{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:10:36Z","timestamp":1793070636567,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jormas.2022.03.020","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T19:42:19Z","timestamp":1653162139000},"page":"616-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence and risk factors associated to Medication-Related Osteo Necrosis of the Jaw (MRONJ) in patients with osteoporosis after tooth extractions. A 12-months observational cohort study"],"prefix":"10.1016","volume":"123","author":[{"given":"Alessandro","family":"Cuozzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Iorio-Siciliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Vaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Mauriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8794","authenticated-orcid":false,"given":"Andrea","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ramaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jormas.2022.03.020_bib0001","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw - 2014 Update","volume":"72","author":"Dodson","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0002","article-title":"Detecting the earliest radiological signs of bisphosphonate-related osteonecrosis","author":"Devlin","year":"2017","journal-title":"British Dental Journal"},{"key":"10.1016\/j.jormas.2022.03.020_bib0003","volume":"2.0","author":"G","year":"2020"},{"key":"10.1016\/j.jormas.2022.03.020_bib0004","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5125\/jkaoms.2020.46.1.78","article-title":"The effect of bisphosphonate discontinuation on the incidence of postoperative medication-related osteonecrosis of the jaw after tooth extraction","volume":"46","author":"Sang-Hoon","year":"2020","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/475859","article-title":"Risk Assessment of BRONJ in Oncologic Patients Treated with Bisphosphonates: Follow-Up to 18 Months","author":"Sparabombe","year":"2014","journal-title":"International Journal of Dentistry"},{"issue":"10","key":"10.1016\/j.jormas.2022.03.020_bib0006","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1600-0714.2005.00351.x","article-title":"Jaw bone necrosis without previous dental extractions associated with the use of bisphosphonates (pamidronate and zoledronate): a four-case report","volume":"34","author":"Merigo","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jormas.2022.03.020_bib0007","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.ijom.2012.06.020","article-title":"Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: A cohort study","volume":"41","author":"Yamazaki","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0008","series-title":"Incidence of Bisphosphonate-associated Osteonecrosis of the Jaws in Breast Cancer Patients","author":"Walter","year":"2009"},{"key":"10.1016\/j.jormas.2022.03.020_bib0009","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00784-017-2325-6","article-title":"Stage-specific therapeutic strategies of medication-related osteonecrosis of the jaws: a systematic review and meta-analysis of the drug suspension protocol","volume":"22","author":"Ramaglia","year":"2018","journal-title":"Clin Oral Investig"},{"issue":"6","key":"10.1016\/j.jormas.2022.03.020_bib0010","article-title":"Principles of oral surgery for prevention of bisphosphonate-related osteonecrosis of the jaw","volume":"117","author":"Heufelder","year":"2014","journal-title":"Oral Maxillofac Surg Vol."},{"issue":"5","key":"10.1016\/j.jormas.2022.03.020_bib0011","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joms.2009.10.010","article-title":"Osteonecrosis of the jaw in a patient on denosumab","volume":"68","author":"Aghaloo","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0012","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.oooo.2015.07.017","article-title":"Denosumab-related osteonecrosis of the jaw: a case report and management based on pharmacokinetics","volume":"120","author":"Min You","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jormas.2022.03.020_bib0013","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1016\/j.oooo.2013.02.001","article-title":"Osteonecrosis of the mandible associated with bevacizumab therapy","volume":"115","author":"Santos-Silva","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.jormas.2022.03.020_bib0014","first-page":"385","article-title":"New non-bisphosphonate drugs that produce osteonecrosis of the jaws","volume":"13","author":"Ram\u00edrez","year":"2015","journal-title":"Oral Health Prev Dent"},{"issue":"1","key":"10.1016\/j.jormas.2022.03.020_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bone.2008.08.132","article-title":"Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma","volume":"44","author":"Brunello","year":"2022","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jormas.2022.03.020_bib0016","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of their pharmacokinetic properties","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.jormas.2022.03.020_bib0017","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/bj3030303","article-title":"Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum","volume":"303","author":"Rogers","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.jormas.2022.03.020_bib0018","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrendo.2010.195","article-title":"Osteonecrosis of the jaw and bisphosphonates in cancer: A narrative review","author":"Migliorati","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"9757","key":"10.1016\/j.jormas.2022.03.020_bib0019","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/S0140-6736(10)62051-X","article-title":"First-line treatment with zoledronic acid as com-pared with clodronic acid in multiple myeloma (MRC Myeloma IX): A randomised controlled trial","volume":"376","author":"Morgan","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jormas.2022.03.020_bib0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/bjh.12861","article-title":"Osteonecrosis of the jaw and renal safe-ty in patients with newly diagnosed multiple myeloma: Medical Research Council Myeloma IX Study results","volume":"166","author":"Jackson","year":"2014","journal-title":"Br J Haematol"},{"issue":"21","key":"10.1016\/j.jormas.2022.03.020_bib0021","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1200\/JCO.2003.08.017","article-title":"American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer","volume":"21","author":"Hillner","year":"2003","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.jormas.2022.03.020_bib0022","volume":"22","author":"Khosla","year":"2007","journal-title":"Bisphosphonate-Associated Osteonecro-sis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research"},{"issue":"11","key":"10.1016\/j.jormas.2022.03.020_bib0023","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","article-title":"Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs","volume":"142","author":"Hellstein","year":"2011","journal-title":"J Am Dent Assoc"},{"issue":"7","key":"10.1016\/j.jormas.2022.03.020_bib0024","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1080\/14740338.2016.1177021","article-title":"Osteone-crosis of jaw beyond antiresorptive (bone-targeted) agents: new horizons in