{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:57:52Z","timestamp":1791205072590,"version":"4.1.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jormas.2026.102904","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:58:20Z","timestamp":1784678300000},"page":"102904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The HGF\/c-Met signaling axis: A master regulator of invasion and metastasis in oral squamous cell carcinoma"],"prefix":"10.1016","volume":"127","author":[{"given":"Wael Sheet","family":"Hussein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Fawzi","family":"Al-Hussainy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael Waleed","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Renuka Jyothi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya Priyadarshini","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bethanney Janney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjant","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashna","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Akhrorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder Naji","family":"Sameer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasim M.","family":"Salih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohaned","family":"Adil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.jormas.2026.102904_bib0001","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.4103\/jpbs.jpbs_593_25","article-title":"A narrative review on oral squamous cell carcinoma","volume":"17","author":"Muralidharan","year":"2025","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.jormas.2026.102904_bib0002","first-page":"373","article-title":"Epithelial-mesenchymal interactions in oral cancer metastasis","author":"Papagerakis","year":"2012","journal-title":"Oral Cancer, KU Ogbureke Tech"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0003","article-title":"Lymph node metastasis in oral squamous cell carcinoma: where we are and where we are going","volume":"3","author":"Cao","year":"2023","journal-title":"Clin Transl Discov"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12943-022-01503-1","article-title":"Molecular mechanism (s) of regulation (s) of c-MET\/HGF signaling in head and neck cancer","volume":"21","author":"Raj","year":"2022","journal-title":"Mol Cancer"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12964-025-02033-1","article-title":"Targeting HGF\/c-MET signaling to regulate the tumor microenvironment: implications for counteracting tumor immune evasion","volume":"23","author":"Xia","year":"2025","journal-title":"Cell Commun Signal"},{"issue":"9","key":"10.1016\/j.jormas.2026.102904_bib0006","article-title":"Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma","volume":"3","author":"Hagege","year":"2022","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0007","first-page":"209","article-title":"Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target","volume":"39","author":"Sun","year":"2018","journal-title":"Oncol Rep"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0008","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28672-8","article-title":"Prognostic role of c-met in head and neck squamous cell cancer tissues: a meta-analysis","volume":"8","author":"Vsiansky","year":"2018","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0009","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3390\/ijms25021300","article-title":"Cancer-associated fibroblast heterogeneity in malignancy with focus on oral squamous cell carcinoma","volume":"25","author":"Arebro","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/cancers9040039","article-title":"Hepatocyte growth factor\/c-met signaling in head and neck cancer and implications for treatment","volume":"9","author":"Rothenberger","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jormas.2026.102904_bib0011","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jtbi.2017.11.025","article-title":"Activation of the HGF\/c-met axis in the tumor microenvironment: a multispecies model","volume":"439","author":"Konstorum","year":"2018","journal-title":"J Theor Biol"},{"issue":"14","key":"10.1016\/j.jormas.2026.102904_bib0012","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1158\/0008-5472.CAN-17-1076","article-title":"Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression","volume":"78","author":"Kumar","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.jormas.2026.102904_bib0013","first-page":"31","article-title":"HGF\/c-met signalling in the tumor microenvironment","author":"Zambelli","year":"2020","journal-title":"Tumor Microenviron: Signal Pathw\u2013B"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0014","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.3892\/or.2020.7799","article-title":"Roles of the HGF\/met signaling in head and neck squamous cell carcinoma: focus on tumor immunity","volume":"44","author":"Liu","year":"2020","journal-title":"Oncol Rep"},{"issue":"1_suppl","key":"10.1016\/j.jormas.2026.102904_bib0015","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/1758834011422557","article-title":"c-MET as a potential therapeutic target and biomarker in cancer","volume":"3","author":"Sierra","year":"2011","journal-title":"Ther Adv Med Oncol"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0016","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/1933719116648212","article-title":"Regulation