{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:07:54Z","timestamp":1789139274894,"version":"build-2803163510"},"reference-count":30,"publisher":"Scientific Scholar","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedics"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.jor.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T11:03:49Z","timestamp":1486119829000},"page":"226-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Atypical femoral shaft fractures secondary to long-term bisphosphonate therapy"],"prefix":"10.25259","volume":"14","author":[{"given":"Cemil","family":"Kayali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taskin","family":"Altay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firat","family":"Ozan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Sozkesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Yamak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"10.1016\/j.jor.2017.01.002_bib0005","doi-asserted-by":"crossref","first-page":"15351541","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group","volume":"348","author":"Black","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jor.2017.01.002_bib0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","article-title":"Bisphosphonates: mechanisms of action","volume":"19","author":"Fleisch","year":"1998","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jor.2017.01.002_bib0015","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1359\/JBMR.040326","article-title":"Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension","volume":"19","author":"Ensrud","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jor.2017.01.002_bib0020","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bone.2011.02.013","article-title":"Guilt by association? Examining the role of bisphosphonate therapy in the development of atypical femur fractures","volume":"48","author":"Girgis","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jor.2017.01.002_bib0025","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1359\/jbmr.090408","article-title":"Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on long-term treatment with alendronate: cluesto the mechanism of increased bone fragility","volume":"24","author":"Somford","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jor.2017.01.002_bib0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/230949901101900121","article-title":"Alendronate-associated femoral insufficiency fractures and femoral stress reactions","volume":"19","author":"Wang","year":"2011","journal-title":"J Orthop Surg"},{"key":"10.1016\/j.jor.2017.01.002_bib0035","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/jc.2005-0057","article-title":"Long-term safety of bisphosphonates","volume":"90","author":"Ott","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jor.2017.01.002_bib0040","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1210\/jc.2004-0952","article-title":"Severely suppressed bone turnover: a potential complication of alendronate therapy","volume":"90","author":"Odvina","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jor.2017.01.002_bib0045","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1302\/0301-620X.93B10.26924","article-title":"Long-term bisphosphonate usage and subtrochanteric insufficiency fractures","volume":"93","author":"Yoon","year":"2011","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jor.2017.01.002_bib0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1258\/mi.2011.011014","article-title":"Role of bisphosphonates in the management of postmenopausal osteoporosis: an update on recent safety anxieties","volume":"17","author":"Hollick","year":"2011","journal-title":"Menopause Int"},{"key":"10.1016\/j.jor.2017.01.002_bib0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11914-010-0007-2","article-title":"Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates","volume":"8","author":"Nieves","year":"2010","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jor.2017.01.002_bib0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bone.2010.05.019","article-title":"Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case\/case series studies","volume":"47","author":"Giusti","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.jor.2017.01.002_bib0065","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.2106\/JBJS.H.01774","article-title":"Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy","volume":"91","author":"Capeci","year":"2009","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jor.2017.01.002_bib0070","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00198-008-0805-x","article-title":"Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study","volume":"20","author":"Lenart","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jor.2017.01.002_bib0075","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/TA.0b013e31821957e3","article-title":"The out come of surgically treated femur fractures associated with long-term bisphosphonate use","volume":"71","author":"Weil","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.jor.2017.01.002_bib0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s002230010036","article-title":"Bisphos phonate treatment suppresses not only stochnasticre modeling but also the target edrepair of micro damage","volume":"69","author":"Li","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jor.2017.01.002_bib0085","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2214\/AJR.10.6262","article-title":"Bisphosphonate-related complete a typical subtrochanteric femoral fractures: diagnosticutility of radiography","volume":"197","author":"Rosenberg","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jor.2017.01.002_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","article-title":"Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research","volume":"29","author":"Shane","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jor.2017.01.002_bib0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/BOT.0b013e31827240ae","article-title":"Surgical treatment improves clinical and functional outcomes for patients who sustain incomplete bisphosphonate related femur fractures","volume":"27","author":"Egol","year":"2013","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jor.2017.01.002_bib0100","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.2214\/AJR.09.3588","article-title":"Subtrochanteric femoral fractures in patients receiving long-term alendronate therapy: imaging features","volume":"194","author":"Chan","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jor.2017.01.002_bib0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1302\/0301-620X.84B1.11347","article-title":"Interobserver and intraobserver variation in the assessment of the healing of tibial fractures after intramedullary fixation","volume":"84","author":"Whelan","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jor.2017.01.002_bib0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00198-007-0451-8","article-title":"Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs","volume":"19","author":"Allen","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jor.2017.01.002_bib0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00223-009-9263-5","article-title":"Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series","volume":"85","author":"Armamento-Villareal","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jor.2017.01.002_bib0120","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures Fracture Intervention Trial Research Group","volume":"348","author":"Black","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jor.2017.01.002_bib0125","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/17453670903139914","article-title":"Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate","volume":"80","author":"Schilcher","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jor.2017.01.002_bib0130","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s11999-013-2963-1","article-title":"Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails","volume":"472","author":"Egol","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jor.2017.01.002_bib0135","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1359\/jbmr.081247","article-title":"Subtrochanteric and diaphyseal femur fractures in patients treated with alendronate: a register-based national cohort study","volume":"24","author":"Abrahamsen","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jor.2017.01.002_bib0140","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1056\/NEJMoa1001086","article-title":"Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur","volume":"362","author":"Black","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jor.2017.01.002_bib0145","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.injury.2007.08.036","article-title":"An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy?","volume":"39","author":"Kwek","year":"2008","journal-title":"Injury"},{"key":"10.1016\/j.jor.2017.01.002_bib0150","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bone.2012.10.006","article-title":"Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy","volume":"52","author":"Chiang","year":"2013","journal-title":"Bone"}],"container-title":["Journal of Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X16303063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X16303063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:10:25Z","timestamp":1789135825000},"score":1,"resource":{"primary":{"URL":"https:\/\/jortho.org\/atypical-femoral-shaft-fractures-secondary-to-long-term-bisphosphonate-therapy\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0972978X16303063"],"URL":"https:\/\/doi.org\/10.1016\/j.jor.2017.01.002","relation":{},"ISSN":["0972-978X"],"issn-type":[{"value":"0972-978X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atypical femoral shaft fractures secondary to long-term bisphosphonate therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jor.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}