{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:46:01Z","timestamp":1790196361555,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572131, 81301341"],"award-info":[{"award-number":["81572131, 81301341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20151210"],"award-info":[{"award-number":["BK20151210"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jot.2017.05.002","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:30:28Z","timestamp":1495575028000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["Macrophages and bone inflammation"],"prefix":"10.1016","volume":"10","author":[{"given":"Qiaoli","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2017.05.002_bib1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jot.2017.05.002_bib2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bone.2012.08.121","article-title":"Osteocyte control of osteoclastogenesis","volume":"54","author":"O'Brien","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.jot.2017.05.002_bib3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jot.2017.05.002_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/SPC.0000000000000090","article-title":"Role of osteocytes in multiple myeloma bone disease","volume":"8","author":"Delgado-Calle","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.jot.2017.05.002_bib5","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1182\/blood-2006-07-037994","article-title":"B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in\u00a0vivo","volume":"109","author":"Li","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jot.2017.05.002_bib6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1600-0765.1989.tb00887.x","article-title":"Increased periodontal bone loss in temporarily B lymphocyte-deficient rats","volume":"24","author":"Klausen","year":"1989","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jot.2017.05.002_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jot.2017.05.002_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bone.2016.01.010","article-title":"Proinflammatory T cells and IL-17 stimulate osteoblast differentiation","volume":"84","author":"Croes","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.jot.2017.05.002_bib9","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.injury.2016.10.008","article-title":"The roles of immune cells in bone healing; what we know, do not know and future perspectives","volume":"47","author":"El-Jawhari","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.jot.2017.05.002_bib10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1136\/ard.2009.121764","article-title":"Baseline RANKL: OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis","volume":"69","author":"van Tuyl","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2017.05.002_bib11","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in\u00a0vitro and in\u00a0vivo","volume":"181","author":"Chang","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib12","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jbmr.2422","article-title":"Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis","volume":"30","author":"Vi","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2017.05.002_bib13","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.ajpath.2014.08.017","article-title":"Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification","volume":"184","author":"Raggatt","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jot.2017.05.002_bib14","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-resident macrophages","volume":"14","author":"Davies","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jot.2017.05.002_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imr.12223","article-title":"Macrophage heterogeneity in tissues: phenotypic diversity and functions","volume":"262","author":"Gordon","year":"2014","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jot.2017.05.002_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/imm.12608","article-title":"Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation","volume":"148","author":"Wu","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.jot.2017.05.002_bib18","doi-asserted-by":"crossref","first-page":"2795090","DOI":"10.1155\/2016\/2795090","article-title":"The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases","volume":"2016","author":"Tan","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jot.2017.05.002_bib19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3389\/fimmu.2014.00683","article-title":"Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages","volume":"5","author":"Dey","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3389\/fimmu.2014.00620","article-title":"Macrophage: SHIP of immunity","volume":"5","author":"Mills","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/jcs.66.1.189","article-title":"The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4\/80: macrophages of bone and associated connective tissue","volume":"66","author":"Hume","year":"1984","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jot.2017.05.002_bib23","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1359\/jbmr.070518","article-title":"Quantifying osteoblast and osteocyte apoptosis: challenges and rewards","volume":"22","author":"Jilka","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2017.05.002_bib24","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in\u00a0vivo intramembranous bone healing in a mouse tibial injury model","volume":"26","author":"Alexander","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jot.2017.05.002_bib25","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1073\/pnas.1315153111","article-title":"Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone","volume":"111","author":"Cho","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jot.2017.05.002_bib26","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/stem.1040","article-title":"Induction of osteogenesis in mesenchymal stem cells by activated monocytes\/macrophages depends on oncostatin M signaling","volume":"30","author":"Guihard","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.jot.2017.05.002_bib27","doi-asserted-by":"crossref","first-page":"e73266","DOI":"10.1371\/journal.pone.0073266","article-title":"Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent manner","volume":"8","author":"Fernandes","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2017.05.002_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12016-015-8519-2","article-title":"Macrophage polarization and bone formation: a review","volume":"51","author":"Horwood","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0394632015593228","article-title":"TNF-a mediated inflammatory macrophage polarization