{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:22:41Z","timestamp":1772972561636,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jormas.2025.102540","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:43:18Z","timestamp":1757000598000},"page":"102540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is the use of intraoperative vasopressors associated with flap failure in head and neck free tissue transfer surgery?"],"prefix":"10.1016","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-788X","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-0708","authenticated-orcid":false,"given":"Xudong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jormas.2025.102540_bib0001","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/01.prs.0000260598.24376.e1","article-title":"Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps","volume":"119","author":"Bui","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.jormas.2025.102540_bib0002","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/lary.20825","article-title":"What makes a good flap go bad? A critical analysis of the literature of intraoperative factors related to free flap failure","volume":"120","author":"Pattani","year":"2010","journal-title":"Laryngoscope"},{"issue":"10","key":"10.1016\/j.jormas.2025.102540_bib0003","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/hed.23471","article-title":"Free flap failure in head and neck reconstruction","volume":"36","author":"Corbitt","year":"2014","journal-title":"Head Neck."},{"issue":"8","key":"10.1016\/j.jormas.2025.102540_bib0004","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijom.2017.03.023","article-title":"Risk factors for free flap failure: a retrospective analysis of 881 free flaps for head and neck defect reconstruction","volume":"46","author":"Zhou","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"4","key":"10.1016\/j.jormas.2025.102540_bib0005","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1177\/0194599819860809","article-title":"Factors Associated with Free Flap Failures in Head and Neck Reconstruction","volume":"161","author":"Crawley","year":"2019","journal-title":"Off. J. Am. Acad. Otolaryngol.-Head Neck Surg."},{"issue":"11","key":"10.1016\/j.jormas.2025.102540_bib0006","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/hed.25190","article-title":"Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck","volume":"40","author":"Kass","year":"2018","journal-title":"Head Neck."},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-0035-1546422","article-title":"Perioperative management for microsurgical free tissue transfer: survey of current practices with a comparison to the literature","volume":"31","author":"Motakef","year":"2015","journal-title":"J. Reconstr. Microsurg."},{"issue":"6","key":"10.1016\/j.jormas.2025.102540_bib0008","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.1097\/SAP.0000000000000096","article-title":"Intraoperative management of free flaps: current practice","volume":"72","author":"Vyas","year":"2014","journal-title":"Ann. Plast. Surg."},{"issue":"10","key":"10.1016\/j.jormas.2025.102540_bib0009","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/aas.12180","article-title":"Perioperative anaesthetic practice for head and neck free tissue transfer \u2013 a UK national survey","volume":"57","author":"Gooneratne","year":"2013","journal-title":"Acta Anaesthesiol. Scand."},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0010","doi-asserted-by":"crossref","DOI":"10.1002\/micr.70095","article-title":"Impact of vasopressors on microvascular free flap perfusion in head and neck reconstruction","volume":"45","author":"Ooms","year":"2025","journal-title":"Microsurgery."},{"issue":"2","key":"10.1016\/j.jormas.2025.102540_bib0011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.otohns.2009.11.001","article-title":"Vasopressor use in free tissue transfer surgery","volume":"142","author":"MM","year":"2010","journal-title":"Off. J. Am. Acad. Otolaryngol.-Head Neck Surg."},{"issue":"1","key":"10.1016\/j.jormas.2025.102540_bib0012","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/micr.20961","article-title":"Impact of vasopressors on outcomes in head and neck free tissue transfer","volume":"32","author":"L","year":"2012","journal-title":"Microsurgery"},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0013","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/micr.22097","article-title":"Safety of intra-operative vasopressor in free jejunal flap reconstruction","volume":"33","author":"JY","year":"2013","journal-title":"Microsurgery"},{"issue":"2","key":"10.1016\/j.jormas.2025.102540_bib0014","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/SLA.0000000000002295","article-title":"Intraoperative use of vasopressors does not increase the risk of free flap compromise and failure in cancer patients","volume":"268","author":"Fang","year":"2018","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.jormas.2025.102540_bib0015","first-page":"87","article-title":"Intraoperative use of vasopressors is safe in head and neck free tissue transfer","volume":"32","author":"EW","year":"2016","journal-title":"J. Reconstr. Microsurg."