{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:55:54Z","timestamp":1768557354951,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014980","name":"Wannan Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jot.2020.10.006","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T06:13:02Z","timestamp":1609135982000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Parathyroid hormone (1\u201334) can reverse the negative effect of valproic acid on the osseointegration of titanium rods in ovariectomized rats"],"prefix":"10.1016","volume":"27","author":[{"given":"Zhou-Shan","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Shu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Guang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jot.2020.10.006_bib1","article-title":"Pentraxin 3 promotes the osteoblastic differentiation of MC3T3-E1 cells through the PI3K\/Akt signaling pathway","volume":"40","author":"Y","year":"2020","journal-title":"Biosci Rep"},{"issue":"5","key":"10.1016\/j.jot.2020.10.006_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1302\/2046-3758.65.BJR-2017-0028.R1","article-title":"The influence of cement thickness on stem subsidence and cement creep in a collarless polished tapered stem:When are thick cement mantles detrimental?","volume":"6","author":"Takahashi","year":"2017","journal-title":"Bone & joint research"},{"issue":"5","key":"10.1016\/j.jot.2020.10.006_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1590\/1678-7757-2016-0561","article-title":"Effects of continual intermittent administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model","volume":"25","author":"Oki","year":"2017","journal-title":"J\u00a0Appl Oral Sci"},{"issue":"10","key":"10.1016\/j.jot.2020.10.006_bib4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.injury.2009.06.218","article-title":"The influence of osteoporosis in femoral fracture healing time","volume":"40","author":"Nikolaou","year":"2009","journal-title":"Inj Extra"},{"issue":"1","key":"10.1016\/j.jot.2020.10.006_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/ID.0b013e31803276c8","article-title":"Medical contraindications to implant therapy: Part II: relative contraindications","volume":"16","author":"Debby","year":"2007","journal-title":"Implant Dent"},{"key":"10.1016\/j.jot.2020.10.006_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.yebeh.2015.01.021","article-title":"Survey of risk factors for osteoporosis and osteoprotective behaviors among patients with epilepsy","volume":"45","author":"M","year":"2015","journal-title":"Epilepsy Behav : E&B"},{"issue":"1","key":"10.1016\/j.jot.2020.10.006_bib7","first-page":"107","article-title":"Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis","volume":"68","author":"N","year":"2011","journal-title":"Arch Neurol"},{"issue":"9","key":"10.1016\/j.jot.2020.10.006_bib8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1212\/01.wnl.0000210503.89488.88","article-title":"Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy","volume":"66","author":"Pc","year":"2006","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jot.2020.10.006_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pediatrneurol.2004.03.021","article-title":"Effect of carbamazepine and valproate on bone mineral density","volume":"31","author":"Ecevit","year":"2004","journal-title":"Pediatr Neurol"},{"issue":"3","key":"10.1016\/j.jot.2020.10.006_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2174\/187152711794653797","article-title":"Homocysteine in neurological disease: a marker or a cause?","volume":"10","author":"S","year":"2011","journal-title":"CNS Neurol Disord - Drug Targets"},{"key":"10.1016\/j.jot.2020.10.006_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.drudis.2009.01.004","article-title":"Insights into liaison between antiepileptic drugs and bone","volume":"14","author":"S","year":"2009","journal-title":"Drug Discov Today"},{"issue":"5","key":"10.1016\/j.jot.2020.10.006_bib12","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00198-019-05183-4","article-title":"Osteoporosis drugs for prevention of clinical fracture in white postmenopausal women: a network meta-analysis of survival data","volume":"31","author":"Ll","year":"2020","journal-title":"Osteoporos Int : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"issue":"3","key":"10.1016\/j.jot.2020.10.006_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jbmr.238","article-title":"Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis","volume":"26","author":"F","year":"2011","journal-title":"J\u00a0Bone Miner Res : the official journal of the American Society for Bone and Mineral Research"},{"issue":"6","key":"10.1016\/j.jot.2020.10.006_bib14","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2106\/JBJS.H.01030","article-title":"Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trials","volume":"91","author":"Ml","year":"2009","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"issue":"3","key":"10.1016\/j.jot.2020.10.006_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10856-015-5650-9","article-title":"The effects of combined human parathyroid hormone (1-34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenia rats femurs","volume":"27","author":"Zs","year":"2016","journal-title":"J\u00a0Mater Sci Mater Med"},{"issue":"7","key":"10.1016\/j.jot.2020.10.006_bib16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1177\/0885328215610898","article-title":"Intermittent administration of human parathyroid hormone (1-34) increases fixation of strontium-doped hydroxyapatite coating titanium implants via electrochemical deposition in ovariectomized rat femur","volume":"30","author":"Zs","year":"2016","journal-title":"J\u00a0Biomater Appl"},{"issue":"2","key":"10.1016\/j.jot.2020.10.006_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00391-018-1376-x","article-title":"Prevention of ovariectomy-induced osteoporosis in rats : comparative study of zoledronic acid, parathyroid hormone (1-34) and strontium ranelate","volume":"52","author":"Zs","year":"2019","journal-title":"Zeitschrift fur Gerontologie und Geriatrie"},{"issue":"5","key":"10.1016\/j.jot.2020.10.006_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00391-015-0949-1","article-title":"Effect of teriparatide on repair of femoral metaphyseal defect in ovariectomized rats","volume":"49","author":"Zs","year":"2016","journal-title":"Zeitschrift fur Gerontologie und Geriatrie"},{"key":"10.1016\/j.jot.2020.10.006_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bone.2018.05.011","article-title":"The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Want inhibitors in normal and ovariectomised rats","volume":"113","author":"Parveen","year":"2018","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.jot.2020.10.006_bib20","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1177\/0885328215610898","article-title":"Intermittent