{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:19:43Z","timestamp":1793657983258,"version":"4.5.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["01.2.2-LMT-K-718-02-0022"],"award-info":[{"award-number":["01.2.2-LMT-K-718-02-0022"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["TKP2020-NKA-04"],"award-info":[{"award-number":["TKP2020-NKA-04"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["EFOP-3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00009"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jot.2021.10.001","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T06:43:38Z","timestamp":1639118618000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Exploring the translational potential of clusterin as a biomarker of early osteoarthritis"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-9382","authenticated-orcid":false,"given":"Ursule","family":"Kalvaityte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-7420","authenticated-orcid":false,"given":"Csaba","family":"Matta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiva","family":"Bernotiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-1880","authenticated-orcid":false,"given":"Peter Natesan","family":"Pushparaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata M.","family":"Kiapour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-1286","authenticated-orcid":false,"given":"Ali","family":"Mobasheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jot.2021.10.001_bib1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11914-018-0477-1","article-title":"Mechanisms of osteoarthritis (OA) pain","volume":"16","author":"O'Neill","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"7","key":"10.1016\/j.jot.2021.10.001_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jot.2021.10.001_bib4","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a lancet commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jot.2021.10.001_bib5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.1780300811","article-title":"The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study","volume":"30","author":"Felson","year":"1987","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.jot.2021.10.001_bib6","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/1529-0131(200109)44:9<2065::AID-ART356>3.0.CO;2-Z","article-title":"Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the Beijing Osteoarthritis Study","volume":"44","author":"Zhang","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"Suppl 8","key":"10.1016\/j.jot.2021.10.001_bib7","doi-asserted-by":"crossref","first-page":"S841","DOI":"10.1007\/s00198-012-2161-0","article-title":"Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis","volume":"23","author":"Mahjoub","year":"2012","journal-title":"Osteoporos Int"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib8","first-page":"929","article-title":"Subchondral bone changes and the impacts on joint pain and articular cartilage degeneration in osteoarthritis","volume":"34","author":"Yu","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jot.2021.10.001_bib9","first-page":"F1000Res","article-title":"Recent advances in understanding the phenotypes of osteoarthritis. [version 1; peer review: 2 approved","volume":"8","author":"Mobasheri","year":"2019"},{"issue":"10","key":"10.1016\/j.jot.2021.10.001_bib10","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jot.2021.10.001_bib11","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet."},{"issue":"11","key":"10.1016\/j.jot.2021.10.001_bib12","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.18632\/aging.103310","article-title":"Clusterin exerts a cytoprotective and antioxidant effect in human osteoarthritic cartilage","volume":"12","author":"Tarquini","year":"2020","journal-title":"Aging (Albany, NY)"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000448711","article-title":"Age-related alterations in signaling pathways in articular chondrocytes: implications for the pathogenesis and progression of osteoarthritis - a mini-review","volume":"63","author":"van der Kraan","year":"2017","journal-title":"Gerontology"},{"issue":"11","key":"10.1016\/j.jot.2021.10.001_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11926-014-0463-2","article-title":"The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis","volume":"16","author":"Andriacchi","year":"2014","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/BOR.0000000000000373","article-title":"Metabolic syndrome-associated osteoarthritis","volume":"29","author":"Courties","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jot.2021.10.001_bib16","first-page":"101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","author":"Zheng","year":"2020","journal-title":"Ageing Res Rev"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/BOR.0000000000000353","article-title":"Role of low-grade inflammation in osteoarthritis","volume":"29","author":"Scanzello","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jot.2021.10.001_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X19864492","article-title":"Update on novel pharmacological therapies for osteoarthritis","volume":"11","author":"Ghouri","year":"2019","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"11","key":"10.1016\/j.jot.2021.10.001_bib19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"american college of