{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:30:28Z","timestamp":1793374228335,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","jopan.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of PeriAnesthesia Nursing"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jopan.2026.08.005","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:23:03Z","timestamp":1792408983000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Cervical Lymphaticovenous Anastomosis (LVA) for Alzheimer's Disease: A Case Report"],"prefix":"10.1016","author":[{"given":"Xiu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Zhug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-0654","authenticated-orcid":false,"given":"Jiamin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jopan.2026.08.005_bib1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4103\/1673-5374.353484","article-title":"Targeting neuroinflammation in Alzheimer's disease: from mechanisms to clinical applications","volume":"18","author":"Si","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jopan.2026.08.005_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jopan.2026.08.005_bib3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.12968\/bjon.2020.29.8.460","article-title":"Role of nurses in addressing modifiable risk factors for early Alzheimer's disease and mild cognitive impairment","volume":"29","author":"Hope","year":"2020","journal-title":"Br J Nurs"},{"key":"10.1016\/j.jopan.2026.08.005_bib4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4103\/1673-5374.380874","article-title":"Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease","volume":"19","author":"Chang","year":"2024","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jopan.2026.08.005_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S1474-4422(20)30440-3","article-title":"New insights into atypical Alzheimer's disease in the era of biomarkers","volume":"20","author":"Graff-Radford","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jopan.2026.08.005_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40035-024-00432-x","article-title":"Updates in Alzheimer's disease: from basic research to diagnosis and therapies","volume":"13","author":"Liu","year":"2024","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.jopan.2026.08.005_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s43587-025-00854-w","article-title":"New biomarkers for early-stage tau pathology in Alzheimer's disease","volume":"5","author":"Luo","year":"2025","journal-title":"Nat Aging"},{"key":"10.1016\/j.jopan.2026.08.005_bib8","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1097\/JS9.0000000000002490","article-title":"Deep cervical lymphovenous anastomosis (LVA) for Alzheimer's disease microsurgical procedure in a prospective cohort study","volume":"111","author":"Chen","year":"2025","journal-title":"Int J Surg"},{"key":"10.1016\/j.jopan.2026.08.005_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/1570159X20666220411091332","article-title":"The lymphatic system in the brain clearance mechanisms - new therapeutic perspectives for Alzheimer's Disease","volume":"21","author":"Chachaj","year":"2023","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jopan.2026.08.005_bib10","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2407246121","article-title":"The perivascular space is a conduit for cerebrospinal fluid flow in humans: a proof-of-principle report","volume":"121","author":"Yamamoto","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jopan.2026.08.005_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3233\/JAD-215699","article-title":"Alzheimer's disease: key insights from two decades of clinical trial failures","volume":"87","author":"Kim","year":"2022","journal-title":"J Alzheimer's dis: JAD"},{"key":"10.1016\/j.jopan.2026.08.005_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/gpsych-2024-101641","article-title":"Promising outcomes 5 weeks after a surgical cervical shunting procedure to unclog cerebral lymphatic systems in a patient with Alzheimer's disease","volume":"37","author":"Li","year":"2024","journal-title":"Gen Psychiatry"},{"key":"10.1016\/j.jopan.2026.08.005_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5582\/bst.2025.01108","article-title":"Deep cervical lymphaticovenous anastomosis in Alzheimer's disease: a promising frontier or premature enthusiasm?","volume":"19","author":"Ma","year":"2025","journal-title":"Biosci Trends"},{"key":"10.1016\/j.jopan.2026.08.005_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/anae.14530","article-title":"Guidelines for the peri-operative care of people with dementia","volume":"74","author":"White","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jopan.2026.08.005_bib15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.fmre.2023.02.007","article-title":"The role of anesthesia in peri\u2011operative neurocognitive disorders: molecular mechanisms and preventive strategies","volume":"4","author":"Li","year":"2024","journal-title":"Fundam Res"},{"key":"10.1016\/j.jopan.2026.08.005_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jopan.2026.08.005_bib17","first-page":"448","article-title":"The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy","volume":"19","author":"Mohs","year":"1983","journal-title":"Psychopharmacol Bull"},{"issue":"2","key":"10.1016\/j.jopan.2026.08.005_bib18","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/00002093-199700112-00005","article-title":"An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease cooperative