{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:10:49Z","timestamp":1790964649200,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K18515"],"award-info":[{"award-number":["JP19K18515"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K09426"],"award-info":[{"award-number":["JP22K09426"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K19587"],"award-info":[{"award-number":["JP22K19587"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H03031"],"award-info":[{"award-number":["JP23H03031"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011692","name":"General Incorporated Foundation The General Insurance Association of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jos.2025.12.009","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:24:51Z","timestamp":1769718291000},"page":"938-948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Zinc chelation therapy mitigates muscle fibrosis and improves functional outcomes in a murine model of crush syndrome"],"prefix":"10.1016","volume":"31","author":[{"given":"Yohei","family":"Haruta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Saiwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazu","family":"Kobayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentaro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kitade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Tarukado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1186\/s12967-023-04416-9","article-title":"Crush syndrome: a review for prehospital providers and emergency clinicians","volume":"21","author":"Usuda","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19903-0","article-title":"Zinc chelator treatment in crush syndrome model mice attenuates ischemia\u2013reperfusion-induced muscle injury due to suppressing of neutrophil infiltration","volume":"12","author":"Haruta","year":"2022","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jos.2025.12.009_bib3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1365-2613.2010.00708.x","article-title":"Ischaemia-reperfusion modulates inflammation and fibrosis of skeletal muscle after contusion injury","volume":"91","author":"Ghaly","year":"2010","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.jos.2025.12.009_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fphys.2020.00087","article-title":"Divergent roles of inflammation in skeletal muscle recovery from injury","volume":"11","author":"Howard","year":"2020","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib5","first-page":"33","article-title":"Long-term physical outcome of patients who suffered crush syndrome after the 1995 hanshin-awaji earthquake: prognostic indicators in retrospect","volume":"52","author":"Matsuoka","year":"2002","journal-title":"J Trauma"},{"issue":"6958","key":"10.1016\/j.jos.2025.12.009_bib6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/bmj.309.6958.857","article-title":"Lesson of the week: crush syndrome following unconsciousness: need for urgent orthopaedic referral","volume":"309","author":"Shaw","year":"1994","journal-title":"Bmj"},{"issue":"5","key":"10.1016\/j.jos.2025.12.009_bib7","doi-asserted-by":"crossref","first-page":"R1173","DOI":"10.1152\/ajpregu.00735.2009","article-title":"Regulatory interactions between muscle and the immune system during muscle regeneration","volume":"298","author":"Tidball","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jos.2025.12.009_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/965631","article-title":"Understanding the process of fibrosis in Duchenne muscular dystrophy","volume":"2014","author":"Kharraz","year":"2014","journal-title":"BioMed Res Int"},{"issue":"18","key":"10.1016\/j.jos.2025.12.009_bib9","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1016\/j.yexcr.2010.05.035","article-title":"Regulation and dysregulation of fibrosis in skeletal muscle","volume":"316","author":"Serrano","year":"2010","journal-title":"Exp Cell Res"},{"issue":"2","key":"10.1016\/j.jos.2025.12.009_bib10","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/physrev.00021.2018","article-title":"Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases","volume":"99","author":"Piera-Velazquez","year":"2019","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.jos.2025.12.009_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embr.201949075","article-title":"Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle","volume":"21","author":"Iavarone","year":"2020","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4049\/jimmunol.1800883","article-title":"Macrophages guard endothelial lineage by hindering Endothelial-to-Mesenchymal transition: implications for the pathogenesis of systemic sclerosis","volume":"203","author":"Nicolosi","year":"2019","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1080\/0886022X.2020.1792928","article-title":"Emerging medical therapies in crush syndrome\u2013progress report from basic sciences and potential future avenues","volume":"42","author":"Li","year":"2020","journal-title":"Ren Fail"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0014-4886(03)00257-7","article-title":"Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury","volume":"184","author":"Gonzalez","year":"2003","journal-title":"Exp Neurol"},{"issue":"9\u201310","key":"10.1016\/j.jos.2025.12.009_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nmd.2005.05.004","article-title":"Genetic background influences muscular dystrophy","volume":"15","author":"Heydemann","year":"2005","journal-title":"Neuromuscul Disord"},{"issue":"12","key":"10.1016\/j.jos.2025.12.009_bib16","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1172\/JCI39845","article-title":"Latent TGF-\u03b2-binding protein 4 modifies muscular dystrophy in mice","volume":"119","author":"Heydemann","year":"2009","journal-title":"J Clin Investig"},{"issue":"6","key":"10.1016\/j.jos.2025.12.009_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s12975-019-0688-5","article-title":"Loss of endothelial laminin \u03b15 exacerbates hemorrhagic brain injury","volume":"10","author":"Gautam","year":"2020","journal-title":"Transl Stroke Res"},{"issue":"6","key":"10.1016\/j.jos.2025.12.009_bib18","first-page":"1267","article-title":"Degradation of basement membrane laminin by human neutrophil elastase and cathepsin G","volume":"136","author":"Heck","year":"1990","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jos.2025.12.009_bib19","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2016-210229","article-title":"Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis","volume":"76","author":"Manetti","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.jos.2025.12.009_bib20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3892\/ijmm.2014.1818","article-title":"Constitutively