{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:29:15Z","timestamp":1772688555169,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,23]],"date-time":"2027-01-23T00:00:00Z","timestamp":1800662400000},"content-version":"am","delay-in-days":267,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsatjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Substance Use and Addiction Treatment"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.josat.2026.209904","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:51:51Z","timestamp":1768776711000},"page":"209904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Assessing the impact of nicotinic partial agonists compared to NRT on opioid and cigarette use: A secondary analysis investigating treatment outcomes for co-occurring nicotine and opioid use"],"prefix":"10.1016","volume":"184","author":[{"given":"Zachary C.","family":"Rich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary A.","family":"Tindle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie M.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Gnatienko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Bendiks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Patts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Krupitsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Freiberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey H.","family":"Samet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10037","key":"10.1016\/j.josat.2026.209904_bb0005","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/S0140-6736(16)30272-0","article-title":"Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): A double-blind, randomised, placebo-controlled clinical trial","volume":"387","author":"Anthenelli","year":"2016","journal-title":"The Lancet"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jsat.2008.06.003","article-title":"Smoking cessation during substance abuse treatment: What you need to know","volume":"36","author":"Baca","year":"2009","journal-title":"Journal of Substance Abuse Treatment"},{"issue":"3","key":"10.1016\/j.josat.2026.209904_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120581","article-title":"Tobacco-related mortality among persons with mental health and substance abuse problems","volume":"10","author":"Bandiera","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.josat.2026.209904_bb0020","first-page":"CD006103","article-title":"Nicotine receptor partial agonists for smoking cessation. The","volume":"2016","author":"Cahill","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"10.1016\/j.josat.2026.209904_bb0025","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/ntr\/nts274","article-title":"A comparison of cigarette smoking profiles in opioid-dependent pregnant patients receiving methadone or buprenorphine","volume":"15","author":"Chisolm","year":"2013","journal-title":"Nicotine & Tobacco Research"},{"key":"10.1016\/j.josat.2026.209904_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2021.12.030","article-title":"Nicotine and opioid co-dependence: Findings from bench research to clinical trials","volume":"134","author":"Custodio","year":"2022","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"6","key":"10.1016\/j.josat.2026.209904_bb0035","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1037\/pha0000258","article-title":"Pack-years of tobacco cigarette smoking as a predictor of spontaneous pain reporting and experimental pain reactivity","volume":"27","author":"De Vita","year":"2019","journal-title":"Experimental and Clinical Psychopharmacology"},{"issue":"7","key":"10.1016\/j.josat.2026.209904_bb0040","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/j.pain.0000000000000572","article-title":"Acute analgesic effects of nicotine and tobacco in humans: A meta-analysis","volume":"157","author":"Ditre","year":"2016","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0045","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/jamapsychiatry.2024.4801","article-title":"Integrated nicotine replacement and behavioral support to reduce smoking in opioid agonist therapy","volume":"82","author":"Druckrey-Fiskaaen","year":"2025","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1001\/jama.2013.285113","article-title":"Maintenance treatment with Varenicline for smoking cessation in patients with schizophrenia and bipolar disorder: A randomized clinical trial","volume":"311","author":"Evins","year":"2014","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jsat.2007.02.006","article-title":"Cigarette smoking cessation services in outpatient substance abuse treatment programs in the United States","volume":"34","author":"Friedmann","year":"2008","journal-title":"Journal of Substance Abuse Treatment"},{"key":"10.1016\/j.josat.2026.209904_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.drugalcdep.2017.07.043","article-title":"Smoking cessation for substance misusers: A systematic review of qualitative studies on participant and provider beliefs and perceptions","volume":"180","author":"Gentry","year":"2017","journal-title":"Drug and Alcohol Dependence"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0065","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0217","article-title":"The burden of opioid-related mortality in the United States","volume":"1","author":"Gomes","year":"2018","journal-title":"JAMA Network Open"},{"issue":"6","key":"10.1016\/j.josat.2026.209904_bb0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/ntr\/ntr048","article-title":"Smoking prevalence in addiction treatment: A review","volume":"13","author":"Guydish","year":"2011","journal-title":"Nicotine & Tobacco Research"},{"issue":"1","key":"10.1016\/j.josat.2026.209904_bb0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/10550490701756112","article-title":"Cigarette smoking in opioid-using patients presenting for hospital-based medical services","volume":"17","author":"Haas","year":"2008","journal-title":"The American Journal on Addictions"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0080","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.neuropharm.2011.05.026","article-title":"The use-dependent, nicotinic antagonist BTMPS reduces the adverse consequences of morphine self-administration in rats in an abstinence model of drug seeking","volume":"61","author":"Hall","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.josat.2026.209904_bb0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.addbeh.2019.02.017","article-title":"Perceived barriers to quitting cigarettes among hospitalized smokers with substance use disorders: A mixed methods study","volume":"95","author":"Kathuria","year":"2019","journal-title":"Addictive Behaviors"},{"issue":"8","key":"10.1016\/j.josat.2026.209904_bb0090","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1097\/j.pain.0000000000001874","article-title":"Pain, nicotine, and tobacco smoking: Current state of the science","volume":"161","author":"LaRowe","year":"2020","journal-title":"PAIN"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s40429-019-00245-3","article-title":"Mechanisms and clinical features of co-occurring opioid and nicotine use","volume":"6","author":"Lichenstein","year":"2019","journal-title":"Current Addiction Reports"},{"key":"10.1016\/j.josat.2026.209904_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jsat.2019.06.005","article-title":"Smokers with opioid use disorder may have worse drug use outcomes after varenicline than nicotine