{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:18:10Z","timestamp":1788419890062,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","jopan.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of PeriAnesthesia Nursing"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jopan.2025.05.014","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:09:33Z","timestamp":1763647773000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Different Doses of Dexmedetomidine on Perioperative Stress Response and Postoperative Recovery in Elderly Patients"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8046-8479","authenticated-orcid":false,"given":"Hongcheng","family":"Zang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jopan.2025.05.014_bib1","article-title":"Global research trends on diseases in the elderly population: a visualization analysis","author":"Zhao","year":"2022","journal-title":"Research Square"},{"issue":"2","key":"10.1016\/j.jopan.2025.05.014_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/AIA.0000000000000396","article-title":"Perioperative medicine for Older People undergoing Surgery (POPS): Comprehensive Geriatric Assessment (CGA) and optimization in the perioperative setting","volume":"61","author":"Stewart","year":"2023","journal-title":"Int Anesthesiol Clin"},{"key":"10.1016\/j.jopan.2025.05.014_bib3","series-title":"Dexmedetomidine","author":"Reel","year":"2025"},{"key":"10.1016\/j.jopan.2025.05.014_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.curtheres.2022.100677","article-title":"Global Research and Scientific Publications on dexmedetomidine use in adults for anesthesia care between 2001 and 2021: a bibliometric analysis","volume":"96","author":"Komonhirun","year":"2022","journal-title":"Curr Ther Res Clin Exp"},{"issue":"48","key":"10.1016\/j.jopan.2025.05.014_bib5","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000027782","article-title":"Dexmedetomidine effect on delirium in elderly patients undergoing general anesthesia: a protocol for systematic review and meta-analysis","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.jopan.2025.05.014_bib6","first-page":"18","article-title":"Effects of dexmedetomidine on perioperative monitoring parameters and recovery in patients undergoing laparoscopic cholecystectomy in a 300 bedded hospital, Jaipur","volume":"10","author":"Kumar","year":"2022","journal-title":"J\u00a0Appl\u00a0Pharm\u00a0Res"},{"key":"10.1016\/j.jopan.2025.05.014_bib7","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.937862","article-title":"A review of the biological mechanisms of dexmedetomidine for postoperative neurocognitive disorders","volume":"28","author":"Yu","year":"2022","journal-title":"Med Sci Monit"},{"issue":"4","key":"10.1016\/j.jopan.2025.05.014_bib8","first-page":"582","article-title":"Effect of dexmedetomidine infusion on stress induced blood glucose levels and intraoperative sevoflurane requirement","volume":"5","author":"V Kameshwar","year":"2020","journal-title":"Indian J\u00a0Clin\u00a0Anaesth"},{"issue":"6","key":"10.1016\/j.jopan.2025.05.014_bib9","first-page":"4685","article-title":"Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting","volume":"16","author":"Gong","year":"2018","journal-title":"Exp Ther Med"},{"issue":"4","key":"10.1016\/j.jopan.2025.05.014_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4103\/ija.ija_526_21","article-title":"A practical guide to the American Society of Anesthesiologists-physical status classification (ASA-PS)","volume":"66","author":"Shivali","year":"2022","journal-title":"Indian J Anaesth"},{"issue":"9","key":"10.1016\/j.jopan.2025.05.014_bib11","first-page":"UC10","article-title":"Comparison of effects of different doses dexmedetomidine on inhibiting tracheal intubation-evoked haemodynamic response in the elderly patients","volume":"9","author":"Zhan-Ying","year":"2015","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"10.1016\/j.jopan.2025.05.014_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12871-022-01811-5","article-title":"Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial","volume":"22","author":"Tan","year":"2022","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.jopan.2025.05.014_bib13","doi-asserted-by":"crossref","unstructured":"Huskisson. Multidimensional pain scales: Visual Analogue Scale (VAS) for pain, Numeric Rating Scales (NRS), and other pain scales. 2020:358-361. https:\/\/www.taylorfrancis.com\/chapters\/edit\/10.4324\/9781003076391-100\/multidimensional-pain-scales-visual-analogue-scale-vas-pain-numeric-rating-scales-nrs-pain-scales-huskisson.","DOI":"10.4324\/9781003076391-100"},{"key":"10.1016\/j.jopan.2025.05.014_bib14","article-title":"Effect of dexmedetomidine-assisted intravenous inhalation combined anesthesia on cerebral oxygen metabolism and serum Th1\/Th2 level in elderly colorectal cancer patients","volume":"8","author":"Tang","year":"2021","journal-title":"Front Surg"},{"issue":"3","key":"10.1016\/j.jopan.2025.05.014_bib15","doi-asserted-by":"crossref","DOI":"10.5812\/aapm-109721","article-title":"A comparison of the sedative effect of dexmedetomidine and midazolam on patients undergoing gastrointestinal endosonography outside the operating room","volume":"13","author":"Ghomeishi","year":"2023","journal-title":"Anesth Pain Med"},{"issue":"3","key":"10.1016\/j.jopan.2025.05.014_bib16","article-title":"A randomized control trial of three intravenous dexmedetomidine doses for procedural sedation in patients undergoing minor gynaecological