rheumatology\/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2019","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.semarthrit.2019.04.008","article-title":"An updated algorithm recommendation for the management of knee osteoarthritis from the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)","volume":"49","author":"Bruy\u00e8re","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jot.2021.10.001_bib23","doi-asserted-by":"crossref","first-page":"15040","DOI":"10.1038\/boneres.2015.40","article-title":"Current research on pharmacologic and regenerative therapies for osteoarthritis","volume":"4","author":"Zhang","year":"2016","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/annrheumdis-2016-209252","article-title":"Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium","volume":"76","author":"Kraus","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40674-016-0042-y","article-title":"Pharmacologic and non-pharmacologic treatment of osteoarthritis","volume":"2","author":"Yusuf","year":"2016","journal-title":"Curr Treatm Opt Rheumatol"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.berh.2005.08.001","article-title":"Do we need radiographs to diagnose osteoarthritis?","volume":"20","author":"Cibere","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00223-020-00701-7","article-title":"Osteoarthritis: current molecular biomarkers and the way forward","volume":"109","author":"Kraus","year":"2021","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.jot.2021.10.001_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1759720X12437353","article-title":"Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis","volume":"4","author":"Goldring","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib29","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/ar2172","article-title":"High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis","volume":"9","author":"Gobezie","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.jot.2021.10.001_bib30","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.drudis.2016.08.011","article-title":"Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options","volume":"21","author":"Vinatier","year":"2016","journal-title":"Drug Discov Today"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/BOR.0000000000000467","article-title":"Development and use of biochemical markers in osteoarthritis: current update","volume":"30","author":"Bay-Jensen","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jot.2021.10.001_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ebiom.2016.05.004","article-title":"The need for predictive, prognostic, objective and complementary blood-based biomarkers in osteoarthritis (OA)","volume":"7","author":"Bay-Jensen","year":"2016","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/14737159.2018.1415757","article-title":"Extracellular genomic biomarkers of osteoarthritis","volume":"18","author":"Budd","year":"2018","journal-title":"Expert Rev Mol Diagn"},{"issue":"12","key":"10.1016\/j.jot.2021.10.001_bib35","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1016\/S0021-9258(18)32238-5","article-title":"Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid","volume":"258","author":"Blaschuk","year":"1983","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib36","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1095\/biolreprod28.5.1173","article-title":"Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interactions in vitro","volume":"28","author":"Fritz","year":"1983","journal-title":"Biol Reprod"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib37","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1432-1033.1994.tb18807.x","article-title":"Molecular characterization of human TRPM-2\/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration","volume":"221","author":"Wong","year":"1994","journal-title":"Eur J Biochem"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1083\/jcb.122.5.1119","article-title":"Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis","volume":"122","author":"French","year":"1993","journal-title":"J\u00a0Cell Biol"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib39","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1006\/bbrc.1994.2580","article-title":"Purification and characterization of brain clusterin","volume":"204","author":"Oda","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/excr.2000.4885","article-title":"Clusterin protects granulosa cells from apoptotic cell death during follicular atresia","volume":"257","author":"Zwain","year":"2000","journal-title":"Exp Cell Res"},{"issue":"11","key":"10.1016\/j.jot.2021.10.001_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111442","article-title":"Clusterin attenuates hepatic fibrosis by inhibiting hepatic stellate cell activation and downregulating the smad3 signaling pathway","volume":"8","author":"Seo","year":"2019","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.jot.2021.10.001_bib42","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.4103\/1673-5374.301013","article-title":"Clusterin: a multifaceted protein in the brain","volume":"16","author":"Moon","year":"2021","journal-title":"Neural Regen Res"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10741-017-9654-z","article-title":"Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes","volume":"23","author":"Pereira","year":"2018","journal-title":"Heart Fail Rev"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/bmc-2015-0026","article-title":"The CLU-files: disentanglement of a mystery","volume":"7","author":"Rohne","year":"2016","journal-title":"Biomol Concepts"},{"issue":"6","key":"10.1016\/j.jot.2021.10.001_bib45","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000351207","article-title":"The molecular chaperone apolipoprotein J\/clusterin as a sensor of oxidative stress: implications in therapeutic approaches - a mini-review","volume":"59","author":"Trougakos","year":"2013","journal-title":"Gerontology"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib46","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1357-2725(01)00155-8","volume":"34","author":"Jones","year":"2002","journal-title":"Clusterin. Int J Biochem Cell Biol."