of HGF and c-MET interaction in normal ovary and ovarian cancer: importance of targeting c-MET and HGF interaction","volume":"24","author":"Kwon","year":"2017","journal-title":"Reprod Sci"},{"key":"10.1016\/j.jormas.2026.102904_bib0017","article-title":"HGF\/c-met: a key promoter in liver regeneration","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0018","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.200701086","article-title":"c-met is essential for wound healing in the skin","volume":"177","author":"Chmielowiec","year":"2007","journal-title":"J Cell Biol"},{"issue":"13","key":"10.1016\/j.jormas.2026.102904_bib0019","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1073\/pnas.0306068101","article-title":"Hepatocyte growth factor\/c-met signaling pathway is required for efficient liver regeneration and repair","volume":"101","author":"Huh","year":"2004","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0020","first-page":"495","article-title":"Biological roles of hepatocyte growth factor\u2011met signaling from genetically modified animals","volume":"7","author":"Kato","year":"2017","journal-title":"Biomed Rep"},{"key":"10.1016\/j.jormas.2026.102904_bib0021","series-title":"Ciba Foundation Symposium 212-Plasminogen-Related Growth Factors: Plasminogen-Related Growth Factors: Ciba Foundation Symposium 212","article-title":"Role of HGF\/SF and c-met in morphogenesis and metastasis of epithelial cells","author":"Birchmeier","year":"2007"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0022","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ijc.21808","article-title":"Hepatocyte growth factor and the Met system as a mediator of tumor\u2013stromal interactions","volume":"119","author":"Matsumoto","year":"2006","journal-title":"Int J Cancer"},{"issue":"14","key":"10.1016\/j.jormas.2026.102904_bib0023","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2174\/138945011798829348","article-title":"HGF\/c-MET targeted therapeutics: novel strategies for cancer medicine","volume":"12","author":"A Yap","year":"2011","journal-title":"Curr Drug Targets"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0024","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1038\/s41467-021-24367-3","article-title":"Structural basis of the activation of c-MET receptor","volume":"12","author":"Uchikawa","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0025","first-page":"49","article-title":"Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)","volume":"9","author":"Longati","year":"1994","journal-title":"Oncogene"},{"issue":"13","key":"10.1016\/j.jormas.2026.102904_bib0026","doi-asserted-by":"crossref","first-page":"11218","DOI":"10.1074\/jbc.M110.204404","article-title":"Structural basis for selective small molecule kinase inhibition of activated c-met","volume":"286","author":"Rickert","year":"2011","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.jormas.2026.102904_bib0027","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1128\/MCB.25.10.3982-3996.2005","article-title":"Negative feedback regulation of met-dependent invasive growth by Notch","volume":"25","author":"Stella","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"10","key":"10.1016\/j.jormas.2026.102904_bib0028","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.bbapap.2012.10.012","article-title":"Structural basis of MET receptor dimerization by the bacterial invasion protein InlB and the HGF\/SF splice variant NK1","volume":"1834","author":"Niemann","year":"2013","journal-title":"Biochim Biophys Acta (BBA)-Proteins Proteom"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015932","article-title":"Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay","volume":"6","author":"Dua","year":"2011","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0030","first-page":"69","article-title":"Prognostic value of c-met expression in oral squamous cell carcinoma","volume":"1","author":"Freudlsperger","year":"2010","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jormas.2026.102904_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.756479","article-title":"Hepatocyte growth factor overexpression slows the progression of 4NQO-induced oral tumorigenesis","volume":"11","author":"He","year":"2021","journal-title":"Front Oncol"},{"issue":"19","key":"10.1016\/j.jormas.2026.102904_bib0032","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.3390\/cancers14194625","article-title":"MAPK signaling pathway in oral squamous cell carcinoma: biological function and targeted therapy","volume":"14","author":"Cheng","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jormas.2026.102904_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-14-240","article-title":"Met receptor-induced Grb2 or shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions","volume":"14","author":"Pomerleau","year":"2014","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0034","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1593\/neo.08164","article-title":"Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC)","volume":"10","author":"Sticht","year":"2008","journal-title":"Neoplasia"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/dna.2017.4095","article-title":"miR-654-5p targets GRAP to promote proliferation, metastasis, and chemoresistance of oral squamous cell carcinoma through Ras\/MAPK signaling","volume":"37","author":"Lu","year":"2018","journal-title":"DNA