surgery","volume":"14","author":"Sharma","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.jopan.2025.05.014_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12871-023-01990-9","article-title":"Effects of dexmedetomidine on evoked potentials in spinal surgery under combined intravenous inhalation anesthesia: a randomized controlled trial","volume":"23","author":"Jiang","year":"2023","journal-title":"BMC Anesthesiol"},{"issue":"7","key":"10.1016\/j.jopan.2025.05.014_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.4103\/ija.IJA_168_21","article-title":"Comparison of dexmedetomidine in two different doses on emergence agitation in children under sevoflurane anaesthesia: a double-blind randomised controlled trial","volume":"65","author":"Ramachandran","year":"2021","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.jopan.2025.05.014_bib19","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820977542","article-title":"Effect of dexmedetomidine on perioperative stress response and immune function in patients with tumors","volume":"19","author":"Zheng","year":"2020","journal-title":"Technol Cancer Res Treat"},{"issue":"5","key":"10.1016\/j.jopan.2025.05.014_bib20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00540-010-0976-4","article-title":"Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery","volume":"24","author":"Sato","year":"2010","journal-title":"J Anesth"},{"issue":"7","key":"10.1016\/j.jopan.2025.05.014_bib21","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.4103\/jcrt.JCRT_164_18","article-title":"Role of dexmedetomidine in reducing the incidence of postoperative cognitive dysfunction caused by sevoflurane inhalation anesthesia in elderly patients with esophageal carcinoma","volume":"14","author":"Zhang","year":"2018","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"10.1016\/j.jopan.2025.05.014_bib22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s13019-024-02939-w","article-title":"Effects of different anesthetic regimens on postoperative cognitive function of elderly patients undergoing thoracic surgery: a double-blinded randomized controlled trial","volume":"19","author":"Xie","year":"2024","journal-title":"J Cardiothorac Surg"},{"issue":"8","key":"10.1016\/j.jopan.2025.05.014_bib23","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211039809","article-title":"Effect of dexmedetomidine on hemodynamics in patients undergoing hysterectomy: a meta-analysis and systematic review","volume":"49","author":"Li","year":"2021","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jopan.2025.05.014_bib24","article-title":"The effects of different doses of alfentanil and dexmedetomidine on prevention of emergence agitation in pediatric tonsillectomy and adenoidectomy surgery","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.jopan.2025.05.014_bib25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12871-023-02315-6","article-title":"Effects of dexmedetomidine dosage on the short-term cognitive function of elderly patients undergoing cardiac surgery","volume":"23","author":"Fang","year":"2023","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"10.1016\/j.jopan.2025.05.014_bib26","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1177\/0300060518821272","article-title":"The brain protective effect of dexmedetomidine during surgery for paediatric patients with congenital heart disease","volume":"47","author":"Gong","year":"2019","journal-title":"J Int Med Res"},{"issue":"1","key":"10.1016\/j.jopan.2025.05.014_bib27","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s13063-023-07384-z","article-title":"Effects of dexmedetomidine at different dosages on perioperative haemodynamics and postoperative recovery quality in elderly patients undergoing hip replacement surgery under general anaesthesia: a randomized controlled trial","volume":"24","author":"Liu","year":"2023","journal-title":"Trials"},{"issue":"2","key":"10.1016\/j.jopan.2025.05.014_bib28","article-title":"Effects of the enhanced recovery after surgery (ERAS) protocol on the postoperative stress state and short-term complications in elderly patients with colorectal cancer","volume":"7","author":"Han","year":"2024","journal-title":"Cancer Rep"},{"issue":"3","key":"10.1016\/j.jopan.2025.05.014_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4103\/joacp.joacp_559_21","article-title":"Suppression of perioperative stress response in elective abdominal surgery: a randomized comparison between dexmedetomidine and epidural block","volume":"39","author":"Salhotra","year":"2023","journal-title":"J Anaesthesiol Clin Pharmacol"}],"container-title":["Journal of PeriAnesthesia Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089947225001637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089947225001637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T23:10:27Z","timestamp":1775517027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089947225001637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1089947225001637"],"URL":"https:\/\/doi.org\/10.1016\/j.jopan.2025.05.014","relation":{},"ISSN":["1089-9472"],"issn-type":[{"value":"1089-9472","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Different Doses of Dexmedetomidine on Perioperative Stress Response and Postoperative Recovery in Elderly Patients","name":"articletitle","label":"Article Title"},{"value":"Journal of PeriAnesthesia Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jopan.2025.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}