{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:04:26Z","timestamp":1793804666349,"version":"4.6.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jos.2020.01.012","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T17:48:14Z","timestamp":1582652894000},"page":"1079-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Treatment outcomes of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw (MRONJ): A multicenter retrospective analysis in Japan"],"prefix":"10.1016","volume":"25","author":[{"given":"Kota","family":"Morishita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Hashidume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritami","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Ohbayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Yoshiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Narai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narikazu","family":"Uzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Kodani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jos.2020.01.012_bib1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"22","key":"10.1016\/j.jos.2020.01.012_bib2","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1200\/JCO.2003.99.132","article-title":"Bisphosphanates and oral cavity avascular bone necrosis","volume":"21","author":"Migliorati","year":"2003","journal-title":"J\u00a0Clin Oncol"},{"issue":"11","key":"10.1016\/j.jos.2020.01.012_bib3","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1016\/j.joms.2011.03.051","article-title":"Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan","volume":"69","author":"Urade","year":"2011","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.jos.2020.01.012_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws","volume":"65","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"5 Suppl","key":"10.1016\/j.jos.2020.01.012_bib5","first-page":"2","article-title":"American association of oral and maxillofacial Surgeons. American association of oral and maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"12","key":"10.1016\/j.jos.2020.01.012_bib6","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/JTO.0b013e31826aec2b","article-title":"Overall survival improvement in patients with lung cancer and bone metastases treated with denosumab versus zoledronic acid: subgroup Analysis from a randomized phase 3 study","volume":"7","author":"Scagliotti","year":"2012","journal-title":"J\u00a0Thorac Oncol"},{"issue":"2","key":"10.1016\/j.jos.2020.01.012_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10147-013-0561-6","article-title":"Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials","volume":"19","author":"Qi","year":"2014","journal-title":"Int J Clin Oncol"},{"issue":"35","key":"10.1016\/j.jos.2020.01.012_bib8","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"9","key":"10.1016\/j.jos.2020.01.012_bib9","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2010.31.3304","article-title":"Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma","volume":"29","author":"Henry","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.jos.2020.01.012_bib10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00774-010-0162-7","volume":"28","author":"Yoneda","year":"2010","journal-title":"J\u00a0Bone Miner Metabol"},{"issue":"4","key":"10.1016\/j.jos.2020.01.012_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tripleo.2007.01.008","article-title":"Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management","volume":"104","author":"Montebugnoli","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"7","key":"10.1016\/j.jos.2020.01.012_bib12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.joms.2009.03.005","article-title":"Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator","volume":"67","author":"O'Ryan","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"8","key":"10.1016\/j.jos.2020.01.012_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00432-010-0907-7","article-title":"Bisphosphonate-induced osteonecrosis of the jaw: a review of 2,400 patient cases","volume":"136","author":"Filleul","year":"2010","journal-title":"J\u00a0Canc Res Clin Oncol"},{"issue":"5 Suppl","key":"10.1016\/j.jos.2020.01.012_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jos.2020.01.012_bib15","first-page":"1299","article-title":"The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw\u2014results of a clinical case series with an average follow-up of 20 months","volume":"18","author":"Stockmann","year":"2014","journal-title":"Clin Oral Invest"},{"issue":"2","key":"10.1016\/j.jos.2020.01.012_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0749-0690(02)00074-5","article-title":"The anabolic effects of parathyroid hormone therapy","volume":"19","author":"Rubin","year":"2003","journal-title":"Clin Geriatr Med"},{"issue":"3","key":"10.1016\/j.jos.2020.01.012_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0501.2007.01342.x","article-title":"The effect of matrix bound parathyroid hormone on bone regeneration","volume":"18","author":"Jung","year":"2007","journal-title":"Clin Oral Implants