Cell Biol"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0036","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/sj.onc.1202607","article-title":"Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis","volume":"18","author":"Bardelli","year":"1999","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.jormas.2026.102904_bib0037","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1600-0714.2012.01139.x","article-title":"Migration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: role of MEK\/ERK, p38 and PI-3 kinase\/akt","volume":"41","author":"Brusevold","year":"2012","journal-title":"J Oral Pathol Med"},{"issue":"16","key":"10.1016\/j.jormas.2026.102904_bib0038","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1158\/1078-0432.CCR-16-0951","article-title":"HGF\/met signaling in head and neck cancer: impact on the tumor microenvironment","volume":"22","author":"Hartmann","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0039","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3727\/096504017X15043589260618","article-title":"Knockdown of Gab1 inhibits cellular proliferation, migration, and invasion in human oral squamous carcinoma cells","volume":"26","author":"Xu","year":"2018","journal-title":"Oncol Res"},{"key":"10.1016\/j.jormas.2026.102904_bib0040","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fmolb.2018.00086","article-title":"The role of PI3K in Met driven cancer: a recap","volume":"5","author":"Hervieu","year":"2018","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jormas.2026.102904_bib0041","doi-asserted-by":"crossref","DOI":"10.32604\/or.2025.064010","article-title":"Dysregulated PI3K\/AKT signaling in oral squamous cell carcinoma: the tumor microenvironment and epigenetic modifiers as key drivers","author":"Veerasamy","year":"2025","journal-title":"Oncol Res"},{"issue":"12","key":"10.1016\/j.jormas.2026.102904_bib0042","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/cancers9120169","article-title":"Activated HGF-c-met axis in head and neck cancer","volume":"9","author":"Arnold","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jormas.2026.102904_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-11-180","article-title":"HGF\/c-met\/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop","volume":"11","author":"Syed","year":"2011","journal-title":"Bmc Cancer"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0044","first-page":"1149","article-title":"Role of the EZH2\/miR-200 axis in STAT3-mediated OSCC invasion corrigendum in\/10.3892\/ijo. 2023.5528","volume":"52","author":"Wang","year":"2018","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jormas.2026.102904_bib0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.canlet.2018.08.009","article-title":"TGF-\u03b2-induced STAT3 overexpression promotes human head and neck squamous cell carcinoma invasion and metastasis through malat1\/miR-30a interactions","volume":"436","author":"Wang","year":"2018","journal-title":"Cancer Lett"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0046","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/cancers17020267","article-title":"Targeting fibroblast-derived interleukin 6: a strategy to overcome epithelial-mesenchymal transition and radioresistance in head and neck cancer","volume":"17","author":"Li","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jormas.2026.102904_bib0047","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fcell.2020.00023","article-title":"Crosstalk mechanisms between HGF\/c-met axis and ncRNAs in malignancy","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jormas.2026.102904_bib0048","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jbior.2017.11.003","article-title":"PLC\u03b31: potential arbitrator of cancer progression","volume":"67","author":"Jang","year":"2018","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.jormas.2026.102904_bib0049","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ebiom.2019.09.027","article-title":"TGF\u03b2 induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma","volume":"48","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0050","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.bbrc.2018.09.127","article-title":"Disproportionately high levels of HGF induce the degradation of the c-met receptor through the proteasomal degradation pathway","volume":"505","author":"Lee","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0051","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","article-title":"Oral squamous cell carcinomas: state of the field and emerging directions","volume":"15","author":"Tan","year":"2023","journal-title":"Int J Oral Sci"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0052","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.0904-2512.2004.00118.x","article-title":"Expression of hepatocyte growth factor and c-met protein is significantly associated with the progression of oral squamous cell carcinoma in Taiwan","volume":"33","author":"Chen","year":"2004","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jormas.2026.102904_bib0053","doi-asserted-by":"crossref","first-page":"229","DOI":"10.12688\/f1000research.22941.1","article-title":"Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis","volume":"9","author":"Bugshan","year":"2020","journal-title":"F1000Res"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0054","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3390\/ijms19051462","article-title":"Invasion-related