},{"issue":"12","key":"10.1016\/j.jot.2021.10.001_bib47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/15216540310001640498","article-title":"Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?","volume":"55","author":"Carver","year":"2003","journal-title":"IUBMB Life"},{"issue":"9","key":"10.1016\/j.jot.2021.10.001_bib48","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.4049\/jimmunol.177.9.6471","article-title":"Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis","volume":"177","author":"Devauchelle","year":"2006","journal-title":"J\u00a0Immunol"},{"issue":"12","key":"10.1016\/j.jot.2021.10.001_bib49","doi-asserted-by":"crossref","first-page":"16276","DOI":"10.1096\/fj.202000551RR","article-title":"Regulation of adipocyte differentiation by clusterin-mediated Kr\u00fcppel-like factor 5 stabilization","volume":"34","author":"Oh","year":"2020","journal-title":"Faseb J"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ki.1995.54","article-title":"Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration","volume":"47","author":"Gob\u00e9","year":"1995","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/14728222.2017.1267142","article-title":"Clusterin as a therapeutic target","volume":"21","author":"Wilson","year":"2017","journal-title":"Expert Opin Ther Targets"},{"issue":"51","key":"10.1016\/j.jot.2021.10.001_bib52","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.1021\/bi002189x","article-title":"Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state","volume":"39","author":"Poon","year":"2000","journal-title":"Biochemistry"},{"issue":"Pt 1","key":"10.1016\/j.jot.2021.10.001_bib53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/bj3280045","article-title":"Stress-induced transcription of the clusterin\/apoJ gene","volume":"328","author":"Michel","year":"1997","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib54","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/bi062082v","article-title":"Effects of glycosylation on the structure and function of the extracellular chaperone clusterin","volume":"46","author":"Stewart","year":"2007","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.jot.2021.10.001_bib55","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.tibs.2021.01.005","article-title":"The dual roles of clusterin in extracellular and intracellular proteostasis","volume":"46","author":"Satapathy","year":"2021","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib56","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1600-0854.2007.00549.x","article-title":"Stress-induced retrotranslocation of clusterin\/ApoJ into the cytosol","volume":"8","author":"Nizard","year":"2007","journal-title":"Traffic"},{"issue":"13","key":"10.1016\/j.jot.2021.10.001_bib57","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M209233200","article-title":"Synthesis and functional analyses of nuclear clusterin, a cell death protein","volume":"278","author":"Leskov","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib58","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/1078-0432.CCR-08-1805","article-title":"Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex","volume":"15","author":"Trougakos","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"16","key":"10.1016\/j.jot.2021.10.001_bib59","doi-asserted-by":"crossref","first-page":"9530","DOI":"10.1073\/pnas.1233633100","article-title":"Clusterin as a biomarker in murine and human intestinal neoplasia","volume":"100","author":"Chen","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.jot.2021.10.001_bib60","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jamaneurol.2013.4560","article-title":"The role of clusterin in amyloid-\u03b2-associated neurodegeneration","volume":"71","author":"Desikan","year":"2014","journal-title":"JAMA Neurol"},{"issue":"7","key":"10.1016\/j.jot.2021.10.001_bib61","doi-asserted-by":"crossref","first-page":"e103351","DOI":"10.1371\/journal.pone.0103351","article-title":"Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation","volume":"9","author":"Won","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2021.10.001_bib62","article-title":"Clusterin is associated with systemic and synovial inflammation in knee osteoarthritis","author":"Ungsudechachai","year":"2020","journal-title":"Cartilage"},{"issue":"7","key":"10.1016\/j.jot.2021.10.001_bib63","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1053\/joca.2001.0421","article-title":"Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries","volume":"9","author":"Kumar","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.jot.2021.10.001_bib64","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1053\/joca.2001.0475","article-title":"Clusterin expression in adult human normal and osteoarthritic