contributes to the pathogenesis of steroid-induced osteonecrosis in mice","volume":"28","author":"Wu","year":"2015","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jot.2017.05.002_bib30","doi-asserted-by":"crossref","first-page":"9853","DOI":"10.1016\/j.biomaterials.2014.08.025","article-title":"Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization","volume":"35","author":"Ma","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib31","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2016.0346","article-title":"In\u00a0vitro response of macrophages to ceramic scaffolds used for bone\u00a0regeneration","volume":"13","author":"Graney","year":"2016","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.jot.2017.05.002_bib32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biomaterials.2015.04.044","article-title":"The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated beta-tricalcium phosphate","volume":"61","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mattod.2015.01.019","article-title":"Biomaterial based modulation of macrophage polarization: a review and suggested design principles","volume":"18","author":"Sridharan","year":"2015","journal-title":"Mater Today"},{"key":"10.1016\/j.jot.2017.05.002_bib34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.actbio.2015.12.003","article-title":"Titanium surface characteristics, including topography and wettability, alter macrophage activation","volume":"31","author":"Hotchkiss","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2017.05.002_bib35","doi-asserted-by":"crossref","first-page":"085101","DOI":"10.1088\/0957-4484\/27\/8\/085101","article-title":"Modulating macrophage polarization with divalent cations in nanostructured titanium implant surfaces","volume":"27","author":"Lee","year":"2016","journal-title":"Nanotechnology"},{"key":"10.1016\/j.jot.2017.05.002_bib36","first-page":"65","article-title":"The macrophage polarization regulates MSC osteoblast differentiation in\u00a0vitro","volume":"46","author":"Gong","year":"2016","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.jot.2017.05.002_bib37","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.biomaterials.2013.11.014","article-title":"Osteogenic differentiation of bone marrow MSCs by beta-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway","volume":"35","author":"Chen","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2017.05.002_bib39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0020-1383(97)00062-4","article-title":"The early stages of the repair of adult human diaphyseal fractures","volume":"28","author":"Oni","year":"1997","journal-title":"Injury"},{"key":"10.1016\/j.jot.2017.05.002_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1242\/dmm.003186","article-title":"Multiple roles for CCR2 during fracture healing","volume":"3","author":"Xing","year":"2010","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jot.2017.05.002_bib41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.bor.0000231911.42666.78","article-title":"Cytokines regulating osteoclast formation and function","volume":"18","author":"Lee","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jot.2017.05.002_bib42","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bone.2007.07.022","article-title":"Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice","volume":"41","author":"Yang","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jot.2017.05.002_bib43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S8756-3282(01)00638-X","article-title":"Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2","volume":"30","author":"Champagne","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.jot.2017.05.002_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ajpath.2014.11.008","article-title":"Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury","volume":"185","author":"Guihard","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jot.2017.05.002_bib45","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.autrev.2013.03.015","article-title":"Biologic therapies and systemic bone loss in rheumatoid arthritis","volume":"12","author":"Dimitroulas","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jot.2017.05.002_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/annrheumdis-2014-206921","article-title":"Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis","volume":"75","author":"Yeo","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2017.05.002_bib47","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1002\/art.22964","article-title":"Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: implications for use of synovial sublining macrophages as a biomarker","volume":"56","author":"Wijbrandts","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib48","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/art.24505","article-title":"The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases","volume":"60","author":"Hamilton","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib49","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4049\/jimmunol.1303188","article-title":"Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats","volume":"194","author":"Kou","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib50","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1196\/annals.1386.043","article-title":"Estrogens and autoimmune diseases","volume":"1089","author":"Cutolo","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jot.2017.05.002_bib51","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.jot.2017.05.002_bib52","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/art.21662","article-title":"CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway","volume":"54","author":"Ruth","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib53","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1002\/art.24075","article-title":"Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis","volume":"58","author":"Egan","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib54","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1002\/art.27622","article-title":"Role of Th17 cells in human autoimmune arthritis","volume":"62","author":"Leipe","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib55","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/cei.12712","article-title":"Synovial macrophage-derived IL-1beta regulates the calcitonin receptor in osteoarthritic mice","volume":"183","author":"Takano","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11926-016-0605-9","article-title":"Is synovial macrophage activation the inflammatory link between obesity and