{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:36:45Z","timestamp":1794483405956,"version":"4.9.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jsatjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Substance Use and Addiction Treatment"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.josat.2026.209996","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:50:28Z","timestamp":1777132228000},"page":"209996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Varenicline for nicotine cessation in youth: A meta-analysis of randomized controlled trials addressing FDA labeling gaps in age and product use"],"prefix":"10.1016","volume":"188","author":[{"given":"Joo Young","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Joon","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.josat.2026.209996_bb0005","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0895-4356(97)00049-8","article-title":"The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials","volume":"50","author":"Bucher","year":"1997","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1016\/j.josat.2026.209996_bb0010","article-title":"Nicotine receptor partial agonists for smoking cessation","volume":"5","author":"Cahill","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"10.1016\/j.josat.2026.209996_bb0015","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1176\/appi.ajp.160.6.1041","article-title":"Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability","volume":"160","author":"Chambers","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.josat.2026.209996_bb0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemporary Clinical Trials"},{"key":"10.1016\/j.josat.2026.209996_bb0025","series-title":"Principles of frontal lobe function","first-page":"201","article-title":"Normal development of prefrontal cortex from birth to young adulthood: Cognitive functions, anatomy, and biochemistry","volume":"466","author":"Diamond","year":"2002"},{"issue":"7109","key":"10.1016\/j.josat.2026.209996_bb0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"bmj"},{"issue":"21","key":"10.1016\/j.josat.2026.209996_bb0035","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1001\/jama.2025.3810","article-title":"Varenicline for youth nicotine vaping cessation: A randomized clinical trial","volume":"333","author":"Evins","year":"2025","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.296.1.47","article-title":"Varenicline, an \u03b14\u03b22 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: A randomized controlled trial","volume":"296","author":"Gonzales","year":"2006","journal-title":"Jama"},{"key":"10.1016\/j.josat.2026.209996_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fnsyn.2012.00003","article-title":"Nicotine exposure during adolescence alters the rules for prefrontal cortical synaptic plasticity during adulthood","volume":"4","author":"Goriounova","year":"2012","journal-title":"Frontiers in Synaptic Neuroscience"},{"issue":"2","key":"10.1016\/j.josat.2026.209996_bb0050","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ntr\/ntr130","article-title":"Varenicline versus bupropion XL for smoking cessation in older adolescents: A randomized, double-blind pilot trial","volume":"14","author":"Gray","year":"2012","journal-title":"Nicotine & Tobacco Research"},{"issue":"12","key":"10.1016\/j.josat.2026.209996_bb0055","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1001\/jamapediatrics.2019.3553","article-title":"Efficacy and safety of varenicline for adolescent smoking cessation: A randomized clinical trial","volume":"173","author":"Gray","year":"2019","journal-title":"JAMA Pediatrics"},{"issue":"11","key":"10.1016\/j.josat.2026.209996_bb0060","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S2352-4642(20)30243-1","article-title":"High-dose and low-dose varenicline for smoking cessation in adolescents: A randomised, placebo-controlled trial","volume":"4","author":"Gray","year":"2020","journal-title":"the Lancet Child & Adolescent Health"},{"issue":"12","key":"10.1016\/j.josat.2026.209996_bb0065","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/sim.791","article-title":"On tests of the overall treatment effect in meta-analysis with normally distributed responses","volume":"20","author":"Hartung","year":"2001","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.josat.2026.209996_bb0070","series-title":"Cochrane handbook for systematic reviews of interventions version 6.0 (updated July 2019)","author":"Higgins","year":"2019"},{"issue":"11","key":"10.1016\/j.josat.2026.209996_bb0075","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statistics in Medicine"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-14-25","article-title":"The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method","volume":"14","author":"IntHout","year":"2014","journal-title":"BMC Medical Research