{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:13:37Z","timestamp":1789136017693,"version":"build-2803163510"},"reference-count":47,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedics"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jor.2020.10.012","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T04:15:10Z","timestamp":1602821710000},"page":"497-502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Management of vasopressor induced ischemia"],"prefix":"10.25259","volume":"22","author":[{"given":"Michael","family":"Livesey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-0241","authenticated-orcid":false,"given":"Julio J.","family":"Jauregui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max C.","family":"Hamaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Pensy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Langhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Andrew","family":"Eglseder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"key":"10.1016\/j.jor.2020.10.012_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.CCM.0000298158.12101.41","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock","volume":"36","author":"Dellinger","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jor.2020.10.012_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13613-017-0261-x","article-title":"Outcome of patients with septic shock and high-dose vasopressor therapy","volume":"7","author":"Auchet","year":"2017","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jor.2020.10.012_bib3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jcrc.2016.11.036","article-title":"Reasons for death in patients with sepsis and septic shock","volume":"38","author":"Moskowitz","year":"2017","journal-title":"J Crit Care"},{"key":"10.1016\/j.jor.2020.10.012_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009241","article-title":"Risk factors for death in septic shock: a retrospective cohort study comparing trauma and non-trauma patients","volume":"96","author":"Medam","year":"2017","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jor.2020.10.012_bib5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/SHK.0000000000001022","article-title":"Vasopressor cumulative dose requirement and risk of early death during septic shock: an analysis from the EPISS cohort","volume":"49","author":"Dargent","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.jor.2020.10.012_bib6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13613-015-0058-8","article-title":"Timing and causes of death in septic shock","volume":"5","author":"Daviaud","year":"2015","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jor.2020.10.012_bib7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1177\/1049909115593065","article-title":"Realistic survival outcomes after vasopressor use in the intensive care unit","volume":"33","author":"Farkas","year":"2016","journal-title":"Am J Hosp Palliat Care"},{"key":"10.1016\/j.jor.2020.10.012_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5935\/0103-507X.20150009","article-title":"Septic shock: a major cause of hospital death after intensive care unit discharge","volume":"27","author":"Giacomini","year":"2015","journal-title":"Rev Bras Ter Intensiva"},{"key":"10.1016\/j.jor.2020.10.012_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF01694349","article-title":"Symmetrical peripheral gangrene: association with noradrenaline administration","volume":"18","author":"Hayes","year":"1992","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jor.2020.10.012_bib10","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1097\/01.CCM.0000059722.94182.79","article-title":"Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine-resistant vasodilatory shock: incidence and risk factors","volume":"31","author":"Dunser","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jor.2020.10.012_bib11","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/ALN.0b013e31826e05a7","article-title":"Symmetric peripheral gangrene","volume":"118","author":"Akamatsu","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jor.2020.10.012_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4037\/ajcc2013748","article-title":"High-dose norepinephrine treatment: determinants of mortality and futility in critically ill patients","volume":"22","author":"Dopp-Zemel","year":"2013","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.jor.2020.10.012_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.ASW.0000431083.77517.fd","article-title":"Bilateral toe necrosis resulting from norepinephrine bitartrate usage","volume":"26","author":"Simman","year":"2013","journal-title":"Adv Skin Wound Care"},{"key":"10.1016\/j.jor.2020.10.012_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12262-012-0576-7","article-title":"Symmetrical peripheral gangrene-a case report and brief review","volume":"75","author":"Shenoy","year":"2013","journal-title":"Indian J Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijscr.2015.07.012","article-title":"Four limb amputations due to peripheral gangrene from inotrope use - case report and review of the literature","volume":"14","author":"Ang","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.jor.2020.10.012_bib16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/SCS.0000000000002463","article-title":"Ischemic necrosis of upper lip, and all fingers and toes after norepinephrine use","volume":"27","author":"Shin","year":"2016","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/2042098617712669","article-title":"Digital necrosis: a potential risk of high-dose norepinephrine","volume":"8","author":"Daroca-Perez","year":"2017","journal-title":"Ther Adv Drug Saf"},{"key":"10.1016\/j.jor.2020.10.012_bib18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1378\/chest.12-1106","article-title":"Survival after shock requiring high-dose vasopressor therapy","volume":"143","author":"Brown","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jor.2020.10.012_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00134-017-4952-4","article-title":"When acrocyanosis in intensive care unit is not due to vasopressor support","volume":"44","author":"Nunes","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jor.2020.10.012_bib20","first-page":"148","article-title":"Acute limb ischemia","volume":"12","author":"Dormandy","year":"1999","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.jp.7210713","article-title":"The use of topical nitroglycerin ointment to treat peripheral tissue ischemia secondary to arterial line complications in neonates","volume":"22","author":"Baserga","year":"2002","journal-title":"J Perinatol"},{"key":"10.1016\/j.jor.2020.10.012_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00006534-198911000-00017","article-title":"Reversal of dopamine extravasation injury with topical nitroglycerin ointment","volume":"84","author":"Denkler","year":"1989","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib23","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0022-3476(05)80356-7","article-title":"Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates","volume":"121","author":"Wong","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.jor.2020.10.012_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/jsre.2000.5971","article-title":"Topical