{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:59:18Z","timestamp":1783742358192,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673144"],"award-info":[{"award-number":["51673144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600769"],"award-info":[{"award-number":["31600769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871777"],"award-info":[{"award-number":["81871777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jot.2020.04.007","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:34:30Z","timestamp":1589848470000},"page":"76-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["MiR-21 nanocapsules promote\u00a0early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2049-1997","authenticated-orcid":false,"given":"Xiaolei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-038X","authenticated-orcid":false,"given":"Hongzhao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2020.04.007_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11914-012-0096-1","article-title":"Intercellular cross-talk among bone cells: new factors and pathways","volume":"10","author":"Sims","year":"2012","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jot.2020.04.007_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.abb.2008.03.027","article-title":"Osteoclast-osteoblast communication","volume":"473","author":"Matsuo","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jot.2020.04.007_bib3","first-page":"4","article-title":"Osteoporosis: teriparatide preferable for fracture prevention","volume":"14","author":"Collison","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2020.04.007_bib4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1302\/0301-620X.88B6.17524","article-title":"The role of growth factors and related agents in accelerating fracture healing","volume":"88","author":"Simpson","year":"2006","journal-title":"J\u00a0Bone Jt Surg Br Vol"},{"key":"10.1016\/j.jot.2020.04.007_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2106\/00004623-200206000-00022","article-title":"The role of growth factors in the repair of bone","volume":"84","author":"Lieberman","year":"2002","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"issue":"Suppl 1","key":"10.1016\/j.jot.2020.04.007_bib6","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/S0020-1383(16)30003-1","article-title":"F\u00e9ron Fracture repair: general aspects and influence of osteoporosis and anti-osteoporosis treatment","volume":"47","author":"F\u00e9ron","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.jot.2020.04.007_bib7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2018.03.034","article-title":"Bone regeneration in osteoporosis by delivery BMP-2 and PRGF from tetronic-alginate composite thermogel","volume":"543","author":"Segredo-Morales","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jot.2020.04.007_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2018.05.025","article-title":"Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice","volume":"114","author":"Yang","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.jot.2020.04.007_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jor.23822","article-title":"MicroRNAs in orthopaedic research: disease associations, potential therapeutic applications, and perspectives","volume":"36","author":"McAlinden","year":"2018","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.jot.2020.04.007_bib10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/wrna.1208","article-title":"The origin, function, and diagnostic potential of extracellular microRNAs in human body fluids","volume":"5","author":"Liang","year":"2014","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10.1016\/j.jot.2020.04.007_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11914-018-0417-0","article-title":"Regulation of bone metabolism by microRNAs","volume":"16","author":"Hanna","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jot.2020.04.007_bib12","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/jcb.24479","article-title":"miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation","volume":"114","author":"Mei","year":"2013","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jot.2020.04.007_bib13","first-page":"709","article-title":"Expression of microRNA-21 in osteoporotic patients and its involvement in the regulation of osteogenic differentiation","volume":"17","author":"Zhao","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jot.2020.04.007_bib14","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00007632-200208151-00010","article-title":"Safety profile for the clinical use of bone morphogenetic proteins in the spine","volume":"27","author":"Poynton","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.jot.2020.04.007_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejpb.2004.03.004","article-title":"Localized delivery of growth factors for bone repair","volume":"58","author":"Luginbuehl","year":"2004","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.jot.2020.04.007_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10517-008-0065-y","article-title":"Antiparkinsonian effect of nerve growth factor adsorbed on polybutylcyanoacrylate nanoparticles coated with polysorbate-80","volume":"145","author":"Kurakhmaeva","year":"2008","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.jot.2020.04.007_bib17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/adma.201403387","article-title":"Efficient delivery of therapeutic miRNA nanocapsules for tumor suppression","volume":"27","author":"Liu","year":"2015","journal-title":"Adv. Mater"},{"key":"10.1016\/j.jot.2020.04.007_bib18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/1354750X.2014.935957","article-title":"Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients","volume":"19","author":"Li","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.jot.2020.04.007_bib19","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.injury.2018.04.016","article-title":"The biology of fracture healing in osteoporosis and in the presence of anti-osteoporotic drugs","volume":"49","author":"Hak","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.jot.2020.04.007_bib20","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00113-019-0669-x","article-title":"Influence of specific osteoporosis drugs on fracture healing","volume":"122","author":"Hesse","year":"2019","journal-title":"Unfallchirurg"},{"key":"10.1016\/j.jot.2020.04.007_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/rheumatology\/kex429","article-title":"Comment on: patients' preferences for anti-osteoporosis drug treatment: a cross-European discrete choice experiment","volume":"57","author":"Armstrong","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.jot.2020.04.007_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00198-017-4320-9","article-title":"Bisphosphonate drug holidays in postmenopausal osteoporosis: effect on clinical fracture risk. Response to comments by Bredemeier","volume":"29","author":"Paccou","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2020.04.007_bib23","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1002\/jcp.26297","article-title":"Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway","volume":"233","author":"Wu","year":"2018","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jot.2020.04.007_bib24","doi-asserted-by":"crossref","first-page":"D360","DOI":"10.1093\/nar\/gkx1144","article-title":"mirDIP 4.1-integrative database of human microRNA target predictions","volume":"46","author":"Tokar","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jot.2020.04.007_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000438607","article-title":"MicroRNA-320a regulates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting HOXA10","volume":"38","author":"Huang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jot.2020.04.007_bib26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/jor.22884","article-title":"microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K\/\u03b2-catenin pathway","volume":"33","author":"Meng","year":"2015","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.jot.2020.04.007_bib27","doi-asserted-by":"crossref","first-page":"115105","DOI":"10.1016\/j.bone.2019.115105","article-title":"Serum microRNAs as novel biomarkers for osteoporotic vertebral fractures","volume":"130","author":"Zarecki","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.jot.2020.04.007_bib28","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3889\/oamjms.2019.271","article-title":"Effect of exercises on quality of life in patients with postmenopausal osteoporosis-randomized trial","volume":"7","author":"Koevska","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.jot.2020.04.007_bib29","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0020-1383(16)47004-X","article-title":"Fracture healing in osteoporotic bone","volume":"47","author":"Cheung","year":"2016","journal-title":"Injury"},{"key":"10.1016\/j.jot.2020.04.007_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.22203\/eCM.v037a25","article-title":"A\u00a0metaphyseal fracture rat model for mechanistic studies of osteoporotic bone healing","volume":"37","author":"Wong","year":"2019","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.jot.2020.04.007_bib31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1055\/s-0029-1240798","article-title":"Effects of black cohosh (Cimicifuga racemosa) and estrogen on metaphyseal fracture healing in the early stage of osteoporosis in ovariectomized rats","volume":"76","author":"Kolios","year":"2010","journal-title":"Planta Med"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:40:45Z","timestamp":1761993645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X20300632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":31,"alternative-id":["S2214031X20300632"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2020.04.007","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-21 nanocapsules promote\u00a0early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2020.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}