articular cartilage","volume":"9","author":"Connor","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.jot.2021.10.001_bib65","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/1354750X.2016.1140930","article-title":"Biomarkers of (osteo)arthritis","volume":"20","author":"Mobasheri","year":"2015","journal-title":"Biomarkers"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1477-5956-10-36","article-title":"Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system","volume":"10","author":"Fukuda","year":"2012","journal-title":"Proteome Sci"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib67","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13075-014-0456-6","article-title":"Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis","volume":"16","author":"Ritter","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"10.1016\/j.jot.2021.10.001_bib68","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1074\/mcp.RA119.001554","article-title":"Analysis of endogenous peptides released from osteoarthritic cartilage unravels novel pathogenic markers","volume":"18","author":"Fern\u00e1ndez-Puente","year":"2019","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib69","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12891-018-2179-3","article-title":"Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain","volume":"19","author":"Krop\u00e1\u010dkov\u00e1","year":"2018","journal-title":"BMC Muscoskel Disord"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212662","article-title":"Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: proteomics analysis of porcine knee synovial fluid","volume":"14","author":"Kiapour","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jot.2021.10.001_bib71","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1947603513477652","article-title":"Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation","volume":"4","author":"McCarthy","year":"2013","journal-title":"Cartilage"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib72","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/rheumatology\/key232","article-title":"Functional analysis of synovial fluid from osteoarthritic knee and carpometacarpal joints unravels different molecular profiles","volume":"58","author":"Barreto","year":"2019","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib73","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/jor.24814","article-title":"Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1\u03b2 and tumor necrosis factor-\u03b1 in models of cartilage degradation","volume":"39","author":"Matta","year":"2021","journal-title":"J\u00a0Orthop Res"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40478-017-0481-1","article-title":"Clusterin protects neurons against intracellular proteotoxicity","volume":"5","author":"Gregory","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.jot.2021.10.001_bib75","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-015-0024-9","article-title":"Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations","volume":"10","author":"Bettens","year":"2015","journal-title":"Mol Neurodegener"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib76","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jprot.2011.02.017","article-title":"High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation","volume":"74","author":"Clutterbuck","year":"2011","journal-title":"J\u00a0Proteomics"},{"issue":"8","key":"10.1016\/j.jot.2021.10.001_bib77","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.joca.2017.02.797","article-title":"Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis","volume":"25","author":"Sanchez","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.jot.2021.10.001_bib78","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/1066896913492195","article-title":"Podoplanin and clusterin are reliable markers of nonneoplastic synovium at various sites","volume":"21","author":"Talmon","year":"2013","journal-title":"Int J Surg Pathol"},{"issue":"5","key":"10.1016\/j.jot.2021.10.001_bib79","first-page":"745","article-title":"Increased expression levels of apolipoprotein J\/clusterin during primary osteoarthritis","volume":"25","author":"Fandridis","year":"2011","journal-title":"In Vivo"},{"issue":"1","key":"10.1016\/j.jot.2021.10.001_bib80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1039\/B712728F","article-title":"Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity","volume":"4","author":"Wilson","year":"2008","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.jot.2021.10.001_bib81","doi-asserted-by":"crossref","first-page":"111174","DOI":"10.1016\/j.biopha.2020.111174","article-title":"Always protecting. Synthesis, function and potential issues","volume":"134","author":"Rodr\u00edguez-Rivera","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X21000760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X21000760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:42:11Z","timestamp":1761993731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X21000760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":81,"alternative-id":["S2214031X21000760"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2021.10.001","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the translational potential of clusterin as a biomarker of early osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2021.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}