Methodology"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Controlled Clinical Trials"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/jama.296.1.56","article-title":"Efficacy of varenicline, an \u03b14\u03b22 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial","volume":"296","author":"Jorenby","year":"2006","journal-title":"Jama"},{"key":"10.1016\/j.josat.2026.209996_bb0095","series-title":"Current electronic cigarette use among adults aged 18 and over: United States, 2021","author":"Kramarow","year":"2023"},{"issue":"6","key":"10.1016\/j.josat.2026.209996_bb0100","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/00004583-200006000-00006","article-title":"A review of tobacco smoking in adolescents: Treatment implications","volume":"39","author":"Moolchan","year":"2000","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"issue":"11","key":"10.1016\/j.josat.2026.209996_bb0105","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/ntr\/nty180","article-title":"Efficacy of pharmacotherapy for smoking cessation in adolescent smokers: A meta-analysis of randomized controlled trials","volume":"21","author":"Myung","year":"2019","journal-title":"Nicotine and Tobacco Research"},{"issue":"5","key":"10.1016\/j.josat.2026.209996_bb0110","doi-asserted-by":"crossref","first-page":"696","DOI":"10.5811\/westjem.2019.7.41661","article-title":"Nicotine gateway effects on adolescent substance use","volume":"20","author":"Ren","year":"2019","journal-title":"The Western Journal of Emergency Medicine"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0115","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1001\/jamainternmed.2023.5239","article-title":"Shift from smoking cigarettes to vaping nicotine in young adults","volume":"184","author":"Sanford","year":"2024","journal-title":"JAMA Internal Medicine"},{"issue":"5","key":"10.1016\/j.josat.2026.209996_bb0120","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/ADM.0000000000001171","article-title":"Effectiveness and safety of varenicline for smoking cessation: An overview and meta-analysis","volume":"17","author":"Shang","year":"2023","journal-title":"Journal of Addiction Medicine"},{"key":"10.1016\/j.josat.2026.209996_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2025.112884","article-title":"Efficacy and safety of Varenicline for electronic cigarette cessation: A systematic review and meta-analysis","volume":"276","author":"Sobral","year":"2025","journal-title":"Drug and Alcohol Dependence"},{"issue":"1","key":"10.1016\/j.josat.2026.209996_bb0130","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/bcpt.12548","article-title":"Varenicline and nicotine patch therapies in young adults motivated to quit smoking: A randomized, placebo-controlled, prospective study","volume":"119","author":"Tuisku","year":"2016","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"10.1016\/j.josat.2026.209996_bb0135","author":"U.S. Food and Drug Administration"},{"key":"10.1016\/j.josat.2026.209996_bb0140","series-title":"Preventing tobacco use among youth and young adults: A report of the surgeon general","author":"United States. Public Health Service. Office of the Surgeon General","year":"2012"},{"key":"10.1016\/j.josat.2026.209996_bb0145","series-title":"E-cigarette use among youth and young adults-a report of the surgeon general","author":"US Department of Health and Human Services","year":"2016"},{"issue":"6","key":"10.1016\/j.josat.2026.209996_bb0150","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jadohealth.2019.02.019","article-title":"Adolescents\u2019 E-cigarette use: Increases in frequency, dependence, and nicotine exposure over 12 months","volume":"64","author":"Vogel","year":"2019","journal-title":"Journal of Adolescent Health"},{"key":"10.1016\/j.josat.2026.209996_bb0155","series-title":"Media centre: Tobacco","author":"World Health Organization","year":"2019"}],"container-title":["Journal of Substance Use and Addiction Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949875926001165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949875926001165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:10:05Z","timestamp":1794481805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949875926001165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S2949875926001165"],"URL":"https:\/\/doi.org\/10.1016\/j.josat.2026.209996","relation":{},"ISSN":["2949-8759"],"issn-type":[{"value":"2949-8759","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Varenicline for nicotine cessation in youth: A meta-analysis of randomized controlled trials addressing FDA labeling gaps in age and product use","name":"articletitle","label":"Article Title"},{"value":"Journal of Substance Use and Addiction Treatment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.josat.2026.209996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"209996"}}