{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:20:14Z","timestamp":1787948414605,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Science"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jos.2026.08.005","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:26:08Z","timestamp":1787862368000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diclofenac etalhyaluronate provides cartilage-protective effects in a mouse model of knee osteoarthritis"],"prefix":"10.1016","author":[{"given":"Yuta","family":"Yanagihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jos.2026.08.005_bib1","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the global burden of disease study 2021","volume":"5","author":"Collaborators","year":"2023","journal-title":"Lancet Rheumatol"},{"issue":"12","key":"10.1016\/j.jos.2026.08.005_bib2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.joca.2022.09.003","article-title":"Osteoarthritis year in review 2022: biology","volume":"30","author":"Han","year":"2022","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.jos.2026.08.005_bib3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI95147","article-title":"Senescent cells and osteoarthritis: a painful connection","volume":"128","author":"Jeon","year":"2018","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.jos.2026.08.005_bib4","doi-asserted-by":"crossref","first-page":"592","DOI":"10.14336\/AD.2022.0831","article-title":"How are aging and osteoarthritis related?","volume":"14","author":"Wakale","year":"2023","journal-title":"Aging Dis"},{"key":"10.1016\/j.jos.2026.08.005_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2025.1523027","article-title":"Recent advances in the management of knee osteoarthritis: a narrative review","volume":"12","author":"Shtroblia","year":"2025","journal-title":"Front Med"},{"issue":"4","key":"10.1016\/j.jos.2026.08.005_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2021.100212","article-title":"Challenges and opportunities of pharmacological interventions for osteoarthritis: a review of current clinical trials and developments","volume":"3","author":"Vrouwe","year":"2021","journal-title":"Osteoarthr Cartil Open"},{"issue":"9","key":"10.1016\/j.jos.2026.08.005_bib7","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/art.41725","article-title":"Efficacy and safety of diclofenac-hyaluronate conjugate (Diclofenac etalhyaluronate) for knee osteoarthritis: a randomized phase III trial in Japan","volume":"73","author":"Nishida","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib8","article-title":"Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes","volume":"20","author":"Kisukeda","year":"2019","journal-title":"BMC Muscoskelet Disord"},{"issue":"9","key":"10.1016\/j.jos.2026.08.005_bib9","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.jos.2026.08.005_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2023.100409","article-title":"Establishment of a uniform histological evaluation method for early stage osteophytes in the destabilization of the medial meniscus mouse model","volume":"5","author":"Jono","year":"2023","journal-title":"Osteoarthr Cartil Open"},{"issue":"Suppl 3","key":"10.1016\/j.jos.2026.08.005_bib11","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"10.1016\/j.jos.2026.08.005_bib12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"7","key":"10.1016\/j.jos.2026.08.005_bib13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1671-x","article-title":"BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing","volume":"20","author":"Alpern","year":"2019","journal-title":"Genome Biol"},{"issue":"8","key":"10.1016\/j.jos.2026.08.005_bib15","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.190116","article-title":"Biochemical analysis of nucleosome targeting by Tn5 transposase","volume":"9","author":"Sato","year":"2019","journal-title":"Open Biol"},{"issue":"12","key":"10.1016\/j.jos.2026.08.005_bib16","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1101\/gr.177881.114","article-title":"Tn5 transposase and tagmentation procedures for massively scaled sequencing projects","volume":"24","author":"Picelli","year":"2014","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinf"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib18","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.jos.2026.08.005_bib19","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1097\/CORR.0000000000000486","article-title":"Cochrane in CORR(R): topical NSAIDs for chronic musculoskeletal pain in adults","volume":"476","author":"Adili","year":"2018","journal-title":"Clin Orthop Relat Res"},{"issue":"10090","key":"10.1016\/j.jos.2026.08.005_bib20","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S0140-6736(17)31744-0","article-title":"Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis","volume":"390","author":"da Costa","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jos.2026.08.005_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/srep32790","article-title":"Intra-articular hyaluronic acid in treating knee osteoarthritis: a PRISMA-Compliant systematic review of overlapping meta-analysis","volume":"6","author":"Xing","year":"2016","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.jos.2026.08.005_bib22","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.jos.2026.08.005_bib23","article-title":"Pain relief improves key motor functions in refractory advanced knee osteoarthritis","volume":"17","author":"Ishii","year":"2025","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib24","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41598-018-21184-5","article-title":"Early changes of articular cartilage and subchondral bone in the DMM mouse model of osteoarthritis","volume":"8","author":"Fang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jos.2026.08.005_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/19476035251393818","article-title":"Mechanistic insights into cartilage protection and extracellular matrix remodeling: transcriptome analysis of diclofenac Etalhyaluronate-Treated knee cartilage in collagen-induced arthritis rats and cytokine-stimulated human chondrocytes","author":"Kitani","year":"2025","journal-title":"Cartilage"},{"issue":"1","key":"10.1016\/j.jos.2026.08.005_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ"},{"issue":"22","key":"10.1016\/j.jos.2026.08.005_bib27","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s00018-020-03524-9","article-title":"P53 vs NF-\u03baB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa","volume":"77","author":"Carr\u00e0","year":"2020","journal-title":"Cell Mol Life Sci"}],"container-title":["Journal of Orthopaedic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265826002381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0949265826002381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:56:05Z","timestamp":1787946965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0949265826002381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":27,"alternative-id":["S0949265826002381"],"URL":"https:\/\/doi.org\/10.1016\/j.jos.2026.08.005","relation":{},"ISSN":["0949-2658"],"issn-type":[{"value":"0949-2658","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diclofenac etalhyaluronate provides cartilage-protective effects in a mouse model of knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jos.2026.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The Japanese Orthopaedic Association.","name":"copyright","label":"Copyright"}]}}