{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:41:56Z","timestamp":1779399716596,"version":"3.53.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jormas.2021.12.002","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T22:12:13Z","timestamp":1639606333000},"page":"e743-e748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is medication related osteonecrosis of the jaw around implants a rare entity? A case series with a focus on etiopathophysiology"],"prefix":"10.1016","volume":"123","author":[{"given":"Jean","family":"Massaad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Magremanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jormas.2021.12.002_bib0001","series-title":"Bisphosphonates in bone disease: from the laboratory to the patient","author":"Fleisch","year":"2000"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","article-title":"Bisphosphonates: the first 40 years","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.jormas.2021.12.002_bib0003","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.jormas.2021.12.002_bib0004","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.jormas.2021.12.002_bib0005","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/odi.13160","article-title":"Workshop of European task force on medication-related osteonecrosis of the jaw-current challenges","volume":"25","author":"Schiodt","year":"2019","journal-title":"Oral Dis"},{"issue":"4","key":"10.1016\/j.jormas.2021.12.002_bib0006","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.coms.2015.06.006","article-title":"Preventive strategies for patients at risk of medication-related osteonecrosis of the jaw","volume":"27","author":"Goodday","year":"2015","journal-title":"Oral Maxillofac Surg Clin N Am"},{"issue":"5","key":"10.1016\/j.jormas.2021.12.002_bib0007","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s11914-018-0474-4","article-title":"Current understanding of the pathophysiology of osteonecrosis of the jaw","volume":"16","author":"Chang","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0008","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.oraloncology.2010.11.007","article-title":"Surgery-triggered and non surgery-triggered bisphosphonate-related osteonecrosis of the jaws (BRONJ): a retrospective analysis of 567 cases in an Italian multicenter study","volume":"47","author":"Vescovi","year":"2011","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0009","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41413-020-0088-1","article-title":"Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors","volume":"8","author":"Wan","year":"2020","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0010","first-page":"74","article-title":"Failure of osseointegrated dental implants after diphosphonate therapy for osteoporosis: a case report","volume":"10","author":"Starck","year":"1995","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0011","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00784-012-0708-2","article-title":"Osteopathology induced by bisphosphonates and dental implants: clinical observations","volume":"17","author":"Jacobsen","year":"2013","journal-title":"Clin Oral Investig"},{"issue":"25","key":"10.1016\/j.jormas.2021.12.002_bib0012","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1200\/JCO.19.01186","article-title":"Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline","volume":"37","author":"Yarom","year":"2019","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.jormas.2021.12.002_bib0013","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jcms.2016.09.018","article-title":"Clinical features of peri-implant medication-related osteonecrosis of the jaw: is there an association to peri-implantitis?","volume":"44","author":"Troeltzsch","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0014","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/SCS.0000000000002564","article-title":"Medication-related osteonecrosis of the jaw around dental implants: implant surgery-triggered or implant presence-triggered osteonecrosis?","volume":"27","author":"Giovannacci","year":"2016","journal-title":"J Craniofac Surg"},{"issue":"5","key":"10.1016\/j.jormas.2021.12.002_bib0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/clr.12088","article-title":"Shin H-I. Osteonecrosis associated with dental implants in patients undergoing bisphosphonate treatment","volume":"25","author":"Kwon","year":"2014","journal-title":"Clin Oral Implants Res"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0016","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jormas.2019.04.012","article-title":"Medication-related osteonecrosis of the jaw. Implant presence-triggered osteonecrosis: Case series and literature review","volume":"121","author":"Escobedo","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jormas.2021.12.002_bib0017","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijom.2017.07.012","article-title":"Previously successful dental implants can fail when patients commence anti-resorptive therapy-a case series","volume":"47","author":"Pogrel","year":"2018","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.jormas.2021.12.002_bib0018","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbm.a.36060","article-title":"Basis of bone metabolism around dental implants during osseointegration and peri-implant bone loss","volume":"105","author":"Insua","year":"2017","journal-title":"J Biomed Mater Res A"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.17096\/jiufd.24812","article-title":"Bisphosphonate-related osteonecrosis of the jaw and dental implants","volume":"50","author":"Qamheya","year":"2016","journal-title":"J Istanb Univ Fac Dent"},{"issue":"4","key":"10.1016\/j.jormas.2021.12.002_bib0020","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00784-018-2612-x","article-title":"Evaluation of bone turnover after