replacement","volume":"104","author":"Martin","year":"2019","journal-title":"Journal of Substance Abuse Treatment"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0105","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/10550490591003693","article-title":"Benefits of and barriers to providing smoking treatment in methadone clinics: Findings from a national study","volume":"14","author":"McCool","year":"2005","journal-title":"The American Journal on Addictions"},{"key":"10.1016\/j.josat.2026.209904_bb0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsat.2016.12.008","article-title":"Perceived barriers to smoking cessation among adults with substance use disorders","volume":"74","author":"McHugh","year":"2017","journal-title":"Journal of Substance Abuse Treatment"},{"issue":"6","key":"10.1016\/j.josat.2026.209904_bb0115","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/07853890.2012.705016","article-title":"Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: A systematic review and multiple treatment meta-analysis","volume":"44","author":"Mills","year":"2012","journal-title":"Annals of Medicine"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11414-020-09712-6","article-title":"Nicotine and opioids: A call for co-treatment as the standard of care","volume":"47","author":"Morris","year":"2020","journal-title":"The Journal of Behavioral Health Services & Research"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0125","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/add.15240","article-title":"Effect of varenicline directly observed therapy versus varenicline self-administered therapy on varenicline adherence and smoking cessation in methadone-maintained smokers: A randomized controlled trial","volume":"116","author":"Nahvi","year":"2021","journal-title":"Addiction (Abingdon, England)"},{"issue":"9","key":"10.1016\/j.josat.2026.209904_bb0130","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/add.12631","article-title":"Varenicline efficacy and safety among methadone maintained smokers: A randomized placebo-controlled trial","volume":"109","author":"Nahvi","year":"2014","journal-title":"Addiction"},{"issue":"11","key":"10.1016\/j.josat.2026.209904_bb0135","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.addbeh.2006.01.006","article-title":"Cigarette smoking and interest in quitting in methadone maintenance patients","volume":"31","author":"Nahvi","year":"2006","journal-title":"Addictive Behaviors"},{"issue":"1\u20132","key":"10.1016\/j.josat.2026.209904_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.drugalcdep.2012.12.026","article-title":"Low incidence of adverse events following varenicline initiation among opioid dependent smokers with comorbid psychiatric illness","volume":"132","author":"Nahvi","year":"2013","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.josat.2026.209904_bb0145","first-page":"1081","article-title":"The health consequences of smoking\u201450 years of Progress: A report of the surgeon general","author":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health","year":"2014","journal-title":"Centers for Disease Control and Prevention (US)"},{"issue":"1","key":"10.1016\/j.josat.2026.209904_bb0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12971-015-0042-y","article-title":"Prevalence of smoking in adults with chronic pain","volume":"13","author":"Orhurhu","year":"2015","journal-title":"Tobacco Induced Diseases"},{"key":"10.1016\/j.josat.2026.209904_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.addbeh.2020.106358","article-title":"Effects of tobacco on affect and craving during opioid addiction recovery: An ecological momentary assessment study","volume":"106","author":"Rhodes","year":"2020","journal-title":"Addictive Behaviors"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0160","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/jama.2023.10042","article-title":"Cytisinicline for smoking cessation: A randomized clinical trial","volume":"330","author":"Rigotti","year":"2023","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.josat.2026.209904_bb0165","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/add.13861","article-title":"Varenicline versus nicotine patch with brief advice for smokers with substance use disorders with or without depression: Effects on smoking, substance use and depressive symptoms","volume":"112","author":"Rohsenow","year":"2017","journal-title":"Addiction"},{"issue":"6","key":"10.1016\/j.josat.2026.209904_bb0170","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/SLA.0b013e31824f632d","article-title":"Wound healing and infection in surgery: The pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: A systematic review","volume":"255","author":"S\u00f8rensen","year":"2012","journal-title":"Annals of Surgery"},{"issue":"2","key":"10.1016\/j.josat.2026.209904_bb0175","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.drugalcdep.2013.07.005","article-title":"Varenicline for smoking cessation among methadone-maintained smokers: A randomized clinical trial","volume":"133","author":"Stein","year":"2013","journal-title":"Drug and Alcohol Dependence"},{"issue":"8","key":"10.1016\/j.josat.2026.209904_bb0180","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.25129","article-title":"Effectiveness of Varenicline and Cytisine for alcohol use reduction among people with HIV and substance use: A randomized clinical trial","volume":"5","author":"Tindle","year":"2022","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.josat.2026.209904_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.conctc.2020.100625","article-title":"Design of a randomized controlled trial of smoking cessation medications for alcohol reduction among HIV-positive heavy drinkers and daily smokers in St. Petersburg, Russia","volume":"19","author":"Tindle","year":"2020","journal-title":"Contemporary Clinical Trials Communications"},{"issue":"4","key":"10.1016\/j.josat.2026.209904_bb0190","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s40263-020-00701-z","article-title":"Achieving smoking cessation among persons with opioid use disorder","volume":"34","author":"Vlad","year":"2020","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.josat.2026.209904_bb0195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/1874473711306010009","article-title":"Cigarette smoking in methadone maintained patients: An up-to-date review","volume":"6","author":"Zirakzadeh","year":"2013","journal-title":"Current Drug Abuse Reviews"}],"container-title":["Journal of Substance Use and Addiction Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S294987592600024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S294987592600024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:28:20Z","timestamp":1772681300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S294987592600024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":39,"alternative-id":["S294987592600024X"],"URL":"https:\/\/doi.org\/10.1016\/j.josat.2026.209904","relation":{},"ISSN":["2949-8759"],"issn-type":[{"value":"2949-8759","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the impact of nicotinic partial agonists compared to NRT on opioid and cigarette use: A secondary analysis investigating treatment outcomes for co-occurring nicotine and opioid use","name":"articletitle","label":"Article Title"},{"value":"Journal of Substance Use and Addiction Treatment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.josat.2026.209904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"209904"}}