{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:17:55Z","timestamp":1789823875252,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jormas.2025.102708","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:14:20Z","timestamp":1767370460000},"page":"102708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrative prognostic modeling and mediation analysis of recurrence risk in extremely early-stage oral squamous cell carcinoma"],"prefix":"10.1016","volume":"127","author":[{"given":"Yi-quan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9525-4435","authenticated-orcid":false,"given":"Hai-jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jormas.2025.102708_bib0001","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.critrevonc.2019.08.003","article-title":"Postoperative radiotherapy (PORT) for early oral cavity cancer (pT1-2,N0-1): A review","volume":"143","author":"Ivaldi","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"issue":"10318","key":"10.1016\/j.jormas.2025.102708_bib0002","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/S0140-6736(21)01550-6","article-title":"Head and neck cancer","volume":"398","author":"Mody","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jormas.2025.102708_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.103883","article-title":"Global and Regional Burden of Periodontal Disease in Adults (1990-2021)","volume":"75","author":"Wang","year":"2025","journal-title":"Int Dent J"},{"issue":"23","key":"10.1016\/j.jormas.2025.102708_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11237061","article-title":"Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma","volume":"11","author":"Blatt","year":"2022","journal-title":"J Clin Med"},{"issue":"3S","key":"10.1016\/j.jormas.2025.102708_bib0005","article-title":"The role of postoperative radiation therapy in early-stage tongue carcinoma: A systematic review and meta-analysis","volume":"126","author":"Yuan","year":"2025","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.jormas.2025.102708_bib0006","article-title":"Salvage Surgery in Recurrent Oral Squamous Cell Carcinoma","volume":"2","author":"Shetty","year":"2021","journal-title":"Front Oral Health"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0007","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40902-024-00443-8","article-title":"The epidemiological and histopathological factors for delayed local recurrence in oral squamous cell carcinoma","volume":"46","author":"Kim","year":"2024","journal-title":"Maxillofac Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0008","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nature reviews. Disease primers."},{"issue":"15","key":"10.1016\/j.jormas.2025.102708_bib0009","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1200\/JCO.23.01106","article-title":"Impact of Postoperative Radiotherapy on the Prognosis of Early-Stage (pT1-2N0M0) Oral Tongue Squamous Cell Carcinoma","volume":"42","author":"Tian","year":"2024","journal-title":"J Clin Oncol: Official J Am Society Clin Oncol"},{"issue":"10","key":"10.1016\/j.jormas.2025.102708_bib0010","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/01455613221078184","article-title":"Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study","volume":"103","author":"Liu","year":"2024","journal-title":"Ear Nose Throat J"},{"issue":"7","key":"10.1016\/j.jormas.2025.102708_bib0011","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jamaoto.2023.1201","article-title":"Margins in Stage I and II oral cavity squamous cell carcinoma: a review from the american head and neck society","volume":"149","author":"Puram","year":"2023","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jormas.2025.102708_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104799","article-title":"Staging and grading of oral squamous cell carcinoma: An update","volume":"107","author":"Almangush","year":"2020","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0013","article-title":"Postoperative radiotherapy to the neck for pN1 status HNSCC patients after neck dissection","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jormas.2025.102708_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2025.107247","article-title":"Histopathological invasion patterns and prognosis in Oral Squamous Cell Carcinoma: A retrospective analysis of 560 cases","volume":"163","author":"Alfertshofer","year":"2025","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14377-x","article-title":"Genomic predictive model for recurrence and metastasis development in head and neck squamous cell carcinoma patients","volume":"7","author":"Ribeiro","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jormas.2025.102708_bib0016","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.oraloncology.2018.09.005","article-title":"A gene expression profile associated with perineural invasion identifies a subset of HNSCC at risk of post-surgical recurrence","volume":"86","author":"Saidak","year":"2018","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0017","first-page":"1","article-title":"Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche","volume":"9","author":"Chen","year":"2019","journal-title":"Am J Cancer Res"},{"issue":"713","key":"10.1016\/j.jormas.2025.102708_bib0018","first-page":"40","article-title":"Oral squamous cell carcinomas: state of the field and emerging directions","volume":"377","year":"2020","journal-title":"Int J Oral Sci"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0019","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-77036-8","article-title":"An increase of CD8(+)\u2009T cell infiltration following recurrence is a good prognosticator in HNSCC","volume":"10","author":"So","year":"2020","journal-title":"Sci Rep"},{"issue":"18","key":"10.1016\/j.jormas.2025.102708_bib0020","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1002\/cncr.34823","article-title":"Patterns of recurrence in head and neck squamous cell carcinoma