{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:54:31Z","timestamp":1792475671607,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jos.2024.04.003","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:57:06Z","timestamp":1714049826000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Toxic effects of local anesthetics on rat fibroblasts: An in-vitro study"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-9145","authenticated-orcid":false,"given":"Keegan M.","family":"Hones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan O.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hartzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Myara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraic P.","family":"Levings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Badman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Ghivizzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael S.","family":"Watson Levings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jos.2024.04.003_bib1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1213\/ANE.0000000000000688","article-title":"Will the real benefits of single-shot interscalene block please stand up? A systematic review and meta-analysis","volume":"120","author":"Abdallah","year":"2015","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1016\/j.jos.2024.04.003_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/00000542-200110000-00015","article-title":"Acute and nonacute complications associated with interscalene block and shoulder surgery","volume":"95","author":"Borgeat","year":"2001","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.jos.2024.04.003_bib3","first-page":"402","article-title":"Brachial plexus anesthesia: essentials of our current understanding","volume":"27","author":"Neal","year":"2002","journal-title":"Reg Anesth Pain Med"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/jars.2002.25976","article-title":"The effectiveness of an anesthetic continuous-infusion device on postoperative pain control","volume":"18","author":"Barber","year":"2002","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"key":"10.1016\/j.jos.2024.04.003_bib5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1213\/01.ANE.0000081733.77457.79","article-title":"Continuous wound infiltration with ropivacaine reduces pain and analgesic requirement after shoulder surgery","author":"Gottschalk","year":"2003","journal-title":"Anesth Analg"},{"issue":"7","key":"10.1016\/j.jos.2024.04.003_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.arthro.2006.05.006","article-title":"In\u00a0vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes","volume":"22","author":"Chu","year":"2006","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"8","key":"10.1016\/j.jos.2024.04.003_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.arthro.2006.06.006","article-title":"Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder","volume":"22","author":"Gomoll","year":"2006","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"6","key":"10.1016\/j.jos.2024.04.003_bib8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jse.2008.03.011","article-title":"Subacromial pain pump use with arthroscopic shoulder surgery: a short-term prospective study of complications in 583 patients","volume":"17","author":"Busfield","year":"2008","journal-title":"J\u00a0Shoulder Elbow Surg"},{"issue":"10","key":"10.1016\/j.jos.2024.04.003_bib9","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1177\/0363546507304136","article-title":"Postarthroscopic glenohumeral chondrolysis","volume":"35","author":"Hansen","year":"2007","journal-title":"Am J Sports Med"},{"issue":"10","key":"10.1016\/j.jos.2024.04.003_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.etp.2016.09.001","article-title":"Comparison of histopathological effects of perineural administration of bupivacaine and bupivacaine-dexmedetomidine in rat sciatic nerve","volume":"68","author":"Memari","year":"2016","journal-title":"Exp Toxicol Pathol"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/ijms17030339","article-title":"Local anesthetic-induced neurotoxicity","volume":"17","author":"Verlinde","year":"2016","journal-title":"IJMS"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib12","first-page":"187","article-title":"Tendon injury and tendinopathy: healing and repair","volume":"87","author":"Sharma","year":"2005","journal-title":"J\u00a0Bone Joint Surg"},{"issue":"12","key":"10.1016\/j.jos.2024.04.003_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146021","article-title":"Dose-response analysis using R","volume":"10","author":"Ritz","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2106\/JBJS.J.00739","article-title":"National trends in rotator cuff repair","volume":"94","author":"Colvin","year":"2012","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jseint.2021.09.016","article-title":"Trends in outpatient versus inpatient total shoulder arthroplasty over time","volume":"6","author":"Mehta","year":"2022","journal-title":"JSES International"},{"issue":"2","key":"10.1016\/j.jos.2024.04.003_bib16","article-title":"Comparison of analgesic efficacy of ultrasound-guided interscalene block versus continuous subacromial infusion for postoperative analgesia following arthroscopic rotator cuff repair surgeries: a randomized trial","volume":"13","author":"Saini","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.jos.2024.04.003_bib17","article-title":"Perioperative management of interscalene block in patients with lung disease","volume":"2013","author":"Schwenk","year":"2013","journal-title":"Case Rep Anesthesiol"},{"issue":"11","key":"10.1016\/j.jos.2024.04.003_bib18","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/NEN.0b013e318270a941","article-title":"Endoneurial fibroblast-like cells","volume":"71","author":"Richard","year":"2012","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"issue":"2","key":"10.1016\/j.jos.2024.04.003_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000471","article-title":"Synovial fibroblasts in 2017","volume":"3","author":"Ospelt","year":"2017","journal-title":"RMD Open"},{"issue":"5","key":"10.1016\/j.jos.2024.04.003_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)80583-8","article-title":"Prospective identification, isolation by flow cytometry, and in\u00a0vivo self-renewal of multipotent mammalian neural crest stem