bisphosphonate withdrawal and its influence on implant osseointegration: an in vivo study in rats","volume":"23","author":"Frizzera","year":"2019","journal-title":"Clin Oral Investig"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0021","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2106\/JBJS.F.00484","article-title":"Alendronate improves screw fixation in osteoporotic bone","volume":"89","author":"Moroni","year":"2007","journal-title":"J Bone Jt Surg Am"},{"issue":"5","key":"10.1016\/j.jormas.2021.12.002_bib0022","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.11607\/jomi.2685","article-title":"The effect of systemically administered bisphosphonates on bony healing after tooth extraction and osseointegration of dental implants in the rabbit maxilla","volume":"28","author":"Kim","year":"2013","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"5","key":"10.1016\/j.jormas.2021.12.002_bib0023","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.bone.2012.02.001","article-title":"A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants","volume":"50","author":"Abtahi","year":"2012","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0024","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/0022034512472335","article-title":"Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw","volume":"92","author":"Abtahi","year":"2013","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.jormas.2021.12.002_bib0025","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1600-051X.2012.01854.x","article-title":"Association between oral bisphosphonate use and dental implant failure among middle-aged women","volume":"39","author":"Yip","year":"2012","journal-title":"J Clin Periodontol"},{"issue":"11","key":"10.1016\/j.jormas.2021.12.002_bib0026","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.3390\/ijerph17113931","article-title":"Risk factors related to late failure of dental implant-A systematic review of recent studies","volume":"17","author":"Do","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"10.1016\/j.jormas.2021.12.002_bib0027","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.joms.2009.09.017","article-title":"Bisphosphonate-related osteonecrosis of the jaw associated with dental implants","volume":"68","author":"Lazarovici","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0028","doi-asserted-by":"crossref","first-page":"e444","DOI":"10.4317\/jced.52234","article-title":"Jaw osteonecrosis management around a dental implant inserted 2 years before starting treatment with zoledronic acid","volume":"7","author":"Mar\u00edn-Fern\u00e1ndez","year":"2015","journal-title":"J Clin Exp Dent"},{"issue":"10","key":"10.1016\/j.jormas.2021.12.002_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.joms.2014.04.037","article-title":"Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws","volume":"72","author":"Holzinger","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40729-016-0041-7","article-title":"Dental implants in patients treated with antiresorptive medication - a systematic literature review","volume":"2","author":"Walter","year":"2016","journal-title":"Int J Implant Dent"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0031","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10266-015-0207-4","article-title":"Evaluation of dental implants as a risk factor for the development of bisphosphonate-related osteonecrosis of the jaw in breast cancer patients","volume":"104","author":"Matsuo","year":"2016","journal-title":"Odontology"},{"issue":"1","key":"10.1016\/j.jormas.2021.12.002_bib0032","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bone.2010.10.159","article-title":"Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don't know","volume":"49","author":"Allen","year":"2011","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0033","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00784-009-0300-6","article-title":"Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings","volume":"14","author":"Hoefert","year":"2010","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jormas.2021.12.002_bib0034","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.archoralbio.2018.09.016","article-title":"The rise and fall of the alveolar process: dependency of teeth and metabolic aspects","volume":"96","author":"Jonasson","year":"2018","journal-title":"Arch Oral Biol"},{"issue":"3","key":"10.1016\/j.jormas.2021.12.002_bib0035","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.joms.2009.09.055","article-title":"Characteristics of implant failures in patients with a history of oral bisphosphonate therapy","volume":"68","author":"Martin","year":"2010","journal-title":"J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jormas.2021.12.002_bib0036","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1563\/aaid-joi-D-18-00212","article-title":"Genetic involvement in dental implant failure: association with polymorphisms of genes modulating inflammatory responses and bone metabolism","volume":"45","author":"Chen","year":"2019","journal-title":"J Oral Implantol"}],"container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246878552100272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246878552100272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:11:30Z","timestamp":1762855890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246878552100272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S246878552100272X"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2021.12.002","relation":{},"ISSN":["2468-7855"],"issn-type":[{"value":"2468-7855","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is medication related osteonecrosis of the jaw around implants a rare entity? A case series with a focus on etiopathophysiology","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology, Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}