administration of human parathyroid hormone (1-34) increases fixation of strontium-doped hydroxyapatite coating titanium implants via electrochemical deposition in ovariectomized rat femur","volume":"30","author":"Tao","year":"2016","journal-title":"J\u00a0Biomater Appl"},{"issue":"3","key":"10.1016\/j.jot.2020.10.006_bib21","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00198-012-2258-5","article-title":"Promotion of peri-implant bone healing by systemically administered parathyroid hormone (1-34) and zoledronic acid adsorbed onto the implant surface","volume":"24","author":"Li","year":"2013","journal-title":"Osteoporos Int : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"issue":"1","key":"10.1016\/j.jot.2020.10.006_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1359\/jbmr.070901","article-title":"Trabecular bone gradient in rat long bone metaphyses: mathematical modeling and application to morphometric measurements and correction of implant positioning","volume":"23","author":"Gabet","year":"2008","journal-title":"J\u00a0Bone Miner Res"},{"issue":"6","key":"10.1016\/j.jot.2020.10.006_bib23","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s00774-019-01008-w","article-title":"Local administration of aspirin with \u03b2-tricalcium phosphate\/poly-lactic-co-glycolic acid (\u03b2-TCP\/PLGA) could enhance osteoporotic bone regeneration","volume":"37","author":"Zs","year":"2019","journal-title":"J\u00a0Bone Miner Metabol"},{"issue":"7","key":"10.1016\/j.jot.2020.10.006_bib24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1177\/0885328219889630","article-title":"Local administration of aspirin improves osseointegration of hydroxyapatite-coated titanium implants in ovariectomized rats through activation of the Notch signaling pathway","volume":"34","author":"Z","year":"2020","journal-title":"J\u00a0Biomater Appl"},{"issue":"34","key":"10.1016\/j.jot.2020.10.006_bib25","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1016\/j.biomaterials.2010.07.112","article-title":"The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats","volume":"31","author":"Li","year":"2010","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jot.2020.10.006_bib26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/0885328219863290","article-title":"Local administration with silymarin could increase osseointegration of hydroxyapatite-coated titanium implants in ovariectomized rats","volume":"34","author":"Zs","year":"2019","journal-title":"J\u00a0Biomater Appl"},{"issue":"6","key":"10.1016\/j.jot.2020.10.006_bib27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jbm.b.32913","article-title":"Hydroxyapatite\/collagen nanocomposite-coated titanium rod for achieving rapid osseointegration onto bone surface \u2020","volume":"101B","author":"Uezono","year":"2013","journal-title":"J\u00a0Biomed Mater Res B Appl Biomater"},{"issue":"7","key":"10.1016\/j.jot.2020.10.006_bib28","article-title":"Bioactive surfaces vs. Conventional surfaces in titanium dental implants: a comparative systematic review","volume":"9","author":"L-V","year":"2020","journal-title":"J\u00a0Clin Med"},{"issue":"12","key":"10.1016\/j.jot.2020.10.006_bib29","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1039\/D0BM00443J","article-title":"Tailorable hierarchical structures of biomimetic hydroxyapatite micro\/nano particles promoting endocytosis and osteogenic differentiation of stem cells","volume":"8","author":"X","year":"2020","journal-title":"Biomaterials science"},{"key":"10.1016\/j.jot.2020.10.006_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bone.2018.05.011","article-title":"The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Want inhibitors in normal and ovariectomised rats","volume":"113","author":"B","year":"2018","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jot.2020.10.006_bib31","first-page":"36","article-title":"Antiepileptic drugs and bone health: current concepts","volume":"50","author":"A","year":"2020","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.jot.2020.10.006_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pediatrneurol.2019.06.020","article-title":"Bone health screening practices among neurologists in patients on antiepileptic drugs: a quality improvement Project","volume":"102","author":"Aa","year":"2020","journal-title":"Pediatr Neurol"},{"issue":"8","key":"10.1016\/j.jot.2020.10.006_bib33","first-page":"511","article-title":"Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: a Meta-Analysis. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","volume":"51","author":"J","year":"2019"},{"issue":"2","key":"10.1016\/j.jot.2020.10.006_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10006-017-0624-3","article-title":"Immunohistochemistry evaluation of BMP-2 with \u03b2-tricalcium phosphate matrix, polylactic and polyglycolic acid gel, and calcium phosphate cement in rats","volume":"21","author":"dSdO","year":"2017","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.jot.2020.10.006_bib35","doi-asserted-by":"crossref","first-page":"115732","DOI":"10.1016\/j.carbpol.2019.115732","article-title":"Two novel polysaccharides from rhizomes of Cibotium barometz promote bone formation via activating the BMP2\/SMAD1 signaling pathway in MC3T3-E1 cells","volume":"231","author":"D","year":"2020","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.jot.2020.10.006_bib36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.biopha.2018.04.084","article-title":"Bacitracin promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by stimulating the bone morphogenetic protein-2\/Smad axis","volume":"103","author":"H","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"13","key":"10.1016\/j.jot.2020.10.006_bib37","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1042\/BCJ20200036","article-title":"Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis","volume":"477","author":"Cy","year":"2020","journal-title":"Biochem J"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20301182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X20301182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:42:30Z","timestamp":1761993750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X20301182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":37,"alternative-id":["S2214031X20301182"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2020.10.006","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid hormone (1\u201334) can reverse the negative effect of valproic acid on the osseointegration of titanium rods in ovariectomized rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2020.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}