factors as potential diagnostic and therapeutic targets in oral squamous cell carcinoma\u2014a review","volume":"19","author":"Siriwardena","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0055","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ijc.1368","article-title":"Role of HGF\/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance","volume":"93","author":"Uchida","year":"2001","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0056","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41368-025-00417-0","article-title":"Partial-EMT in oral squamous cell carcinoma: molecular circuitry and clinical translation","volume":"18","author":"Wang","year":"2026","journal-title":"Int J Oral Sci"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0057","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3892\/ijo.25.4.831","article-title":"Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion","volume":"25","author":"Murai","year":"2004","journal-title":"Int J Oncol"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0058","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1568009613666131126115012","article-title":"The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage","volume":"14","author":"Pannone","year":"2014","journal-title":"Curr Cancer Drug Targets"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0059","first-page":"3150","article-title":"Expression of E-cadherin and vimentin in oral squamous cell carcinoma","volume":"8","author":"Zhou","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"24","key":"10.1016\/j.jormas.2026.102904_bib0060","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1007\/s00018-016-2313-z","article-title":"Roles and epigenetic regulation of epithelial\u2013mesenchymal transition and its transcription factors in cancer initiation and progression","volume":"73","author":"Lee","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0061","first-page":"4177","article-title":"Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-met blockade","volume":"19","author":"Ohnishi","year":"2020","journal-title":"Oncol Lett"},{"issue":"9","key":"10.1016\/j.jormas.2026.102904_bib0062","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.18632\/oncotarget.3180","article-title":"Snail and slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma","volume":"6","author":"Zheng","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.jormas.2026.102904_bib0063","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/jid.2011.142","article-title":"Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial\u2013mesenchymal transition-like phenotype in melanoma","volume":"131","author":"Wels","year":"2011","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.jormas.2026.102904_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104904","article-title":"Biological role of epithelial\u2013mesenchymal-transition-inducing transcription factors in head and neck squamous cell carcinoma: a systematic review","volume":"119","author":"de Morais","year":"2020","journal-title":"Arch Oral Biol"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0065","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/carcin\/21.6.1079","article-title":"Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes","volume":"21","author":"Hanzawa","year":"2000","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0066","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1067\/moe.2003.121","article-title":"Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations","volume":"95","author":"Tsai","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0067","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/cancers9050044","article-title":"HGF\/met signaling in cancer invasion: the impact on cytoskeleton remodeling","volume":"9","author":"Xiang","year":"2017","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0068","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.3892\/or.2017.5587","article-title":"Migration of oral squamous cell carcinoma cells are induced by HGF\/c-met signalling via lamellipodia and filopodia formation","volume":"37","author":"Yasui","year":"2017","journal-title":"Oncol Rep"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0069","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3892\/ijo.2013.1761","article-title":"Functional analysis of zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells corrigendum in\/10.3892\/ijo. 2016.3702","volume":"42","author":"Yamamura","year":"2013","journal-title":"Int J Oncol"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0070","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1158\/1078-0432.CCR-08-3252","article-title":"HGF and c-met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer","volume":"15","author":"Knowles","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0071","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12943-019-0983-5","article-title":"Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review","volume":"18","author":"Peltanova","year":"2019","journal-title":"Mol Cancer"},{"issue":"10","key":"10.1016\/j.jormas.2026.102904_bib0072","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1111\/cas.15081","article-title":"Improving function of cytotoxic T-lymphocytes by transforming growth factor-\u03b2 inhibitor in oral squamous cell