{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:59:22Z","timestamp":1777964362651,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jos.2020.06.011","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:55:13Z","timestamp":1598410513000},"page":"690-697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model"],"prefix":"10.1016","volume":"26","author":[{"given":"Hiroko","family":"Ueki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunikazu","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Miyatake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Muneta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jos.2020.06.011_bib1","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1177\/0363546513508376","article-title":"Anterior cruciate ligament injury and radiologic progression of knee osteoarthritis: a systematic review and meta-analysis","volume":"42","author":"Ajuied","year":"2014","journal-title":"Am J Sports Med"},{"issue":"5","key":"10.1016\/j.jos.2020.06.011_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00167-008-0498-x","article-title":"Function, osteoarthritis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment","volume":"16","author":"Kessler","year":"2008","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5411","key":"10.1016\/j.jos.2020.06.011_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jos.2020.06.011_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00441-008-0633-5","article-title":"Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit","volume":"333","author":"Koga","year":"2008","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jos.2020.06.011_bib5","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.21212","article-title":"Comparison of human stem cells derived from various mesenchymal tissues","volume":"52","author":"Sakaguchi","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.jos.2020.06.011_bib6","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1007\/s11999-015-4324-8","article-title":"Arthroscopic transplantation of synovial stem cells improves clinical outcomes in knees with cartilage defects","volume":"473","author":"Sekiya","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jos.2020.06.011_bib7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2015.12.018","article-title":"Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats","volume":"24","author":"Ozeki","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jos.2020.06.011_bib8","first-page":"1","article-title":"Allogeneic mesenchymal stem cells in combination with hyaluronic acid for the treatment of osteoarthritis in rabbits","author":"Chiang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.jos.2020.06.011_bib9","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1177\/0363546515599632","article-title":"Comparative matched-pair analysis of the injection versus implantation of mesenchymal stem cells for knee osteoarthritis","volume":"43","author":"Kim","year":"2015","journal-title":"Am J Sports Med"},{"issue":"12","key":"10.1016\/j.jos.2020.06.011_bib10","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.joca.2013.08.024","article-title":"The clinical status of cartilage tissue regeneration in humans","volume":"21","author":"Mollon","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jos.2020.06.011_bib11","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1634","article-title":"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial","volume":"32","author":"Jo","year":"2014","journal-title":"Stem Cell"},{"issue":"4","key":"10.1016\/j.jos.2020.06.011_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bbrc.2013.05.026","article-title":"Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect","volume":"435","author":"Katagiri","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.jos.2020.06.011_bib13","first-page":"101","article-title":"Exogenous synovial stem cells adhere to defect of meniscus and differentiate into cartilage cells","volume":"55","author":"Mizuno","year":"2008","journal-title":"J\u00a0Med Dent Sci"},{"issue":"10","key":"10.1016\/j.jos.2020.06.011_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00402-015-2272-0","article-title":"The volume of the human knee joint","volume":"135","author":"Matziolis","year":"2015","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"10.1016\/j.jos.2020.06.011_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/03009748609092587","article-title":"Arthroscopic volume of the knee joint in young male adults","volume":"15","author":"Visuri","year":"1986","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jos.2020.06.011_bib16","doi-asserted-by":"crossref","first-page":"106658","DOI":"10.1016\/j.vascn.2019.106658","article-title":"Evaluation of different intraarticular injection volumes to assess optimum efficient amount; an experimental study in rat knee joints","volume":"101","author":"Aytekin","year":"2020","journal-title":"J\u00a0Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jos.2020.06.011_bib17","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00167-006-0124-8","article-title":"Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration","volume":"14","author":"Muhammad Agung","year":"2006","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"10.1016\/j.jos.2020.06.011_bib18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13287-016-0420-2","article-title":"In\u00a0vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model","volume":"7","author":"Li","year":"2016","journal-title":"Stem Cell Res Ther"},{"issue":"Suppl.\u00a03","key":"10.1016\/j.jos.2020.06.011_bib19","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"1\u20132","key":"10.1016\/j.jos.2020.06.011_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2004.08.004","article-title":"Pain related behaviour in two models of osteoarthritis in the rat knee","volume":"112","author":"Fernihough","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.jos.2020.06.011_bib21","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1097\/00003086-199910001-00017","article-title":"Autologous mesenchymal progenitor cells in articular cartilage repair","volume":"367","author":"Johnstone","year":"1999","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"10.1016\/j.jos.2020.06.011_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13287-017-0572-8","article-title":"Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients","volume":"8","author":"Kohno","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jos.2020.06.011_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3892\/etm.2016.3325","article-title":"Osteoarthritis prevention and meniscus regeneration induced by transplantation of mesenchymal stem cell sheet in a rat meniscal defect model","volume":"12","author":"Qi","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jos.2020.06.011_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.21037\/sci.2019.08.11","article-title":"A revealing review of mesenchymal stem cells therapy, clinical perspectives and modification strategies","volume":"6","author":"Saeedi","year":"2019","journal-title":"Stem Cell Invest"},{"issue":"3","key":"10.1016\/j.jos.2020.06.011_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.knee.2001.06.001","article-title":"Meniscal repair using bone marrow-derived mesenchymal stem cells: experimental study using green fluorescent protein transgenic rats","volume":"12","author":"Izuta","year":"2005","journal-title":"Knee"},{"issue":"12","key":"10.1016\/j.jos.2020.06.011_bib26","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/acr.20314","article-title":"Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study","volume":"62","author":"Cibere","year":"2010","journal-title":"Arthritis Care Res"},{"issue":"2","key":"10.1016\/j.jos.2020.06.011_bib27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.gene.2013.11.091","article-title":"Pain assessment in animal models of osteoarthritis","volume":"537","author":"Piel","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.jos.2020.06.011_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/j.1532-2149.2013.00406.x","article-title":"Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour","volume":"18","author":"Yang","year":"2014","journal-title":"Eur J Pain"},{"issue":"12","key":"10.1016\/j.jos.2020.06.011_bib29","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1136\/gut.2010.215152","article-title":"Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study","volume":"59","author":"Duijvestein","year":"2010","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jos.2020.06.011_bib30","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/ar4156","article-title":"Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model","volume":"15","author":"Desando","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.jos.2020.06.011_bib31","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.37908","article-title":"Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2","volume":"65","author":"Manferdini","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.jos.2020.06.011_bib32","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.joca.2016.06.012","article-title":"Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA)","volume":"24","author":"Nwosu","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.jos.2020.06.011_bib33","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.joca.2013.06.013","article-title":"Osteoarthritis pain mechanisms: basic studies in animal models","volume":"21","author":"Zhang","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jos.2020.06.011_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.joca.2014.09.007","article-title":"Intra-articular administration of xenogeneic neonatal mesenchymal stromal cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis","volume":"23","author":"Saulnier","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.jos.2020.06.011_bib35","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.joca.2015.03.001","article-title":"Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis","volume":"23","author":"Hamilton","year":"2015","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265820302050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265820302050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:33:22Z","timestamp":1760556802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265820302050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0949265820302050"],"URL":"https:\/\/doi.org\/10.1016\/j.jos.2020.06.011","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jos.2020.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}