{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:41:25Z","timestamp":1777531285130,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["5150010028"],"award-info":[{"award-number":["5150010028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171773"],"award-info":[{"award-number":["81171773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1104900"],"award-info":[{"award-number":["2017YFC1104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2019YFS0122"],"award-info":[{"award-number":["2019YFS0122"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jot.2020.06.004","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:59:23Z","timestamp":1601326763000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["An animal model of early-stage femoral head osteonecrosis induced by cryo-insult in small tailed Han sheep"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-0777","authenticated-orcid":false,"given":"Cairu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2020.06.004_bib1","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.2106\/JBJS.O.00071","article-title":"Nontraumatic osteonecrosis of the femoral head: where do we stand today?: a ten-year update","volume":"97","author":"Mont","year":"2015","journal-title":"J\u00a0Bone Joint Surg"},{"key":"10.1016\/j.jot.2020.06.004_bib2","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2106\/JBJS.I.00575","article-title":"The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review","volume":"92","author":"Mont","year":"2010","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.jot.2020.06.004_bib3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1302\/0301-620X.99B10.BJJ-2017-0233.R2","article-title":"An evidence-based guide to the treatment of osteonecrosis of the femoral head","volume":"99-B","author":"Chughtai","year":"2017","journal-title":"Bone Jt J"},{"key":"10.1016\/j.jot.2020.06.004_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0736-0266(01)00108-5","article-title":"A\u00a0new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure","volume":"20","author":"Conzemius","year":"2002","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.jot.2020.06.004_bib5","article-title":"Steroid-associated hip joint collapse in bipedal emus","volume":"8","author":"Zheng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2020.06.004_bib6","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0021-9290(03)00154-4","article-title":"Focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields","volume":"36","author":"Reed","year":"2003","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.jot.2020.06.004_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.bone.2006.04.018","article-title":"Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone","volume":"39","author":"Qin","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jot.2020.06.004_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.7150\/ijms.6314","article-title":"A\u00a0canine model of femoral head osteonecrosis induced by an ethanol injection navigated by a novel template","volume":"10","author":"Wang","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jot.2020.06.004_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1258\/0023677021912460","article-title":"A\u00a0new animal model of femoral head necrosis induced by intraosseous injection of ethanol","volume":"36","author":"Manggold","year":"2002","journal-title":"Lab Anim"},{"key":"10.1016\/j.jot.2020.06.004_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00013611-200103000-00011","article-title":"Animal models of osteonecrosis","volume":"16","author":"Conzemius","year":"2001","journal-title":"Tech Orthop"},{"key":"10.1016\/j.jot.2020.06.004_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12018-011-9090-x","article-title":"Animal models of osteonecrosis","volume":"9","author":"Jones","year":"2011","journal-title":"Clin Rev Bone Miner Metabol"},{"key":"10.1016\/j.jot.2020.06.004_bib12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.7150\/ijms.30832","article-title":"A\u00a03D printed porous titanium alloy rod with diamond crystal lattice for treatment of the early-stage femoral head osteonecrosis in sheep","volume":"16","author":"Wang","year":"2019","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jot.2020.06.004_bib13","doi-asserted-by":"crossref","first-page":"103738","DOI":"10.1016\/j.jmbbm.2020.103738","article-title":"A\u00a03D printed porous titanium alloy rod with biogenic lamellar configuration for treatment of the early-stage femoral head osteonecrosis in sheep","volume":"106","author":"Wang","year":"2020","journal-title":"J\u00a0Mech Behavior Biomed Mater"},{"key":"10.1016\/j.jot.2020.06.004_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00402-010-1084-5","article-title":"A\u00a0new preclinical femoral head osteonecrosis model in sheep","volume":"131","author":"Velez","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jot.2020.06.004_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00390048","article-title":"Pathological and hemodynamic study in a new model of femoral head necrosis following traumatic dislocation","volume":"116","author":"Nishino","year":"1997","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jot.2020.06.004_bib16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jor.1100110306","article-title":"An experimental canine model of osteonecrosis: characterization of the repair process","volume":"11","author":"Malizos","year":"1993","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.jot.2020.06.004_bib17","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2106\/JBJS.F.00847","article-title":"Histopathologic retrieval analysis of clinically failed porous tantalum osteonecrosis implants","volume":"90","author":"Tanzer","year":"2008","journal-title":"J\u00a0Bone Jt Surg Am"},{"issue":"Suppl 3","key":"10.1016\/j.jot.2020.06.004_bib18","first-page":"48","article-title":"Survivorship analysis and radiographic outcome following tantalum rod insertion for osteonecrosis of the femoral head","volume":"88","author":"Veillette","year":"2006","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.jot.2020.06.004_bib19","doi-asserted-by":"crossref","first-page":"40755","DOI":"10.1038\/srep40755","article-title":"Novel bio-functional magnesium coating on porous Ti6Al4V orthopaedic implants:in vitroandIn vivoStudy","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jot.2020.06.004_bib20","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1016\/j.biomaterials.2014.03.075","article-title":"A\u00a0polycaprolactone-tricalcium phosphate composite scaffold as an autograft-free spinal fusion cage in a sheep model","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jot.2020.06.004_bib21","doi-asserted-by":"crossref","first-page":"E191","DOI":"10.1111\/aor.12153","article-title":"Porous titanium-6 aluminum-4 vanadium cage has better osseointegration and less micromotion than a poly-ether-ether-ketone cage in sheep vertebral fusion","volume":"37","author":"Wu","year":"2013","journal-title":"Artif Organs"},{"key":"10.1016\/j.jot.2020.06.004_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00389746","article-title":"The repair process in experimentally induced avascular necrosis of the femoral head in dogs","volume":"99","author":"Takaoka","year":"1981","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jot.2020.06.004_bib23","first-page":"1117","article-title":"Nontraumatic osteonecrosis of the femoral head: ten years later","volume":"88","author":"Mont","year":"2006","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.jot.2020.06.004_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1302\/2058-5241.4.180036","article-title":"Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment","volume":"4","author":"Petek","year":"2019","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.jot.2020.06.004_bib25","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/jor.24124","article-title":"Effects of sclerotic changes on stress concentration in early-stage osteonecrosis: a patient-specific, 3D finite element analysis","volume":"36","author":"Utsunomiya","year":"2018","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.jot.2020.06.004_bib26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jss.2014.12.007","article-title":"Core decompression treatment of early-stage osteonecrosis of femoral head resulted from venous stasis or artery blood supply insufficiency","volume":"194","author":"Zhao","year":"2015","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jot.2020.06.004_bib27","doi-asserted-by":"crossref","first-page":"601763","DOI":"10.1155\/2012\/601763","article-title":"The pathogenesis of nontraumatic osteonecrosis","volume":"2012","author":"Seamon","year":"2012","journal-title":"Arthritis"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:41:15Z","timestamp":1761993675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X20300838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":27,"alternative-id":["S2214031X20300838"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2020.06.004","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An animal model of early-stage femoral head osteonecrosis induced by cryo-insult in small tailed Han sheep","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2020.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}