{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:37:26Z","timestamp":1770021446810,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Major State Basic Research Program of China","award":["2014CB942904"],"award-info":[{"award-number":["2014CB942904"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830075"],"award-info":[{"award-number":["81830075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772306"],"award-info":[{"award-number":["81772306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jot.2018.12.001","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T23:33:04Z","timestamp":1546990384000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-6920","authenticated-orcid":false,"given":"Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoyan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengtao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianding","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruobin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2018.12.001_bib1","doi-asserted-by":"crossref","first-page":"f2508","DOI":"10.1136\/bmj.f2508","article-title":"Adolescent idiopathic scoliosis","volume":"346","author":"Altaf","year":"2013","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.jot.2018.12.001_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jspd.2016.05.003","article-title":"Results of the scoliosis Research society morbidity and mortality database 2009\u20132012: a report from the morbidity and mortality committee","volume":"4","author":"Burton","year":"2016","journal-title":"Spine Deformity"},{"issue":"Suppl 3","key":"10.1016\/j.jot.2018.12.001_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00586-018-5604-2","article-title":"The etiology of congenital scoliosis: genetic vs. environmental-a report of three monozygotic twin cases","volume":"27","author":"Cho","year":"2018","journal-title":"Eur Spine J"},{"issue":"9623","key":"10.1016\/j.jot.2018.12.001_bib4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(08)60658-3","article-title":"Adolescent idiopathic scoliosis","volume":"371","author":"Weinstein","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jot.2018.12.001_bib5","first-page":"85","article-title":"Adolescent idiopathic scoliosis: surgical treatment and quality of life","volume":"25","author":"Rodrigues","year":"2017"},{"key":"10.1016\/j.jot.2018.12.001_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13013-016-0105-8","article-title":"Genetics and pathogenesis of idiopathic scoliosis","volume":"11","author":"Grauers","year":"2016","journal-title":"Scoliosis Spinal Disord"},{"key":"10.1016\/j.jot.2018.12.001_bib7","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/ncomms7452","article-title":"A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females","volume":"6","author":"Sharma","year":"2015","journal-title":"Nat Commun"},{"issue":"19","key":"10.1016\/j.jot.2018.12.001_bib8","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1093\/hmg\/ddu224","article-title":"Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis","volume":"23","author":"Buchan","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.jot.2018.12.001_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2639","article-title":"Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis","volume":"45","author":"Kou","year":"2013","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.jot.2018.12.001_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1406829","article-title":"TBX6 null variants and a common hypomorphic allele in congenital scoliosis","volume":"372","author":"Wu","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jot.2018.12.001_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fendo.2015.00038","article-title":"Micro CT analysis of spine architecture in a mouse model of scoliosis","volume":"6","author":"Gao","year":"2015","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.jot.2018.12.001_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","article-title":"Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3","volume":"12","author":"Colvin","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.jot.2018.12.001_bib13","first-page":"8215805","article-title":"Chondrocyte-specific knockout of TSC-1 leads to congenital spinal deformity in mice","volume":"2017","author":"Yang","year":"2017","journal-title":"BioMed Res Int"},{"issue":"10","key":"10.1016\/j.jot.2018.12.001_bib14","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00402-017-2756-1","article-title":"Current insights into the aetiology of adolescent idiopathic scoliosis","volume":"137","author":"Latalski","year":"2017","journal-title":"Arch Orthop Trauma Surg"},{"issue":"6","key":"10.1016\/j.jot.2018.12.001_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.spinee.2016.02.033","article-title":"Trunk imbalance in adolescent idiopathic scoliosis","volume":"16","author":"Fortin","year":"2016","journal-title":"Spine J : official journal of the North American Spine Society"},{"issue":"6","key":"10.1016\/j.jot.2018.12.001_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1442-200X.2006.02277.x","article-title":"Histomorphometric study of the spinal