active Notch1 signaling promotes endothelial - mesenchymal transition in a conditional transgenic mouse model","volume":"34","author":"Liu","year":"2014","journal-title":"Int J Mol Med"},{"issue":"11","key":"10.1016\/j.jos.2025.12.009_bib21","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41419-018-1083-y","article-title":"Positive feedback loop between mitochondrial fussionssion and notch signaling promotes survivin-mediated survival of TNBC cells","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib22","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1038\/s41467-019-10226-9","article-title":"DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass","volume":"10","author":"Favaro","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jos.2025.12.009_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12079-020-00553-8","article-title":"HIF-hypoxia signaling in skeletal muscle physiology and fibrosis","volume":"14","author":"Valle-Tenney","year":"2020","journal-title":"J Cell Commun Signal"},{"issue":"4","key":"10.1016\/j.jos.2025.12.009_bib24","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.3390\/ijms24044004","article-title":"Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation","volume":"24","author":"Antar","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jos.2025.12.009_bib25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.jos.2025.12.009_bib26","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1681\/ASN.2008050513","article-title":"Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition","volume":"19","author":"Zeisberg","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-0765.2007.01036.x","article-title":"Involvement of laminin and integrins in adhesion and migration of junctional epithelium cells","volume":"44","author":"Kinumatsu","year":"2009","journal-title":"J Periodontal Res"},{"issue":"11","key":"10.1016\/j.jos.2025.12.009_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejcb.2016.06.002","article-title":"Basement membrane fragments in the context of the epithelial-to-mesenchymal transition","volume":"95","author":"Horejs","year":"2016","journal-title":"Eur J Cell Biol"},{"issue":"20","key":"10.1016\/j.jos.2025.12.009_bib29","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1111\/jcmm.15827","article-title":"Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells","volume":"24","author":"Zhou","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"7","key":"10.1016\/j.jos.2025.12.009_bib30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ncb1739","article-title":"RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation","volume":"10","author":"Nakaya","year":"2008","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/s41232-021-00186-3","article-title":"Emerging roles of inflammation-mediated endothelial\u2013mesenchymal transition in health and disease","volume":"42","author":"Yoshimatsu","year":"2022","journal-title":"Inflamm Regen"},{"issue":"3","key":"10.1016\/j.jos.2025.12.009_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/path.5193","article-title":"Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2","volume":"247","author":"S\u00e1nchez-Duffhues","year":"2019","journal-title":"J Pathol"},{"issue":"5","key":"10.1016\/j.jos.2025.12.009_bib33","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.amjsurg.2017.08.003","article-title":"Cancer-promoting mechanisms of tumor-associated neutrophils","volume":"214","author":"Hurt","year":"2017","journal-title":"Am J Surg"},{"issue":"6","key":"10.1016\/j.jos.2025.12.009_bib34","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1167\/iovs.05-1491","article-title":"Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane","volume":"47","author":"Li","year":"2006","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.jos.2025.12.009_bib35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2018.00294","article-title":"Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction","volume":"9","author":"Cho","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jos.2025.12.009_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jim.2018.03.006","article-title":"Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis","volume":"457","author":"Movila","year":"2018","journal-title":"J Immunol Methods"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib37","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1038\/s41467-024-54407-7","article-title":"NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to- mesenchymal transition in mice","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jos.2025.12.009_bib38","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1083\/jcb.201110058","article-title":"DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis","volume":"197","author":"Mitra","year":"2012","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.jos.2025.12.009_bib39","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/s41467-022-30619-7","article-title":"Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy","volume":"13","author":"Boyer","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jos.2025.12.009_bib40","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161638","article-title":"A mitofusin 2\/HIF1\u03b1 axis sets a maturation checkpoint in regenerating skeletal muscle","volume":"132","author":"Wang","year":"2022","journal-title":"J Clin Investig"},{"issue":"7","key":"10.1016\/j.jos.2025.12.009_bib41","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0041-0101(96)00215-2","article-title":"Protection by the heavy metal chelator N,N,N\u2019,N\u2019-tetrakis (2- pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B","volume":"35","author":"Adler","year":"1997","journal-title":"Toxicon"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265826000096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265826000096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:46:44Z","timestamp":1785901604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265826000096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0949265826000096"],"URL":"https:\/\/doi.org\/10.1016\/j.jos.2025.12.009","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc chelation therapy mitigates muscle fibrosis and improves functional outcomes in a murine model of crush syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jos.2025.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The Japanese Orthopaedic Association.","name":"copyright","label":"Copyright"}]}}