cells","volume":"96","author":"Morrison","year":"1999","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/dbio.1993.1291","article-title":"Fibroblasts promote Schwann cell basal lamina deposition and elongation in the absence of neurons in culture","volume":"160","author":"Obremski","year":"1993","journal-title":"Dev Biol"},{"issue":"4","key":"10.1016\/j.jos.2024.04.003_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0749-8063(00)90076-8","article-title":"The pain control infusion pump for postoperative pain control in shoulder surgery","volume":"16","author":"Savoie","year":"2000","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"5","key":"10.1016\/j.jos.2024.04.003_bib23","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.arthro.2021.11.054","article-title":"Peripheral nerve blocks outperform general anesthesia for pain control in arthroscopic rotator cuff repair: a systematic review and meta-analysis","volume":"38","author":"Kalthoff","year":"2022","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"issue":"2","key":"10.1016\/j.jos.2024.04.003_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2106\/00004623-200402000-00002","article-title":"The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears","volume":"86","author":"Galatz","year":"2004","journal-title":"J\u00a0Bone Joint Surg"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2106\/JBJS.I.00267","article-title":"Revision arthroscopic rotator cuff repair: repair integrity and clinical outcome","volume":"92","author":"Keener","year":"2010","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"10.1016\/j.jos.2024.04.003_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1302\/0301-620X.88B4.16845","article-title":"Pathology of the torn rotator cuff tendon: reduction in potential for repair as tear size increases","volume":"88-B","author":"Matthews","year":"2006","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/2000656X.2020.1720999","article-title":"Comparison of the pharmacological properties of 0.375% bupivacaine with epinephrine, 0.5% ropivacaine and a mixture of bupivacaine with epinephrine and lignocaine \u2013 a randomized prospective study","volume":"54","author":"Bobik","year":"2020","journal-title":"J Plast Surg Hand Surg"},{"issue":"23","key":"10.1016\/j.jos.2024.04.003_bib28","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000029394","article-title":"Comparison of lidocaine and ropivacaine stellate ganglion blockade in treating upper limb postherpetic neuralgia","volume":"101","author":"Fan","year":"2022","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.jos.2024.04.003_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/0019-5049.79875","article-title":"Ropivacaine: a review of its pharmacology and clinical use","volume":"55","author":"Kuthiala","year":"2011","journal-title":"Indian J Anaesth"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib30","first-page":"UC01","article-title":"Comparision between bupivacaine and ropivacaine in patients undergoing forearm surgeries under axillary brachial plexus block: a prospective randomized study","volume":"9","author":"Kaur","year":"2015","journal-title":"J\u00a0Clin Diagn Res"},{"issue":"7","key":"10.1016\/j.jos.2024.04.003_bib31","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1177\/0363546516667906","article-title":"Pain management after outpatient shoulder arthroscopy: a systematic review of randomized controlled trials","volume":"45","author":"Warrender","year":"2017","journal-title":"Am J Sports Med"},{"issue":"2","key":"10.1016\/j.jos.2024.04.003_bib32","first-page":"117","article-title":"Analgesia after arthroscopic rotator cuff repair: subacromial versus interscalene continuous infusion of ropivacaine","volume":"30","author":"Delaunay","year":"2005","journal-title":"Reg Anesth Pain Med"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40981-020-0315-1","article-title":"Severe and persistent nerve palsy after ultrasound-guided continuous interscalene brachial plexus block in a teenager undergoing shoulder surgery: a case report","volume":"6","author":"Shio","year":"2020","journal-title":"JA Clin Rep"},{"issue":"1","key":"10.1016\/j.jos.2024.04.003_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/CJ9.0000000000000086","article-title":"Prolonged brachial plexopathy following interscalene block for shoulder arthroplasty","volume":"47","author":"Villar","year":"2019","journal-title":"Colomb J Anesthesiol"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib35","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1213\/ane.0b013e31819385e1","article-title":"Cytotoxicity of local anesthetics in human neuronal cells","volume":"108","author":"Perez-Castro","year":"2009","journal-title":"Anesth Analg"},{"issue":"5","key":"10.1016\/j.jos.2024.04.003_bib36","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/AAP.0b013e318228c835","article-title":"Local anesthetic Schwann cell toxicity is time and concentration dependent","volume":"36","author":"Yang","year":"2011","journal-title":"Reg Anesth Pain Med"},{"issue":"3","key":"10.1016\/j.jos.2024.04.003_bib37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00402-010-1246-5","article-title":"Rotator cuff changes in a full thickness tear rat model: verification of the optimal time interval until reconstruction for comparison to the healing process of chronic lesions in humans","volume":"131","author":"Buchmann","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"issue":"5","key":"10.1016\/j.jos.2024.04.003_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/03008207.2018.1485666","article-title":"Partial-width injuries of the rat rotator cuff heal with fibrosis","volume":"59","author":"Lemmon","year":"2018","journal-title":"Connect Tissue Res"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265824000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265824000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:23:41Z","timestamp":1741710221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265824000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0949265824000605"],"URL":"https:\/\/doi.org\/10.1016\/j.jos.2024.04.003","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic effects of local anesthetics on rat fibroblasts: An in-vitro study","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jos.2024.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}