Res"},{"issue":"2","key":"10.1016\/j.jos.2020.01.012_bib18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1359\/jbmr.090731","article-title":"Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures","volume":"25","author":"Aspenberg","year":"2010","journal-title":"J\u00a0Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jos.2020.01.012_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.joms.2006.10.076","article-title":"Resolution of bisphosphonate-associated osteonecrosis of the mandible: possible application for intermittent low-dose parathyroid hormone [rhPTH(1-34)]","volume":"65","author":"Harper","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jos.2020.01.012_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1754-4505.2009.00128.x","article-title":"Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: a review of the literature and a case report","volume":"30","author":"Narongroeknawin","year":"2010","journal-title":"Spec Care Dent"},{"issue":"8","key":"10.1016\/j.jos.2020.01.012_bib21","first-page":"547","article-title":"Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly Japanese woman with severe osteoporosis","volume":"32","author":"Iwamoto","year":"2012","journal-title":"Clin Drug Invest"},{"issue":"5","key":"10.1016\/j.jos.2020.01.012_bib22","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00198-014-2622-8","article-title":"Distinctive role of 6-month teriparatide treatment on intractable bisphosphonate-related osteonecrosis of the jaw","volume":"25","author":"Kim","year":"2014","journal-title":"Osteoporos Int"},{"issue":"12","key":"10.1016\/j.jos.2020.01.012_bib23","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.ijom.2015.07.018","article-title":"Administration of teriparatide improves the symptoms of advanced bisphosphonate-related osteonecrosis of the jaw: preliminary findings","volume":"44","author":"Kakehashi","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jos.2020.01.012_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00774-016-0810-7","article-title":"Antiresorptive agent-related osteonecrosis of the jaw: position paper 2017 of the Japanese allied committee on osteonecrosis of the jaw","volume":"35","author":"Yoneda","year":"2017","journal-title":"J\u00a0Bone Miner Metabol"},{"issue":"10","key":"10.1016\/j.jos.2020.01.012_bib25","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jbmr.3191","article-title":"Evaluation of the treatment strategies for medication-related osteonecrosis of the jaws (MRONJ) and the factors affecting treatment outcome: a multicenter retrospective study with propensity score matching analysis","volume":"32","author":"Hayashida","year":"2017","journal-title":"J\u00a0Bone Miner Res"},{"issue":"2","key":"10.1016\/j.jos.2020.01.012_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbrc.2008.12.035","article-title":"BMP\/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: potential therapeutic targets for glucocorticoid-induced osteoporosis","volume":"379","author":"Hayashi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jos.2020.01.012_bib27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2147\/CIA.S107285","article-title":"Safety and effectiveness of daily teriparatide in a prospective observational study in patients with osteoporosis at high risk of fracture in Japan: final report","volume":"11","author":"Nishikawa","year":"2016","journal-title":"Clin Interv Aging"},{"issue":"3","key":"10.1016\/j.jos.2020.01.012_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bone.2010.05.022","article-title":"Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-Month, randomized, placebo-controlled, double-blind and 12-month open-label phases","volume":"47","author":"Miyauchi","year":"2010","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jos.2020.01.012_bib29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00198-013-2516-1","article-title":"Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis","volume":"25","author":"Sugimoto","year":"2014","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.jos.2020.01.012_bib30","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.bone.2009.07.091","article-title":"Rapid and robust response of biochemical markers of bone formation to teriparatide therapy","volume":"45","author":"Glover","year":"2009","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.jos.2020.01.012_bib31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00774-008-0871-3","article-title":"Effect of teriparatide on bone mineral density and biochemical markers in Japanese women with postmenopausal osteoporosis: a 6-month dose-response study","volume":"26","author":"Miyauchi","year":"2008","journal-title":"J\u00a0Bone Miner Metabol"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094926582030018X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094926582030018X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:32:27Z","timestamp":1760556747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094926582030018X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S094926582030018X"],"URL":"https:\/\/doi.org\/10.1016\/j.jos.2020.01.012","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment outcomes of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw (MRONJ): A multicenter retrospective analysis in Japan","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jos.2020.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}