carcinoma","volume":"112","author":"Kondo","year":"2021","journal-title":"Cancer Sci"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0073","article-title":"The effect of cancer-associated fibroblasts on oral squamous cell carcinoma","volume":"2","author":"Rafiq","year":"2025","journal-title":"J Med Health Sci Rev"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0074","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.bjc.6601611","article-title":"Tumour-derived TGF-\u03b21 modulates myofibroblast differentiation and promotes HGF\/SF-dependent invasion of squamous carcinoma cells","volume":"90","author":"Lewis","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jormas.2026.102904_bib0075","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s13402-016-0281-9","article-title":"The role of lymphangiogenesis and angiogenesis in tumor metastasis","volume":"39","author":"Paduch","year":"2016","journal-title":"Cell Oncol"},{"issue":"10","key":"10.1016\/j.jormas.2026.102904_bib0076","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.humpath.2010.03.012","article-title":"Intratumoral c-met expression is associated with vascular endothelial growth factor C expression, lymphangiogenesis, and lymph node metastasis in oral squamous cell carcinoma: implications for use as a prognostic marker","volume":"42","author":"Zhao","year":"2011","journal-title":"Hum Pathol"},{"issue":"17","key":"10.1016\/j.jormas.2026.102904_bib0077","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1158\/1078-0432.CCR-04-2553","article-title":"Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas","volume":"11","author":"Ren","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0078","first-page":"331","article-title":"Carcinoma associated fibroblasts derived from oral squamous cell carcinoma promote lymphangiogenesis via c-met\/PI3K\/AKT in vitro","volume":"15","author":"Gao","year":"2018","journal-title":"Oncol Lett"},{"issue":"7","key":"10.1016\/j.jormas.2026.102904_bib0079","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.prp.2017.01.023","article-title":"Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma","volume":"213","author":"Wang","year":"2017","journal-title":"Pathol-Res Pract"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0080","first-page":"374","article-title":"Lingual lymph node metastases as a prognostic factor in oral squamous cell carcinoma\u2014a retrospective multicenter study","volume":"57","author":"Kikuchi","year":"2021","journal-title":"Med (B Aires)"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0081","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.oooo.2014.10.004","article-title":"Impact of perineural invasion as independent prognostic factor for local and regional failure in oral squamous cell carcinoma","volume":"119","author":"Tarsitano","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0082","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jcms.2017.02.022","article-title":"The role of perineural invasion in treatment decisions for oral cancer patients: a review of the literature","volume":"45","author":"Chatzistefanou","year":"2017","journal-title":"J Cranio-Maxillofac Surg"},{"issue":"23","key":"10.1016\/j.jormas.2026.102904_bib0083","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.3390\/cancers13236011","article-title":"Molecular and cellular mechanisms of perineural invasion in oral squamous cell carcinoma: potential targets for therapeutic intervention","volume":"13","author":"Misztal","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jormas.2026.102904_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113691","article-title":"Perineural invasion-associated biomarkers for tumor development","volume":"155","author":"Liu","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41419-022-04799-5","article-title":"HGF\/c-met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR\/NGF axis","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis"},{"issue":"9\u201310","key":"10.1016\/j.jormas.2026.102904_bib0086","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1177\/0963689719851772","article-title":"Pancreatic stellate cells facilitate perineural invasion of pancreatic cancer via HGF\/c-Met pathway","volume":"28","author":"Nan","year":"2019","journal-title":"Cell Transpl"},{"issue":"15","key":"10.1016\/j.jormas.2026.102904_bib0087","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.7150\/jca.16686","article-title":"Alteration status and prognostic value of MET in head and neck squamous cell carcinoma","volume":"7","author":"Cho","year":"2016","journal-title":"J Cancer"},{"issue":"68","key":"10.1016\/j.jormas.2026.102904_bib0088","doi-asserted-by":"crossref","first-page":"113120","DOI":"10.18632\/oncotarget.21303","article-title":"Clinicopathological impacts of high c-met expression in head and neck squamous cell carcinoma: a meta-analysis and review","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0089","first-page":"2370","article-title":"Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma","volume":"11","author":"Yang","year":"2019","journal-title":"Am J Transl Res"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0090","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/ijc.32170","article-title":"MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer","volume":"145","author":"Novoplansky","year":"2019","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0091","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1158\/1078-0432.CCR-12-1555","article-title":"c-src