{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:13:31Z","timestamp":1789136011833,"version":"build-2803163510"},"reference-count":44,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedics"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jor.2021.05.004","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T22:49:53Z","timestamp":1620341393000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Platelet-rich plasma in non-operative management of mild to moderate carpal tunnel syndrome \u2013 A systematic review &amp; meta-analysis of short-term outcomes"],"prefix":"10.25259","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-6032","authenticated-orcid":false,"given":"Martin S.","family":"Davey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoghan T.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Tristan","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannan","family":"Mullett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall M.","family":"McInerney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Galbraith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"issue":"6","key":"10.1016\/j.jor.2021.05.004_bib1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4329\/wjr.v6.i6.284","article-title":"A handy review of carpal tunnel syndrome: from anatomy to diagnosis and treatment","volume":"6","author":"Ghasemi-Rad","year":"2014","journal-title":"World J Radiol"},{"issue":"3","key":"10.1016\/j.jor.2021.05.004_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5271\/sjweh.3855","article-title":"Applying two general population job exposure matrices to predict incident carpal tunnel syndrome: a cross-national approach to improve estimation of workplace physical exposures","volume":"46","author":"Yung","year":"2020","journal-title":"Scand J Work Environ Health"},{"issue":"2","key":"10.1016\/j.jor.2021.05.004_bib3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10926-008-9125-4","article-title":"Association of occupational and non-occupational risk factors with the prevalence of work related carpal tunnel syndrome","volume":"18","author":"Maghsoudipour","year":"2008","journal-title":"J Occup Rehabil"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0266-7681_90_90061-8","article-title":"Predictive factors in the non-surgical treatment of carpal tunnel syndrome","volume":"15","author":"Kaplan","year":"1990","journal-title":"J Hand Surg Eur"},{"issue":"2","key":"10.1016\/j.jor.2021.05.004_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0363-5023(86)80055-7","article-title":"An industrial cause of carpal tunnel syndrome","volume":"11","author":"Masear","year":"1986","journal-title":"J Hand Surg Am"},{"issue":"6","key":"10.1016\/j.jor.2021.05.004_bib6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jhsa.2016.04.003","article-title":"The clinical practice guideline on carpal tunnel syndrome and workers' compensation","volume":"41","author":"Goldfarb","year":"2016","journal-title":"J Hand Surg"},{"issue":"4","key":"10.1016\/j.jor.2021.05.004_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/J.JHSB.2004.03.002","article-title":"Carpal tunnel syndrome and work","volume":"29","author":"Dias","year":"2004","journal-title":"J Hand Surg Eur"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib8","first-page":"4","article-title":"Pathophysiology of carpal tunnel syndrome","volume":"20","author":"Aboonq","year":"2015","journal-title":"Neurosci"},{"issue":"9","key":"10.1016\/j.jor.2021.05.004_bib9","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S1388-2457(02)00169-4","article-title":"Carpal tunnel syndrome: pathophysiology and clinical neurophysiology","volume":"113","author":"Werner","year":"2002","journal-title":"Clin Neurophysiol : Off J Int Feder Clin Neurophysiol"},{"issue":"12","key":"10.1016\/j.jor.2021.05.004_bib10","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol"},{"issue":"9","key":"10.1016\/j.jor.2021.05.004_bib11","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/1753193417721456","article-title":"Patient-reported outcomes of carpal tunnel release surgery in patients with bilateral severe carpal tunnel syndrome","volume":"42","author":"Tang","year":"2017","journal-title":"J Hand Surg Eur"},{"issue":"3","key":"10.1016\/j.jor.2021.05.004_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0266-7681(05)80202-5","article-title":"Steroid injection for carpal tunnel syndrome","volume":"21","author":"Irwin","year":"1996","journal-title":"J Hand Surg Eur"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.apmr.2019.10.193","article-title":"Effectiveness of platelet-rich plasma injections for nonsurgical management of carpal tunnel syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"101","author":"Catapano","year":"2020","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib14","first-page":"25","article-title":"The use of autologous blood-derived growth factors in bone regeneration","volume":"8","author":"Civinini","year":"2011","journal-title":"Clin Cases Min Bone Metabol"},{"issue":"6","key":"10.1016\/j.jor.2021.05.004_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067303","article-title":"HGF mediates the anti-inflammatory effects of PRP on injured tendons","volume":"8","author":"Zhang","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jor.2021.05.004_bib16","unstructured":"Group OLoEW. The Oxford 2011 levels of evidence. Oxf Cent Evid Based Med. Available from: http:\/\/www.cebm.net\/index."