application of amrinone (a selective phosphodiesterase III inhibitor) for relief of vasospasm","volume":"93","author":"Ichioka","year":"2000","journal-title":"J Surg Res"},{"key":"10.1016\/j.jor.2020.10.012_bib25","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1445-2197.2006.03954.x","article-title":"Adrenaline-induced digital ischaemia reversed with phentolamine","volume":"76","author":"Molony","year":"2006","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib26","doi-asserted-by":"crossref","first-page":"479 e471","DOI":"10.1016\/j.jhsa.2017.01.006","article-title":"Delayed-onset digital ischemia after local anesthetic with epinephrine injection requiring phentolamine reversal","volume":"42","author":"Zhu","year":"2017","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.jor.2020.10.012_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archfami.3.2.193","article-title":"Phentolamine reversal of epinephrine-induced digital vasospasm. How to save an ischemic finger","volume":"3","author":"Hinterberger","year":"1994","journal-title":"Arch Fam Med"},{"key":"10.1016\/j.jor.2020.10.012_bib28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.apsb.2016.12.009","article-title":"Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine","volume":"7","author":"Jin","year":"2017","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jor.2020.10.012_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.hcl.2014.09.003","article-title":"The role of botulinum toxin in vasospastic disorders of the hand","volume":"31","author":"Neumeister","year":"2015","journal-title":"Hand Clin"},{"key":"10.1016\/j.jor.2020.10.012_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/01.prs.0000244860.00674.57","article-title":"Management of vasospastic disorders with botulinum toxin A","volume":"119","author":"Van Beek","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/AAP.0000000000000595","article-title":"Regional to the rescue! Axillary brachial plexus nerve block facilitates removal of entrapped transradial catheter placed for cardiac catheterization","volume":"42","author":"Fitzgerald","year":"2017","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jor.2020.10.012_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2147\/JPR.S124627","article-title":"Retention of finger blood flow against postural change as an indicator of successful sympathetic block in the upper limb","volume":"10","author":"Nakatani","year":"2017","journal-title":"J Pain Res"},{"key":"10.1016\/j.jor.2020.10.012_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mvr.2018.10.004","article-title":"The presence of synchronized perfusion dips in the microcirculation of the resting nail bed","volume":"121","author":"Mirdell","year":"2019","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jor.2020.10.012_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00068-014-0414-7","article-title":"The diagnosis of acute compartment syndrome: a review","volume":"40","author":"McQueen","year":"2014","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00006534-198601000-00016","article-title":"Resolution of experimental microvascular spasm and improvement in anastomotic patency by direct topical agent application","volume":"77","author":"Geter","year":"1986","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/00000637-198812000-00014","article-title":"Resolution of experimental microvascular vasoconstriction in rats by topical application of lidocaine hydrochloride in varying concentrations","volume":"21","author":"Beekman","year":"1988","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-2007-1006780","article-title":"Topical use of Xylocaine for relieving vasospasm: effect of concentration","volume":"7","author":"Ohta","year":"1991","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.jor.2020.10.012_bib38","first-page":"1551","article-title":"Evaluation and management of peripheral vascular injury. Part 1. Western Trauma Association\/critical decisions in trauma","volume":"70","author":"Feliciano","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.jor.2020.10.012_bib39","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.jvs.2013.05.011","article-title":"Open surgical management of complications from indwelling radial artery catheters","volume":"58","author":"Garg","year":"2013","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/j.semvascsurg.2008.12.003","article-title":"Clinical staging of acute limb ischemia as the basis for choice of revascularization method: when and how to intervene","volume":"22","author":"Rutherford","year":"2009","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.jor.2020.10.012_bib41","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.anplas.2017.03.006","article-title":"[Superficial circumflex iliac artery perforator flap (SCIP flap): revival of the inguinal donor site?]","volume":"62","author":"Sidhoum","year":"2017","journal-title":"Ann Chir Plast Esthet"},{"key":"10.1016\/j.jor.2020.10.012_bib42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jhsa.2014.12.006","article-title":"Paraumbilical perforator flap for soft tissue reconstruction of the forearm","volume":"40","author":"Gutwein","year":"2015","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.jor.2020.10.012_bib43","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1055\/s-0038-1675369","article-title":"The first dorsal metacarpal artery flap family: a review","volume":"4","author":"Couceiro","year":"2018","journal-title":"Surg J"},{"key":"10.1016\/j.jor.2020.10.012_bib44","first-page":"411","article-title":"[Exoprosthetic replacement of the upper extremity]","volume":"154","author":"Salminger","year":"2016","journal-title":"Z Orthop Unfall"},{"key":"10.1016\/j.jor.2020.10.012_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pmr.2018.08.011","article-title":"Upper extremity amputation and prosthetics care across the active duty military and veteran populations","volume":"30","author":"Cancio","year":"2019","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"10.1016\/j.jor.2020.10.012_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10856-017-5880-0","article-title":"Outcomes after hand and upper extremity transplantation","volume":"28","author":"Shores","year":"2017","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.jor.2020.10.012_bib47","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/tri.12652","article-title":"Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration","volume":"29","author":"Kueckelhaus","year":"2016","journal-title":"Transpl Int"}],"container-title":["Journal of Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X20303287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X20303287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:04:19Z","timestamp":1789135459000},"score":1,"resource":{"primary":{"URL":"https:\/\/jortho.org\/management-of-vasopressor-induced-ischemia\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":47,"alternative-id":["S0972978X20303287"],"URL":"https:\/\/doi.org\/10.1016\/j.jor.2020.10.012","relation":{},"ISSN":["0972-978X"],"issn-type":[{"value":"0972-978X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of vasopressor induced ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jor.2020.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}