{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:12:32Z","timestamp":1789135952704,"version":"build-2803163510"},"reference-count":28,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jor.2025.06.013","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T11:07:37Z","timestamp":1750504057000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Ferulic acid\/GRB2\/NF-\u03baB signaling pathway that alleviates ferroptosis-induced apoptosis of nucleus pulposus cells is a potential mechanism for intervertebral disc degeneration"],"prefix":"10.25259","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-1172","authenticated-orcid":false,"given":"Minde","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","reference":[{"issue":"10159","key":"10.1016\/j.jor.2025.06.013_bib1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global,regional,and national incidence,prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories,1990-2017:a systematic analy\u2043 sis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jor.2025.06.013_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.36076\/ppj.2012\/15\/525","article-title":"Prospective clinical study on natural history of discogenic low back pain at 4 years of followup","volume":"15","author":"Peng","year":"2012","journal-title":"Pain Physician"},{"issue":"1","key":"10.1016\/j.jor.2025.06.013_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1076","article-title":"Pathomechanism of inter\u2043 vertebral disc degeneration","volume":"3","author":"Oichi","year":"2020","journal-title":"JOR Spine"},{"issue":"51","key":"10.1016\/j.jor.2025.06.013_bib4","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.1073\/pnas.2006828117","article-title":"Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer","volume":"117","author":"Lee","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.jor.2025.06.013_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol Ther"},{"issue":"11","key":"10.1016\/j.jor.2025.06.013_bib6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jor.2025.06.013_bib7","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.actbio.2021.11.042","article-title":"ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy","volume":"140","author":"Yang","year":"2022","journal-title":"Acta Biomater"},{"issue":"7784","key":"10.1016\/j.jor.2025.06.013_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jor.2025.06.013_bib9","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1111\/cns.14265","article-title":"Ferulic acid as a therapeutic agent in depression: evidence from preclinical studies","volume":"29","author":"Dong","year":"2023","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"10.1016\/j.jor.2025.06.013_bib10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/cns.14060","article-title":"Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"10.1016\/j.jor.2025.06.013_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41413-024-00355-3","article-title":"Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-\u03baB signaling to recruit macrophages and activate the NLRP3 inflammasome","volume":"12","author":"Wang","year":"2024","journal-title":"Bone Res"},{"issue":"7","key":"10.1016\/j.jor.2025.06.013_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847563","article-title":"Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53","volume":"20","author":"Wang","year":"2019","journal-title":"EMBO Rep"},{"issue":"10","key":"10.1016\/j.jor.2025.06.013_bib13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","article-title":"BAP1 links metabolic regulation of ferroptosis to tumour suppression","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jor.2025.06.013_bib14","unstructured":"Lee H, Zandkarimi F, Zhang Y, et al. Energy-Stressmediated AMPK Activation Inhibits.."},{"issue":"3","key":"10.1016\/j.jor.2025.06.013_bib15","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/iid3.424","article-title":"Ferulic acid suppresses interleukin-1\u03b2-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1\/AMPK\/PGC-1\u03b1 signaling pathway","volume":"9","author":"Du","year":"2021","journal-title":"Immun Inflamm Dis"},{"issue":"3","key":"10.1016\/j.jor.2025.06.013_bib16","first-page":"317","article-title":"Ferulic acid attenuates osteoporosis induced by glucocorticoid through regulating the GSK-3\u03b2\/Lrp-5\/ERK signalling pathways","volume":"108","author":"Zhou","year":"2021","journal-title":"Phys Int"},{"issue":"37","key":"10.1016\/j.jor.2025.06.013_bib17","doi-asserted-by":"crossref","first-page":"61440","DOI":"10.18632\/oncotarget.18374","article-title":"Wogonoside inhibits IL-1beta induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jor.2025.06.013_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.spinee.2017.09.018","article-title":"Accumulation and localization of macrophage phenotypes with human intevertebral disc degeneration","volume":"18","author":"Nakazawa","year":"2018","journal-title":"Spine J"},{"key":"10.1016\/j.jor.2025.06.013_bib19","article-title":"HSP90 inhibitor 17-AAG attenuates nucleus pulposus inflammation and catabolism induced by M1-Polarized macropha-ges","volume":"9","author":"Zhang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jor.2025.06.013_bib20","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2147\/DDDT.S448807","article-title":"The emerging roles of nanocarrier drug delivery system in treatment of intervertebral disc degeneration-current knowledge, hot spots, challenges and future perspectives","volume":"18","author":"Hu","year":"2024","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.jor.2025.06.013_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jot.2023.10.004","article-title":"Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction","volume":"46","author":"Jia","year":"2024","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jor.2025.06.013_bib22","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/ijms24021367","article-title":"Macrophages and intervertebral disc degeneration","volume":"24","author":"Koroth","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jor.2025.06.013_bib23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ajpath.2022.12.014","article-title":"Ferrostatin-1 inhibits toll-like receptor 4\/NF-\u03baB signaling to alleviate intervertebral disc degeneration in rats","volume":"193","author":"Wang","year":"2023","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.jor.2025.06.013_bib24","article-title":"TNF\u03b1-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis","volume":"12","author":"Qiu","year":"2024","journal-title":"Genes Dis"},{"key":"10.1016\/j.jor.2025.06.013_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci"},{"issue":"9","key":"10.1016\/j.jor.2025.06.013_bib26","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/tox.22417","article-title":"Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K\/AKT and NF-\u03baB signaling pathways","volume":"32","author":"Shih","year":"2017","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.jor.2025.06.013_bib27","article-title":"The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus","volume":"13","author":"Dong","year":"2022","journal-title":"Front Endocrinol"},{"issue":"23","key":"10.1016\/j.jor.2025.06.013_bib28","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.3390\/ijms21239181","article-title":"NF-\u03baB and disease","volume":"21","author":"Poma","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X25002375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972978X25002375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:03:16Z","timestamp":1789135396000},"score":1,"resource":{"primary":{"URL":"https:\/\/jortho.org\/ferulic-acid-grb2-nf-%ce%bab-signaling-pathway-that-alleviates-ferroptosis-induced-apoptosis-of-nucleus-pulposus-cells-is-a-potential-mechanism-for-intervertebral-disc-degeneration\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":28,"alternative-id":["S0972978X25002375"],"URL":"https:\/\/doi.org\/10.1016\/j.jor.2025.06.013","relation":{},"ISSN":["0972-978X"],"issn-type":[{"value":"0972-978X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferulic acid\/GRB2\/NF-\u03baB signaling pathway that alleviates ferroptosis-induced apoptosis of nucleus pulposus cells is a potential mechanism for intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jor.2025.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Professor P K Surendran Memorial Education Foundation.","name":"copyright","label":"Copyright"}]}}