growth plates in idiopathic scoliosis and congenital scoliosis","volume":"48","author":"Zhu","year":"2006","journal-title":"Pediatr Int"},{"issue":"7","key":"10.1016\/j.jot.2018.12.001_bib17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1302\/0301-620X.85B7.14046","article-title":"Relative anterior spinal overgrowth in adolescent idiopathic scoliosis. Results of disproportionate endochondral-membranous bone growth","volume":"85","author":"Guo","year":"2003","journal-title":"J Bone Joint Surg Br Vol"},{"issue":"9","key":"10.1016\/j.jot.2018.12.001_bib18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00586-005-1002-7","article-title":"Relative anterior spinal overgrowth in adolescent idiopathic scoliosis--result of disproportionate endochondral-membranous bone growth? Summary of an electronic focus group debate of the IBSE","volume":"14","author":"Guo","year":"2005","journal-title":"Eur Spine J"},{"issue":"7","key":"10.1016\/j.jot.2018.12.001_bib19","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1302\/0301-620X.85B7.14046","article-title":"Relative anterior spinal overgrowth in adolescent idiopathic scoliosis","volume":"85","author":"Guo","year":"2003","journal-title":"J Bone Joint Surg"},{"issue":"19","key":"10.1016\/j.jot.2018.12.001_bib20","doi-asserted-by":"crossref","first-page":"E1209","DOI":"10.1097\/BRS.0b013e31829e0309","article-title":"Chest cage angle difference and rotation of main thoracic curve are independent risk factors of postoperative shoulder imbalance in surgically treated patients with adolescent idiopathic scoliosis","volume":"38","author":"Yagi","year":"2013","journal-title":"Spine"},{"issue":"12","key":"10.1016\/j.jot.2018.12.001_bib21","doi-asserted-by":"crossref","first-page":"E726","DOI":"10.1097\/BRS.0000000000001946","article-title":"Restrained differential growth: the initiating event of adolescent idiopathic scoliosis?","volume":"42","author":"Crijns","year":"2017","journal-title":"Spine"},{"issue":"6","key":"10.1016\/j.jot.2018.12.001_bib22","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","article-title":"Fibroblast growth factor receptor 3 is a negative regulator of bone growth","volume":"84","author":"Deng","year":"1996","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.jot.2018.12.001_bib23","doi-asserted-by":"crossref","first-page":"E1041","DOI":"10.1097\/BRS.0000000000001060","article-title":"Role of enhanced central leptin activity in a scoliosis model created in bipedal amputated mice","volume":"40","author":"Wu","year":"2015","journal-title":"Spine"},{"issue":"9","key":"10.1016\/j.jot.2018.12.001_bib24","doi-asserted-by":"crossref","first-page":"16484","DOI":"10.3390\/ijms150916484","article-title":"A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis","volume":"15","author":"Wai","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jot.2018.12.001_bib25","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.3892\/mmr.2016.5927","article-title":"Etiopathogenesis of adolescent idiopathic scoliosis: expression of melatonin receptors 1A\/1B, calmodulin and estrogen receptor 2 in deep paravertebral muscles revisited","volume":"14","author":"Zamecnik","year":"2016","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jot.2018.12.001_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-328X(98)00273-3","article-title":"Natural melatonin 'knockdown' in C57BL\/6J mice: rare mechanism truncates serotonin N-acetyltransferase","volume":"63","author":"Roseboom","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"issue":"2","key":"10.1016\/j.jot.2018.12.001_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4184\/asj.2015.9.2.315","article-title":"Response to: evidence-based of nonoperative treatment in adolescent idiopathic scoliosis","volume":"9","author":"Kim","year":"2015","journal-title":"Asian Spine J"},{"key":"10.1016\/j.jot.2018.12.001_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1748-7161-9-14","article-title":"A shallow chest correlates with the aortic position in the normal spine: features resembling those observed in structural scoliosis","volume":"9","author":"Doi","year":"2014","journal-title":"Scoliosis"},{"issue":"1","key":"10.1016\/j.jot.2018.12.001_bib29","first-page":"14","article-title":"Aortic location and flat chest in scoliosis: a prospective study","volume":"102","author":"Doi","year":"2011","journal-title":"Fukuoka Igaku Zasshi"},{"issue":"8","key":"10.1016\/j.jot.2018.12.001_bib30","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/BPO.0b013e31822da7d5","article-title":"Correlations of adolescent idiopathic scoliosis and pectus excavatum","volume":"31","author":"Hong","year":"2011","journal-title":"J Pediatr Orthoped"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X18301761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X18301761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:40:51Z","timestamp":1761993651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X18301761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":30,"alternative-id":["S2214031X18301761"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2018.12.001","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}