{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T02:18:24Z","timestamp":1770603504605,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017E0274"],"award-info":[{"award-number":["2017E0274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972047"],"award-info":[{"award-number":["81972047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jot.2020.08.005","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T04:20:24Z","timestamp":1615263624000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-7656","authenticated-orcid":false,"given":"Jun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5964-579X","authenticated-orcid":false,"given":"Shibi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoye","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-5758","authenticated-orcid":false,"given":"Yiqun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-3730","authenticated-orcid":false,"given":"Sida","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-9288","authenticated-orcid":false,"given":"Jiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jot.2020.08.005_bib1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/14397595.2014.932038","article-title":"Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan","volume":"25","author":"Ikeuchi","year":"2015","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.jot.2020.08.005_bib2","first-page":"337","volume":"vol. 52","author":"Lieberman","year":"2003"},{"issue":"21","key":"10.1016\/j.jot.2020.08.005_bib3","first-page":"2843","article-title":"Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative","volume":"128","author":"Zhao","year":"2015","journal-title":"Survey"},{"issue":"19","key":"10.1016\/j.jot.2020.08.005_bib4","first-page":"1604","article-title":"Nontraumatic osteonecrosis of the femoral head: where do we stand today?","volume":"97","author":"Mont","year":"2015","journal-title":"A\u00a0Ten-Year Update"},{"issue":"5484","key":"10.1016\/j.jot.2020.08.005_bib5","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science"},{"issue":"34","key":"10.1016\/j.jot.2020.08.005_bib6","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1016\/j.biomaterials.2005.04.059","article-title":"Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells","volume":"26","author":"von Knoch","year":"2005","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jot.2020.08.005_bib7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.orthres.2004.11.015","article-title":"zoledronic acid improves femoral head sphericity in a rat model of perthes disease","volume":"23","author":"Graham Little","year":"2005","journal-title":"J\u00a0Orthoped Res"},{"issue":"6","key":"10.1016\/j.jot.2020.08.005_bib8","first-page":"547","article-title":"Effects of zoledronic acid and vitamin E on surgical- induced osteonecrosis of the femoral head in rabbit","volume":"6","author":"Gharanizadeh","year":"2018","journal-title":"Archives Bone Jt Surg"},{"issue":"1","key":"10.1016\/j.jot.2020.08.005_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-019-1152-7","article-title":"Bisphosphonate combination therapy for non-femoral avascular necrosis","volume":"14","author":"Agarwala","year":"2019","journal-title":"J\u00a0Orthop Surg Res"},{"issue":"14","key":"10.1016\/j.jot.2020.08.005_bib10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2106\/JBJS.N.01157","article-title":"Does zoledronate prevent femoral head Collapse from osteonecrosis? A prospective, randomized, open-label, multicenter study","volume":"97","author":"Lee","year":"2015","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"key":"10.1016\/j.jot.2020.08.005_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jot.2020.04.007","article-title":"MiR-21 nanocapsules promote early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"24","author":"Sun","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"issue":"9","key":"10.1016\/j.jot.2020.08.005_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5312\/wjo.v9.i9.120","article-title":"Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: an experimental study in canines","volume":"9","author":"Dailiana","year":"2018","journal-title":"World J Orthoped"},{"issue":"22","key":"10.1016\/j.jot.2020.08.005_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJM199205283262206","article-title":"Nontraumatic necrosis of bone (osteonecrosis)","volume":"326","author":"Mankin","year":"1992","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.jot.2020.08.005_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0049-0172(05)80026-5","article-title":"Osteonecrosis: current perspectives on pathogenesis and treatment","volume":"23","author":"Chang","year":"1993","journal-title":"Seminars Arthritis Rheumat"},{"issue":"8","key":"10.1016\/j.jot.2020.08.005_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.5312\/wjo.v6.i8.590","article-title":"Current concepts on osteonecrosis of the femoral head","volume":"6","author":"Moya-Angeler","year":"2015","journal-title":"World J Orthoped"},{"issue":"2","key":"10.1016\/j.jot.2020.08.005_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5435\/JAAOS-D-14-00431","article-title":"Osteonecrosis of the femoral head: evaluation and treatment","volume":"23","author":"van der Jagt","year":"2015","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"17","key":"10.1016\/j.jot.2020.08.005_bib17","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s40265-016-0662-4","article-title":"zoledronic