},{"issue":"3","key":"10.1016\/j.jor.2021.05.004_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jrsm.1102","article-title":"Practicalities of using a modified version of the Cochrane Collaboration risk of bias tool for randomised and non-randomised study designs applied in a health technology assessment setting","volume":"5","author":"Robertson","year":"2014","journal-title":"Res Synth Method"},{"issue":"3","key":"10.1016\/j.jor.2021.05.004_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ejr.2018.07.008","article-title":"Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome: clinical and electrophysiological study","volume":"41","author":"Atwa","year":"2019","journal-title":"Egypt Rheumatol"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/term.2815","article-title":"Short-term effectiveness of platelet-rich plasma in carpal tunnel syndrome: a controlled study","volume":"13","author":"G\u00fcven","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jor.2021.05.004_bib20","article-title":"Platelet-rich plasma versus corticosteroid intra-articular injections for the treatment of trapeziometacarpal arthritis: a prospective randomized controlled clinical trial","author":"Malahias","year":"2018","journal-title":"Cartilage"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12891-018-1963-4","article-title":"Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial","volume":"19","author":"Raeissadat","year":"2018","journal-title":"BMC Muscoskel Disord"},{"issue":"12","key":"10.1016\/j.jor.2021.05.004_bib22","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1007\/s10067-019-04719-7","article-title":"Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndrome","volume":"38","author":"Senna","year":"2019","journal-title":"Clin Rheumatol"},{"issue":"11","key":"10.1016\/j.jor.2021.05.004_bib23","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/term.2950","article-title":"Comparison of perineural platelet-rich plasma and dextrose injections for moderate carpal tunnel syndrome: a prospective randomized, single-blind, head-to-head comparative trial","volume":"13","author":"Shen","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/2000656X.2016.1260025","article-title":"Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome","volume":"51","author":"Uzun","year":"2017","journal-title":"J Plast Surg Hand Surg"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41598-017-00224-6","article-title":"Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: a prospective randomized, single-blind controlled trial","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.jor.2021.05.004_bib26","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.2106\/00004623-199311000-00002","article-title":"A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome","volume":"75","author":"Levine","year":"1993","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.jor.2021.05.004_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2474-7-78","article-title":"A systematic review of the psychometric properties of the Boston Carpal Tunnel Questionnaire","volume":"7","author":"Leite","year":"2006","journal-title":"BMC Muscoskel Disord"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib28","first-page":"1","article-title":"Platelet-rich plasma injections for carpal tunnel syndrome: a systematic and comprehensive review","volume":"29","author":"Malahias","year":"2019","journal-title":"Eur J Orthop Surg"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib29","first-page":"65","article-title":"The effect of platelet-rich plasma on Achilles tendon healing in a rabbit model","volume":"51","author":"Takamura","year":"2017","journal-title":"Acta Orthop Traumatol"},{"key":"10.1016\/j.jor.2021.05.004_bib30","first-page":"150","article-title":"Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries","volume":"32","author":"Middleton","year":"2012","journal-title":"Iowa Orthop J"},{"issue":"1","key":"10.1016\/j.jor.2021.05.004_bib31","first-page":"28","article-title":"The history of carpal tunnel syndrome","volume":"13","author":"Pfeffer","year":"1988","journal-title":"J Hand