{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:19:17Z","timestamp":1762856357064,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jormas.2022.05.010","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T09:55:39Z","timestamp":1652003739000},"page":"e682-e686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The therapeutic effect of bovine colostrum on 5-Fluorouracil-Induced oral mucositis in rats"],"prefix":"10.1016","volume":"123","author":[{"given":"Adalet","family":"\u00c7ELEB\u0130","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bahaeddin","family":"D\u00f6rtbudak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayd\u0131n","family":"Keskinr\u00fczgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayati","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jormas.2022.05.010_bib0001","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.oraloncology.2010.11.013","article-title":"A randomized controlled trial ofvisible- light therapy for the prevention of oral mucositis","volume":"47","author":"Elad","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jormas.2022.05.010_bib0002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10103-014-1624-2","article-title":"Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study","volume":"30","author":"Silva","year":"2015","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.jormas.2022.05.010_bib0003","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.ejca.2003.10.023","article-title":"Prevention of oral mucositis in pediatric patients treated with chemotherapy: a randomized cross- over trial comparing two protocols of oral care","volume":"40","author":"Cheng","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jormas.2022.05.010_bib0004","first-page":"3165","article-title":"Mucositis study group of the multinational association of supportive care in cancer\/Interna- tional Society of Oral Oncology (MASCC\/ISOO). Systematic review of basic oral care for the management of oral mucositis in cancer patients","volume":"21","author":"McGuire","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jormas.2022.05.010_bib0005","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/S0959-8049(01)00098-3","article-title":"Evalu- ation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients","volume":"37","author":"Cheng","year":"2001","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.jormas.2022.05.010_bib0006","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/idh.12226","volume":"14","author":"Bardellini","year":"2016","journal-title":"Int J Dental Hyg"},{"issue":"2","key":"10.1016\/j.jormas.2022.05.010_bib0007","first-page":"181","article-title":"Trophic factors in the treatment and prevention of alimentary tract mucositis","volume":"12","author":"Rathe","year":"2018","journal-title":"Curr Opin Supp Palliat Care"},{"issue":"2","key":"10.1016\/j.jormas.2022.05.010_bib0008","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clnu.2013.05.013","article-title":"Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs","volume":"33","author":"Stoy","year":"2014","journal-title":"Clin Nutr"},{"issue":"4","key":"10.1016\/j.jormas.2022.05.010_bib0009","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/nure.12089","article-title":"Clinical applica- tions of bovine colostrum therapy: a systematic review","volume":"72","author":"Rathe","year":"2014","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jormas.2022.05.010_bib0010","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.biocel.2013.04.028","article-title":"Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns","volume":"45","author":"Chatterton","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jormas.2022.05.010_bib0011","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1017\/S0022029906002093","article-title":"Biological activity of bovine milk on proliferation of human intestinal cells","volume":"74","author":"Purup","year":"2007","journal-title":"J Dairy Res"},{"key":"10.1016\/j.jormas.2022.05.010_bib0012","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3168\/jds.2012-5928","article-title":"Biological components in a standardized derivative of bovine colostrum","volume":"96","author":"Sacerdote","year":"2013","journal-title":"J Dairy Sci"},{"issue":"13","key":"10.1016\/j.jormas.2022.05.010_bib0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2527\/jas.2008-1377","article-title":"Immune components of bovine colos- trum and milk","volume":"87","author":"Stelwagen","year":"2009","journal-title":"J Anim Sci"},{"issue":"4","key":"10.1016\/j.jormas.2022.05.010_bib0014","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s12272-013-0255-7","article-title":"Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide","volume":"37","author":"Xu","year":"2014","journal-title":"Arch Pharm Res"},{"issue":"9","key":"10.1016\/j.jormas.2022.05.010_bib0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ejcn.2012.93","article-title":"Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome","volume":"66","author":"Lund","year":"2012","journal-title":"Eur J Clin Nutr"},{"issue":"8","key":"10.1016\/j.jormas.2022.05.010_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202929","article-title":"Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice","volume":"13","author":"Filipescu","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jormas.2022.05.010_bib0017","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.pdpdt.2014.12.007","article-title":"Clinical, bio- chemical