{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:57:09Z","timestamp":1770836229858,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["2020-JYB-YJ-023"],"award-info":[{"award-number":["2020-JYB-YJ-023"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2021-XJ-KYQD-001"],"award-info":[{"award-number":["2021-XJ-KYQD-001"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019ZX09731-002"],"award-info":[{"award-number":["2019ZX09731-002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030122"],"award-info":[{"award-number":["82030122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jot.2021.09.005","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T03:34:53Z","timestamp":1634873693000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19"],"prefix":"10.1016","volume":"31","author":[{"given":"Wenlong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-9850","authenticated-orcid":false,"given":"Biao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xugui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruizheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-3418","authenticated-orcid":false,"given":"Ruihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-8657","authenticated-orcid":false,"given":"Hengli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongpeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoran","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsheng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanguang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-1201","authenticated-orcid":false,"given":"Weiheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2021.09.005_bib1","author":"Reported"},{"key":"10.1016\/j.jot.2021.09.005_bib2","article-title":"Long-term respiratory and neurological sequelae of COVID-19","volume":"26","author":"Wang","year":"2020","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"issue":"8","key":"10.1016\/j.jot.2021.09.005_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","article-title":"Dexamethasone in hospitalized patients with covid-19","volume":"384","author":"Horby","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jot.2021.09.005_bib4","article-title":"Calycosin modulates inflammation via suppressing TLR4\/NF-\u03baB pathway and promotes bone formation to ameliorate glucocorticoid-induced osteonecrosis of the femoral head in rat","author":"Zhu","year":"2021","journal-title":"Phytother Res"},{"issue":"12","key":"10.1016\/j.jot.2021.09.005_bib5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.19.01271","article-title":"Nontraumatic osteonecrosis of the femoral head: where do we stand today?: a 5-year update","volume":"102","author":"Mont","year":"2020","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.jot.2021.09.005_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00223-010-9385-9","article-title":"Effects of p-glycoprotein on steroid-induced osteonecrosis of the femoral head","volume":"87","author":"Han","year":"2010","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"10.1016\/j.jot.2021.09.005_bib7","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1111\/os.12810","article-title":"Current treatment modalities for osteonecrosis of femoral head in mainland China: a cross-sectional study","volume":"12","author":"Huang","year":"2020","journal-title":"Orthop Surg"},{"issue":"2","key":"10.1016\/j.jot.2021.09.005_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/RHU.0b013e3181cf3464","article-title":"Osteonecrosis in patients after severe acute respiratory syndrome (SARS): possible role of anticardiolipin antibodies","volume":"16","author":"Sun","year":"2010","journal-title":"J\u00a0Clin Rheumatol"},{"key":"10.1016\/j.jot.2021.09.005_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jot.2020.03.014","article-title":"Chinese herbal Huo-Gu formula for the treatment of steroid-associated osteonecrosis of femoral head: a 14-year follow-up of convalescent SARS patients","volume":"23","author":"Huang","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"issue":"1","key":"10.1016\/j.jot.2021.09.005_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.arth.2018.09.005","article-title":"Etiologic classification criteria of ARCO on femoral head osteonecrosis Part 1: glucocorticoid-associated osteonecrosis","volume":"34","author":"Yoon","year":"2019","journal-title":"J\u00a0Arthroplasty"},{"issue":"15","key":"10.1016\/j.jot.2021.09.005_bib11","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"J\u00a0Am Med Assoc"},{"issue":"3","key":"10.1016\/j.jot.2021.09.005_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/XEB.0000000000000055","article-title":"Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach","volume":"13","author":"Aromataris","year":"2015","journal-title":"Int J Evid Base Healthc"},{"issue":"3","key":"10.1016\/j.jot.2021.09.005_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00264-018-4172-8","article-title":"Osteonecrosis of the femoral head: genetic basis","volume":"43","author":"Wang","year":"2019","journal-title":"Int Orthop"},{"issue":"5","key":"10.1016\/j.jot.2021.09.005_bib15","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s11033-014-3173-y","article-title":"Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population","volume":"41","author":"Zhang","year":"2014","journal-title":"Mol Biol Rep"},{"issue":"11","key":"10.1016\/j.jot.2021.09.005_bib16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/00008571-200311000-00003","article-title":"ABCB1 C3435T and G2677T\/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation","volume":"13","author":"Asano","year":"2003","journal-title":"Pharmacogenetics"},{"issue":"12","key":"10.1016\/j.jot.2021.09.005_bib17","first-page":"930","article-title":"MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus","volume":"62","author":"Yang","year":"2007","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.jot.2021.09.005_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2015.03.023","article-title":"Association