acid (reclast, aclasta): a review in osteoporosis","volume":"76","author":"Dhillon","year":"2016","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/j.jot.2020.08.005_bib18","first-page":"81","article-title":"Antiresorptive therapies for osteoporosis: a clinical overview","volume":"8","author":"Chen","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jot.2020.08.005_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2106\/JBJS.G.01193","article-title":"The effect of a single infusion of zoledronic acid on early implant migration in total hip arthroplasty. A randomized, double-blind, controlled trial","volume":"91","author":"Friedl","year":"2009","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"issue":"4","key":"10.1016\/j.jot.2020.08.005_bib20","first-page":"330","article-title":"Effect and mechanism of zoledronate on prevention of collapse in osteonecrosis of the femoral head. Zhongguo yi xue ke xue yuan xue bao","volume":"34","author":"Fan","year":"2012","journal-title":"Acta Acad Med Sin"},{"issue":"5","key":"10.1016\/j.jot.2020.08.005_bib21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bone.2009.04.255","article-title":"Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease","volume":"45","author":"Johannesen","year":"2009","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.jot.2020.08.005_bib22","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.2106\/JBJS.F.00964","article-title":"Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents","volume":"89","author":"Ramachandran","year":"2007","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"7","key":"10.1016\/j.jot.2020.08.005_bib23","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/pbc.22428","article-title":"Use of bisphosphonates for the treatment of osteonecrosis as a complication of therapy for childhood acute lymphoblastic leukaemia (ALL)","volume":"54","author":"Kotecha","year":"2010","journal-title":"Pediatr Blood Canc"},{"issue":"2","key":"10.1016\/j.jot.2020.08.005_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1515\/JPEM.2006.19.2.161","article-title":"Pamidronate treatment of steroid associated osteonecrosis in young patients treated for acute lymphoblastic leukaemia--two-year outcomes","volume":"19","author":"Nguyen","year":"2006","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.jot.2020.08.005_bib25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2106\/JBJS.J.00716","article-title":"Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that stimulates bone formation and decreases femoral head deformity","volume":"93","author":"Vandermeer","year":"2011","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"5","key":"10.1016\/j.jot.2020.08.005_bib26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jot.2020.08.005_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119828","article-title":"Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model","volume":"238","author":"Zheng","year":"2020","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jot.2020.08.005_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","article-title":"Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws","volume":"144","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jot.2020.08.005_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biomaterials.2018.09.030","article-title":"The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis","volume":"187","author":"Maruyama","year":"2018","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jot.2020.08.005_bib30","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1159\/000484026","article-title":"Adenovirus-mediated expression of BMP-2 and BFGF in bone marrow mesenchymal stem cells combined with demineralized bone matrix for repair of femoral head osteonecrosis in beagle dogs","volume":"43","author":"Peng","year":"2017","journal-title":"Cell Physiol Biochem"},{"issue":"17\u201318","key":"10.1016\/j.jot.2020.08.005_bib31","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/ten.tea.2019.0339","article-title":"Effect of allogeneic cell-based tissue engineered treatments in a sheep osteonecrosis model","volume":"26","author":"L\u00f3pez-Fern\u00e1ndez","year":"2020","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.jot.2020.08.005_bib32","first-page":"406","article-title":"The combined therapy of tantalum rod implantation and vascularized bone transplantation for femoral head osteonecrosis: a retrospective long-term follow-up survival analysis","volume":"35","author":"Zhao","year":"2019","journal-title":"Surg Technol Int"},{"key":"10.1016\/j.jot.2020.08.005_bib33","article-title":"Addition of bone marrow stem cells therapy achieves better clinical outcomes and lower rates of disease progression compared with core decompression alone for early stage osteonecrosis of the femoral head: a systematic review and meta-analysis","author":"Zhang","year":"2020","journal-title":"J\u00a0Am Acad Orthop Surg"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20300991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:41:46Z","timestamp":1761993706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X20300991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":33,"alternative-id":["S2214031X20300991"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2020.08.005","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2020.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}