article-title":"Potential risk factors for jaw osteoradionecrosis after radiotherapy for head and neck cancer","volume":"11","author":"Kuhnt","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: Therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib7","doi-asserted-by":"crossref","first-page":"E559","DOI":"10.1002\/lary.28399","article-title":"Efficacy of pentoxifilline-tocopherol-clodronate in mandibular osteoradionecrosis","volume":"130","author":"Dissard","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.joms.2024.08.002_bib8","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury","volume":"4","author":"Bennett","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joms.2024.08.002_bib9","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1200\/JCO.2004.09.006","article-title":"Hyperbaric oxygen therapy for radionecrosis of the jaw: A randomized, placebo-controlled, double-blind trial from the ORN96 study group","volume":"22","author":"Annane","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2021.11.021","article-title":"Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1","volume":"166","author":"Forner","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/hed.20121","article-title":"Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: A phase II trial","volume":"27","author":"Delanian","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2024.08.002_bib12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bjoms.2015.11.027","article-title":"Use of pentoxifylline and tocopherol in the management of osteoradionecrosis","volume":"54","author":"Patel","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib13","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1016\/j.oooo.2021.08.007","article-title":"Prophylactic pentoxifylline and vitamin E use for dental extractions in irradiated patients with head and neck cancer","volume":"133","author":"Samani","year":"2022","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.joms.2024.08.002_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijom.2018.08.007","article-title":"Management of osteoradionecrosis of the jaws with pentoxifylline-tocopherol: A systematic review of the literature and meta-analysis","volume":"48","author":"Kolokythas","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/bmb\/ldq044","article-title":"Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents","volume":"97","author":"Fritz","year":"2011","journal-title":"Br Med Bull"},{"key":"10.1016\/j.joms.2024.08.002_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/antiox5030022","article-title":"Protection against radiotherapy-induced toxicity","volume":"5","author":"Hall","year":"2016","journal-title":"Antioxidants"},{"key":"10.1016\/j.joms.2024.08.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109560","article-title":"Advances in pathogenic mechanisms and management of radiation-induced fibrosis","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.joms.2024.08.002_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijrobp.2019.02.024","article-title":"Pravastatin reverses established radiation-induced cutaneous and subcutaneous fibrosis in patients with head and neck cancer: Results of the biology-driven phase 2 clinical trial Pravascur","volume":"104","author":"Bourgier","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.joms.2024.08.002_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/idj.12318","article-title":"Osteoradionecrosis of the jaws: Definition, epidemiology, staging and clinical and radiological findings. A concise review","volume":"68","author":"Chronopoulos","year":"2018","journal-title":"Int Dent J"},{"key":"10.1016\/j.joms.2024.08.002_bib21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bjoms.2014.02.017","article-title":"Osteoradionecrosis\u2014a review of current concepts in defining the extent of the disease and a new classification proposal","volume":"52","author":"Lyons","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib22","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2174\/156800909789057033","article-title":"Targeting the mevalonate pathway for improved anticancer therapy","volume":"9","author":"Fritz","year":"2009","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.joms.2024.08.002_bib23","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1136\/gut.2009.190900","article-title":"Effect of statin therapy on colorectal cancer","volume":"59","author":"Bardou","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.joms.2024.08.002_bib24","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/79510","article-title":"The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals","volume":"6","author":"Kureishi","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.joms.2024.08.002_bib25","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1096\/fj.01-0415fje","article-title":"Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia","volume":"15","author":"Sata","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.joms.2024.08.002_bib26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/hc0602.103393","article-title":"Statins have biphasic effects on angiogenesis","volume":"105","author":"Weis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.joms.2024.08.002_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pharmthera.2009.01.002","article-title":"Statins and cardioprotection--more than just lipid lowering?","volume":"122","author":"Ludman","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.joms.2024.08.002_bib28","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.radonc.2009.06.020","article-title":"Lovastatin attenuates ionizing radiation-induced normal tissue damage in\u00a0vivo","volume":"92","author":"Ostrau","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0021-9150(02)00063-1","article-title":"Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes","volume":"164","author":"Fuhrman","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.joms.2024.08.002_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ Res"},{"issue":"5446","key":"10.1016\/j.joms.2024.08.002_bib31","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in\u00a0vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.joms.2024.08.002_bib32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1677\/JOE-07-0532","article-title":"Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras\/Rho-mitogen-activated protein kinase pathway","volume":"196","author":"Yamashita","year":"2008","journal-title":"J Endocrinol"},{"key":"10.1016\/j.joms.2024.08.002_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13534","article-title":"The role of statins in the differentiation and function of bone cells","volume":"51","author":"Chamani","year":"2021","journal-title":"Eur J Clin Investig"},{"key":"10.1016\/j.joms.2024.08.002_bib34","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.ijrobp.2007.03.036","article-title":"Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism","volume":"68","author":"Wang","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.joms.2024.08.002_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1165\/rcmb.2010-0122OC","article-title":"Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression","volume":"44","author":"Mathew","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.joms.2024.08.002_bib36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1667\/RR14075.1","article-title":"Atorvastatin ameliorates radiation-induced cardiac fibrosis in rats","volume":"184","author":"Zhang","year":"2015","journal-title":"Radiat Res"},{"key":"10.1016\/j.joms.2024.08.002_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/09553002.2018.1420926","article-title":"Radioprotective effect of atorvastatin against ionizing radiation-induced nephrotoxicity in mice","volume":"94","author":"Talebpour Amiri","year":"2018","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.joms.2024.08.002_bib38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.radonc.2005.06.029","article-title":"Induction of CTGF by TGF-beta1 in normal and radiation enteritis human smooth muscle cells: Smad\/Rho balance and therapeutic perspectives","volume":"76","author":"Haydont","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3164\/jcbn.18-48","article-title":"Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors","volume":"64","author":"Umeda","year":"2019","journal-title":"J Clin Biochem Nutr"},{"key":"10.1016\/j.joms.2024.08.002_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.oraloncology.2018.02.021","article-title":"The risk of carotid stenosis in head and neck cancer patients after radiation therapy","volume":"80","author":"Carpenter","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110389","article-title":"Effects of neck radiation therapy on extra-cranial carotid arteries atherosclerosis disease prevalence: Systematic review and a meta-analysis","volume":"9","author":"Bashar","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.joms.2024.08.002_bib42","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1200\/JCO.2008.16.6546","article-title":"Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy","volume":"26","author":"Smith","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joms.2024.08.002_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005996","article-title":"Statin use and risk of vascular events among cancer patients after radiotherapy to the thorax, head, and neck","volume":"8","author":"Boulet","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.joms.2024.08.002_bib44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/000331970005100406","article-title":"Calf and forearm blood flow in hypercholesterolemic patients","volume":"51","author":"Cortella","year":"2000","journal-title":"Angiology"},{"key":"10.1016\/j.joms.2024.08.002_bib45","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/joms.2000.9562","article-title":"Osteoradionecrosis of the jaws: Clinical characteristics and relation to the field of irradiation","volume":"58","author":"Thorn","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijrobp.2005.06.021","article-title":"A clinical staging system and treatment guidelines for maxillary osteoradionecrosis in irradiated nasopharyngeal carcinoma patients","volume":"64","author":"Chen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.joms.2024.08.002_bib47","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0278-2391(97)90478-X","article-title":"Osteoradionecrosis of the jaws: A retrospective study of the background factors and treatment in 104 cases","volume":"55","author":"Curi","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2024.08.002_bib48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hed.24577","article-title":"Hyperbaric oxygen therapy for maxillary bone radiation-induced injury: A 15-year single-center experience","volume":"39","author":"Gavriel","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.joms.2024.08.002_bib49","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jac\/47.5.631","article-title":"Therapeutic possibilities of long-term roxithromycin treatment for chronic diffuse sclerosing osteomyelitis of the mandible","volume":"47","author":"Yoshii","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.joms.2024.08.002_bib50","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.200441","article-title":"Suppression of the TGF-\u03b2 pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro","volume":"7","author":"Stahnke","year":"2020","journal-title":"R Soc Open Sci"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239124006876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239124006876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T02:54:35Z","timestamp":1733021675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239124006876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0278239124006876"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2024.08.002","relation":{},"ISSN":["0278-2391"],"issn-type":[{"type":"print","value":"0278-2391"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Statins on Patients With Osteoradionecrosis of the Jaw","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2024.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Oral and Maxillofacial Surgeons","name":"copyright","label":"Copyright"}]}}