of ABCB1\/MDR1 polymorphisms in patients with glucocorticoid-induced osteonecrosis of the femoral head: evidence for a meta-analysis","volume":"569","author":"Zhou","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.jot.2021.09.005_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2019.03.008","article-title":"Discovery and validation an eight-biomarker serum gene signature for the diagnosis of steroid-induced osteonecrosis of the femoral head","volume":"122","author":"Li","year":"2019","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jot.2021.09.005_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00264-013-1775-y","article-title":"The natural history of asymptomatic osteonecrosis of the femoral head","volume":"37","author":"Kang","year":"2013","journal-title":"Int Orthop"},{"issue":"2","key":"10.1016\/j.jot.2021.09.005_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5435\/JAAOS-D-14-00431","article-title":"Osteonecrosis of the femoral head: evaluation and treatment","volume":"23","author":"van der Jagt","year":"2015","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"21","key":"10.1016\/j.jot.2021.09.005_bib22","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.4103\/0366-6999.217094","article-title":"Corticosteroid-induced osteonecrosis of the femoral head: detection, diagnosis, and treatment in earlier stages","volume":"130","author":"Liu","year":"2017","journal-title":"Chin Med J"},{"key":"10.1016\/j.jot.2021.09.005_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","article-title":"Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)","volume":"21","author":"Zhao","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"issue":"6","key":"10.1016\/j.jot.2021.09.005_bib24","first-page":"849","article-title":"[Diagnostic criteria, staging system and classification of idiopathic osteonecrosis of the femoral head]","volume":"17","author":"Ohzono","year":"2007","journal-title":"Clin Calcium"},{"key":"10.1016\/j.jot.2021.09.005_bib25","doi-asserted-by":"crossref","first-page":"551470","DOI":"10.3389\/fnhum.2020.551470","article-title":"Abnormal spatial patterns of intrinsic brain activity in osteonecrosis of the femoral head: a resting-state functional magnetic resonance imaging study","volume":"14","author":"Feng","year":"2020","journal-title":"Front Hum Neurosci"},{"issue":"3","key":"10.1016\/j.jot.2021.09.005_bib26","first-page":"4","volume":"32","year":"2020","journal-title":"Chinese medicine Osteopathy"},{"issue":"8","key":"10.1016\/j.jot.2021.09.005_bib27","first-page":"1031","volume":"34","author":"Bone","year":"2020","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"issue":"12","key":"10.1016\/j.jot.2021.09.005_bib28","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2106\/JBJS.I.00575","article-title":"The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review","volume":"92","author":"Mont","year":"2010","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jot.2021.09.005_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s13018-020-02069-8","article-title":"Dynamic evolution of osseous structure in osteonecrosis of the femoral head and dynamic collapse risks: a preliminary CT image study","volume":"15","author":"Huang","year":"2020","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.jot.2021.09.005_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jot.2019.10.010","article-title":"Three-dimensional distribution of cystic lesions in osteonecrosis of the femoral head","volume":"22","author":"Liu","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"issue":"1","key":"10.1016\/j.jot.2021.09.005_bib31","first-page":"13","article-title":"Is there a role of pharmacological treatments in the prevention or treatment of osteonecrosis of the femoral head?: a systematic review","volume":"26","author":"Lee","year":"2019","journal-title":"J\u00a0Bone Metab"},{"key":"10.1016\/j.jot.2021.09.005_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jot.2017.11.001","article-title":"Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial","volume":"12","author":"Li","year":"2018","journal-title":"J\u00a0Orthop Translat"},{"issue":"21","key":"10.1016\/j.jot.2021.09.005_bib33","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4103\/0366-6999.244111","article-title":"Pericollapse stage of osteonecrosis of the femoral head: a last chance for joint preservation","volume":"131","author":"Zhang","year":"2018","journal-title":"Chin Med J"},{"issue":"36","key":"10.1016\/j.jot.2021.09.005_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012196","article-title":"Chinese herbal medicine formulas as adjuvant therapy for osteonecrosis of the femoral head: a systematic review and meta-analysis of randomized controlled trials","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jot.2021.09.005_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jot.2018.11.002","article-title":"Huo Xue Tong Luo capsule, a vasoactive herbal formula prevents progression of asymptomatic osteonecrosis of femoral head: a prospective study","volume":"18","author":"Wei","year":"2019","journal-title":"J\u00a0Orthop Translat"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X21000723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X21000723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:42:02Z","timestamp":1761993722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X21000723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"alternative-id":["S2214031X21000723"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2021.09.005","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2021.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}