osteoarthritis?","volume":"18","author":"Sun","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jot.2017.05.002_bib58","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/art.30363","article-title":"Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography\/computed tomography","volume":"63","author":"Piscaer","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jot.2017.05.002_bib59","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/jor.23009","article-title":"Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis","volume":"34","author":"Geurts","year":"2016","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2017.05.002_bib60","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/art.39006","article-title":"Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis","volume":"67","author":"Daghestani","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jot.2017.05.002_bib61","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar2099","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jot.2017.05.002_bib62","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jot.2017.05.002_bib63","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.joca.2016.07.018","article-title":"Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in\u00a0vitro, but not inhibited directly by anti-inflammatory (M2) macrophages","volume":"24","author":"Utomo","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jot.2017.05.002_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.046","article-title":"Inhibition of titanium-particle-induced inflammatory osteolysis after local administration of dopamine and suppression of osteoclastogenesis via D2-like receptor signaling pathway","volume":"80","author":"Yang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib65","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biomaterials.2015.04.048","article-title":"Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model","volume":"60","author":"Shao","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib66","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.actbio.2012.03.042","article-title":"Revision joint replacement, wear particles, and macrophage polarization","volume":"8","author":"Rao","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2017.05.002_bib67","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1007\/s11999-014-3786-4","article-title":"Do genetic susceptibility, Toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear?","volume":"472","author":"Greenfield","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jot.2017.05.002_bib68","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/jor.20275","article-title":"Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris","volume":"24","author":"Rakshit","year":"2006","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jot.2017.05.002_bib69","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biomaterials.2016.10.038","article-title":"Macrophage integrins modulate response to ultra-high molecular weight polyethylene particles and direct particle-induced osteolysis","volume":"115","author":"Zaveri","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2017.05.002_bib70","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5312\/wjo.v6.i2.172","article-title":"Biological response to prosthetic debris","volume":"6","author":"Bitar","year":"2015","journal-title":"World J Orthop"},{"key":"10.1016\/j.jot.2017.05.002_bib71","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jbm.a.35913","article-title":"Correlations between macrophage polarizing cytokines, inflammatory mediators, osteoclast activity, and toll-like receptors in tissues around aseptically loosened hip implants","volume":"105","author":"Jamsen","year":"2017","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.jot.2017.05.002_bib72","doi-asserted-by":"crossref","first-page":"9229","DOI":"10.1016\/j.actbio.2013.06.027","article-title":"The response of macrophages to titanium particles is determined by macrophage polarization","volume":"9","author":"Pajarinen","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jot.2017.05.002_bib73","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/jbm.a.34486","article-title":"Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium","volume":"101","author":"Rao","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.jot.2017.05.002_bib74","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00109-016-1402-7","article-title":"SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis","volume":"94","author":"Park","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jot.2017.05.002_bib75","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.4049\/jimmunol.1402155","article-title":"IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages","volume":"194","author":"Shimizu","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jot.2017.05.002_bib76","doi-asserted-by":"crossref","first-page":"e2524","DOI":"10.1038\/cddis.2016.442","article-title":"Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis","volume":"7","author":"Shin","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jot.2017.05.002_bib77","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/jbm.a.34779","article-title":"Delivery of S1P receptor-targeted drugs via biodegradable polymer scaffolds enhances bone regeneration in a critical size cranial defect","volume":"102","author":"Das","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.jot.2017.05.002_bib78","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.autrev.2012.10.020","article-title":"Different effects of biological drugs in rheumatoid arthritis","volume":"12","author":"Atzeni","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jot.2017.05.002_bib79","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/ard.2006.053272","article-title":"Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade","volume":"65","author":"Grunke","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2017.05.002_bib80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/09273940802204527","article-title":"Infliximab therapy for 2 patients with Vogt-Koyanagi-Harada syndrome","volume":"16","author":"Wang","year":"2008","journal-title":"Ocul Immunol Inflamm"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X17300177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X17300177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:39:30Z","timestamp":1761993570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X17300177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":80,"alternative-id":["S2214031X17300177"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2017.05.002","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophages and bone inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2017.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}