study","volume":"11","author":"Galasko","year":"1997","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.jopan.2026.08.005_bib19","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.jopan.2026.08.005_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijsu.2015.04.079","article-title":"ASA class is a reliable independent predictor of medical complications and mortality following surgery","volume":"18","author":"Hackett","year":"2015","journal-title":"Int J Surg"},{"key":"10.1016\/j.jopan.2026.08.005_bib21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2044.1990.tb14342.x","article-title":"Problems with the Mallampati sign","volume":"45","author":"Wilson","year":"1990","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jopan.2026.08.005_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/aorn.14364","article-title":"Guidelines in practice: patient temperature management","volume":"122","author":"Speth","year":"2025","journal-title":"AORN J"},{"key":"10.1016\/j.jopan.2026.08.005_bib23","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jopan.2026.03.002","article-title":"The effect of prewarming on early postoperative thermal comfort and shivering in adult surgical patients: a systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Tat \u00c7atal","year":"2026","journal-title":"J PeriAnesth Nurs"},{"key":"10.1016\/j.jopan.2026.08.005_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/aorn.13929","article-title":"Guidelines in practice: positioning the patient","volume":"117","author":"Speth","year":"2023","journal-title":"AORN J"},{"key":"10.1016\/j.jopan.2026.08.005_bib25","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/jan.16278","article-title":"Positioning the surgical patient \u2013 roles, responsibilities and challenges. A qualitative study","volume":"81","author":"Wevling","year":"2025","journal-title":"J Adv Nurs"},{"key":"10.1016\/j.jopan.2026.08.005_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jtv.2019.01.001","article-title":"Prevention and treatment of pressure ulcers\/injuries: the protocol for the second update of the international Clinical Practice Guideline 2019","volume":"28","author":"Kottner","year":"2019","journal-title":"J Tissue Viability"},{"key":"10.1016\/j.jopan.2026.08.005_bib27","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1002\/alz.13770","article-title":"Minimal clinically important difference in Alzheimer's disease: rapid review","volume":"20","author":"Muir","year":"2024","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.jopan.2026.08.005_bib28","article-title":"Perioperative care and recovery outcome of deep jugular venous lymphatic anastomosis in Alzheimer's disease: a case report","volume":"9","author":"Chen","year":"2025","journal-title":"J Alzheimer's Dis Rep"},{"key":"10.1016\/j.jopan.2026.08.005_bib29","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jopan.2026.08.005_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jopan.2021.01.002","article-title":"ISBAR as a structured tool for patient handover during postoperative recovery","volume":"37","author":"Kaltoft","year":"2022","journal-title":"J PeriAnesth Nurs"},{"key":"10.1016\/j.jopan.2026.08.005_bib31","article-title":"Postoperative changes in cervical hemodynamics and cognitive function following cervical lymphatic-venous surgery in Alzheimer's disease","author":"Zheng","year":"2026","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jopan.2026.08.005_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/scd.70201","article-title":"Postoperative experiences after dental treatment under general anesthesia in people living with Alzheimer's Disease: a descriptive study with caregiver and staff reports","volume":"46","author":"Abed","year":"2026","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.jopan.2026.08.005_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/arclin\/acad046","article-title":"A closer look at practice effects in mild cognitive impairment and Alzheimer's Disease","volume":"39","author":"Duff","year":"2024","journal-title":"Arch Clin Neuropsychol"},{"key":"10.1016\/j.jopan.2026.08.005_bib34","article-title":"Effects of informant replacement in Alzheimer's disease clinical trials","volume":"9","author":"Nishida","year":"2023","journal-title":"Alzheimer's Dement: Transl Res Clin Interv"},{"key":"10.1016\/j.jopan.2026.08.005_bib35","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1002\/alz.13757","article-title":"Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: psychometric properties, convergent validation, and contrasts with established measures","volume":"20","author":"Kim","year":"2024","journal-title":"Alzheimer's Dement"}],"container-title":["Journal of PeriAnesthesia Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089947226004521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089947226004521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:30:59Z","timestamp":1793370659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089947226004521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S1089947226004521"],"URL":"https:\/\/doi.org\/10.1016\/j.jopan.2026.08.005","relation":{},"ISSN":["1089-9472"],"issn-type":[{"value":"1089-9472","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep Cervical Lymphaticovenous Anastomosis (LVA) for Alzheimer's Disease: A Case Report","name":"articletitle","label":"Article Title"},{"value":"Journal of PeriAnesthesia Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jopan.2026.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of The American Society of PeriAnesthesia Nurses.","name":"copyright","label":"Copyright"}]}}