to inform personalized surveillance protocols","volume":"129","author":"Haring","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.jormas.2025.102708_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2024.1426709","article-title":"Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma","volume":"5","author":"Damazo","year":"2024","journal-title":"Front Oral Health"},{"issue":"5-6","key":"10.1016\/j.jormas.2025.102708_bib0022","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s10495-023-01832-6","article-title":"Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma","volume":"28","author":"Xu","year":"2023","journal-title":"Apoptosis: Int J Programm Cell Death"},{"issue":"6","key":"10.1016\/j.jormas.2025.102708_bib0023","first-page":"1000","article-title":"Simulation-based sensitivity analysis for causal mediation studies","volume":"27","author":"Qin","year":"2022","journal-title":"Psychol Methods"},{"issue":"4","key":"10.1016\/j.jormas.2025.102708_bib0024","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.jormas.2025.102708_bib0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/10543406.2023.2198593","article-title":"Quantile regression shrinkage and selection via the Lqsso","volume":"34","author":"Daneshvar","year":"2024","journal-title":"J Biopharm Stat"},{"key":"10.1016\/j.jormas.2025.102708_bib0026","unstructured":"National Comprehensive Cancer Network - Home. Vol 2025:Explore the National Comprehensive Cancer Network\u2014leading cancer care guidelines, resources, research, and global initiatives."},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0027","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12672-023-00765-5","article-title":"Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance","volume":"14","author":"Liu","year":"2023","journal-title":"Discover oncology"},{"issue":"21","key":"10.1016\/j.jormas.2025.102708_bib0028","article-title":"Perineural invasion is a significant prognostic factor in oral squamous cell carcinoma: a systematic review and meta-analysis","volume":"13","author":"Binmadi","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"10.1016\/j.jormas.2025.102708_bib0029","article-title":"Prognostic value of perineural invasion on survival and recurrence in oral squamous cell carcinoma","volume":"12","author":"Spoerl","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0030","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s12672-025-02811-w","article-title":"Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer","volume":"16","author":"Chen","year":"2025","journal-title":"Discover oncology"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0031","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1007\/s12672-025-03068-z","article-title":"Single\u2011cell RNA sequencing reveals TMEM71 as an immunomodulatory biomarker predicting immune checkpoint blockade response in breast cancer","volume":"16","author":"Li","year":"2025","journal-title":"Discover oncology"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0032","article-title":"Combined preoperative platelet-albumin ratio and cancer inflammation prognostic index predicts prognosis in colorectal cancer: a retrospective study","volume":"15","author":"Wang","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0033","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1186\/s12885-024-12539-5","article-title":"Prognostic role of tumor-infiltrating lymphocytes in oral squamous cell carcinoma","volume":"24","author":"Wongpattaraworakul","year":"2024","journal-title":"BMC Cancer"},{"issue":"46","key":"10.1016\/j.jormas.2025.102708_bib0034","article-title":"Protecting against postsurgery oral cancer recurrence with an implantable hydrogel vaccine for in situ photoimmunotherapy","volume":"11","author":"Chen","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jormas.2025.102708_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1168376","article-title":"Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern","volume":"13","author":"Kugimoto","year":"2023","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.jormas.2025.102708_bib0036","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/his.12754","article-title":"Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma","volume":"68","author":"Heerema","year":"2016","journal-title":"Histopathology"},{"issue":"Pt 1","key":"10.1016\/j.jormas.2025.102708_bib0037","article-title":"Lactate-related genes signature as a novel prognostic landscape in laryngeal squamous cell carcinoma: insights from 156 machine learning algorithms and in vitro validation","volume":"323","author":"Liu","year":"2025","journal-title":"Int J Biol Macromol"},{"issue":"21","key":"10.1016\/j.jormas.2025.102708_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.71317","article-title":"Metabolic reprogramming in lung cancer: hallmarks, mechanisms, and targeted strategies to overcome immune resistance","volume":"14","author":"Chen","year":"2025","journal-title":"Cancer Med"},{"issue":"1","key":"10.1016\/j.jormas.2025.102708_bib0039","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s12967-024-05237-0","volume":"22","author":"Zhang","year":"2024","journal-title":"J Transl Med"}],"container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785525004938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785525004938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:09:49Z","timestamp":1784531389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468785525004938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2468785525004938"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2025.102708","relation":{},"ISSN":["2468-7855"],"issn-type":[{"value":"2468-7855","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative prognostic modeling and mediation analysis of recurrence risk in extremely early-stage oral squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2025.102708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"102708"}}