Surg"},{"issue":"10","key":"10.1016\/j.jor.2021.05.004_bib32","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/jama.288.10.1245","article-title":"Splinting vs surgery in the treatment of carpal tunnel syndrome: a randomized controlled trial","volume":"288","author":"Gerritsen","year":"2002","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.jor.2021.05.004_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/jama.289.4.420-g","article-title":"Splinting vs surgery for carpal tunnel syndrome","volume":"289","author":"Weintraub","year":"2003","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.jor.2021.05.004_bib34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jama.289.4.420-c","article-title":"Splinting vs surgery for carpal tunnel syndrome","volume":"289","author":"Menkes","year":"2003","journal-title":"Jama"},{"issue":"6","key":"10.1016\/j.jor.2021.05.004_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/1753193415625404","article-title":"Gender differences in carpal tunnel relative cross-sectional area: a possible causative factor in idiopathic carpal tunnel syndrome","volume":"41","author":"Sassi","year":"2016","journal-title":"J Hand Surg Eur"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib36","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jama.1957.02980050014005","article-title":"Compression neuropathy of the median nerve in the carpal tunnel","volume":"164","author":"Phalen","year":"1957","journal-title":"J Am Med Assoc"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/rheumatology\/kei218","article-title":"Ultrasonography shows increased cross-sectional area of the median nerve in patients with arthritis and carpal tunnel syndrome","volume":"45","author":"Hammer","year":"2006","journal-title":"Rheumatology"},{"issue":"6","key":"10.1016\/j.jor.2021.05.004_bib38","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.asjsur.2019.08.001","article-title":"Value of cross-sectional area of median nerve by MRI in carpal tunnel syndrome","volume":"43","author":"Park","year":"2020","journal-title":"Asian J Surg"},{"issue":"2","key":"10.1016\/j.jor.2021.05.004_bib39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0266-7681_90_90131-M","article-title":"Magnetic resonance imaging of the carpal tunnel","volume":"15","author":"Healy","year":"1990","journal-title":"J Hand Surg"},{"key":"10.1016\/j.jor.2021.05.004_bib40","article-title":"Three-dimensional MRI of the median nerve in the carpal tunnel","author":"Funahashi","year":"2020","journal-title":"J Hand Surg Eur"},{"issue":"4","key":"10.1016\/j.jor.2021.05.004_bib41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4103\/0976-3147.120191","article-title":"Finding relief at the end of the (Carpal) tunnel: electrophysiological clues","volume":"4","author":"Yip","year":"2013","journal-title":"J Neurosci Rural Pract"},{"issue":"5","key":"10.1016\/j.jor.2021.05.004_bib42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/term.1756","article-title":"Effect of platelet-rich plasma (PRP) concentration on proliferation, neurotrophic function and migration of Schwann cells in vitro","volume":"10","author":"Zheng","year":"2016","journal-title":"J Tissue Eng Regener Med"},{"issue":"3","key":"10.1016\/j.jor.2021.05.004_bib43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/1753193418815546","article-title":"Utility of 'baseline' electrodiagnostic studies for carpal tunnel release","volume":"44","author":"Zhang","year":"2019","journal-title":"J Hand Surg Eur"},{"issue":"20","key":"10.1016\/j.jor.2021.05.004_bib44","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2106\/JBJS.16.01374","article-title":"A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature","volume":"99","author":"Chahla","year":"2017","journal-title":"J Bone Jt Surg Am"}],"container-title":["Journal of Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X21001124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X21001124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:04:53Z","timestamp":1789135493000},"score":1,"resource":{"primary":{"URL":"https:\/\/jortho.org\/platelet-rich-plasma-in-non-operative-management-of-mild-to-moderate-carpal-tunnel-syndrome-a-systematic-review-meta-analysis-of-short-term-outcomes\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":44,"alternative-id":["S0972978X21001124"],"URL":"https:\/\/doi.org\/10.1016\/j.jor.2021.05.004","relation":{},"ISSN":["0972-978X"],"issn-type":[{"value":"0972-978X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-rich plasma in non-operative management of mild to moderate carpal tunnel syndrome \u2013 A systematic review & meta-analysis of short-term outcomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jor.2021.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of Professor P K Surendran Memorial Education Foundation.","name":"copyright","label":"Copyright"}]}}