},{"issue":"3","key":"10.1016\/j.jormas.2025.102540_bib0016","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/hed.27289","article-title":"Outcomes of perioperative vasopressor use for hemodynamic management of patients undergoing free flap surgery: a systematic review and meta-analysis","volume":"45","author":"Michelle","year":"2023","journal-title":"Head Neck."},{"issue":"6","key":"10.1016\/j.jormas.2025.102540_bib0017","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/0194599811401313","article-title":"Safety of vasopressor use in head and neck microvascular reconstruction: a prospective observational study","volume":"144","author":"MM","year":"2011","journal-title":"Off. J. Am. Acad. Otolaryngol.-Head Neck Surg."},{"issue":"1","key":"10.1016\/j.jormas.2025.102540_bib0018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/micr.22223","article-title":"Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database","volume":"35","author":"Wong","year":"2015","journal-title":"Microsurgery"},{"key":"10.1016\/j.jormas.2025.102540_bib0019","doi-asserted-by":"crossref","unstructured":"Thiele R., Nemergut E., Lynch C.J.A., analgesia: the physiologic implications of isolated alpha(1) adrenergic stimulation. 2011, 113(2):284\u201396.","DOI":"10.1213\/ANE.0b013e3182124c0e"},{"key":"10.1016\/j.jormas.2025.102540_bib0020","doi-asserted-by":"crossref","unstructured":"Loeb H., Saudye A., Croke R., Talano J., Klodnycky M., Gunnar R.J.C.: Effects of pharmacologically-induced hypertension on myocardial ischemia and coronary hemodynamics in patients with fixed coronary obstruction. 1978, 57(1):41\u201346.","DOI":"10.1161\/01.CIR.57.1.41"},{"key":"10.1016\/j.jormas.2025.102540_bib0021","doi-asserted-by":"crossref","unstructured":"Zandberg P., Timmermans P., van Zwieten PJJocp: Hemodynamic profiles of methoxamine and B-HT 933 in spinalized ganglion-blocked dogs. 1984, 6(2):256\u201362.","DOI":"10.1097\/00005344-198403000-00008"},{"key":"10.1016\/j.jormas.2025.102540_bib0022","doi-asserted-by":"crossref","unstructured":"Sun D., Wu Y., Yang L., Han J., Liu R., Wang LJMsmimjoe, research c: effects of continuous intravenous infusion of methoxamine on the intraoperative hemodynamics of elderly patients undergoing total hip arthroplasty. 2014, 20:1969\u201376.","DOI":"10.12659\/MSM.890760"},{"key":"10.1016\/j.jormas.2025.102540_bib0023","doi-asserted-by":"crossref","unstructured":"Guo X., Hu J., Xiao H., Liu T., Niu Z., Wang M., Qi DJBa: Effect of continuous intraoperative infusion of methoxamine on renal function in elderly patients undergoing gastrointestinal tumor surgery: a randomized controlled trial. 2020, 20(1):148.","DOI":"10.1186\/s12871-020-01064-0"},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0024","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/1098-2752(2000)20:5<217::AID-MICR1>3.0.CO;2-Z","article-title":"Catecholamine sensitivity in the rat femoral artery after microvascular anastomosis","volume":"20","author":"Godden","year":"2000","journal-title":"Microsurgery."},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0025","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/00000637-199711000-00013","article-title":"Effects of vasoactive medications on the blood flow of island musculocutaneous flaps in swine","volume":"39","author":"Cordeiro","year":"1997","journal-title":"Ann. Plast. Surg."},{"issue":"5","key":"10.1016\/j.jormas.2025.102540_bib0026","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/01.prs.0000279371.63439.8d","article-title":"The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps","volume":"120","author":"Massey","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"issue":"6","key":"10.1016\/j.jormas.2025.102540_bib0027","doi-asserted-by":"crossref","DOI":"10.1097\/00003643-199811000-00048","article-title":"Effects of sodium nitroprusside and phenylephrine on blood flow in free musculocutaneous flaps during general anaesthesia","volume":"15","author":"Sigurdsson","year":"1998","journal-title":"Eur. J. Anaesthesiol."}],"container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246878552500326X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246878552500326X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:31:38Z","timestamp":1772937098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246878552500326X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S246878552500326X"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2025.102540","relation":{},"ISSN":["2468-7855"],"issn-type":[{"value":"2468-7855","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is the use of intraoperative vasopressors associated with flap failure in head and neck free tissue transfer surgery?","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2025.102540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"102540"}}