{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:45:07Z","timestamp":1782920707401,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","joms.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.joms.2026.01.018","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:08:51Z","timestamp":1770077331000},"page":"1123-1132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological Margins and Recurrence Risk in Oral Squamous Cell Carcinoma: Is 3 mm Enough?"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0871-377X","authenticated-orcid":false,"given":"Camiel C.E.","family":"van de Schoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-8169","authenticated-orcid":false,"given":"Gerhard K.P.","family":"Bittermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza R.C.","family":"Hagens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-6146","authenticated-orcid":false,"given":"Lauretta A.A.","family":"Vaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-1374","authenticated-orcid":false,"given":"Peter A.W.H.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.joms.2026.01.018_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.soc.2015.03.006","article-title":"Cancer of the oral cavity","volume":"24","author":"Montero","year":"2015","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.joms.2026.01.018_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105451","article-title":"Overview of oral cavity squamous cell carcinoma: risk factors, mechanisms, and diagnostics","volume":"121","author":"Chamoli","year":"2021","journal-title":"Oral Oncol"},{"issue":"4","key":"10.1016\/j.joms.2026.01.018_bib3","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.3390\/curroncol30040283","article-title":"Oral squamous cell carcinoma and concomitant primary tumors, what do we know? A review of the literature","volume":"30","author":"Badwelan","year":"2023","journal-title":"Curr Oncol"},{"issue":"4","key":"10.1016\/j.joms.2026.01.018_bib4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.hoc.2021.05.003","article-title":"Lip and oral cavity squamous cell carcinoma","volume":"35","author":"Howard","year":"2021","journal-title":"Hematol Oncol Clin North Am"},{"issue":"9","key":"10.1016\/j.joms.2026.01.018_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.bdj.2018.926","article-title":"The pathology of oral cancer","volume":"225","author":"Speight","year":"2018","journal-title":"Br Dent J"},{"issue":"11","key":"10.1016\/j.joms.2026.01.018_bib7","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.annonc.2020.07.011","article-title":"Squamous cell carcinoma of the oral cavity, larynx, oropharynx, and hypopharynx: EHNS\u2013ESMO\u2013ESTRO clinical practice guidelines","volume":"31","author":"Machiels","year":"2020","journal-title":"Ann Oncol"},{"key":"10.1016\/j.joms.2026.01.018_bib8","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"10.1016\/j.joms.2026.01.018_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.oraloncology.2015.01.015","article-title":"A meta-analysis of margin size and local recurrence in oral squamous cell carcinoma","volume":"51","author":"Anderson","year":"2015","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2026.01.018_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104913","article-title":"The relevance of surgical margins in clinically early oral squamous cell carcinoma","volume":"110","author":"Bajwa","year":"2020","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.joms.2026.01.018_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.joms.2017.10.025","article-title":"Close resection margins do not influence local recurrence in patients with oral squamous cell carcinoma: a prospective cohort study","volume":"76","author":"Stathopoulos","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2026.01.018_bib13","first-page":"79","article-title":"Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence","volume":"5","author":"Chiou","year":"2010","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.joms.2026.01.018_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bjoms.2011.05.008","article-title":"Influence of close resection margins on local recurrence and disease-specific survival in oral and oropharyngeal carcinoma","volume":"50","author":"Wong","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joms.2026.01.018_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2023.106609","article-title":"Margin distance in oral tongue cancer surgery: a systematic review of survival and recurrence outcomes","volume":"147","author":"Spence","year":"2023","journal-title":"Oral Oncol"},{"issue":"4","key":"10.1016\/j.joms.2026.01.018_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5858\/arpa.2018-0411-SA","article-title":"Data set for the reporting of oral cavity carcinomas: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting","volume":"143","author":"M\u00fcller","year":"2018","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"10.1016\/j.joms.2026.01.018_bib17","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1002\/cam4.1221","article-title":"Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis","volume":"6","author":"Sroussi","year":"2017","journal-title":"Cancer Med"},{"issue":"6","key":"10.1016\/j.joms.2026.01.018_bib18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.oraloncology.2014.02.014","article-title":"Resection of early oral squamous cell carcinoma with positive or close margins: relevance of adjuvant treatment in relation to local recurrence","volume":"50","author":"Dik","year":"2014","journal-title":"Oral Oncol"},{"issue":"2","key":"10.1016\/j.joms.2026.01.018_bib19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/0194599819839006","article-title":"Does clearance of positive margins improve local control in oral cavity cancer? A meta-analysis","volume":"161","author":"Bulbul","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.joms.2026.01.018_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/his.12754","article-title":"Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma","volume":"68","author":"Heerema","year":"2016","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.joms.2026.01.018_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.joms.2007.08.040","article-title":"Oral squamous cell carcinoma margin discrepancy after resection and pathologic processing","volume":"66","author":"Cheng","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.joms.2026.01.018_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jso.20285","article-title":"Post-resection mucosal margin shrinkage in oral cancer: quantification and significance","volume":"91","author":"Mistry","year":"2005","journal-title":"J Surg Oncol"},{"issue":"5","key":"10.1016\/j.joms.2026.01.018_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jcms.2015.01.009","article-title":"Significance of post-resection tissue shrinkage on surgical margins of oral squamous cell carcinoma","volume":"43","author":"El-Fol","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"issue":"9","key":"10.1016\/j.joms.2026.01.018_bib24","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00403-023-02632-3","article-title":"Systematic review of benefits and practical challenges for application of Mohs surgery for oral tumors","volume":"315","author":"Hussain","year":"2023","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"10.1016\/j.joms.2026.01.018_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/CCO.0000000000000824","article-title":"Image-guided surgery in oral cancer: toward improved margin control","volume":"34","author":"Noorlag","year":"2022","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.joms.2026.01.018_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105249","article-title":"Feasibility study of ultrasound-guided resection of tongue cancer with immediate specimen examination to improve margin control: comparison with conventional treatment","volume":"116","author":"de Koning","year":"2021","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joms.2026.01.018_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104799","article-title":"Staging and grading of oral squamous cell carcinoma: an update","volume":"107","author":"Almangush","year":"2020","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.joms.2026.01.018_bib28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/bjc.2017.425","article-title":"Tumour budding in oral squamous cell carcinoma: a meta-analysis","volume":"118","author":"Almangush","year":"2018","journal-title":"Br J Cancer"}],"container-title":["Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239126000650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278239126000650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:54:14Z","timestamp":1782917654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278239126000650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0278239126000650"],"URL":"https:\/\/doi.org\/10.1016\/j.joms.2026.01.018","relation":{},"ISSN":["0278-2391"],"issn-type":[{"value":"0278-2391","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathological Margins and Recurrence Risk in Oral Squamous Cell Carcinoma: Is 3 mm Enough?","name":"articletitle","label":"Article Title"},{"value":"Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joms.2026.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the American Association of Oral and Maxillofacial Surgeons.","name":"copyright","label":"Copyright"}]}}