oncology","volume":"15","author":"Fusco","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jormas.2022.03.020_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lanced Diabetes Endo"},{"key":"10.1016\/j.jormas.2022.03.020_bib0026","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jcms.2015.03.039","article-title":"Jambrovic V Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: A trigger for BRONJ development?","volume":"43","author":"Otto","year":"2015","journal-title":"J Cranio Maxill Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0027","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(06)70726-4","article-title":"Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment","volume":"7","author":"Migliorati","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jormas.2022.03.020_bib0028","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijom.2015.01.014","article-title":"Risk factors influencing BRONJ staging in patients receiving intravenous bisphosphonates: a multivariate analysis","volume":"44","author":"Nisi","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0029","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.joms.2013.02.016","article-title":"Oral health risk factors for bisphosphonate-associated jaw osteonecrosis","volume":"71","author":"Tsao","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0031","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0032","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10147-013-0561-6","article-title":"Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: A meta-analysis of seven randomized controlled trials","volume":"19","author":"Qi","year":"2014","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.jormas.2022.03.020_bib0033","article-title":"Clinical treatment outcomes for 40 patients with bisphosphonates-related osteonecrosis of the jaws","author":"Li-Wan","year":"2014","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jormas.2022.03.020_bib0034","unstructured":"United States Food and Drug Administration: Background document for meeting of advisory committee for reproductive health drugs and drug safety and risk management advisory committee; 2011"},{"key":"10.1016\/j.jormas.2022.03.020_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03795","article-title":"Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review","volume":"6","author":"Ottesen","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jormas.2022.03.020_bib0036","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00774-019-01035-7","article-title":"Drug holiday clinical relevance verification for antiresorptive agents in medication\u2011related osteonecrosis cases of the jaw","volume":"38","author":"Saki","year":"2020","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jormas.2022.03.020_bib0037","first-page":"63","article-title":"The Prevention of Medication-related Osteonecrosis of the Jaw","volume":"114","author":"Poxleitner","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jormas.2022.03.020_bib0038","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.oraloncology.2010.11.007","article-title":"Surgery-triggered and non-surgery triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Italian multicentred study","volume":"47","author":"Vescovi","year":"2011","journal-title":"Oral Oncology"},{"issue":"1","key":"10.1016\/j.jormas.2022.03.020_bib0039","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.surge.2011.09.002","article-title":"Bisphosphonate osteonecrosis of the jaw: a historical and contemporary review","volume":"10","author":"McLeod","year":"2012","journal-title":"Surgeon"},{"key":"10.1016\/j.jormas.2022.03.020_bib0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcms.2011.05.003","article-title":"Bisphosphonate-related osteonecrosis of the jaws Characteristics, risk factors, clinical features, localization and impact on oncological treatment","volume":"40","author":"Otto","year":"2012","journal-title":"J Craniomaxillofac Surg"},{"issue":"6","key":"10.1016\/j.jormas.2022.03.020_bib0041","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1563\/1548-1336(2007)33[371:UOPPIT]2.0.CO;2","article-title":"Use of platelet-rich plasma in the management of oral bisphosphonate-associated osteonecrosis of the jaw: a report of 2 cases","volume":"33","author":"Lee","year":"2007","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.jormas.2022.03.020_bib0042","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bjoms.2016.06.015","article-title":"Conservative surgical management of patients with bisphosphonate-related osteonecrosis of the jaws: a series of 120 patients","volume":"54","author":"Nisi","year":"2016","journal-title":"Brit J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0043","first-page":"e141","article-title":"Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates","volume":"9","author":"Berm\u00fadez-Bejarano","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.jormas.2022.03.020_bib0044","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.joms.2009.07.068","article-title":"Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series","volume":"68","author":"Lodi","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0045","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.joms.2010.07.026","article-title":"Initial experience on the outcome of teeth extractions in intravenous bisphosphonate-treated patients: a cautionary report","volume":"69","author":"Scoletta","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0046","doi-asserted-by":"crossref","DOI":"10.2165\/00003088-199936050-00002","article-title":"Pharmacokinetics of alendronate","author":"Porras","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jormas.2022.03.020_bib0047","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol. Vol."},{"key":"10.1016\/j.jormas.2022.03.020_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcms.2017.05.028","article-title":"What is the effect of anti-resorptive drugs (ARDs) on the development of medication-related osteonecrosis of the jaw (MRONJ) in osteoporosis patients: A systematic review","author":"Aljohani","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.jormas.2022.03.020_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115412","article-title":"Alendronate or Zoledronic acid do not impair wound healing after tooth extraction in postmenopausal women with osteoporosis","volume":"137","author":"Lesclous","year":"2020","journal-title":"Bone"}],"container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785522000866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785522000866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:14:09Z","timestamp":1762856049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468785522000866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S2468785522000866"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2022.03.020","relation":{},"ISSN":["2468-7855"],"issn-type":[{"value":"2468-7855","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence and risk factors associated to Medication-Related Osteo Necrosis of the Jaw (MRONJ) in patients with osteoporosis after tooth extractions. A 12-months observational cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology, Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2022.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}