and histological study of the effect of antimicrobial pho- todynamic therapy on oral mucositis induced by 5-fluorouracil in hamsters","volume":"12","author":"Cruz Ede","year":"2015","journal-title":"Photodiagn Photodyn Ther"},{"key":"10.1016\/j.jormas.2022.05.010_bib0018","doi-asserted-by":"crossref","unstructured":"Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers in medical science 2017:32(3), 673-677.","DOI":"10.1007\/s10103-017-2166-1"},{"key":"10.1016\/j.jormas.2022.05.010_bib0019","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.oraloncology.2009.08.006","article-title":"Mucositis: the impact, biology and therapeutic opportunities of oral mucositis","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jormas.2022.05.010_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2012.00074","article-title":"Are epigenetic mechanisms involved in radiation-induced bystander effects?","volume":"3","author":"Mothersill","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.jormas.2022.05.010_bib0021","first-page":"367","article-title":"Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation","volume":"20","author":"Kashiwazaki","year":"2012","journal-title":"Support. Care Cancer"},{"issue":"1","key":"10.1016\/j.jormas.2022.05.010_bib0022","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/jir.2008.0015","article-title":"Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin","volume":"29","author":"Shing","year":"2009","journal-title":"J Interf Cytokine Res"},{"key":"10.1016\/j.jormas.2022.05.010_bib0023","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2741\/s467","article-title":"Potential benefits of colostrum in gastrointestinal diseases","volume":"8","author":"Menchetti","year":"2016","journal-title":"Front Biosci (Schol Ed). [Internet]"},{"issue":"3","key":"10.1016\/j.jormas.2022.05.010_bib0024","doi-asserted-by":"crossref","first-page":"411","DOI":"10.18388\/abp.2009_2474","article-title":"Szlagatys-Sidorkiewicz A. TGF-\u03b21, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers","volume":"56","author":"Marek","year":"2009","journal-title":"Acta Biochim Pol"},{"issue":"3","key":"10.1016\/j.jormas.2022.05.010_bib0025","first-page":"1","article-title":"Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease","volume":"10","author":"Jones-Hall","year":"2015","journal-title":"PLoS One [Internet]"},{"issue":"4","key":"10.1016\/j.jormas.2022.05.010_bib0026","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1368-8375(00)00012-9","article-title":"Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucosi- tis in hamsters","volume":"36","author":"Sonis","year":"2000","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.jormas.2022.05.010_bib0027","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00280-006-0301-y","article-title":"Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral muco- sitis in hamster","volume":"59","author":"Leitao","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"issue":"12","key":"10.1016\/j.jormas.2022.05.010_bib0028","doi-asserted-by":"crossref","first-page":"e82834","DOI":"10.1371\/journal.pone.0082834","article-title":"Alteration of the redox state with reactive oxygen species for 5-fluorouracil-induced oral mucositis in ham- sters","volume":"8","author":"Yoshino","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jormas.2022.05.010_bib0029","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s10103-019-02757-w","article-title":"Comparison of the efficacy of low-level laser therapy and photodynamic therapy on oral mucositis in rats","volume":"34","author":"Alinca","year":"2019","journal-title":"Lasers Med Sci"},{"issue":"2","key":"10.1016\/j.jormas.2022.05.010_bib0030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jpen.1528","article-title":"Bovine colostrum against chemotherapy-induced gastrointestinal toxicity in children with acute lymphoblastic leukemia: a randomized, double-blind, placebo-controlled trial","volume":"44","author":"Rathe","year":"2020","journal-title":"J Parenteral Enteral Nutr"},{"issue":"4","key":"10.1016\/j.jormas.2022.05.010_bib0031","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/emm.2006.49","article-title":"Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression","volume":"38","author":"Kim","year":"2006","journal-title":"Exp Mol Med"},{"issue":"10","key":"10.1016\/j.jormas.2022.05.010_bib0032","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/molecules21101378","article-title":"The inhibition effect of cell DNA oxidative damage and LDL oxidation by bovine colostrums","volume":"21","author":"Chen","year":"2016","journal-title":"Molecules"}],"container-title":["Journal of Stomatology, Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785522001409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785522001409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:15:26Z","timestamp":1762856126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468785522001409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S2468785522001409"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2022.05.010","relation":{},"ISSN":["2468-7855"],"issn-type":[{"type":"print","value":"2468-7855"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic effect of bovine colostrum on 5-Fluorouracil-Induced oral mucositis in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology, Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2022.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}