{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:01Z","timestamp":1791400921106,"version":"4.3.3"},"reference-count":20,"publisher":"Scientific Scholar","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jor.2018.08.042","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T12:45:57Z","timestamp":1536324357000},"page":"984-987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of MTHFR and TNF-\u03b1 genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study"],"prefix":"10.25259","volume":"15","author":[{"given":"Mohammad Reza","family":"Azarpira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Ghilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Sobhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Mehdinezhad-Yazdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Aghili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohsen","family":"Miresmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Neamatzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"10.1016\/j.jor.2018.08.042_bib1","first-page":"1","article-title":"The epidemiology and demographics of Legg-Calv\u00e9-Perthes\u2019 disease","volume":"2011","author":"Loder","year":"2011","journal-title":"ISRN Orthop"},{"issue":"3","key":"10.1016\/j.jor.2018.08.042_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/aje\/kwr293","article-title":"Racial and geographic factors in the incidence of Legg-Calv\u00e9-Perthes' disease: a systematic review","volume":"175","author":"Perry","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.jor.2018.08.042_bib3","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/j.otsr.2017.04.012","article-title":"Legg-Calv\u00e9-Perthes disease","volume":"104","author":"Leroux","year":"2018","journal-title":"Orthop Traumatol Surg Res"},{"issue":"2","key":"10.1016\/j.jor.2018.08.042_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11832-010-0309-z","article-title":"Treatment outcome in the most severely affected Legg-Perthes patients, comparing prolonged traction in abduction with femoral varus derotation treatment","volume":"5","author":"Wagenaar","year":"2011","journal-title":"J Child Orthop"},{"issue":"6","key":"10.1016\/j.jor.2018.08.042_bib5","doi-asserted-by":"crossref","first-page":"e100505","DOI":"10.1371\/journal.pone.0100505","article-title":"A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg\u2013Calv\u00e9\u2013Perthes disease or avascular necrosis of the femoral head. Zhou Z, ed","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jor.2018.08.042_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/230949901302100230","article-title":"Legg-calve-perthes disease in two generations of male family members: a case report","volume":"21","author":"Al-Omran","year":"2013","journal-title":"J Orthop Surg"},{"key":"10.1016\/j.jor.2018.08.042_bib7","unstructured":"Chris Souder. Legg-Calve-Perthes Disease (Coxa plana) - Pediatrics - Orthobullets. https:\/\/www.orthobullets.com\/pediatrics\/4119\/legg-calve-perthes-disease-coxa-plana. Accessed May 28, 2018."},{"key":"10.1016\/j.jor.2018.08.042_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/196495","article-title":"Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head","volume":"2015","author":"Chai","year":"2015","journal-title":"BioMed Res Int"},{"issue":"3","key":"10.1016\/j.jor.2018.08.042_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/CS20080196","article-title":"Role of TNF-\u03b1 in vascular dysfunction","volume":"116","author":"Zhang","year":"2009","journal-title":"Clin Sci"},{"issue":"8","key":"10.1016\/j.jor.2018.08.042_bib10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1302\/0301-620X.86B8.14834","article-title":"Apoptosis \u2013 a significant cause of bone cell death in osteonecrosis of the femoral head","volume":"8686","author":"Calder","year":"2004","journal-title":"J Bone Jt Surg [Br]"},{"issue":"8","key":"10.1016\/j.jor.2018.08.042_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00431-015-2510-z","article-title":"Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease\u2014Serbian experience","volume":"174","author":"Srzenti\u0107","year":"2015","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jor.2018.08.042_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003086-200105000-00004","article-title":"Hypofibrinolysis, thrombophilia, osteonecrosis","volume":"386","author":"Glueck","year":"2001","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"10.1016\/j.jor.2018.08.042_bib13","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1007\/s11033-012-1540-0","article-title":"Association between MTHFR C677T polymorphism and osteonecrosis of the femoral head: a meta-analysis","volume":"39","author":"Shang","year":"2012","journal-title":"Mol Biol Rep"},{"issue":"2","key":"10.1016\/j.jor.2018.08.042_bib14","article-title":"Association between thrombophilic genes polymorphisms and recurrent pregnancy loss susceptibility in the iranian population: a systematic review and meta-analysis","volume":"22","author":"Kamali","year":"2018","journal-title":"Iran Biomed J"},{"issue":"11","key":"10.1016\/j.jor.2018.08.042_bib15","article-title":"Association between MTHFR C677T polymorphism and risk of prostate cancer: evidence from 22 studies with 10,832 cases and 11,993 controls","volume":"16","author":"Abedinzadeh","year":"2015","journal-title":"Asian Pac J Cancer Prev APJCP"},{"issue":"4","key":"10.1016\/j.jor.2018.08.042_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10059-010-0054-7","article-title":"Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population","volume":"29","author":"Kim","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.jor.2018.08.042_bib17","doi-asserted-by":"crossref","unstructured":"Ma L, Zhao J, Li T, et al. Association between Tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis. https:\/\/doi.org\/10.1186\/1746-1596-9-74.","DOI":"10.1186\/1746-1596-9-74"},{"issue":"3","key":"10.1016\/j.jor.2018.08.042_bib18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jor.2018.05.047","article-title":"Association of TNF-\u03b1-308G>A and \u2212238G>A polymorphisms with knee osteoarthritis risk: a case-control study and meta-analysis","volume":"15","author":"Sobhan","year":"2018","journal-title":"J Orthop"},{"issue":"4","key":"10.1016\/j.jor.2018.08.042_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1155\/2012\/896986","article-title":"Predictive role of cytokine gene polymorphisms for the development of femoral head osteonecrosis","volume":"33","author":"Samara","year":"2012","journal-title":"Dis Markers"},{"key":"10.1016\/j.jor.2018.08.042_bib20","doi-asserted-by":"crossref","DOI":"10.1007\/s00264-018-3859-1","article-title":"Association of TNF-\u03b1-308(G\/A) and -238(G\/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: a meta-analysis","author":"Peng","year":"2018","journal-title":"Int Orthop"}],"container-title":["Journal of Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X18302472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X18302472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:11:26Z","timestamp":1789135886000},"score":1,"resource":{"primary":{"URL":"https:\/\/jortho.org\/association-of-mthfr-and-tnf-%ce%b1-genes-polymorphisms-with-susceptibility-to-legg-calve-perthes-disease-in-iranian-children-a-case-control-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0972978X18302472"],"URL":"https:\/\/doi.org\/10.1016\/j.jor.2018.08.042","relation":{},"ISSN":["0972-978X"],"issn-type":[{"value":"0972-978X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of MTHFR and TNF-\u03b1 genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jor.2018.08.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Prof. PK Surendran Memorial Education Foundation. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}