{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T02:53:54Z","timestamp":1778986434855,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003803","name":"The University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic Translation"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jot.2022.12.006","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T17:09:03Z","timestamp":1673370543000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model"],"prefix":"10.1016","volume":"39","author":[{"given":"Wang-yong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-3705","authenticated-orcid":false,"given":"Wei-fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmiao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-ying","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-7081","authenticated-orcid":false,"given":"Jiaxin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7143-3370","authenticated-orcid":false,"given":"Yu-xiong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jot.2022.12.006_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.jot.2022.12.006_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jot.2022.12.006_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jbmr.2708","article-title":"Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a Task Force of the American society for bone and mineral Research","volume":"31","author":"Adler","year":"2016","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jot.2022.12.006_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"Medication-related osteonecrosis of the jaw: prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat Rev"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jocd.2016.09.005","article-title":"Case-based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the international Task Force on ONJ","volume":"20","author":"Khan","year":"2017","journal-title":"J\u00a0Clin Densitom"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1620\/tjem.247.75","article-title":"Antiresorptive agent-related osteonecrosis of the jaw (ARONJ): a twist of fate in the bone","volume":"247","author":"Shibahara","year":"2019","journal-title":"Tohoku J Exp Med"},{"issue":"5","key":"10.1016\/j.jot.2022.12.006_bib8","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American association of oral and maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jot.2022.12.006_bib10","series-title":"Antiresorptive drug-related osteonecrosis of the jaw (ARONJ): a guide to research. Davos Platz, Switzerland Stuttgart","author":"Fleisher","year":"2016"},{"issue":"5","key":"10.1016\/j.jot.2022.12.006_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/annonc\/mdr435","article-title":"Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases","volume":"23","author":"Saad","year":"2012","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1016\/j.jot.2022.12.006_bib12","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2010.31.3304","article-title":"Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma","volume":"29","author":"Henry","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"9","key":"10.1016\/j.jot.2022.12.006_bib13","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1470-2045(13)70277-8","article-title":"Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study","volume":"14","author":"Chawla","year":"2013","journal-title":"Lancet Oncol"},{"issue":"11","key":"10.1016\/j.jot.2022.12.006_bib14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14219\/jada.archive.2010.0082","article-title":"The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program","volume":"141","author":"Grbic","year":"2010","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib15","first-page":"447","article-title":"Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer","volume":"24","author":"Stopeck","year":"2016","journal-title":"Support Care Cancer"},{"issue":"35","key":"10.1016\/j.jot.2022.12.006_bib16","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.jot.2022.12.006_bib17","first-page":"33","article-title":"Bisphosphonate-related osteonecrosis of the jaws: a potential alternative to drug holidays","volume":"61","author":"Damm","year":"2013","journal-title":"Gen Dent"},{"issue":"12","key":"10.1016\/j.jot.2022.12.006_bib18","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","article-title":"Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment","volume":"65","author":"Marx","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.jot.2022.12.006_bib19","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib20","first-page":"151","article-title":"Medication related osteonecrosis of the jaw: 2015 position statement of the Korean society for bone and mineral Research and the Korean association of oral and maxillofacial Surgeons","volume":"22","author":"Kim","year":"2015","journal-title":"J\u00a0Bone Metab"},{"issue":"8","key":"10.1016\/j.jot.2022.12.006_bib21","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00198-017-4063-7","article-title":"A\u00a0multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ?","volume":"28","author":"Hasegawa","year":"2017","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00198-018-4746-8","article-title":"Medication-related osteonecrosis of the jaw after tooth extraction in cancer patients: a multicenter retrospective study","volume":"30","author":"Hasegawa","year":"2018","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s13167-019-0160-3","article-title":"Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study","volume":"10","author":"Salgueiro","year":"2019","journal-title":"EPMA J"},{"key":"10.1016\/j.jot.2022.12.006_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115412","article-title":"Alendronate or Zoledronic acid do not impair wound healing after tooth extraction in postmenopausal women with