activation mediates erlotinib resistance in head and neck cancer by stimulating c-met","volume":"19","author":"Stabile","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jormas.2026.102904_bib0092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-015-0633-7","article-title":"Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer","volume":"13","author":"Madoz-G\u00farpide","year":"2015","journal-title":"J Transl Med"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0093","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1158\/1535-7163.MCT-08-0374","article-title":"HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells","volume":"7","author":"Bachleitner-Hofmann","year":"2008","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0094","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128159","article-title":"The EGFR\/ErbB3 pathway acts as a compensatory survival mechanism upon c-met inhibition in human c-met+ hepatocellular carcinoma","volume":"10","author":"Steinway","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jormas.2026.102904_bib0095","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3390\/cancers13081865","article-title":"Tyrosine kinase c-MET as therapeutic target for radiosensitization of head and neck squamous cell carcinomas","volume":"13","author":"Luettich","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"24","key":"10.1016\/j.jormas.2026.102904_bib0096","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1158\/1078-0432.CCR-19-0994","article-title":"Crizotinib in MET-deregulated or ROS1-rearranged pretreated non-small cell lung cancer (METROS): a phase II, prospective, multicenter, two-arms trial","volume":"25","author":"Landi","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"23","key":"10.1016\/j.jormas.2026.102904_bib0097","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1158\/1078-0432.CCR-24-1925","article-title":"Safety, efficacy, and biomarker analysis of Crizotinib in MET-mutated non-small cell lung cancer-results from the drug rediscovery protocol","volume":"30","author":"Verkerk","year":"2024","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0098","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1158\/2159-8290.CD-22-0586","article-title":"Osimertinib + Savolitinib to overcome acquired MET-mediated resistance in epidermal growth factor receptor-mutated, MET-amplified non-small cell lung cancer: TATTON","volume":"13","author":"Hartmaier","year":"2023","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jormas.2026.102904_bib0099","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.105074","article-title":"Combinatorial approaches targeting the EGFR family and c-met in SCCHN","volume":"112","author":"Wang","year":"2021","journal-title":"Oral Oncol"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0100","first-page":"448","article-title":"Rilotumumab, a mAb against human hepatocyte growth factor for the treatment of cancer","volume":"11","author":"Giordano","year":"2009","journal-title":"Curr Opin Mol Ther"},{"issue":"9","key":"10.1016\/j.jormas.2026.102904_bib0101","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S1470-2045(14)70023-3","article-title":"Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study","volume":"15","author":"Iveson","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jormas.2026.102904_bib0102","series-title":"MAbs","article-title":"Incomplete target neutralization by the anti-cancer antibody rilotumumab","author":"Greenall","year":"2016"},{"issue":"32","key":"10.1016\/j.jormas.2026.102904_bib0103","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1200\/JCO.2012.47.4189","article-title":"Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non\u2013small-cell lung cancer","volume":"31","author":"Spigel","year":"2013","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0104","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1200\/JCO.2016.69.2160","article-title":"Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non\u2013small-cell lung cancer: mETLung","volume":"35","author":"Spigel","year":"2017","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cllc.2016.05.011","article-title":"Efficacy and safety results from a phase II, placebo-controlled study of onartuzumab plus first-line platinum-doublet chemotherapy for advanced squamous cell non\u2013small-cell lung cancer","volume":"18","author":"Hirsch","year":"2017","journal-title":"Clin Lung Cancer"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0106","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1158\/1535-7163.MCT-18-1274","article-title":"Targeting the MET receptor tyrosine kinase as a strategy for radiosensitization in locoregionally advanced head and neck squamous cell carcinoma","volume":"19","author":"Nisa","year":"2020","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"10.1016\/j.jormas.2026.102904_bib0107","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ijrobp.2023.11.013","article-title":"MET inhibitor capmatinib radiosensitizes MET exon 14-mutated and MET-amplified non-small cell lung cancer","volume":"118","author":"Ramesh","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0108","first-page":"5973","article-title":"Crizotinib fails to enhance the effect of radiation in head and neck squamous cell carcinoma