osteoporosis","volume":"137","author":"Lesclous","year":"2020","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.oooo.2021.06.003","article-title":"Tooth extractions in patients with cancer receiving high-dose antiresorptive medication: a randomized clinical feasibility trial of drug holiday versus drug continuation","volume":"133","author":"Ottesen","year":"2022","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"8","key":"10.1016\/j.jot.2022.12.006_bib26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.adaj.2017.04.002","article-title":"Effectiveness of treatments for medication-related osteonecrosis of the jaw: a systematic review and meta-analysis","volume":"148","author":"El-Rabbany","year":"2017","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"7","key":"10.1016\/j.jot.2022.12.006_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132520","article-title":"A\u00a0model for osteonecrosis of the jaw with zoledronate treatment following repeated major trauma","volume":"10","author":"Howie","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jot.2022.12.006_bib28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bone.2015.08.012","article-title":"Animal model for medication-related osteonecrosis of the jaw with precedent metabolic bone disease","volume":"81","author":"Kim","year":"2015","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","article-title":"Denosumab and bisphosphonates: different mechanisms of action and effects","volume":"48","author":"Baron","year":"2011","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00044011-200525020-00003","article-title":"Pharmacokinetic considerations in determining the terminal elimination half-lives of bisphosphonates","volume":"25","author":"Lasseter","year":"2005","journal-title":"Clin Drug Invest"},{"issue":"1","key":"10.1016\/j.jot.2022.12.006_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00774-019-01035-7","article-title":"Drug holiday clinical relevance verification for antiresorptive agents in medication-related osteonecrosis cases of the jaw","volume":"38","author":"Hayashida","year":"2019","journal-title":"J\u00a0Bone Miner Metabol"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/hed.21708","article-title":"Factors influencing surgical treatment of bisphosphonate-related osteonecrosis of the jaws","volume":"34","author":"Wutzl","year":"2012","journal-title":"Head Neck"},{"issue":"5","key":"10.1016\/j.jot.2022.12.006_bib33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5125\/jkaoms.2014.40.5.206","article-title":"Drug holiday as a prognostic factor of medication-related osteonecrosis of the jaw","volume":"40","author":"Kim","year":"2014","journal-title":"J\u00a0Korean Assoc Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.jot.2022.12.006_bib34","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijom.2006.02.022","article-title":"Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases","volume":"35","author":"Dimitrakopoulos","year":"2006","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/odi.12966","article-title":"Drug holiday patterns and bisphosphonate-related osteonecrosis of the jaw","volume":"25","author":"Jung","year":"2019","journal-title":"Oral Dis"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03795","article-title":"Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): a systematic review","volume":"6","author":"Ottesen","year":"2020","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.jot.2022.12.006_bib37","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/jbmr.2490","article-title":"OPG-fc but not zoledronic acid discontinuation reverses osteonecrosis of the jaws (ONJ) in mice","volume":"30","author":"de Molon","year":"2015","journal-title":"J\u00a0Bone Miner Res"},{"issue":"9","key":"10.1016\/j.jot.2022.12.006_bib38","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.jcms.2015.08.008","article-title":"Perioperative discontinuation of intravenous bisphosphonate therapy reduces the incidence and severity of bisphosphonate-related osteonecrosis of the jaw: a randomized, controlled, prospective experimental study in rats","volume":"43","author":"Zandi","year":"2015","journal-title":"J\u00a0Cranio-Maxillo-Fac Surg"},{"key":"10.1016\/j.jot.2022.12.006_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/0022034520986804","article-title":"Antiresorptive-type and discontinuation-timing affect ONJ burden","author":"Hadaya","year":"2021","journal-title":"J\u00a0Dent Res"},{"issue":"11","key":"10.1016\/j.jot.2022.12.006_bib40","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/jbmr.4119","article-title":"A\u00a0drug holiday reduces the frequency and severity of medication-related osteonecrosis of the jaw in a minipig model","volume":"35","author":"Otto","year":"2020","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jot.2022.12.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115560","article-title":"Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice","volume":"141","author":"Tamaki","year":"2020","journal-title":"Bone"},{"issue":"3 Suppl","key":"10.1016\/j.jot.2022.12.006_bib42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1532-3382(12)70046-5","article-title":"Antiresorptives and osteonecrosis of the jaw","volume":"12","author":"Yamashita","year":"2012","journal-title":"J\u00a0Evid Base Dent Pract"},{"issue":"5 Suppl","key":"10.1016\/j.jot.2022.12.006_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jot.2022.12.006_bib44","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.2010.05835.x","article-title":"Potential pathophysiological mechanisms in osteonecrosis of the jaw","volume":"1218","author":"Landesberg","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"10.1016\/j.jot.2022.12.006_bib45","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1359\/jbmr.070609","article-title":"Microcrack frequency and bone remodeling in postmenopausal osteoporotic women on