xenografts","volume":"35","author":"Baschnagel","year":"2015","journal-title":"Anticancer Res"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0109","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000092716","article-title":"Effect of c-met expression on survival in head and neck squamous cell carcinoma","volume":"27","author":"Lo Muzio","year":"2006","journal-title":"Tumor Biol"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0110","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jnutbio.2010.09.005","article-title":"Green tea (\u2212)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF\/c-met","volume":"22","author":"Koh","year":"2011","journal-title":"J Nutr Biochem"},{"issue":"30","key":"10.1016\/j.jormas.2026.102904_bib0111","doi-asserted-by":"crossref","first-page":"30088","DOI":"10.18632\/oncotarget.3937","article-title":"The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.jormas.2026.102904_bib0112","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1080\/15384047.2019.1647051","article-title":"C7 peptide inhibits hepatocellular carcinoma metastasis by targeting the HGF\/c-Met signaling pathway","volume":"20","author":"Zhao","year":"2019","journal-title":"Cancer Biol Ther"},{"issue":"3","key":"10.1016\/j.jormas.2026.102904_bib0113","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3892\/ijo.2016.3602","article-title":"The tumor-suppressive microRNA-23b\/27b cluster regulates the MET oncogene in oral squamous cell carcinoma","volume":"49","author":"Fukumoto","year":"2016","journal-title":"Int J Oncol"},{"issue":"2","key":"10.1016\/j.jormas.2026.102904_bib0114","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/jcm8020273","article-title":"The oncogenic activity of miR-29b-1-5p induces the epithelial-mesenchymal transition in oral squamous cell carcinoma","volume":"8","author":"Kurihara-Shimomura","year":"2019","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.jormas.2026.102904_bib0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2217\/bmm.09.67","article-title":"Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers","volume":"4","author":"Goetsch","year":"2010","journal-title":"Biomark Med"},{"issue":"6","key":"10.1016\/j.jormas.2026.102904_bib0116","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1158\/1078-0432.CCR-13-2070","article-title":"Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies","volume":"20","author":"Salgia","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.jormas.2026.102904_bib0117","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1158\/0008-5472.CAN-09-3620","article-title":"Acquired resistance of non\u2013small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency","volume":"70","author":"McDermott","year":"2010","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0118","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1158\/1078-0432.CCR-19-3608","article-title":"Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors in patients with MET exon 14\u2013mutant NSCLC","volume":"26","author":"Recondo","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.jormas.2026.102904_bib0119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078398","article-title":"Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer","volume":"8","author":"Fong","year":"2013","journal-title":"PloS One"},{"issue":"10","key":"10.1016\/j.jormas.2026.102904_bib0120","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1158\/1078-0432.CCR-14-3258","article-title":"The c-met tyrosine kinase inhibitor JNJ-38877605 causes renal toxicity through species-specific insoluble metabolite formation","volume":"21","author":"Lolkema","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jormas.2026.102904_bib0121","series-title":"First-in-human phase i study of a selective c-Met inhibitor volitinib (HMP504\/AZD6094) in patients with advanced solid tumors","author":"Gan","year":"2014"},{"key":"10.1016\/j.jormas.2026.102904_bib0122","article-title":"Emerging targeted therapies in oral oncology: focus on EGFR inhibition","volume":"11","author":"Veeraraghavan","year":"2024","journal-title":"Oral Oncol Rep"},{"issue":"12_Supplement","key":"10.1016\/j.jormas.2026.102904_bib0123","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2022-4213","article-title":"Targeting the cMet inhibitors combined with anti-PD-1 therapy: preclinical approach to turn the resistance into opportunities for overcoming tumor evasion","volume":"82","author":"de Azevedo","year":"2022","journal-title":"Cancer Res"}],"container-title":["Journal of Stomatology Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785526002004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468785526002004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:44:27Z","timestamp":1791204267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468785526002004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":123,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2468785526002004"],"URL":"https:\/\/doi.org\/10.1016\/j.jormas.2026.102904","relation":{},"ISSN":["2468-7855"],"issn-type":[{"value":"2468-7855","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The HGF\/c-Met signaling axis: A master regulator of invasion and metastasis in oral squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Stomatology Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jormas.2026.102904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102904"}}