long-term bisphosphonates: a bone biopsy study","volume":"22","author":"Chapurlat","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"issue":"11","key":"10.1016\/j.jot.2022.12.006_bib46","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (Osteonecrosis\/Osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jot.2022.12.006_bib47","first-page":"175","article-title":"Advanced Hydrogel systems for mandibular reconstruction","volume":"21","author":"Guo","year":"2023","journal-title":"Bioact Mater"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib48","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrrheum.2011.181","article-title":"Epidemiology and pathogenesis of osteonecrosis of the jaw","volume":"8","author":"Reid","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.jot.2022.12.006_bib49","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bone.2009.07.011","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?","volume":"45","author":"Lesclous","year":"2009","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jot.2022.12.006_bib50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/jnci\/djq516","article-title":"Osteonecrosis of the jaw and the role of macrophages","volume":"103","author":"Pazianas","year":"2010","journal-title":"JNCI Journal of the National Cancer Institute"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib51","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrrheum.2011.181","article-title":"Epidemiology and pathogenesis of osteonecrosis of the jaw","volume":"8","author":"Reid","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bjoms.2014.01.021","article-title":"Effect of antiresorptive drugs on bony turnover in the jaw: denosumab compared with bisphosphonates","volume":"52","author":"Ristow","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.jot.2022.12.006_bib53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jot.2020.08.005","article-title":"Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model","volume":"27","author":"Zhao","year":"2021","journal-title":"J\u00a0Orthop Translat"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/ger.12416","article-title":"Medication-related osteonecrosis of the jaw-like lesions in rodents: a comprehensive systematic review and meta-analysis","volume":"36","author":"Kuroshima","year":"2019","journal-title":"Gerodontology"},{"issue":"2","key":"10.1016\/j.jot.2022.12.006_bib55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jcms.2017.11.008","article-title":"The risk of osteonecrosis on alveolar healing after tooth extraction and systemic administration of antiresorptive drugs in rodents: a systematic review","volume":"46","author":"Poubel","year":"2018","journal-title":"J\u00a0Cranio-Maxillo-Fac Surg"},{"issue":"6","key":"10.1016\/j.jot.2022.12.006_bib56","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00223-015-0045-y","article-title":"Impact of osteonecrosis of the jaw on osteoporosis treatment in Japan: results of a questionnaire-based survey by the adequate treatment of osteoporosis (A-TOP) Research group","volume":"97","author":"Taguchi","year":"2015","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"10.1016\/j.jot.2022.12.006_bib57","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1185\/03007995.2016.1170005","article-title":"Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw","volume":"32","author":"Taguchi","year":"2016","journal-title":"Curr Med Res Opin"},{"issue":"11","key":"10.1016\/j.jot.2022.12.006_bib58","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00198-008-0604-4","article-title":"Risk of hip fracture after bisphosphonate discontinuation: implications for a drug holiday","volume":"19","author":"Curtis","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jot.2022.12.006_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jot.2019.08.004","article-title":"The efficacy and safety of denosumab in postmenopausal women with osteoporosis previously treated with bisphosphonates: a review","volume":"22","author":"Zhu","year":"2020","journal-title":"J\u00a0Orthop Translat"},{"issue":"4","key":"10.1016\/j.jot.2022.12.006_bib60","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.maturitas.2013.05.013","article-title":"Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: national Osteoporosis Guideline Group (NOGG) update 2013","volume":"75","author":"Compston","year":"2013","journal-title":"Maturitas"},{"issue":"6","key":"10.1016\/j.jot.2022.12.006_bib61","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4158\/EP.16.6.1016","article-title":"American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis: executive summary of recommendations","volume":"16","author":"Watts","year":"2010","journal-title":"Endocr Pract"},{"key":"10.1016\/j.jot.2022.12.006_bib62","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0020-1383(16)30004-3","article-title":"Main differences in osteoporotic fracture models: which should I use?","volume":"47","author":"Simpson","year":"2016","journal-title":"Injury"}],"container-title":["Journal of Orthopaedic Translation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X22001565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214031X22001565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:44:50Z","timestamp":1761993890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214031X22001565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":62,"alternative-id":["S2214031X22001565"],"URL":"https:\/\/doi.org\/10.1016\/j.jot.2022.12.006","relation":{},"ISSN":["2214-031X"],"issn-type":[{"value":"2214-031X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model","name":"articletitle","label":"Article Title"},{"value":"Journal of Orthopaedic Translation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jot.2022.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.","name":"copyright","label":"Copyright"}]}}